On the topic of NE: Maybe a2-adreno receptor blockade increased NE transmission such that post-synaptic a2 receptors were agonized and downregulated while a1 receptors were antagonized by the mirtazapine and upregulated. So upon withdrawal, a2 autoreceptors are upregulated, decreasing NE transmission (postsynaptic a2) and a1 receptors are by contrast sensitized. Then you take some time off, the NE system tries to normalize. You resume mirtazapine and then it is stimulating again because post-synaptic a2 receptors were upregulated. Speculation. If that were the case then it would just take time off the drug. It could also involve the 5-ht system. 5-ht1a upregulation would lower 5-ht transmission. Funny, the only thing I can think of that rapidly normalizes both systems is estrogen
Absolute HORSECRAP, why would you even suggest estrogen to someone suffering a panic attack?
There's no evidence that 5-HT1AR would upregulate, more than likely it would DE-SENSITIZE..
So therefore TROLL who decides to write the opposite that I have, you have zero clue and making statements like this is grounds for leaving prematurely.