5 replies to this topic

[Area-1255]

According to these studies and quotes, could we gather that skullcap is an effective 5-hT 7 ANTAGONIST?

 

Thoughts please....

 

 

J Nat Prod. 2003 Apr;66(4):535-7.

Inhibition of [3H]-LSD binding to 5-HT7 receptors by flavonoids from Scutellaria lateriflora.

Gafner S1, Bergeron C, Batcha LL, Reich J, Arnason JT, Burdette JE, Pezzuto JM, Angerhofer CK.

Author information

 

Abstract

The hot water and 70% ethanol extracts of dried mad-dog skullcap (Scutellaria lateriflora) both bound to the 5-HT(7) receptor, with 87.2 +/- 6.2% and 56.7 +/- 1.3% inhibition of [(3)H]-LSD binding to the receptor at 100 microg/mL, respectively. The on-line analysis of a 70% ethanol extract by HPLC-UV/MS resulted in the identification of five flavones (1-5). Fractionation of the ethanol extract resulted in the isolation of three flavone-glucuronides (6-8) and a flavanone-glucuronide (9), including one new compound, lateriflorin (5,6,-dihydroxy-7-glucuronyloxy-2'-methoxyflavone) (8). The structure of 8 was determined by NMR ((1)H NMR, (13)C NMR, and NOESY experiments) and MS analysis. From the results obtained in the testing of the pure compounds, it is evident that the activity on the 5-HT(7) receptor is at least partly due to the presence of flavonoids. Scutellarin and ikonnikoside I showed the highest inhibition of [(3)H]-LSD binding with IC(50) values of 63.4 and 135.1 microM, respectively.

PMID:   12713409   [PubMed - indexed for MEDLINE]

 

 

 

The applicable parts of skullcap are the above ground parts. The principle flavonoids of skullcap are baicalin and wogonin (12104, 12216). Other flavonoids found in skullcap include scutellarin, methoxyflavone, and catalpol. Skullcap also contains lignins, resins, tannins, and volatile oils (12104).
It is thought that the flavonoid constituents of skullcap might act as GABA agonists and therefore have a sedating and anxiolytic effect (12216).
Constituents of skullcap seem to bind the serotonin receptor 5-HT7. But it's not known if these constituents have agonist or antagonist properties on the receptor(12104). Skullcap's effects on the serotonin receptor may be involved in potential sedative properties.

http://westminsterresearch.wmin.ac.uk/9075/1/Brock_et_al_2010_final_author.pdf

 

 

 

 

http://examine.com/s...ia baicalensis/

http://wenku.baidu.c...9eef8c75ebfb304

http://www.mdidea.co...roper04706.html

[The Brain]

Tried Baicalin from Liftmode before with no discernible effects.

[Area-1255]

Tried Baicalin from Liftmode before with no discernible effects.

Interesting, thanks for the feedback!

[deeptrance]

I have some baicalin from Liftmode as well, and I am also experiencing no discernible effects. But some effects may not be noticeable. Any positive or negative influence on one or more aspect of physiology and/or neurology, is not discernible to the conscious mind.

[Area-1255]

I have some baicalin from Liftmode as well, and I am also experiencing no discernible effects. But some effects may not be noticeable. Any positive or negative influence on one or more aspect of physiology and/or neurology, is not discernible to the conscious mind.

Thanks for your feedback!

[the_apollo]

Tried Baicalin from Liftmode before with no discernible effects.

 

Old thread, but diddo..

Tried Baicalin (about 500mg per dosage), what i felt at most was some somnolence, no effect on anxiety, mood or cognitive functions.

though i am a bad responder at most nootropics, herbs and drugs, for me it was a waste of money, in my opinion anyway.