Word of courage there's a faint chance I might wipe the floor with sens n wilt here but as we know there are 40k year old plants that have functioning nDNA mtDNA, ribosomes, much like our own. That human systems are improvable to match that is natural.
There are different aging mechanisms. SENS only appears to cover cyte area
Newscientist has published a popular version of the science of mosaic chromosome people, these are people have phenotypes with items like patterned sweat checkerboards as clumps of body tissue use different entire genes. Women that have different versions of their two >< chromosomes at different tissue clumps have patterned sweat checkerboards. "Almost every woman is a mixture of two genetically different types of cell, and sometimes these cells can come into conflict with dramatic effect. We now believe that women's dual nature can split them into identical twins, divide them into discrete zones of disease"reference http://www.newscient...=mg17823944.200
It is published that octopus n salmon have organ directed senescence: remove the organ they live multiples longer.
A fiesty gerontologist might argue:
beyond cyte functional sens there is possible evidence that humans may have developmental program:
20th century brain grows till 10 with most people
puberty
gray hair patterns:
aside from pattern baldness one notices obvious patterning of gray at temples. with pattern baldness scalp hair transplanted to non bald area thrives, hair transplanted to patterned ares dwindles. Thinking on not-from-the-bottom-up bulk tissue effect: does gray hair transplanted from temples elsewhere go to original color. a few of my hairs have gone from gray to natural color. This transplant idea is rapidly testable, moving that to a human or mouse with mosaic chromosome dermis that has obvious varying rates of aging we may identify a new aging mechanism to conquor.
Breed Dr. Austad's long life Idaho wilderness wild type mouse with an
ordinary lab mouse to create daughter mouse with tissue mosaicism. tissue macromosaicism is then studied to describe the factors that cause, block, ameliorate the mouse's "age sag" spots with various organ systems just like characterizing the macro perspire non perspire spots on a mosaic human.
briefly: humans show developmental patterns not sourced from immediate area tissues at different times of life. brain growth, puberty, head hair patterns. These may also direct aging. Mosaic studies will test mechanisms.
telelogical nonsense:
There might be a genetic value placed on elders that have senescence programming . That is a tropism towards just the right quantity of community elderlyness builds a group's fitness. SENS is perhaps commingled with the idea that:
genes make it that we live till we reproduce, then raise kids, scientists go on to speculate that why we have oldness rather than salmon or octopus like death is related to the value of wise elders to survival. Genes that create wise elders contribute to group fitness, thusly gene survival. It is equally valid to note that a surplus of elders uses calories n changes decision making. If the gene argument is valid it is also potentially valid to note: the elderly may be programmed to wear out rapidly. It creeps me out but the unneeded Eskimo walking out onto the ice floe or the rapid catastrophic senescence of the emotionally nonattached tilt, just a wee bit, to gene programming.
opposing that argument is that S shaped curves like senescence are common to numerous processes, sens proceeds from the idea that the mean nasty high grade slope of elderly death is a nonspecific cumulative cytological thing rather programmed phenomena. Mosaic mice may tell.
Technology Yay this is basically supportive.
different than my perception of wilt, radio controlled DNA technology creates latitude to work with rapid proliferation tissues like lung, Gi tract, dermis.
MIT letter to nature about Ghz microantenna that switches DNA chemistry at breathing rates. K. Hamad-Schifferli, J.J. Schwartz, A.T. Santos, S. Zhang, J.M. Jacobson, “Remote electronic control of DNA hybridization through inductive coupling to an attached metal nanocrystal antenna”, Nature, 415 (6868), 152-5, (2002) http://www.nature.co...415152a_fs.html
That radio control technology may be a much more user happy technology to address legal cyte proliferation with tissues like GI tract that renew rapidly . I've also read that viruses which create silver nanoparticles have been created. That suggests creating an antenna virus that is radio controllable.
A different way to control mitochondia:
I thought of a way to best the: short mtDNA grab the enzymes, with thenonfunctional mitochondria ratio population result. with that idea there are Two mitochondrial DNA types: NormalmtDNA n NaughtymtDNA I think that dosing the organism with treated DNA that is more rapidly assimilated when NaughtymtDNA replicates is possible. The treatment is isotopic substitution. NaughtymtDNA that have a bunch of deuterated atoms will bog down their own replication due to the isotope effect. I may have verified that. That means that a cyte with both NormalmtDNA n NaughtymtDNA environmentally supplied with isotopically loaded DNA (molasses DNA) will favor reproduction of the high functioning normal DNA That is a way to youthify, that is change the ratio to favor normalmtDNA With old cytes like those of the elderly where up to 4/5 of the mitochondria n mtDNA are from NaughtymtDNA. Isotopic molasses DNA moves the system to favor normal mitochonrial dna.
I think that creating molasses DNA then targeting it to tissues with the MIT Ghz radio control chemistry thing creates the capacity to adjust rate of tissue activity n proliferation. Thats a way to address tissues like lungs n dermis GI tract that have rapid proliferation that might challenge "wilt". It also addresses the heart n brains as their mitochondria reproduce. The antenna virus has utility here as well.
Funny things:
telomeres are compared to shoelace tips. I think molasses DNA might be a little like um, wilderness garment gear spring tubes, I mention that as rather than having or not having telomeres one might prefer a telomere topology controller. with radio control at breathing rate.
bacteria without mitochondria are published, do they age, or do they...
regarding the ability of organisms to degrade gunk (glycosylation lipofuscin idea) There's a thing called hopanoid that is like cholesterol with more \/\/\/ The mass of hopanoid on earth is equal to the mass of plant matter. Plants given more CO2 double or better their growth. animals might degrade hopanoid I don't know. cholesterol is a known gunk. Pills that control cholesterol save lives. Pills that stimulate the liver to create enzymes might degrade hopanoids, a new potentially valuable gunk removal lifespan improver.
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