14 replies to this topic

[HappyShoe]

I noticed there are a few threads mentioning GDNF on the forums, but nothing specifically discussing it as a whole. With all the interest in BDNF and NGF enhancing compounds, and all the people here at longecity with dopamine dysfunction or just plain interested in cognitive enhancement, you'd think there would be a lot more interest in it.
This is the wikipedia link as an overview.
http://en.wikipedia....otrophic_factor

These mention it's function in the substantia nigra and the midbrain respectively
http://www.nature.co...s/373335a0.html

http://www.sciencema...t/260/5111/1130



I'm aware that pro-GDNF peptides are still in their infancy, but what about other substances which indirectly promote GDNF?

[Metagene]

The effect of gastrodin on the expression of TNF-α and GDNF in Parkinsonism rat

 

http://en.cnki.com.c...XG201001026.htm

 

Flex posted more information on gastrodin here:

 

http://www.longecity...esting-effects/

Edited by Metagene, 26 December 2014 - 07:44 PM.

[meth_use_lah]

Nice topic, I found a great in-depth article on the subject which I have attached.

 gdnf090090091.pdf   1.26MB   25 downloads

 

[eml256]

Ibogaine (Ibocaine) is a substance whose primary mechanism of action is thought to be an increase in GDNF.  It was banned in the 60's ostensibly because of its potential to induce hallucinations , though most individuals interested in its application to treat medical conditions, especially addictions, feel it was banned because of its great potential in treating addiction and the inability to patent it.  The committee that had it banned was reported to be  composed of more than a few pharmaceutical representatives and many "experts" in the addiction industry.  It was hoped to revolutionize the treatment of addictions.  A researcher from the univ of Miami,  Deborah Mash ,has processed ibogaine to remove the compound which caused hallucinations, leaving the substance which increases GDNF intact.  

http://www.ibogaine....ami-update.html

the drug is being studied for alcohol addiction at the Univ of San Francisco Med center at present.  have no idea the status of the clinical trials.

[Fenix_]

According to this article, cerebrolysin contains GDNF.

 

http://www.ncbi.nlm....pubmed/21886595

 

 

Since activation of pain pathways result in exhaustion of growth factors, we examined the influence of cerebrolysin, a mixture of potent growth factors (BDNF, GDNF, NGF, CNTF etc,) on morphine induced HSP expression.

 

Also, I am not sure if ibogaine could ever be considered an effective nootropic .

[Metagene]

Ibogaine (Ibocaine) is a substance whose primary mechanism of action is thought to be an increase in GDNF. It was banned in the 60's ostensibly because of its potential to induce hallucinations , though most individuals interested in its application to treat medical conditions, especially addictions, feel it was banned because of its great potential in treating addiction and the inability to patent it. The committee that had it banned was reported to be composed of more than a few pharmaceutical representatives and many "experts" in the addiction industry. It was hoped to revolutionize the treatment of addictions. A researcher from the univ of Miami, Deborah Mash ,has processed ibogaine to remove the compound which caused hallucinations, leaving the substance which increases GDNF intact.
http://www.ibogaine....ami-update.html
the drug is being studied for alcohol addiction at the Univ of San Francisco Med center at present. have no idea the status of the clinical trials.

http://en.m.wikipedi...oxycoronaridine
http://www.savanthwp.com/index.html

Human safety trials started in September with no clinical studies at this time.

Savant HWP Confirms Initiation of a Human Safety Trial for 18-MC, a Potential Anti-Addiction Therapy

http://www.prnewswir...-276441461.html

Edited by Metagene, 28 December 2014 - 05:23 AM.

[HappyShoe]

Want... Synth... =P

[HappyShoe]

Oh... It's probably also schedule 1 under the analogues act... =(

[Flex]

Stumbled upon this:

It seems that too much Gdnf could be problematic according to this one

Effect of GDNF on depressive-like behavior, spatial learning and key genes of the brain dopamine system in genetically predisposed to behavioral disorders mouse strains.

http://www.ncbi.nlm....pubmed/25101543

 

Catalpol increases GDNF in damaged tissue, but doesnt affect it in healthy tissue:

Catalpol attenuates MPTP induced neuronal degeneration of nigral-striatal dopaminergic pathway in mice through elevating glial cell derived neurotrophic factor in striatum.

http://www.ncbi.nlm....pubmed/20123001

 

This one also increases GDNF:

Harpagoside attenuates MPTP/MPP⁺ induced dopaminergic neurodegeneration and movement disorder via elevating glial cell line-derived neurotrophic factor.

http://www.ncbi.nlm....pubmed/22192054

derived from Scrophularia ningpoensis

 

Btw: According to this paper,

Protective effects of kidney-tonifying Chinese herbal preparation on substantia nigra neurons in a mouse model of Parkinson’s diseas

http://wenku.baidu.c...175e0e4801.html

 

Rhizoma Polygonati and Fructus Ligustri Lucidi had stronger effects than Selegiline in increasing BDNF and NGF in MPTP treatet Mice, whereas herba epidemii ( horny goat weed) could restore Tyrosine Hydroxylase (TH) to baseline

 

...Herba Epimedii increased the BDNF level in the substantia nigra-striatum (36.33%).

Rhizoma Polygonati could increase BDNF and NGF levels (53.06%

and 15.91%, respectively) in the substantia nigra and striatum...

 

Rhizoma Polygonati = Polygonatum sibiricum

http://www.nutragree...-extract-powder

 

As usual, ask somebody about any interactions (e.g. bleeding) before usage, if You are interrested.

Edited by Flex, 04 January 2015 - 06:13 PM.

[Flex]

In regards of Ibogaine, be careful.

Take it better in presence with somebody, who can call the emergency

Because Ibogaine can cause heart arrhythmias and vagus nerve overstimulation even within a normal dose.

 

http://www.drugwarfa...h.j4qcdHeB.dpbs

http://www.pubfacts....rdiac-death-cau

 

Afaik the Natives use it in a state of trance to prevent this.

But dont pin me down on that all.

Do allways re-check claims, even mine 

[gamesguru]

Safer than Ibogaine, but probably less effective.

 

Oral administration of royal jelly facilitates mRNA expression of glial cell line-derived neurotrophic factor and neurofilament H in the hippocampus of the adult mouse brain.

[HappyShoe]

Dasheenster, can you link that source and put it in the royal jelly thread? I'd look myself but don't wanna steal your thunder, and am trying to encourage more participation, since I don't think RJ gets enough credit.

[kurdishfella]

GDNF, and it is found to be biologically active as long as 14 days post injection in some studies in rodents and non-human primates.

 

here is a link to a couple of papers demonstrating the stability of GDNF post delivery as demonstrated in a Immunohistochemistry assay.

 

https://www.ncbi.nlm...pubmed/20883692

 

https://www.ncbi.nlm...pubmed/20153340

 

 

as for do i believe GDNF is biologically active through intranasal delivery in rodents.... yes i do. We did significant work in identifying markers of dopaminergic denisities, histology, and Immunohistochem to verify the presence and effect of treatment.

 

As for bypassing BBB, GDNF is a typical constituent of interstitial fluid and CSF, so its not something that is particularly ejected by the BBB.

 

GDNF is a protein, and proteins are inherently more stable than some other molecules you think about when you consider half-life. Protease activity and glial cells are factors in GDNF metabolism and clearance.

 

 

 

Edited by farshad, 26 August 2019 - 06:25 AM.

[Automail]

NSI-189

9-me-bc

[DaveX]

As mentioned somewhere else before, HDAC inhibitors, like Sodium Butyrate.
https://www.ncbi.nlm...les/PMC2579941/

And the green tea components EGCG and theanine. However, theanine just seems to "significantly attenuate the down-regulation of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) production" (https://www.ncbi.nlm...ubmed/18452993/) (different than promoting it).
Lots of herbs, probably, like the above.

And, as the name indicates, physical training (Gym-Derived-Nootrophic-Factor)

Edited by DaveX, 17 September 2019 - 11:53 PM.