37 replies to this topic

[tintinet]

Most of these studies are quite old now. Not much in the way of follow up or use in the Mprize, AFAIK.

[GhostBuster]

Most of these studies are quite old now. Not much in the way of follow up or use in the Mprize, AFAIK.

The reduction of the lipofuscin is serious stuff. Centrophenoxine lowers lipofuscin in the brain 25 - 42 % and it is known to reduce lipofuscin throughout the body. And once the lipofuscin is gone, it´s gone, so one gets the permanent gain even from the temporary use. This thing alone is the sufficient reason to use centrophenoxine at least for a short period of time every now and then, imo.

Edited by GhostBuster, 05 December 2011 - 04:08 PM.

[sapentia]

I took Centrophenoxine for nearly a year at 1,000mg/day specifically for cognitive improvement and the removal of lipofuscin. Could I tell a difference?, maybe. I was on several other supplements and didn't take the time to separate them in order to adequately assess the viability of each. The reason I am currently not on it is budget; I hope begin taking it again in a few months. Ideally, I would take 2,000mg per day. I could only find two sources when I took it. One was a Canadian company and the other was Cognitive Nutrition with the latter being about half the price as the former.

[GhostBuster]

I took Centrophenoxine for nearly a year at 1,000mg/day specifically for cognitive improvement and the removal of lipofuscin. Could I tell a difference?, maybe. I was on several other supplements and didn't take the time to separate them in order to adequately assess the viability of each. The reason I am currently not on it is budget; I hope begin taking it again in a few months. Ideally, I would take 2,000mg per day. I could only find two sources when I took it. One was a Canadian company and the other was Cognitive Nutrition with the latter being about half the price as the former.

How did you come up with those dosages? Zs-Nagy, the leading CPH researcher, recommends 500 mg for healthy people. At least some of the effects are not dose dependent (if my memory serves me right, cant find a source right now) and a smaller dose could be even better. 2000 mg would be kind of pricey.

[tintinet]

Most of these studies are quite old now. Not much in the way of follow up or use in the Mprize, AFAIK.

The reduction of the lipofuscin is serious stuff. Centrophenoxine lowers lipofuscin in the brain 25 - 42 % and it is known to reduce lipofuscin throughout the body. And once the lipofuscin is gone, it´s gone, so one gets the permanent gain even from the temporary use. This thing alone is the sufficient reason to use centrophenoxine at least for a short period of time every now and then, imo.

If it works at all for anyone but rats and mice:


Lipofuscin in retinal pigment epithelium of rhesus monkey: lack of diminution with centrophenoxine treatment.




Author(s):

Andrews LD, Brizzee KR.

Citation:

Neurobiol Aging 1986;7(2):107-113.

Abstract:

An experiment was performed to test the ability of Centrophenoxine to reduce the amount of lipofuscin (age pigment) in the retinal pigment epithelium (RPE) of aged rhesus monkeys. Centrophenoxine is reputed to have this action in neurons of lower mammals. Quantitative electron microscopic analysis was performed on sections from the perifovea of ten rhesus monkeys, all approximately 20 years of age. Four of the animals received 80 mg/kg Centrophenoxine (IM injection) daily for 12 weeks. No significant difference between the treated and control groups could be demonstrated statistically (Mann-Whitney U-test) either in the fraction of RPE cell cytoplasm occupied by lipofuscin granules or in the average size of the granules.

PubMed ID:

3083280

Edited by tintinet, 06 December 2011 - 06:39 PM.

[sapentia]

I took Centrophenoxine for nearly a year at 1,000mg/day specifically for cognitive improvement and the removal of lipofuscin. Could I tell a difference?, maybe. I was on several other supplements and didn't take the time to separate them in order to adequately assess the viability of each. The reason I am currently not on it is budget; I hope begin taking it again in a few months. Ideally, I would take 2,000mg per day. I could only find two sources when I took it. One was a Canadian company and the other was Cognitive Nutrition with the latter being about half the price as the former.

How did you come up with those dosages? Zs-Nagy, the leading CPH researcher, recommends 500 mg for healthy people. At least some of the effects are not dose dependent (if my memory serves me right, cant find a source right now) and a smaller dose could be even better. 2000 mg would be kind of pricey.

It's been a while since my research in centrophenoxine, but from what I remember the effective doses were in the range I mentioned. Actually, for someone older I believe the recommended dosage is around 3,000mg. I am healthy mid-thirties so 1,000 - 2,000 mg seems like a safe preventative dosing.

On a side note, I have read some mention of PQQ as a preventative for Alzheimer's disease. The combination of PQQ and centrophenoxine could be a very effective neuro-protective combination.





Protective effect of pyrroloquinoline quinone against Aβ-induced neurotoxicity in human neuroblastoma SH-SY5Y cells

Jun-Jing Zhang, Rui-Fang Zhang, Xing-Kai Meng
Neuroscience Letters
Volume 464, Issue 3, 30 October 2009, Pages 165-169
Abstract

The neurotoxicity of aggregated β-amyloid (Aβ) has been implicated as a critical cause in the pathogenesis of Alzheimer's disease (AD). It can cause neurotoxicity in AD by evoking a cascade of oxidative damage-dependent apoptosis to neurons. In the present study, we for the first time investigated the protective effect of pyrroloquinoline quinone (PQQ), an anionic, water soluble compound that acts as a redox cofactor of bacterial dehydrogenases, on Aβ-induced SH-SY5Y cytotoxicity. Aβ_25–35 significantly reduced cell viability, increased the number of apoptotic-like cells, and increased ROS production. All of these phenotypes induced by Aβ_25–35 were markedly reversed by PQQ. PQQ pretreatment recovered cells from Aβ_25–35-induced cell death, prevented Aβ_25–35-induced apoptosis, and decreased ROS production. PQQ strikingly decreased Bax/Bcl-2 ratio, and suppressed the cleavage of caspase-3. These results indicated that PQQ could protect SH-SY5Y cells against β-amyloid induced neurotoxicity.

[GhostBuster]

Most of these studies are quite old now. Not much in the way of follow up or use in the Mprize, AFAIK.

The reduction of the lipofuscin is serious stuff. Centrophenoxine lowers lipofuscin in the brain 25 - 42 % and it is known to reduce lipofuscin throughout the body. And once the lipofuscin is gone, it´s gone, so one gets the permanent gain even from the temporary use. This thing alone is the sufficient reason to use centrophenoxine at least for a short period of time every now and then, imo.

If it works at all for anyone but rats and mice:


Lipofuscin in retinal pigment epithelium of rhesus monkey: lack of diminution with centrophenoxine treatment.




Author(s):

Andrews LD, Brizzee KR.

Citation:

Neurobiol Aging 1986;7(2):107-113.

Abstract:

An experiment was performed to test the ability of Centrophenoxine to reduce the amount of lipofuscin (age pigment) in the retinal pigment epithelium (RPE) of aged rhesus monkeys. Centrophenoxine is reputed to have this action in neurons of lower mammals. Quantitative electron microscopic analysis was performed on sections from the perifovea of ten rhesus monkeys, all approximately 20 years of age. Four of the animals received 80 mg/kg Centrophenoxine (IM injection) daily for 12 weeks. No significant difference between the treated and control groups could be demonstrated statistically (Mann-Whitney U-test) either in the fraction of RPE cell cytoplasm occupied by lipofuscin granules or in the average size of the granules.

PubMed ID:

3083280

I won´t go to the details, but your conclusion is non sequitur. Centrophenoxine apparently also increases collagen both human (according to anecdotal evidence) and lizards:

Changes in the characteristics of collagen of young male garden lizards following centrophenoxine and lysine treatment.

http://www.sciencedi...531556582900407

[tintinet]

I don't think my post is nearly as non sequitur as yours. Centrophenoxine has been advocated as a lipofuscin reducing supplement, but this may not be true for humans. I don't know whether it does so in lizards.