179 replies to this topic

[Metagene]

One use or a hundred uses, double blind studies will not change the fact cocaine abuse is very dangerous. I don't denie damaging effects in some cocaine users could be due to adulterants, individual susceptibility, underlying health conditions, a prior history of drug abuse, etc.

Of course it's dangerous. I'm not arguing that. What I am arguing against is permanent brain damage from a single use.

OP, how do you feel about starting with the EGCG and 5-HTP I mentioned?

I never meant to imply cocaine assuredly causes permanent brain damage from a single use. I just find your "Psychogenic" explanation of clinical symptoms rather dismissive.

"Severe headaches have been associated with cocaine use and they may provide a diagnostic dilemma. Early severe headaches occur in 50% of patients with cocaine related stroke, and 18% of these have seizures. Cases have been reported of migraine-like headaches attributable to the after effects of cocaine bingeing. These headaches subsided immediately with the readministration of cocaine, but were sufficiently aversive to motivate quitting the use of the drug. The authors highlighted the effects of cocaine in first increasing and then decreasing the levels of serotonin, a potent vasoactive neurotransmitter. The resolution of the headache with further cocaine was consistent with the rapid response of migraine to serotonin enhancing agents like ergot."


"Cocaine, in various forms, has been reported to contain a plethora of adulterants. These include local anaesthetics such as lidocaine, sugars, stimulants such as amphetamine, toxins such as strychnine and quinine, and inert compounds such as talc and cornstarch. All of these, especially the toxins and stimulants, may have multiple side-effects of their own, many of them possibly lethal."

https://ispub.com/IJEM/2/1/7862

One use or a hundred uses, double blind studies will not change the fact cocaine abuse is very dangerous. I don't denie damaging effects in some cocaine users could be due to adulterants, individual susceptibility, underlying health conditions, a prior history of drug abuse, etc.

Of course it's dangerous. I'm not arguing that. What I am arguing against is permanent brain damage from a single use.

OP, how do you feel about starting with the EGCG and 5-HTP I mentioned?

It might be possible solely because Cocaine and Amphetamine do increase the risk of a stroke within 24 hours.
A stroke or silent stroke could freely occur in this case.
and as mentioned before, cocaine causes a strong vasoconstriction that lasts longer than 45 min so some Brain cells do defineately die, though not so many i.e. no noticable brain damage.

Yes the cocaine metabolite Benzoylecgonine has a half-life around 6 hours.

"Cocaine and its metabolites do undoubtedly have major effects on cerebral (and other) arteries. The acute vasospasm has been demonstrated in animals, and by magnetic resonance angiography (MRA) and transcranial Doppler in human volunteers, and occurs in large and medium sized arteries, probably mediated by endothelin 1. In patients, angiography may show beading and focal stenosis, and there may also be associated large vessel occlusion. Such abnormalities may arise through vasospasm caused by the drug itself but the possibility of additional subarachnoid haemorrhage needs excluding. Postmortem specimens in a few patients have shown that arteries may sustain damage to the media and elastic lamina, but no abnormality has been detectable in most studies and in some patients no vasculopathy can be demonstrated (other than aneurysms and AVMs in cases with intracranial haemorrhage)."

"In half the cases of cocaine infarcts, angiography is unremarkable and does not show the above abnormalities. Occasionally intraluminal clot is seen in the internal carotid artery, perhaps possibly because of “stasis” distant to extracranial carotid artery spasm. Artery-to-artery embolism is therefore another possible mechanism for vessel occlusion, in addition to spasm, in situ thrombosis, and embolism from the heart."

http://jnnp.bmj.com/...ppl_3/iii9.full

Cocaine-induced cerebral vasoconstriction detected in humans with magnetic resonance angiography.

http://jama.jamanetw...REF-JCI71030-33

Edited by Metagene, 13 May 2015 - 06:50 PM.

[savagek]

 

 

Yes, those things can happen. But what he's far more concerned with seems to be fog, reading comprehension and problem solving. I want to see the double-blind studies that show this as a result off a single use of cocaine. In a scientific context, that's not asking for much. Hell, it's the bare minimum.

 

Well i did use xanax and alcohol in combination with the cocaine. Not to sure there would be a scientific study on all three together.

 

 

Have You tried something that increases or lowers GABA ?

dyhydromyrtecine or Thujone could decrease it but I´m not sure about the former

 

increase is easy: Alcohol or herbs like lemonbalm, centella asiatica, kava kava

 

I guess its somehow concerning to sugest something like this but it could be a lucky shot.

 

 

I've had alcohol a few times. I didn't feel any different just alittled buzzed

 

Don't think I've had anything that would lower gaba

[mani16]

Is it possible that the vision symptoms are a result of some sort of Cortical Vision Impairment/Cortical Blindness?

[mani16]

For starters I would take 100mg of 5-HTP at night (usually sold at this dose) with 500mg of EGCG (usually sold that that dose). Skip the L-Dopa for now. I have to think a bit in depth about other possibilities, let me get back to you soon. Do you think you could try that?

 

I could try giving it a go.  Do these things have side effects?

[OneScrewLoose]

Might have a little sleepiness. They tend not to. As long as you're not on an SSRI you should be fine. Effects tend to take only 1-4 days.

@Metagene, why are you so obsessed with the worst possible outcome? It may be possible that something drastic happened, but it's statistically quite unlikely. Why do you insist that this is the case, when there are so many other possibilities with higher statistical likelihood?

[Metagene]

Might have a little sleepiness. They tend not to. As long as you're not on an SSRI you should be fine. Effects tend to take only 1-4 days.

@Metagene, why are you so obsessed with the worst possible outcome?It may be possible that something drastic happened, but it's statistically quite unlikely. Why do you insist that this is the case, when there are so many other possibilities with higher statistical likelihood?

The real question is why do you think that I am?

I will examine the facts but I'm not here to play doctor.

[OneScrewLoose]

I already asked the real question to you. I'm not going to play a guessing game to find out the source of your negativity towards this situation.

OP, do you think we can work from a variety of possibilities? From no damage to some damage, and see which hypothesis ends up being the most productive through trial and error?

[savagek]

I already asked the real question to you. I'm not going to play a guessing game to find out the source of your negativity towards this situation.

OP, do you think we can work from a variety of possibilities? From no damage to some damage, and see which hypothesis ends up being the most productive through trial and error?

 

I have no idea whats wrong with me so willing to consider any possibilities.

 

All I know is that after this one time cocaine usage I haven't been the same. The issues caused by this have been serve enough that i haven't been able to run my business.

 

Its been 5 months for me and the symptoms haven't changed. They don't get better or worse throughout the day and I've remained this way since the day i woke up altered.

Doesn't matter what mood I'm in. Some weeks I'm super positive and tell myself I'm gonna get better. Other times I'm not so positive and think this is gonna be permanent. However, no matter how I feel about it things it has no effect on my impairments. 

 

My exact symptoms are:

 

Vision - I don't process what i see correctly which makes watching tv or reading extremely difficult 

Hearing - I cannot listen to music. It just doesn't sound right

Memory - Things that happened recently feel like they happened a long time ago 

Thinking - I have considerable problems with complex problem solving and decision making

 

I also have a tingling/itching sensation in my face on my left cheek.

 

I'll appreciate any reasonable suggestions from anyone because as of right now I have no idea what to do.

.

[Flex]

 

 

 

Its been 5 months for me and the symptoms haven't changed. They don't get better or worse throughout the day and I've remained this way since the day i woke up altered.

Doesn't matter what mood I'm in. Some weeks I'm super positive and tell myself I'm gonna get better. Other times I'm not so positive and think this is gonna be permanent. However, no matter how I feel about it things it has no effect on my impairments. 

 

 

 

Exact my situation..

 

In regards of help: Pehaps an idea could pop up but I told what I have to tell more or less.
 

Edited by Flex, 17 May 2015 - 01:03 PM.

[Metagene]

I already asked the real question to you. I'm not going to play a guessing game to find out the source of your negativity towards this situation.

OP, do you think we can work from a variety of possibilities? From no damage to some damage, and see which hypothesis ends up being the most productive through trial and error?

 

I have no source of negativity towards this situation beyond what you wrongly attribute to it. Serious =/= negative. 

[OneScrewLoose]

Can you get modafinil/armodafinil? Based on what you write it might help reset of the the changes that may have happened.

[savagek]

 

 

 

 

Its been 5 months for me and the symptoms haven't changed. They don't get better or worse throughout the day and I've remained this way since the day i woke up altered.

Doesn't matter what mood I'm in. Some weeks I'm super positive and tell myself I'm gonna get better. Other times I'm not so positive and think this is gonna be permanent. However, no matter how I feel about it things it has no effect on my impairments. 

 

 

 

Exact my situation..

 

In regards of help: Pehaps an idea could pop up but I told what I have to tell more or less.
 

 

 

Thanks. Your like the cocaine specialist on these fourms lol

 

Can you get modafinil/armodafinil? Based on what you write it might help reset of the the changes that may have happened.

 

How would i get my hands on that and isn't a prescription required?

[Metagene]

You could try online tests such as this one to check for possible hearing loss: http://www.beltonehearingtest.com/us/

[OneScrewLoose]

Do you have a psychiatrist?

[OneScrewLoose]

 

I already asked the real question to you. I'm not going to play a guessing game to find out the source of your negativity towards this situation.

OP, do you think we can work from a variety of possibilities? From no damage to some damage, and see which hypothesis ends up being the most productive through trial and error?

 

I have no source of negativity towards this situation beyond what you wrongly attribute to it. Serious =/= negative. 

 

You're negativity lies in that you are almost certain that the most likely outcome was the most serious and damaging one, without anything more than his anecdotal evidence. That's about as unscience you can get. Sure, something may have happened, I don't disregard it completely, but the probability is low, and I think every possible option needs to be explored. I feel your posts are harmful because they doom OP to permanent damage and a life of suffering, when that is the lowest probability of all the likely causes.

[savagek]

You could try online tests such as this one to check for possible hearing loss: [LR]

Thanks. I gave it a shot but it didn't indicate any hearloss. Still I definitely can tell my hearing is not the same. 

 

Do you have a psychiatrist?

No I don't. I've never seen one before.

Edited by YOLF, 31 May 2015 - 03:24 AM.

[Metagene]

I already asked the real question to you. I'm not going to play a guessing game to find out the source of your negativity towards this situation.

OP, do you think we can work from a variety of possibilities? From no damage to some damage, and see which hypothesis ends up being the most productive through trial and error?

I have no source of negativity towards this situation beyond what you wrongly attribute to it. Serious =/= negative.

You're negativity lies in that you are almost certain that the most likely outcome was the most serious and damaging one, without anything more than his anecdotal evidence. That's about as unscience you can get. Sure, something may have happened, I don't disregard it completely, but the probability is low, and I think every possible option needs to be explored. I feel your posts are harmful because they doom OP to permanent damage and a life of suffering, when that is the lowest probability of all the likely causes.

"Nocebo effects"? "Psychogenic problems"? Those words sound dismissive to me. I didn't realize simply posting could doom another person to a life of pain and suffering as you loosely put it. Let's get something straight. I never said anyone was permanently damaged. I know very little about cocaine so the information posted serves to educate myself as well others. It doesn't strictly apply to one individual or circumstance. If highlighting the possible dangers of cocaine use is considered negative to you then fine. My intention was to help savagek and mani16 not to take the place of a medical professional. Anecdotal evidence is all we've got.

Edited by Metagene, 18 May 2015 - 11:57 PM.

[OneScrewLoose]

You assume that psychogenic effects are dismissive because you make the false, and common, assumption that susceptibility to these are effects are correlated with mental strength or willpower. However, studies have shown that there is no correlation whatsoever; it's something that happens in everyone and happens more in others (like me, I found out the hard way that I am very susceptible).

The psychogenic effects are guaranteed if not but for where his concentration is focused on in his stream of consciousness. He will experience his problems more deeply if he is more focused/worried about them than if he focuses on other things in his body, like how the tip of his nose feels (try that as a meditation exercise, btw, when you feel overwhelmed. Put some focus into the parts of your body that aren't being affected for a bit) That's just a matter of attention.

 

I would not say that it's this or that amount psychogenic: it could be a small or big part, I have no way of knowing. I can guarantee, however, that there is at least some component of it involved here, even if it's small. There's obviously a very strong biological component right now, whether the cocaine was a weak instigator or strong instigator. Both of these aspects of this problem need to be addressed at the same time. OP, I highly recommend you take up light meditation with whatever you end up taking. Even if it doesn't end up helping this, it's fantastic for you anyway.

OP, have you looked into the 5-HTP + EGCG? What kinds of things are you willing to take, anything OTC? Would you be willing to get and go to a psychiatrist so you have access to more options? How are you doing overall, and since you've started this thread?

[Metagene]

You assume that psychogenic effects are dismissive because you make the false, and common, assumption that susceptibility to these are effects are correlated with mental strength or willpower. However, studies have shown that there is no correlation whatsoever; it's something that happens in everyone and happens more in others (like me, I found out the hard way that I am very susceptible).

 

That's a straw man and you need to make a clear distinction between psychosomatic disease and somatoform disorder to avoid confusion.

 

"In most cases, a structural or anatomical abnormality has not been identified, as seen in an organic disease, however this does not account for possible genetic, biochemical, electrophysiological or other abnormalities that may be present but for which we do not have the technology or background to identify.[2]

 

Psychogenic disease is a broader category than psychosomatic disease, in that it can include the hysterical form, where there is no physiologic change in peripheral tissues, as well as the psychosomatic form, where there is some physiologic alteration.[3]"

 

http://en.wikipedia....hogenic_disease

 

 

"psychosomatic disorder (psychosomatic illness) a disorder in which the physical symptoms are caused or exacerbated by psychological factors, such as migraine headache, lower back pain, or irritable bowel syndrome; see also somatoform disorders. It is now recognized that emotional factors play a role in the development of nearly all organic illnesses and that the physical symptoms experienced by the patient are related to many interdependent factors, including psychological and cultural. The physical manifestations of an illness, unless caused by mechanical trauma, cannot be divorced from a person's emotional life. Each person responds in a unique way to stress; emotions affect one's sensitivity to trauma and to irritating elements in the environment, susceptibility to infection, and ability to recover from the effects of illness. Physical conditions to which psychological factors are shown to be contributory are currently classified as psychological factors affecting medical condition."

 

http://medical-dicti...omatic disorder

 

 

"The somatoform disorders are a group of mental disturbances placed in a common category on the basis of their external symptoms. These disorders are characterized by physical complaints that appear to be medical in origin but that cannot be explained in terms of a physical disease, the results of substance abuse, or by another mental disorder. In order to meet the criteria for a somatoform disorder, the physical symptoms must be serious enough to interfere with the patient's employment or relationships, and must be symptoms that are not under the patient's voluntary control."

 

http://medical-dicti...oform disorders

 

The psychogenic effects are guaranteed if not but for where his concentration is focused on in his stream of consciousness. He will experience his problems more deeply if he is more focused/worried about them than if he focuses on other things in his body, like how the tip of his nose feels (try that as a meditation exercise, btw, when you feel overwhelmed. Put some focus into the parts of your body that aren't being affected for a bit) That's just a matter of attention.

 

Huh? I don't even. 

 

I would not say that it's this or that amount psychogenic: it could be a small or big part, I have no way of knowing. I can guarantee, however, that there is at least some component of it involved here, even if it's small. There's obviously a very strong biological component right now, whether the cocaine was a weak instigator or strong instigator. Both of these aspects of this problem need to be addressed at the same time. OP, I highly recommend you take up light meditation with whatever you end up taking. Even if it doesn't end up helping this, it's fantastic for you anyway.

 

 

If you want to advocate CBT or meditation then by all means. Just leave out the pseudo intellectual nonsense.

Edited by Metagene, 19 May 2015 - 05:37 PM.

[OneScrewLoose]

 

You assume that psychogenic effects are dismissive because you make the false, and common, assumption that susceptibility to these are effects are correlated with mental strength or willpower. However, studies have shown that there is no correlation whatsoever; it's something that happens in everyone and happens more in others (like me, I found out the hard way that I am very susceptible).

 

That's a straw man and you need to make a clear distinction between psychosomatic disease and somatoform disorder to avoid confusion.

 

"In most cases, a structural or anatomical abnormality has not been identified, as seen in an organic disease, however this does not account for possible genetic, biochemical, electrophysiological or other abnormalities that may be present but for which we do not have the technology or background to identify.[2]

 

Psychogenic disease is a broader category than psychosomatic disease, in that it can include the hysterical form, where there is no physiologic change in peripheral tissues, as well as the psychosomatic form, where there is some physiologic alteration.[3]"

 

http://en.wikipedia....hogenic_disease

 

 

"psychosomatic disorder (psychosomatic illness) a disorder in which the physical symptoms are caused or exacerbated by psychological factors, such as migraine headache, lower back pain, or irritable bowel syndrome; see also somatoform disorders. It is now recognized that emotional factors play a role in the development of nearly all organic illnesses and that the physical symptoms experienced by the patient are related to many interdependent factors, including psychological and cultural. The physical manifestations of an illness, unless caused by mechanical trauma, cannot be divorced from a person's emotional life. Each person responds in a unique way to stress; emotions affect one's sensitivity to trauma and to irritating elements in the environment, susceptibility to infection, and ability to recover from the effects of illness. Physical conditions to which psychological factors are shown to be contributory are currently classified as psychological factors affecting medical condition."

 

http://medical-dicti...omatic disorder

 

 

"The somatoform disorders are a group of mental disturbances placed in a common category on the basis of their external symptoms. These disorders are characterized by physical complaints that appear to be medical in origin but that cannot be explained in terms of a physical disease, the results of substance abuse, or by another mental disorder. In order to meet the criteria for a somatoform disorder, the physical symptoms must be serious enough to interfere with the patient's employment or relationships, and must be symptoms that are not under the patient's voluntary control."

 

http://medical-dicti...oform disorders

 

The psychogenic effects are guaranteed if not but for where his concentration is focused on in his stream of consciousness. He will experience his problems more deeply if he is more focused/worried about them than if he focuses on other things in his body, like how the tip of his nose feels (try that as a meditation exercise, btw, when you feel overwhelmed. Put some focus into the parts of your body that aren't being affected for a bit) That's just a matter of attention.

 

Huh? I don't even. 

 

I would not say that it's this or that amount psychogenic: it could be a small or big part, I have no way of knowing. I can guarantee, however, that there is at least some component of it involved here, even if it's small. There's obviously a very strong biological component right now, whether the cocaine was a weak instigator or strong instigator. Both of these aspects of this problem need to be addressed at the same time. OP, I highly recommend you take up light meditation with whatever you end up taking. Even if it doesn't end up helping this, it's fantastic for you anyway.

 

 

If you want to advocate CBT or meditation then by all means. Just leave out the pseudo intellectual nonsense.

 

Yes, I was using them interchangeably, and that was a mistake. Psychosomatic is a subset of psychogenic, but not the other way around. In this case, there would be would be examples of both those things here, but I'll stick to psychogenic as an overarching term.
 

 

Huh? I don't even.

 

You don't even what? Try to understand a viewpoint that isn't yours? Ask what I meant to demonstrate/say as good-faith interest in mutual understanding and debate instead of being a prick? Don't even care?

Here's an example I used in another post:

 

 ...but they are high levels of concentration on the stress. Look at it this way, imagine you stubbed your toe, and then you did one of two things: the first thing you did was sit there and focus on the pain. The second thing you did was play video games or watch a movie. Which do you think would cause you to experience more of the pain? Do you see my point?

 

His intense focus on his symptoms will increase his symptoms. Whether the basis is purely biological or has a psychogenic component, it is assuredly being increased on where he's putting his attention.

 

 

If you want to advocate CBT or meditation then by all means. Just leave out the pseudo intellectual nonsense.

 

How nice of you to debate with such mannerisms that display mutual respect. You're so kind.

Edited by OneScrewLoose, 23 May 2015 - 09:49 PM.

[Metagene]

Your argument is barely substantive. If you had expressed your viewpoint in a coherent manner it might be more understandable.

Your very first statement for example:

I really think you need to consider nocebo effects.

The nocebo effects of what? How does this apply to savagek?

"In medicine, a nocebo (Latin for "I shall harm") is an inert substance or form of therapy that creates harmful effects in a patient."

http://en.m.wikipedia.org/wiki/Nocebo

Let me tell you about my experiences. After 1 DXM trip, 3 weeks later I started to get bad HPPD (visual distortions). it seemed so strange that one trip, especially from a dissociative instead of a psychedelic, could cause this, but I accepted it....

Ironic that you acuse me of being unscientific for relying on anecdotal evidence from the OP. DXM acts as a dissociative hallucinogen i.e psychedelic at higher doses and can cause serve Hallucinogen persisting perception disorder after one trip. Notice HPPD episodes may emerge spontaneously and may be suddenly paroxysmal or worsening. This completely undermines your concept of a nocebo response. If you had simply framed your experience around the benefits of positive thinking or meditation there would be less of an issue. That still doesn't make your situation comparable to savagek's from a pathological standpoint.

Flashbacks and HPPD: A Clinical-oriented Concise Review.

HPPD I may slowly commence whereas HPPD II might abruptly erupt. Episodes of HPPD I and II may sponta- neously emerge or be precipitated by identified triggers. Episodes may be continuous, intermittent or suddenly paroxysmal. Duration of episodes may range from one long-lasting experience, e.g., “to be stuck,” to multiple episodes lasting from almost imperceptible fractions of seconds to longer periods of time. Duration between episodes may be shorter for HPPD I than HPPD II. Episodes may immediately or gradually disappear (23).
HPPD I and II onsets may be preceded by already pre- existing mental disorders such as anxiety, mood, somato- form, sleep and dissociative disorders or severe mental illnesses like schizophrenia, but may also contribute to the development of these disorders acting as a trigger (23).

http://www.ncbi.nlm....ubmed/25841228/
https://www.erowid.o.../hppd_faq.shtml

Edited by Metagene, 24 May 2015 - 04:35 PM.

[OneScrewLoose]

Nocebo simply means placebo but a negative effect instead of a positive effect. It's the subjective negative of placebo's subjective positive. That's all it means.

Dissociatives are NOT psychedelics, period. It's very unlikely that dissociatives will cause HPPD, especially after 1 use.

 

Episodes may immediately or gradually disappear (23).

HPPD I and II onsets may be preceded by already pre- existing mental disorders such as anxiety, mood, ***somato- form***, sleep and dissociative disorders or severe mental illnesses like schizophrenia, but may also contribute to the development of these disorders acting as a trigger 

 

So, you're agreeing? I was going through severe anxiety on the time, which is what perpetuated the HPPD, which is a psychogenic aspect of it, even if the original HPPD wasn't.

How's the whether up there on that horse, btw?
 

[Metagene]

How do nocebo effects relate to savagek condition? I was referring specifically to DXM not dissociatives in general but since we are splitting hairs:

"At sub-anesthetic doses, dissociatives alter many of the same cognitive and perceptual processes affected by other hallucinogenic drugs such as mescaline, LSD, and psilocybin; hence they are also considered hallucinogenic, and psychedelic."

http://en.m.wikipedi...ki/Dissociative

High doses of dextromethorphan, an NMDA antagonist, produce effects similar to classic hallucinogens.

http://www.ncbi.nlm....ubmed/22526529/

Flashbacks and HPPD: A Clinical-oriented Concise Review.

"Other substances that have been associated with the development of this condi- tion include: psilocybin (Magic Mushrooms or Shrooms) (4), mescaline (San Pedro and Peyote Hallucinogenic Cacti) (5), cannabis (6), 5-MeO-DiPT (Synthetic Hallucinogen) (7), Ecstasy (MDMA) (8), Phencyclidine (PCP) (9, 10), dextromethorphan (11) and ketamine (12). Datura, salvia divinorum, ayahuasca, ibogaine, synthetic cannabis and inhalants also appeared to be implicated (13)."

http://www.ncbi.nlm....ubmed/22526529/

I also got increased social anxiety from about everything I took around this period.

You didn't say what else you took besides Green tea extract and CBD.

[OneScrewLoose]

I'm not going to list everything I took just for you, no thanks.

 

Sometime psychedelic is used a term to include any hallucinogen. A far more useful definition is drugs that agonize the 5HT2 receptors.

 

But arguing is pointless. I'll leave you with your vested interested that there's no possible way OP can be experiencing anything psychogenic. It seems to be really important to, perhaps you experience quite a few such effects according to the doctors you've visited and refuse to believe it.

Whatever. OP, if you want an approach that doesn't assume you're just broken, PM me for more info.

[Ark]

I'm just wondering if your getting almost pure cocaine or whether you got something cut into it that caused the damage?

[Ark]

I'm not saying your wrong about the cocaine being the cause, just to be clear. But it is important to make sure you have the right culprit, as some of the nasty things that drug dealers use to cut the block to make more powder might be more toxic than the cocaine, which could easily be what has you screwed up.
One other thing outside of herbal noots and Rxs. You could try a HIT workout schedule and you should try and run a detox program to make sure there's nothing lingering.



I wish you the best of luck, get well soon...

CHEERS

Edited by Ark, 25 May 2015 - 07:01 AM.

[Metagene]

 

I already asked the real question to you. I'm not going to play a guessing game to find out the source of your negativity towards this situation.

OP, do you think we can work from a variety of possibilities? From no damage to some damage, and see which hypothesis ends up being the most productive through trial and error?

 

I have no idea whats wrong with me so willing to consider any possibilities.

 

All I know is that after this one time cocaine usage I haven't been the same. The issues caused by this have been serve enough that i haven't been able to run my business.

 

Its been 5 months for me and the symptoms haven't changed. They don't get better or worse throughout the day and I've remained this way since the day i woke up altered.

Doesn't matter what mood I'm in. Some weeks I'm super positive and tell myself I'm gonna get better. Other times I'm not so positive and think this is gonna be permanent. However, no matter how I feel about it things it has no effect on my impairments. 

 

My exact symptoms are:

 

Vision - I don't process what i see correctly which makes watching tv or reading extremely difficult 

Hearing - I cannot listen to music. It just doesn't sound right

Memory - Things that happened recently feel like they happened a long time ago 

Thinking - I have considerable problems with complex problem solving and decision making

 

I also have a tingling/itching sensation in my face on my left cheek.

 

I'll appreciate any reasonable suggestions from anyone because as of right now I have no idea what to do.

.

 

 

I didn't think to ask but how often did you drink alcohol before the incident?

 

I'm not saying your wrong about the cocaine being the cause, just to be clear. But it is important to make sure you have the right culprit, as some of the nasty things that drug dealers use to cut the block to make more powder might be more toxic than the cocaine, which could easily be what has you screwed up.
One other thing outside of herbal noots and Rxs. You could try a HIT workout schedule and you should try and run a detox program to make sure there's nothing lingering.



I wish you the best of luck, get well soon...

CHEERS

 

renfr brought that up on page one. Unfortunately there maybe no way to isolate the real culprit.

 

I thought this was interesting:

 

"Endothelin 1, also known as preproendothelin-1 (PPET1), is a protein that in humans is encoded by the EDN1 gene. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 is one of three isoforms of human endothelin (ET-1)."

 

http://en.wikipedia....ki/Endothelin_1

 

Cocaine Increases the Endothelial Release of Immunoreactive Endothelin and Its Concentrations in Human Plasma and Urine

 

http://circ.ahajourn...t/98/5/385.long

 

Acute cocaine induces endothelin-1-dependent constriction of rabbit basilar artery.

 

"It has been postulated that ischemic stroke due to acute cocaine usage involves constriction of the cerebral vasculature. However, the mechanism underlying the constriction remains unclear. This study tested whether cocaine constriction was mediated via endothelin-1. Cocaine suffusion induced maintained constriction in the rabbit basilar artery in situ. The constriction was relaxed by PD145065, an endothelin A and B receptor antagonist. These results support the hypothesis that constriction of the cerebral vasculature due to acute cocaine exposure is via endothelin-1 release. Endothelin receptor antagonists may be of therapeutic benefit in cerebrovascular pathophysiologies involving cocaine constriction."

 

http://www.ncbi.nlm....pubmed/17578707

Edited by Metagene, 25 May 2015 - 06:15 PM.

[Metagene]

Okay I'm gonna try to wrap my head around this one.

 

The interdependence of Endothelin-1 and Calcium: A Review

 

The 21 amino acid peptide endothelin-1 (ET-1) regulates a diverse array of physiological processes, including vasoconstriction, angiogenesis, nociception, and cell proliferation. Most of the effects of ET-1 are associated with an increase in intracellular calcium concentration.

 

Molecules that increase endothelial cell [Ca+2]i augment expression of preproendothelin-1 (ppET-1) mRNA via a calcium/calmodulin/calmodulin kinase (Ca2+/CaM/CaM-K) pathway [45, 46]

 

http://www.ncbi.nlm....les/PMC3960801/

 

Cocaine increases the intracellular calcium concentration in brain independently of its cerebrovascular effects.

 

It is well recognized that cocaine abuse is associated with neurological deficits that can be mild and transient such as facial paralysis to severe and irreversible such as permanent tetraplegia (Spivey and Euerle, 1990). In as much as increases in [Ca2+]i are associated with cell death (Schanne et al., 1979), cocaine-induced increases in [Ca2+]i are likely to be clinically relevant, particularly when considering that they occur in parallel to cocaine-induced decreases in MABP, blood volume, tissue oxygenation, and CBF. The increases in [Ca2+]i would make the tissue more vulnerable to ischemia secondary to decreases in CBF that would otherwise not induce ischemia and/or cell damage.

 

In summary, we show that acute cocaine at a dose used by cocaine abusers for recreational purposes induced large increases in [Ca2+]i in the cortex of the rat brain that are independent of its decreases in CBV and in tissue oxygenation. We also document that the mechanism behind the cocaine-induced [Ca2+]i increases are related to the local anesthetic actions of cocaine and not its sympathomimetic effects.

 

http://www.jneurosci...6/45/11522.full

 

 

Edited by Metagene, 25 May 2015 - 08:46 PM.

[Metagene]

I'm not going to list everything I took just for you, no thanks.

Sometime psychedelic is used a term to include any hallucinogen. A far more useful definition is drugs that agonize the 5HT2 receptors.

But arguing is pointless. I'll leave you with your vested interested that there's no possible way OP can be experiencing anything psychogenic. It seems to be really important to, perhaps you experience quite a few such effects according to the doctors you've visited and refuse to believe it.
Whatever. OP, if you want an approach that doesn't assume you're just broken, PM me for more info.

Regardless of it's classification DXM is associated with HPPD. I'm willing to believe the dosage matters more than the number of trips.

"It remains puzzling, however, why there is no apparent correlation between the number of episodes of hallucinogen exposure and the presence of flashbacks"

http://www.ncbi.nlm....ubmed/12609692/

I never claimed to know what is wrong with the OP much less assume that he is just broken. You pushed the psychogenic angle above everything else with a very dubious personal anecdote. I can't imagine why some of us got the wrong idea. The OP should verify any information with a qualified professional not me or you.

[OneScrewLoose]

Yes, I did push that above other possibilities, just as a matter of statistics. The likelihood that he had severe damage from one use is statistically low. Is it possible? Of course, and I do not discount underlying biological issues. I think it's far more probable that there was some small damage, instead of severe, being exacerbated by his perception of it. Additionally, just the fact that he is extremely focused on it has a psychogenic effect in and of itself. It's like having a body pain and either focusing on it, which increases the experience of it, or doing something like playing video games, which takes the focus off and in and of itself reduces the experience of the pain.

 

The OP should verify any information with a qualified professional not me or you.

Well, we finally agree on something.