9 replies to this topic

[ironfistx]

A lot of people have said this supplement is good for a lot of things.  Lots of joint supplements contain it.  You can get it by itself.  There was a video posted about health in Japan or Okinawa because their diets have lots of this.

 

If you google it, though, it seems there are some warnings

 

 

 

"A hyaluronan-rich environment often correlate with tumor progression, and may be one mechanism for the invasive behavior of malignancies. Eradication of hyaluronan by hyaluronidase administration could reduce tumor aggressiveness and would provide, therefore, a new anti-cancer strategy."

 

 

 

In a paper on hyaluronic acid and colon cancer, researchers wrote that "Hyaluronan (HA) is a cell-surface glycosaminoglycan that has been implicated in cancer progression......These data suggest that HA promotes adhesion to laminin and may thereby facilitate invasion of the basement membrane and metastasis in colon carcinoma."

 

http://www.ctds.info...nic_acid_2.html

 

 

 

 

Subject: Hyaluronic Acid, although promoted for many therapeutic uses, including counteracting side effects of aromatase inhibitors, may promote growth and spread of cancer cells and should not be used by cancer patients.

 

 

 

 

Hyaluronic acid is also known as hyaluronen (typing either term is tedious so I will abbreviate it as HA for the rest of this letter) is a relatively new on the market and is being promoted for a vast range of therapeutic uses. I am not going to focus on potential beneficial uses; this is a cautionary letter. This chemical appears important in the growth and spread of cancer tumors and should be avoided by anyone with cancer, particularly patients with breast cancer.

 

http://www.denvernat...uronicacid.html

 

On Swanson there is a product that contains Verisol that I was interested in because it was a better price than other products but it contains hyaluronic acid which made me want to see if this is something that is alright to supplement.

Edited by ironfistx, 29 January 2015 - 06:30 PM.

[Maxpower]

This warning concerns me as I have recently been supplementing with Eggshell membrane which contains hyaluronic acid. Any ideas if the amount of Hyaluronic acid in eggshell membrane could be an issue with cancer? Cancer runs in my family, so it is of some concern for me.

[selenic]

A couple of studies seem to suggest the opposite also.

 

The rate of cancer also varies widely among mammals and interestingly, the naked mole rat is essentially cancer-free (Gorbunova et al., Nat Rev Genet 15(531):540, 2014). A series of elegant studies (Tian et al. Nature 499:346-349, 2013) has revealed that this cancer resistance derives from the abundant production of high molecular weight hyaluronic acid. Remarkably, high molecular weight hyaluronic acid, which accumulates within the extracellular matrix, stimulates an intracellular pathway that induces expression of p16^ink4a and suppresses oncogenic transformation.

http://www.ncbi.nlm....pubmed/23783513

http://www.ncbi.nlm....pubmed/25740467

[ironfistx]

WOuld hyaluronic acid applied directly to the skin promote this same risk?

 

[aconita]

The misunderstanding here is that HA is one of the markers for some cancers.

 

It seems very unlikely to cause cancer (actually it may be an anti-cancer), some cancers may cause an over expression of it, which is a whole different thing, of course.

 

Applied topically HA is able to get into the blood flow if the molecular weight is below 400KDA, otherwise it just act as moisture barrier and a very good one indeed but little more than that since it is not able to penetrate very deep into the dermis.

 

Highly unlikely to be able to cause any skin issue, leave alone cancer.

 

 

[Castiel]

Hi,  was wondering the same thing about oral HA, since I've heard it can help counter bone loss, and sounds interesting.  Rather than create a new thread thought it better to leave comment here.

 

Has there been any new research on HA and cancer risk?

 

Searching for animal studies and HA, wasn't able to find anything suggesting increased cancer risk.    But I might have missed something.

 

 

Edited by Castiel, 06 April 2021 - 06:20 PM.

[JamesPaul]

The DoNotAge site, https://donotage.org...yaluronic-acid/, says that "Hyaluronic acid of high molecular size stops cancer cells from growing and stops your immune system from overreacting. Low molecular weight hyaluronic acid can cause inflammation, so it is vital that high molecular weight is the one you consume."

 

The DoNotAge page contains a link to a video of Prof. Gorbunova, an author of one of the papers cited by selenic above.  In the video, she spoke about naked mole rats, their longevity, and their high-molecular-weight hyaluronan.  She adds that the bodies Shar-Pei dogs, bred to have skin folds, also over-produce hyaluronan.  She said that veterinary records show that Shar-Pei dogs are resistant to certain types of cancer.  In the video she didn't say whether the hyaluronan in Shar-Pei dogs has a high or low molecular weight.

 

The abstract of this paper seems to say that high-molecular-weight hyaluronan is a promising treatment for metastatic bone cancer.

https://pubmed.ncbi....h.gov/33039536/

 

 

Edited by JamesPaul, 18 June 2021 - 08:36 PM.

[Castiel]

The DoNotAge site, https://donotage.org...yaluronic-acid/, says that "Hyaluronic acid of high molecular size stops cancer cells from growing and stops your immune system from overreacting. Low molecular weight hyaluronic acid can cause inflammation, so it is vital that high molecular weight is the one you consume."

 

The DoNotAge page contains a link to a video of Prof. Gorbunova, an author of one of the papers cited by selenic above.  In the video, she spoke about naked mole rats, their longevity, and their high-molecular-weight hyaluronan.  She adds that the bodies Shar-Pei dogs, bred to have skin folds, also over-produce hyaluronan.  She said that veterinary records show that Shar-Pei dogs are resistant to certain types of cancer.  In the video she didn't say whether the hyaluronan in Shar-Pei dogs has a high or low molecular weight.

 

The abstract of this paper seems to say that high-molecular-weight hyaluronan is a promising treatment for metastatic bone cancer.

https://pubmed.ncbi....h.gov/33039536/

 

My issue with larger Hyaluronic acid is that it will likely have to be broken down by the digestive track to be absorbed, not sure it can be absorbed intact.

[elc202]

How can you tell if Hyaluronic Acid is  low or high molecular weight?

It seems that Biocell is low molecular weight https://www.biocellt...ll-collagen-ii®

does that mean all Hyaluronic Acid extracted from chicken is low molecular weight?

 

[Dorian Grey]

No info on supplemental HA, but my step dad (82) had a series of HA injections into his knee for arthritis.  I seem to recall, the doc really didn't want to do more than one or two for some reason, but step dad talked him into several over the coarse of a year.  Don't recall exactly how long it was after this, but he developed difficulty swallowing and was diagnosed with esophageal cancer.  

 

He was 82, so prime time for cancers to pop-up.  I remember he found the HA cancer link while researching online, & wondered if his HA injections might have had anything to do with his cancer.  No smoking gun in this study of one, but I remember thinking I would try to remember this and avoid HA.