4 replies to this topic

[AgeVivo]

I suggest we pool the life extensions communities around the world to do an everolimus versus placebo testing on health in healthy persons, especially healthy elderlies.

 

In order to keep this post short I put a FAQ just after. Please discuss it between one another.

 

Edited by AgeVivo, 08 February 2015 - 01:15 AM.

[AgeVivo]

FAQ

 

-- why everolimus: because it is an mTOR inhibitor like rapamycin and because mTOR inhibition is the most robust life extension technique so far (eg in mice it extends life even when started late in life) and because such low-risk-but-effective doses have been already established in healthy persons in various research studies (http://www.ncbi.nlm....ed/?term=rad001). The most well known is likely the recent 6-week use as a premedication to increase the response to the flu vaccine in elderlies (http://www.ncbi.nlm....pubmed/25540326)

 

-- is it allowed? It would be best to do it in a legal way. Since there has been discussions on the matter over the years without answer, I suggest to start and to be receptive to propositions to make it well recognized along the way.

 

-- how long would it last? what should we measure? We should typically report health (whenever we go to the doctor and report some health issue, have a sore throat, some flu, take some medicine...), during say one year before and then during the treatment. We should also indicate if we smoke/specific things that may make us healthy or not. The outcome would be a scoring system of health (eg counting 1 whenever we go to the doctor, take some medicine, etc.). Ideally we should report during say 5 years (epidemiologic studies of low-dose aspirin report positive results over 5 years)

 

-- would the data be public? Yes but people will be defined by a nickname that they don't use elsewhere so that their self-reporting is less biased by some potential avoidance to indicate bad health.

 

-- who would pay? the people who take the placebo-or-drug.

 

-- who would make the placebo-or-drug and send it? To be organized here.

[Logic]

A summary of Everolimus research with positive and side effects would be nice Agevivo.
People are lazy like that and many don't have the background to digest the meaning of clinical studies.

Other than that you face the same issue that I spoke of in the C60oo @ home idea:
People don't want to go to all this trouble if they may be receiving a placebo in much the same way as the lady with her pet rats point blank refused to have placebo controls.
Especially if they have to pay for it!

Also you make no mention of other supps that most here take that would muddy the water and perhaps interact with Everolimus?

[Mind]

I would participate but it depends on the cost. I don't have a lot of spare cash lying around.

[Sir Shagsalot]

Hi,

A summary of Everolimus research with positive and side effects would be nice Agevivo.

Seconded.

a placebo in much the same way as the lady with her pet rats point blank refused to have placebo controls.
Especially if they have to pay for it!

This is easily solved (as we do in vivo human testing) by providing the control group (the ones who get the sugar pills) with their full allocation of the real stuff after the test is over, fair's fair.

Controls are essential in testing.

Greez SSAL

Edited by Sir Shagsalot, 16 April 2015 - 05:01 AM.