By consuming ketone esters, it's possible to raise blood ketones well above the level achievable with medium chain triglycerides (MCTs) from coconut oil. This might enable the prevention or stabilization of Alzheimer's, especially in APOE4-positive individuals, who apparently require deeper ketosis in order to achieve the same therapeutic effect. Yet this appears to be possible (if suboptimal) in the presence of carbohydrate consumption, so a starvation diet is unnecessary to achieve substantial benefits. On account of murky reports of coconut oil being atherogenic in the presence of dietary carbohydrate, proper intake of a high quality vitamin K2 (MK4 and MK7 forms) supplement is advisable. Extra virgin olive oil, MitoQ, and carbon 60 olive oil would likely help as well.
Here is the metabolic diagram. As you can see, the idea is to avoid glucose metabolism entirely because PDH is dysfunctional in type 3 diabetes (brain diabetes, which appears to be the most common form of Alzheimer's). Granted, insulin nasal spray should relieve the PDH logjam, but at the cost of accelerated insulin resistence, so it's better just to avoid glucose metabolism entirely. Note that MCT in this diagram stands for "monocarboxylate transporter", which has nothing to do with the above definition. Why does this work? Probably because the brain evolved to detect starvation based on the presence of ketones in the blood, indicating fat burning in a nutritionally defficient environment, resulting in a preferential use of ketones for energy in order to preserve glucose for the muscles so the individual can find food.
And here is the full text. Note the coauthor, Dr. Richard Veech, who has pioneered ketone research at the National Institutes of Health.
As to commercial sources of ketone monoesters and related compounds, the market is obviously nascent. But Prototype Nutrition and T Delta S are 2 examples. Note that the former's KetoForce supplement contains massive amounts of salt, so needless to say, this is an evolving area which surely requires different products for different applications.
It's fortunate that ketogenic diets also feature prominently in aggressive cancer reversal. See the Dominic D'Agostino video in this thread for details.
Edited by resveratrol_guy, 20 February 2015 - 06:41 PM.
