11 replies to this topic

[ta5]

I've been taking an olive leaf extract standardized to 18% Oleuropein. I don't know how much Hydroxytyrosol is in it, but I would guess only a little bit.

 

There are olive extracts standardized for Hydroxytyrosol. Would that be better?

 

Olea25 is an extract with 25% Hydroxytyrosol. Swanson sells it. In their marketing material they brag that it contains no Oleuropein:

 

Often considered nature's perfect antioxidant, hydroxytyrosol is one of the key active ingredients in the olive that is largely responsible for the olive's tremendous health benefits. Hydroxytyrosol is a natural phytochemical with the highest antioxidant properties discovered to date.*

 

Olea25™ is the result of a unique patent pending production and purification process that yields an unprecedented 25% hydroxytyrosol content. The Oleuropein has been completely tranferred through a biotransformation process into the bioactive hydroxytyrosol. No Oleuropein residue remains in final product!

 

 

[theobroma]

Isn't oleuropein metabolised into hydroxytyrosol so there shouldn't be much difference? Also standardising to 18% oleuropein should concentrate the other polyphenols to a roughly equal degree, I think. Have been taking the viridian 18% oleuropein extract on this assumption anyhow.   

[Fred C. Dobbs]

 

In their marketing material they brag that it contains no Oleuropein:

 

That is just dishonest marketing. It insinuates that Oleuropein is bad or inferior. Some people will read that and think they should avoid competing products.

 

Oleuropein is mainly an anti-microbial. It generally comes from the leaf.

 

Hydroxytyrosol is mainly an antioxidant. It generally comes from the fruit.

[theobroma]

 

 

In their marketing material they brag that it contains no Oleuropein:

 

That is just dishonest marketing. It insinuates that Oleuropein is bad or inferior. Some people will read that and think they should avoid competing products.

 

Oleuropein is mainly an anti-microbial. It generally comes from the leaf.

 

Hydroxytyrosol is mainly an antioxidant. It generally comes from the fruit.

 

 

Agree about the shady marketing. Oleuropein has a wide variety of activities though: http://www.ncbi.nlm....term=oleuropein

[Fred C. Dobbs]

Thanks, theobroma,

 

I should have mentioned that oleuropein and hydroxytyrosol are both extraordinary extracts.

 

Hydroxytyrosol hasn't really caught on in the U.S. I think it is big in Japan as a beauty supplement.

 

Interestingly, PubMed has more search results for Hydroxytyrosol (over 700) than for Oleuropein (over 500):

http://www.ncbi.nlm....=hydroxytyrosol

 

The gimmick with the product in the OP is that it is Hydroxytyrosol from the Olive Leaf instead of from the Olive Fruit. This makes for a more expensive extract, probably made with all-kinds of chemical solvents and processes protected by patent. It gives the manufacturer something to spin for marketing, but it is inferior to the fruit extracts that are produced using only water as the solvent. The chemically produced, highly purified Hydroxytyrosol extracted from the Leaf will not have as much (or any) of the related compounds such as Tyrosol that are included in the simply produced full-spectrum Fruit extracts.

 

Leaf is for Oleuropein. Fruit is for Hydroxytyrosol.

Edited by WmChurch, 30 August 2015 - 04:00 PM.

[theobroma]

Interesting about Japan. Do they use it orally or topically?

 

OLE seems a good source of hydroxytyrosol as oleuropein is metabolised to hydroxytyrosol:

 

Mol Nutr Food Res. 2013 Nov;57(11):2079-85. doi: 10.1002/mnfr.201200795. Epub 2013 Jun 14.

Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaea L.) leaf extract.

de Bock M1, Thorstensen EB, Derraik JG, Henderson HV, Hofman PL, Cutfield WS.

Author information

 

Abstract

Phenolic compounds derived from the olive plant (Olea europaea L.), particularly hydroxytyrosol and oleuropein, have many beneficial effects in vitro. Olive leaves are the richest source of olive phenolic compounds, and olive leaf extract (OLE) is now a popular nutraceutical taken either as liquid or capsules. To quantify the bioavailability and metabolism of oleuropein and hydroxytyrosol when taken as OLE, nine volunteers (five males) aged 42.8 ± 7.4 years were randomized to receive either capsulated or liquid OLE as a single lower (51.1 mg oleuropein, 9.7 mg hydroxytyrosol) or higher (76.6 mg oleuropein, 14.5 mg hydroxytyrosol) dose, and then the opposite strength (but same formulation) a week later. Plasma and urine samples were collected at fixed intervals for 24 h post-ingestion. Phenolic content was analyzed by LC-ESI-MS/MS. Conjugated metabolites of hydroxytyrosol were the primary metabolites recovered in plasma and urine after OLE ingestion. Peak oleuropein concentrations in plasma were greater following ingestion of liquid than capsule preparations (0.47 versus 2.74 ng/mL; p = 0.004), but no such effect was observed for peak concentrations of conjugated (sulfated and glucuronidated) hydroxytyrosol (p = 0.94). However, the latter peak was reached earlier with liquid preparation (93 versus 64 min; p = 0.031). There was a gender effect on the bioavailability of phenolic compounds, with males displaying greater plasma area under the curve for conjugated hydroxytyrosol (11,600 versus 2550 ng/mL; p = 0.048). All conjugated hydroxytyrosol metabolites were recovered in the urine within 8 h. There was wide inter-individual variation. OLE effectively delivers oleuropein and hydroxytrosol metabolites to plasma in humans.

 

 

I wonder if the wide inter-intervidual variation was down to the gut flora of participants:

 

World J Microbiol Biotechnol. 2012 Jun;28(6):2435-40. doi: 10.1007/s11274-012-1036-z. Epub 2012 Mar 20.

Bioconversion of oleuropein to hydroxytyrosol by lactic acid bacteria.

Santos MM1, Piccirillo C, Castro PM, Kalogerakis N, Pintado ME.

Author information

 

Abstract

The aim of this work is to study the conversion of oleuropein-a polyphenol present in olives and olive oil by-products-into hydroxytyrosol, a polyphenol with antioxidant and antibacterial properties. The hydrolysis reaction is performed by lactic acid bacteria. Six bacterial strains (Lactobacillus plantarum 6907, Lactobacillus paracasei 9192, Lactobacillus casei, Bifidobacterium lactis BO, Enterococcus faecium 32, Lactobacillus LAFTI 10) were tested under aerobic and anaerobic conditions. The oleuropein degradation and hydroxytyrosol formation were monitored by HPLC. Results showed that oleuropein could be successfully converted into hydroxytyrosol. The most effective strain was Lactobacillus plantarum 6907, with a reaction yield of hydroxytyrosol of about 30 %. Different reaction mechanisms were observed for different microorganisms; a different yield was observed for Lactobacillus paracasei 9192 under aerobic or anaerobic conditions and an intermediate metabolite (oleuropein aglycone) was detected for Lactobacillus paracasei 9192 and Lactobacillus plantarum 6907 only. This study could have significant applications, as this reaction can be used to increase the value of olive oil by-products and/or to improve the taste of unripe olives.

 

 

Is anyone aware of cost-effective olive (fruit) extracts? I take olive leaf for this purpose but would consider switching for the right fruit concentrate (aside from the oil!).

[Rorororo]

Old thread but has anyone found a decent olive leaf extract? I'm currently shopping around and I'm a bit hesitant to make a purchase as there are a lot of no name companies making this stuff.

[Oakman]

Old thread but has anyone found a decent olive leaf extract? I'm currently shopping around and I'm a bit hesitant to make a purchase as there are a lot of no name companies making this stuff.

 

I've taken a lot of this one and no problems, definitely legit

 

Barlean's Olive Leaf Extract

[Rorororo]

Oakman thanks, just bought 2 bottles.

[GABAergic]

i got the natures way oleuropein and sent them a msg to ask where is the hydroxytyrosol? then they sent me email back advertising their new products if im interested (which i am not, thanks for the spam) and then finally answered me that they do not standardized for it. well, yes thanks, i knew that already my question was why?? damn

 

im considering trying another product now. this barlean product i had in the past, but i hate consuming oil products. i wish they made it in softgels or something to consume easier. any type of oil i consume, i get sick and throw up it doesnt matter how good quality it is. this barlean product made me throw up few times, especially that menthol cold taste aftertaste of grease yuck.

 

maybe i should just stick with oleuropein product since from the study above, it is converted to hydroxytyrosol in the gut? too bad natures way couldnt answer me.

[elc202]

This one contains both Oleuropein & Hydroxytyrosol
https://www.amazon.c...l/dp/B0756FYGFV
I have not tried it, too expensive. They claim 1 capsule = 1litre organic extra virgin olive oil!
 

[GABAergic]

This one contains both Oleuropein & Hydroxytyrosol
https://www.amazon.c...l/dp/B0756FYGFV
I have not tried it, too expensive. They claim 1 capsule = 1litre organic extra virgin olive oil!
 

 

i thought this product seems pretty damn cool UNTIL it was put to the test https://www.fakespot...-hydroxytyrosol yikes grade F with only 25% reliable reviews!?

well anyway regardless we have seen from studies that oleuropein is converted to hydroxytyrosol in the gut so why bother getting any supplement claiming to have both? in fact, every oleuropein supplement should mention this but they dont which sucks. especially natures way response sucks a lot.