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[bluecity]

Pawhuskin A – selective; naturally-occurring[37] (kappa antogonist)

 

 

http://en.wikipedia....tor#Antagonists

 

 

Pawhuskin A is a naturally-occurring prenylated stilbene isolated from Dalea purpurea which acts as a competitive silent antagonist of the κ-, μ-, and δ-opioid receptors (Ke = 203 nM, 570 nM, and 2900 nM, respectively)

 

 

http://en.wikipedia....iki/Pawhuskin_A

 

 

Purple prairie clover provides food for a number of animals, such as pronghorn. It also grows in cultivated fields and becomes included in hay for livestock. It is nutritious and is "considered one of the most important legumes in native grasslands on the Great Plains." It also had a number of uses for Native Americans. The leaves are edible and good for making tea and medicines, and the roots are palatable when chewed.

 

 

http://en.wikipedia..../Dalea_purpurea

 

Being an antogonist at everywhere, no abuse potential. Perhaps, no risk of being regulated.

 

Is it safe and practical? What do you think?

 

[Mind_Paralysis]

I'm not so sure it is... since unlike JDtic this isn't selective at all, and hits pretty much every single opiod-receptor at the same time. What is the actual effects of antagonizing the other receptors? I'm aware of the effects of K-opiod receptor antagonism, and the theoretical mode of action of JDtic, but I'm completely in the dark on these other ones.

 

And then there's the fact that it's a plant, so it'll be hard to get consistent dosing, and there's bound to be a lot of other confounding phyto-chemicals in there.

 

What are the medicinal effects that the Native Americans used this plant for? Is there anywhere that such information can be obtained? Has it been used as a traditional anxiolytic or antidepressant by them?