731 replies to this topic

[Freebytes]

 

[quote name="Nate-2004" post="789991" timestamp="1474549119"]
I don't recall why offhand, but Quercetin also struck me as something to be taken infrequently, due to an undesirable epigenetic effect IIRC.

Just curious. What undesirable epigentic effect are you referencing?

[LOOKINGFORTIME]

I would take 5grams

I hope I did not repeat myself, but I will take 5 grams.

[Ygdrasil]

Finally made an account to get in on this. I will take 5g. Thank you for setting this up.

[Rocket]

Add me to the buy for 5g.

[DareDevil]

Please bump up my order from 10g to 20g - Thanks !

 

DareDevil

[Rocket]

Is this still a go?

[JamesBhoy]

Hey folks.
Put me down for 5 grams please.
Also ideally tested

Edited by JamesBhoy, 04 November 2016 - 06:00 PM.

[ceridwen]

5g please

[mikey]

Dasitinib Group Buy.  By Logic

 

SearchingForAnswers    6 grams
Niner                               10
Logic                               10
Fafner55                         10

mikey                                5

Cosmicalstorm                 5

Total                                46

 

454 grams to go to get to the 500 gram minimum.

 

Please state your preference regard testing or not.  

ie:  $ 5.82/g tested, or $ 4.62 untested.

 

Please 'advertise' the buy so we can get to the 500 gram minimum!

 

Please raise mine to 10 g., tested.

 

I've just started experimenting with dasitinib and liposomal quercitin.

 

Thanks, again, Nyles, for organizing this group buy.

Edited by mikey, 06 November 2016 - 05:15 AM.

[Ygdrasil]

Raise mine to 10g, tested as well. Thank you.

[Vantika]

Hey, Logic.

 

Put me down for fifty grams (50g), tested.

 

I've PMed you my info.

 

[Haste]

Hi Logic,

 

I'd be up for 5g tested for the Dasitinib Group Buy.

[DareDevil]

Hi Nyles,

 

I didn't realize we were far from minimum quantity.

 

Let's move this Group Buy forward:

 

original 20g + new 30g = 50 grams tested

 

Thanks for keeping us updated

 

DareDevil

[ceridwen]

Sorry changed my mind again. Opting out

[Colorow]

I will also take 5 grams. Not sure if this is still active.

[Colorow]

Upping to 10 grams, tested. Thanks,
Upping to 10 grams, tested. Thanks,
Upping to 10 grams, tested. Thanks,

[mikey]

Hello,

 

I'm flooded busy and have't had time to read.

 

Is there a consensus on optimum dosing/situation for dasatinib with quercitin?

 

Thank you!

[DareDevil]

Hi Mikey,

 

I am new at this so don't take my suggestion as a rule to follow. I tried Quercetin with the smallest pharmaceutically available dosage of Dasatinib called Sprycel and it was in 10mg doses. I took two per day making my dosage 20mg. I noticed it having a definite positive effect and I will therefore start my own protocol, unless I hear otherwise from board members here, with 30mg daily of Dasatinib and 300mg daily of Quercetin. Others may propose entirely different proticols. But I think this is new enough that we don't have a lot of dosage data to work with. Starting small and working your way up seems wisest.

 

DareDevil

[Captain Obvious]

I'll raise my amount from 5 g to 10 g, thanks.

What's the status? Has anybody calculated the current total amount and how much we are lacking?

[Logic]

Dasitinib Group Buy.  By Logic

SearchingForAnswers     20 grams
Niner                               10
Logic                               10
Fafner55                         10
mikey                                5
Cosmicalstorm                  5
Rarefied                           10
ClarkSims                         20
Nate-2004                        10

ceridwen                           5

prophets                           5

Authentic                          5

mkp6019                          5

DareDevil                         50

Captain Obvious               5-10

LookingForTime               5

Ygdrasil                            5

Vantika                             50

Haste                                5

Katkay                              10

 

Total                                250-255

 

Well! This list and quantity has grown while I've been away!  (Setting up a gold mine in Mozambique etc-etc...)

 

However; Price:

I was extremely embarresed when I realised that I had omitted to add the $ 600 dollar cost of testing to the 50 and 100 gram price worked out:

• 100g at $ 6.72 per gram
• 50g   at $ 9.22 per gram

But the point is now moot at 250 grams in total.

At that volume I may just be able to negotiate a better price from the supplier and currently await a reply to that end.

The cost of testing is $ 600.  Divided by 250 grams = $ 2.40 per gram.

 

As the price for 500 grams was $ 4.62 and for 100 grams was $ 6.60, I am guessing that 250 grams will be around $5 per gram. (untested and undelivered to the lab)
Delivery to the lab and testing should give a final price in the region of ~$ 7.50 per gram.  (Final postage from the lab excluded. See USPS)
I will post the final price as soon as I get it, assuming work does not interfere.

I apologise for omitting to add the testing price to the 100 gram quote. and the ever changing price.  Hopefully Dasatinib will kill of the stupid, forgetful brain cells!  

[Logic]

Hi, just found this topic.

Please, count me in for 5 grams if international airmailing is not an issue.

I could go for 10 g, but I'm unsure of the dosage (20-30 mg per day vs every couple of months) and how long it would keep in a freezer.

 

 

Let me answer by quoting a message I sent to a Nilotinib buyer:

 

I have no problem with the keeping of the N in the freezer or fridge as long as the following law of physics are understood:
Moisture in the air will condense on a cold surface.  (much like the droplets formed on a cold glass of water)
If that cold surface happens to be a Particle of N; that is what the moisture will condense on.

So lets imagine you put the N in a jam jar with an airtight lid and put it in the freezer for long term storage.
Now the powder itself eventually cools down to around -20C.
When you take the jar out, but leave it sealed moisture will form on the cold outer surface of the jar.
That's fine, but if you open the jar while the powder is cooler than ambient temperature; then the powder itself becomes a cold surface on which moisture condenses and you don't want that.
ie:  You need to wait for the jar and powder to warm up to ambient temperature before opening the jar.

Now lets assume you take out your month's supply reseal the jar and put it back in the freezer.
The moisture in the air in the bottle will condense on the surface that is coldest 'firstest'; the glass wall of the jar.
The powder touching the glass wall of the jar will be affected by this condensation...
Also the condensed moisture /water on the glass above the powder may run down and affect more than just the particles touching the glass surface...
ie: You need to absorb the moisture in the air in the jar with silica gel sachets before cooling it down again...
     Also the less air/free space in the sealed container; the less water vapour there will be...

Because this is so difficult to explain and confusing to most, most medication manufacturers simply recommend keeping the medication in a cool, dry place.
I think the proper thawing and pre freezing drying  of N is a good idea.

(Because light also oxidises things; they recommend a cool, dry, dark place...
ie:  Any supps that are sold in clear containers should be avoided.
They especially like to sell fish oil caps in clear containers so that you can see the lovely golden hued gelcaps.
Oils are especially susceptible to light, so don't fall for this marketing gimmick. 
Buy oils that come in dark containers. Fish and olive oil in clear containers are very bad for you and sure sign that the marketer is unscrupulous and to be avoided, at the very least!)

 

Then there is this product which is ideal for keeping powders and C60oo etc with the minimum amount of air, to no air, in the container:
http://beanvac.com.au/

https://www.amazon.c...12[b|lifehacker

Edited by Logic, 28 November 2016 - 10:11 PM.

[Logic]

 

 

[quote name="Nate-2004" post="789991" timestamp="1474549119"]
I don't recall why offhand, but Quercetin also struck me as something to be taken infrequently, due to an undesirable epigenetic effect IIRC.

Just curious. What undesirable epigentic effect are you referencing?

 

 

I dont remember what caught my eye, so did a quick search:

https://www.ncbi.nlm...pubmed/15613018

http://www.livestron...etin-bromelain/

https://www.ncbi.nlm...pubmed/20548785

 

That last one is a little ambiguous, but what I find especially worrying is the fact that Q seems to mess with HSPs. (Heat Shock Proteins)
Now HSPs switch off  seems to be the reason for  nematodes aging and dying soon after mating and may just be a big part of the programmed aging argument..?

https://cse.google.c...ematodes sexual

[Ygdrasil]

 

Raise mine to 10g, tested as well. Thank you.

 

Reconfirming 10g tested. Thank you.

[Fred_CALICO]

I would take 10 grams (tested). I live in europe (france), does this pose a problem for delivery?

[Logic]

I would take 10 grams (tested). I live in europe (france), does this pose a problem for delivery?

 

No it doesn't Fred:  I have sent Nilotinib there before and will use the same method for the D.

[Vantika]

I tried Quercetin with the smallest pharmaceutically available dosage of Dasatinib called Sprycel and it was in 10mg doses. I took two per day making my dosage 20mg. I noticed it having a definite positive effect...

 

Can you elaborate on what effects you noticed?

[Logic]

Dasitinib Group Buy.  By Logic

 

SearchingForAnswers     20 grams
Niner                               10
Logic                               10
Fafner55                         10
mikey                                5
Cosmicalstorm                  5
Rarefied                           10
ClarkSims                         20
Nate-2004                        10
ceridwen                           5
prophets                           5
Authentic                          5
mkp6019                          5
DareDevil                         50
Captain Obvious               5-10
LookingForTime                5
Ygdrasil                            10
Vantika                             50
Haste                                5
Katkay                              10

Fred_CALICO                  10

Total                                265 -270

 

Price:

The price was not as low as I anticipated:

Best I could get @ 255 grams is $ 6.46/g
Shipping:                                     $ 0.12
Testing:                                       $  2.35
Total:                              $ 8.93 (Excluding Paypal Fees (0.5% + $0.30 IIRC) and postage from the lab which varies depending on your location. ($ 6.80 in the USA )

Order and Payment procedure:

• PM me your name and postal address and confirm the amount in grams of D you would like.
• Optional info:  Your Email address as an alternate means of communication and a phone # for USPS should you be away when they deliver.

I will then send you a costing that includes the PayPal fee and Postage and my PayPal details.

Once all the funds are received I will place the order and pay the supplier.

Shipping to the lab takes about a week. (It may take longer at this time of year)
The good doctor at the testing lab 'marches to the tune of his own drum' so it can take anything from 5 days to 2 weeks for him to do the testing, aliquoting (Lab Conditions) and postage.

Amongst more general updates, I will post a redacted copy of the mass spectrography lab report here, as well as send the full report to Niner for confirmation.

(For those that are new; Niner used to be our trusted mentor and moderator here, before it was required he pay for membership!? He still is to my mind.

Check his post count and TY score here: http://www.longecity...ser/4238-niner/ )

I will PM or Email you your tracking # when I get it from the lab.

I have done 3 group buys (4th in progress) for Nilotinib so far and due to some diligent research, have not had any issues (customs etc) posting anywhere in the world. (touch wood) 
 

Disclaimer:
I am not a doctor, nor do I claim to have any formal medical background.
I am not liable, either expressly or in an implied manner, nor claim any responsibility for any physical or emotional problems that may occur directly or indirectly from the use of any supplement or medication, or advice on this forum.

Products currently covered by valid patents are offered for R&D use in accordance with (i) 35 USC 271(e)+A13(1) in the U.S.; (ii) Section 69.1 of Japanese Patent Law in Japan; (iii) Section 11, No. 2 of the German Patent Act of 1981 in Germany; (iv) Section 60, Paragraph 5b of the U.K. Patents Act of 1977 in the U.K.; (v) Section 68B of the Patents Act of 1953 in New Zealand; (vi) such related legislation and/or case law as may be or become applicable in the aforementioned countries; and (vii) such similar laws and rules as may apply in various other countries. In the European Union, equivalent exemptions are allowed under the terms of EC Directives 2001/82/EC (as amended by Directive 2004/28/EC) and 2001/83/EC (as amended by Directives 2002/98/EC, 2003/63/EC, 2004/24/EC and 2004/27/EC). Any patent infringement issue and resulting liability is solely at buyer's risk.

Please read the warnings and contraindications etc carefully before beginning any research with Dasatinib or any other concomitant medication or supplement:

http://www.sprycel.com/side-effects

https://www.accessda...021986s7s8lbl.p

 

 

 

[Rocket]

Put rocket down for 10g please.

[mikey]

Hi Mikey,

 

I am new at this so don't take my suggestion as a rule to follow. I tried Quercetin with the smallest pharmaceutically available dosage of Dasatinib called Sprycel and it was in 10mg doses. I took two per day making my dosage 20mg. I noticed it having a definite positive effect and I will therefore start my own protocol, unless I hear otherwise from board members here, with 30mg daily of Dasatinib and 300mg daily of Quercetin. Others may propose entirely different proticols. But I think this is new enough that we don't have a lot of dosage data to work with. Starting small and working your way up seems wisest.

 

DareDevil

 

As to Dasatinib dosage - I wish I had retained the data - I can't find it now and I'm rushed.

I came up with about 300 mg for my body weight, 185 lbs.

 

So, I've taken 300 mg with about ten times as much quercitin, two times, spaced a month apart -- but as liposomal quercitin, and noticed tremendous age-reversal effects, this last time the most.

 

AND -- more importantly I had two friends independently, and without any prompting on my part, remark that my "hair was getting darker..." 

I have noticed a distinct diminishing of the depth of wrinkles on my face.

Edited by mikey, 01 December 2016 - 12:56 AM.

[niner]

As to Dasatinib dosage - I wish I had retained the data - I can't find it now and I'm rushed.

I came up with about 300 mg for my body weight, 185 lbs.

 

So, I've taken 300 mg with about ten times as much quercitin, two times, spaced a month apart -- but as liposomal quercitin, and noticed tremendous age-reversal effects, this last time the most.

 

Mikey, are you sure it was 300 mg?  That's a pretty large dose of Dasatinib.  The normal starting dose for Chronic Myeloid Leukemia is 100 or 140 mg/day, and the drug is supplied in dosage sizes as low as 20 mg.

 

Did you get it from TLR or was it pharmaceutical?  What did it look like?

 

This is the Dasatinib Package Insert from Bristol-Myers Squibb.  It's a very useful resource.