2 replies to this topic

[zorba990]

So, here,
http://austinpublish...b-v1-id1001.php

They say
" However, since GDF11 (potential CSEF) expression has been documented to be highly expressed in the immunological organs, including the spleen (the organ with highest expression) and the thymus (third highest expression), and the expression of GDF11 declines with age in these organs [20], it is reasonable to assume that GDF11 should impact the aged immune system. Since CSEF can be used for rejuvenating therapy for age-related changes to the CNS, muscle, and myocardium, it becomes increasingly important to determine how CSEF may affect the immune system: beneficial, detrimental, or otherwise. The work will help the rejuvenation of age-related risk factors to cardiovascular and neurodegenerative diseases [52,53]."


So does maximizing function or somehow inducting rejuvenation of these organs make more sense than trying to introduce endogenous gdf-11?
Thymic stem cells or ?

Thymic regeneration by a single transcriptikn factor
http://www.nature.co...bs/ncb3023.html

Edited by zorba990, 21 March 2015 - 10:42 PM.

[Logic]

Here we report that, at low doses, SkQ1 (250 nmol/kg per day) inhibited age-dependent involution of the thymus in normal (Wistar) and senescence-prone (OXYS) rats. SkQ1 preserved total weight and volume of the organ, the volume of thymic cortex and medulla, the thymic cellularity, and the number of CD3+, CD4+, and CD8+ cells in the thymus

http://www.longecity...nti-aging-pill/

 

Thymus Rejuvenation

http://www.longecity...s-rejuvenation/

http://lang-leben.xo...on-Program.html

 

http://www.longecity...-in-the-thymus/

 

Q10 and the thymus

http://www.longecity...and-the-thymus/

 

Russian Anti-Aging Injection..

http://www.longecity...ging-injection/

 

http://www.longecity...ndpost&p=520456

 

ntervene Immune is using HGH and DHEA to regrow the thymus. Greg Fahy, who is associated with this company, claims that he has regrown his thymus according to MRI scans. His level of good, naive T-cells has also increased.

http://www.longecity...nation-efforts/

 

 

[HighDesertWizard]

Logic... You're interested in Rejuvenation... I like that... I appreciate the lead about GDF-11... I have a lead for you...

 

http://journals.plos...al.pone.0078478

 

Notice that Creb phosphorylation is involved... And then notice here that Creb Phosphorylation is involved in the functioning of the Vagus-HRV-CAIP Nexus and Heterochronic Parabiosis...

 

I've begun to think that Creb Phosphorylation is a huge puzzle piece...

 

Because there's this and this and this and this and, OMG, how about this?

 

And remember... the graphic figure below highlights what we're looking for... The complete set of 8 slides, that highlights the Mechanism driving the two graphic figures below is here... Notice that one of the last gears of the Mechanism is Creb Phosphorylation...

 

 

 

Edited by HighDesertWizard, 28 April 2015 - 12:17 PM.