33 replies to this topic

[jaiho]

Yep those symptoms match mine. I only got Anhedonia after SSRI use. 

No idea how to reverse excess serotonin and get my dopamine going again. St johns wort makes me tired and irritable as hell, damnit

[Area-1255]

Yep those symptoms match mine. I only got Anhedonia after SSRI use. 

No idea how to reverse excess serotonin and get my dopamine going again. St johns wort makes me tired and irritable as hell, damnit

Shilajit extract; Black Indian Shilajit..there are two kinds you can buy though.

 

• High Mountain Shilajit 
• Black Indian Shilajit

 

Amazon and the contracting companies sell the first one, I think there is only one supplier that sells the second one..that's Rootofthematter.ca - but whether it is in stock atm IDK.

[Michael Rian]

Yep those symptoms match mine. I only got Anhedonia after SSRI use.
No idea how to reverse excess serotonin and get my dopamine going again. St johns wort makes me tired and irritable as hell, damnit

Shilajit extract; Black Indian Shilajit..there are two kinds you can buy though.

• High Mountain Shilajit
• Black Indian Shilajit

Amazon and the contracting companies sell the first one, I think there is only one supplier that sells the second one..that's Rootofthematter.ca - but whether it is in stock atm IDK.

I think my anhedonia is also from years of ssris.

I've tried plenty of natural supplements and herbs over the years, but none seem to help the anhedonia.

Would you be able to suggest any prescription medications that might help someone with anhedonia? I also have crohns disease, which I think there is data on an imbalance of serotonin and dopamine.

Any help would be great.

Ref:ncbi.nlm.nih.gov/pmc/articles/PMC3108661/#__abstractid177755title

[Area-1255]

 

 

Yep those symptoms match mine. I only got Anhedonia after SSRI use.
No idea how to reverse excess serotonin and get my dopamine going again. St johns wort makes me tired and irritable as hell, damnit

Shilajit extract; Black Indian Shilajit..there are two kinds you can buy though.

• High Mountain Shilajit
• Black Indian Shilajit

Amazon and the contracting companies sell the first one, I think there is only one supplier that sells the second one..that's Rootofthematter.ca - but whether it is in stock atm IDK.

I think my anhedonia is also from years of ssris.

I've tried plenty of natural supplements and herbs over the years, but none seem to help the anhedonia.

Would you be able to suggest any prescription medications that might help someone with anhedonia? I also have crohns disease, which I think there is data on an imbalance of serotonin and dopamine.

Any help would be great.

Ref:ncbi.nlm.nih.gov/pmc/articles/PMC3108661/#__abstractid177755title

 

Shilajit should help; it decreases serotonin production and in the periphery it modulates serotonin-induced contractions. 

 

Yes, that's correct though - Crohn's Disease & Diarrhea Predominant-IBS are both rooted in, at least in part, high serotonin levels..too much serotonin contributes to an over-active gut / aka spastic colon as well as other issues with digestion...whereas low serotonin is the opposite - producing a tendency towards constipation although this isn't the case much of the time if your beta-adrenergic reactivity and nitric oxide production is on point.

 

Role of serotonin in the pathophysiology of the irritable bowel syndrome Serotonin receptor modulators in the treatment of irritable bowel syndrome

 

 

Serotonin receptor modulators in the treatment of irritable bowel syndrome

 

 

Effects of Shilajit on memory, anxiety and brain monoamines in rats

AK Jaiswal, SK Bhattacharya
, 

Correspondence Address:
A K Jaiswal

Source of Support: None, Conflict of Interest: None

 

 

  The effect of Shilajit was investigated for putative nootropic and anxiolytic activity, and its effect on rat brain monoamines using Charles Foster strain albino rats. Nootropic activity was assessed by passive avoidance learning and active avoidance learning acquisition and retention. Anxiolytic activity was evaluated by the elevated plus-maze technique. Rat brain monoamines and monoamine metaboliteswere estimated by a HPLC technique. The results indicated that Shilajit had significant nootropic and anxiolytic activity. The biochemical studies indicated that acute treatment with Shilajit had insignificant effects on rat brain monoamine and monoamine metabolite levels. However, following subacute (5days) treatment, there was decrease in 5-hydroxytryptamine and 5-hydroxyindole acetic acid concentrations and an increase in the levels of dopamine, homovanillic acid and 3.4-dihydroxyphenyl-acetic acid concentrations, with insignificant effects on noradrenaline and 3-methoxy-4- hydroxyphenylethylene glycol levels. The observed neurochemical effects induced by Shilajit, indicating a decrease in rat brain 5-hydroxytryptamine turnover, associated with an increase in dopaminergic activity, helps to explain the observed nootropic and anxiolytic effects of the drug. 

Edited by Area-1255, 12 September 2015 - 11:12 PM.