232 replies to this topic

[niner]

This is the thought that floated through my mind while estimating what an optimal daily dose of glycine might be as it relates to MR.   It seems some people are taking upwards of 10grams, that sounded a bit high to me and then I came across the above cited paper. Understood that the paper does not directly apply to what we're doing w/ MR, but still had me thinking because methionine was one of the methyl groups mentioned.

This paper shows glycine alleviates liver injury induced by defeciency in methionine:
 
http://www.ncbi.nlm....pubmed/22913202

 

I've been wondering about dose, and also timing of dose.  Since the half life of Gly is not very long, I've been taking it around the same time that I consume proteins, particularly animal proteins.  It seems like a very safe substance, but consuming a lot of free glycine is not something that we evolved doing.  Collagen is a good source of Gly, for what it's worth.  We've been eating that forever.

[motorcitykid]

 

This is the thought that floated through my mind while estimating what an optimal daily dose of glycine might be as it relates to MR.   It seems some people are taking upwards of 10grams, that sounded a bit high to me and then I came across the above cited paper. Understood that the paper does not directly apply to what we're doing w/ MR, but still had me thinking because methionine was one of the methyl groups mentioned.

This paper shows glycine alleviates liver injury induced by defeciency in methionine:
 
http://www.ncbi.nlm....pubmed/22913202

 

I've been wondering about dose, and also timing of dose.  Since the half life of Gly is not very long, I've been taking it around the same time that I consume proteins, particularly animal proteins.  It seems like a very safe substance, but consuming a lot of free glycine is not something that we evolved doing. 

 

I've been doing the same, taking free glycine with each of my animal protein meals- so that's 2 grams of glycine 3 x per day. But like you said, even though free glycine's considered safe it's not something we've evolved consuming. The thought of taking it 3 x per day for the next 50 years to mimic MR makes me a little uneasy, but for now I'll stay on that path.

 

I've noticed that taking glycine in the amount described above seems to have a positive effect on my memory. I think I might have been deficient in glycine. I went through the list of foods consumed in my lean, high animal protein diet and there's not much glycine there. Plenty of methionine though.  

 

I take hydrolyzed collagen. Logic mentioned Gelatin as a good glycine source as well, I've been looking into it.

 

 

 

Edited by motorcitykid, 17 November 2015 - 05:24 AM.

[cuprous]

 

This is the thought that floated through my mind while estimating what an optimal daily dose of glycine might be as it relates to MR.   It seems some people are taking upwards of 10grams, that sounded a bit high to me and then I came across the above cited paper. Understood that the paper does not directly apply to what we're doing w/ MR, but still had me thinking because methionine was one of the methyl groups mentioned.

This paper shows glycine alleviates liver injury induced by defeciency in methionine:
 
http://www.ncbi.nlm....pubmed/22913202

 

I've been wondering about dose, and also timing of dose.  Since the half life of Gly is not very long, I've been taking it around the same time that I consume proteins, particularly animal proteins.  It seems like a very safe substance, but consuming a lot of free glycine is not something that we evolved doing.  Collagen is a good source of Gly, for what it's worth.  We've been eating that forever.

 

 

From what I have anecdotally read we don't consume glycine like we used to because we now only eat the meats of animals and not the glycine-rich ligaments that used to go into broths and the like.

[niner]

From what I have anecdotally read we don't consume glycine like we used to because we now only eat the meats of animals and not the glycine-rich ligaments that used to go into broths and the like.

 

Yeah, the whole animal is a pretty good nutrient package.   It wasn't that long ago that people used a lot more of the animal, but the factory farm system has been optimized to give people only what they really want to eat.  That's not such a good thing...

[Skyguy2005]

 

From what I have anecdotally read we don't consume glycine like we used to because we now only eat the meats of animals and not the glycine-rich ligaments that used to go into broths and the like.

 

Yeah, the whole animal is a pretty good nutrient package.   It wasn't that long ago that people used a lot more of the animal, but the factory farm system has been optimized to give people only what they really want to eat.  That's not such a good thing...

 

 

What about just eating Tofu? It's called Glycine Max, so I assume it's high in glycine and it's pretty low in methionine/cysteine. I also get a nice uplifting feeling from, it, something I first noticed in Ginkgo Biloba, then Reishi, and vitamin D (and a little from vitamin C).

 

I tried gelatin one time and it made me feel so bad, so I won't eat it again. I even threw out some Reishi and vitamin D that I realised had gelatin capsules.

Edited by Skyguy2005, 21 November 2015 - 07:15 PM.

[aribadabar]

.I even threw out some Reishi and vitamin D that I realised had gelatin capsules.

You overreacted - the  gelatin capsule is such a negligible amount that it would be irrelevant in your overall daily dietary intake unless you take 30+ tabs/day.

 

That being said, you can buy USP glycine powder pretty cheaply if you are so sensitive to gelatin.

[Skyguy2005]

 

.I even threw out some Reishi and vitamin D that I realised had gelatin capsules.

You overreacted - the  gelatin capsule is such a negligible amount that it would be irrelevant in your overall daily dietary intake unless you take 30+ tabs/day.

 

That being said, you can buy USP glycine powder pretty cheaply if you are so sensitive to gelatin.

 

 

I disagree. I listen to whatever "body" says, no matter the wisdom or foolishness, and in this case I did not like Gelatin.

 

Glycine was OK. However it has made me cautious around protein powders (this may be overreaction). As I said, I would prefer to just eat Tofu.

[aribadabar]

Tofu is a lousy source of glycine. You need to eat ~1kg tofu to get 3g of glycine!

 

Glycine Max is derived from the Latin name of soybeans species , not for its rich glycine amino acid content.

 

Unfortunately, there is nothing plant-based that can even remotely compare to gelatin if you are looking for glycine consumption.

[Skyguy2005]

Tofu is a lousy source of glycine. You need to eat ~1kg tofu to get 3g of glycine!

 

Glycine Max is derived from the Latin name of soybeans species , not for its rich glycine amino acid content.

 

Unfortunately, there is nothing plant-based that can even remotely compare to gelatin if you are looking for glycine consumption.

 

In any case, the maximal content of glycine in animal foods (if glycine is as good as everyone seems to say) which are known to be *bad* surely makes methionine (also high in animal foods) really, really, really *bad*?

 

Perhaps time spent consuming glycine is better spent avoiding sources of methionine?

[aribadabar]

 

Perhaps time spent consuming glycine is better spent avoiding sources of methionine?

 

 

And what's wrong with taking USP glycine powder and get the best of both Gly supplementation and Met restriction?

That's what I personally do ( in addition to a non-ovo-lacto pescetarian diet) and if I happen to have some gelatin caps on my supplements I don't break a sweat of the minuscule Met consumption from it.Beans/legumes become your best friend and you are all set

 

As already mentioned in this thread, Glycine (as a supplemental powder) seems to have demonstrated enough positive effects to have convinced me that consuming it is time (and money) well spent.

[aza]

 

Tofu is a lousy source of glycine. You need to eat ~1kg tofu to get 3g of glycine!

 

Glycine Max is derived from the Latin name of soybeans species , not for its rich glycine amino acid content.

 

Unfortunately, there is nothing plant-based that can even remotely compare to gelatin if you are looking for glycine consumption.

 

In any case, the maximal content of glycine in animal foods (if glycine is as good as everyone seems to say) which are known to be *bad* surely makes methionine (also high in animal foods) really, really, really *bad*?

 

Perhaps time spent consuming glycine is better spent avoiding sources of methionine?

 

Well, if it is semi essential like the study i posted earlier suggests, It would be much better to actually eat the glycine. High glycine parts of the animal are usually low in methionine im pretty sure.

[Skyguy2005]

 

 

Perhaps time spent consuming glycine is better spent avoiding sources of methionine?

 

 

And what's wrong with taking USP glycine powder and get the best of both Gly supplementation and Met restriction?

That's what I personally do ( in addition to a non-ovo-lacto pescetarian diet) and if I happen to have some gelatin caps on my supplements I don't break a sweat of the minuscule Met consumption from it.Beans/legumes become your best friend and you are all set

 

As already mentioned in this thread, Glycine (as a supplemental powder) seems to have demonstrated enough positive effects to have convinced me that consuming it is time (and money) well spent.

 

 

I'm just remembering how much I hate gelatin really (if God existed somewhere and could hold wagers between mortals, I would wager any amount of money against anyone at any odds that gelatin has bad effects on me). I actually have vegan glycine somewhere, haven't tried it for some time.

Edited by Skyguy2005, 23 November 2015 - 07:45 PM.

[PerfectSeek]

I notice Glycine helps with sleep quality as well as accelerating fat loss on a hypocaloric diet.  I am taking ~7g before bed.  The effects on sleep become less noticeable over time.  

[motorcitykid]

I believe glycine is responsible for shrinking a cyst I had on the back of my neck. I had this cyst for a few years-the cyst was not a visual protrusion it was something you'd have to feel with your finger to know it was there.

 

My dermatologist told me(a few years ago) that it was too deep for him to perform a biopsy-he wanted to send me to a specialist but I declined. He said that if it wasn't getting any larger that it would probably shrink in time. Well, it wasn't getting any larger but it wasn't shrinking either. It stayed the same size for approx two years.

 

I had never taken glycine or beef gelatin before nor do I eat foods that contain much glycine. I would describe my diet as cross-bred Paleo/Mediterranean.  Approx 2 months ago, I started taking 2grams of glycine(NOW brand) with every meal and two glasses of Great Lakes Gelatin every day.

 

I am completely blown away by the fact that the cyst has shrunken to about 2/3 the size of what it was. Remember now, for two years the cyst was the same size. I started taking glycine approx 2 months ago and it has diminished in size significantly. It could be a coincidence but I don't think so.

 

Just for the record, I also added Myo-X and BCAA's to my regimen over the past few months as well, but based on what we know about  Myo-X and BCAA's I doubt they had anything to do w/ the cyst's size reduction.

 

Will post update as to whether the cyst continues to shrink in size.

 

It also might be worth mentioning that I had a nagging pain in my left shoulder which developed over the past few years. It was affecting my workouts, particularly my bench press. Since I started taking the glycine and gelatin over the past few months, the pain has reduced significantly. I would describe the pain as being minute compared to what it was. It has been reduced from a consistent nagging pain to minor discomfort I feel now and then.

Edited by motorcitykid, 22 January 2016 - 05:41 PM.

[docmaas]

Have you seen this?

 

http://www.lipomaboa...ml#.VqJuMlMrLdT

 

 

I believe glycine is responsible for shrinking a cyst I had on the back of my neck. I had this cyst for a few years-the cyst was not a visual protrusion it was something you'd have to feel with your finger to know it was there.

 

My dermatologist told me(a few years ago) that it was too deep for him to perform a biopsy-he wanted to send me to a specialist but I declined. He said that if it wasn't getting any larger that it would probably shrink in time. Well, it wasn't getting any larger but it wasn't shrinking either. It stayed the same size for approx two years.

 

I had never taken glycine or beef gelatin before nor do I eat foods that contain much glycine. I would describe my diet as cross-bred Paleo/Mediterranean.  Approx 2 months ago, I started taking 2grams of glycine(NOW brand) with every meal and two glasses of Great Lakes Gelatin every day.

 

I am completely blown away by the fact that the cyst has shrunken to about 2/3 the size of what it was. Remember now, for two years the cyst was the same size. I started taking glycine approx 2 months ago and it has diminished in size significantly. It could be a coincidence but I don't think so.

 

Just for the record, I also added Myo-X and BCAA's to my regimen over the past few months as well, but based on what we know about  Myo-X and BCAA's I doubt they had anything to do w/ the cyst's size reduction.

 

Will post update as to whether the cyst continues to shrink in size.

 

It also might be worth mentioning that I had a nagging pain in my left shoulder which developed over the past few years. It was affecting my workouts, particularly my bench press. Since I started taking the glycine and gelatin over the past few months, the pain has reduced significantly. I would describe the pain as being minute compared to what it was. It has been reduced from a consistent nagging pain to minor discomfort I feel now and then.

 

[docmaas]

Potential negative impact of glycine in enhanced cell proliferation in cancer.

 

This is of concern.  There is other research that indicates that Glycine is of benefit in some cancers but this research started off as an in vitro metabolomic assessment of what changes with regard to a large panel of substances on a large set of cancer cell lines.  This was followed by more research that appears to confirm the association between existing cancer, glycine expression/availability, and mortality.

 

http://www.ncbi.nlm....les/PMC3526189/

 

Certainly gives me pause.

 

 

[motorcitykid]

 

Have you seen this?

 

http://www.lipomaboa...ml#.VqJuMlMrLdT

 

 

 

 

 

I believe glycine is responsible for shrinking a cyst I had on the back of my neck. I had this cyst for a few years-the cyst was not a visual protrusion it was something you'd have to feel with your finger to know it was there.

 

My dermatologist told me(a few years ago) that it was too deep for him to perform a biopsy-he wanted to send me to a specialist but I declined. He said that if it wasn't getting any larger that it would probably shrink in time. Well, it wasn't getting any larger but it wasn't shrinking either. It stayed the same size for approx two years.

 

I had never taken glycine or beef gelatin before nor do I eat foods that contain much glycine. I would describe my diet as cross-bred Paleo/Mediterranean.  Approx 2 months ago, I started taking 2grams of glycine(NOW brand) with every meal and two glasses of Great Lakes Gelatin every day.

 

I am completely blown away by the fact that the cyst has shrunken to about 2/3 the size of what it was. Remember now, for two years the cyst was the same size. I started taking glycine approx 2 months ago and it has diminished in size significantly. It could be a coincidence but I don't think so.

 

Just for the record, I also added Myo-X and BCAA's to my regimen over the past few months as well, but based on what we know about  Myo-X and BCAA's I doubt they had anything to do w/ the cyst's size reduction.

 

Will post update as to whether the cyst continues to shrink in size.

 

It also might be worth mentioning that I had a nagging pain in my left shoulder which developed over the past few years. It was affecting my workouts, particularly my bench press. Since I started taking the glycine and gelatin over the past few months, the pain has reduced significantly. I would describe the pain as being minute compared to what it was. It has been reduced from a consistent nagging pain to minor discomfort I feel now and then.

 

 

 

No I have not seen this, thanks for sending. I assumed the glycine acted as a methionine metabolite, hence the cyst reduction size but that's a broad explanation and doesn't really get down to what the mechanism of action is.

Because of conflicting reports for glycine both pro/anti tumor, the thought remains in my mind as to whether it acts the same on both benign and malignant tumors(even though it seems that there is more data suggesting it's anit-carcinogenic). I'm assuming the cyst I had was benign because it remained the same size for 2 years and I get bloodwork every six months w/ no red flags.

 

Just wondering what the prospects are for glycine reducing the size of a benign tumor, and in other cases, causing dormant pre-cancerous cells to proliferate.

 

Edited by motorcitykid, 22 January 2016 - 06:42 PM.

[motorcitykid]

Potential negative impact of glycine in enhanced cell proliferation in cancer.

 

This is of concern.  There is other research that indicates that Glycine is of benefit in some cancers but this research started off as an in vitro metabolomic assessment of what changes with regard to a large panel of substances on a large set of cancer cell lines.  This was followed by more research that appears to confirm the association between existing cancer, glycine expression/availability, and mortality.

 

http://www.ncbi.nlm....les/PMC3526189/

 

Certainly gives me pause.

 

I'm taking into consideration that in addition to the shrunken cyst, my shoulder pain has diminished significantly. I'm hoping that in my particular genetic makeup, glycine happens to be engaging the restorative and preventative systems through methionine metabolism or some other means.

 

I could be wrong, but my rationale is that if glycine reduced my shoulder pain and shrunk a cyst in a few months time, it's more likely than not exerting an overall protective effect throughout all of my cells and gene pathways. However, I understand your reluctance to start using glycine based on the conflicting data. I still have concerns for myself but they're less now. 

[aribadabar]

Potential negative impact of glycine in enhanced cell proliferation in cancer.

 

This is of concern.  There is other research that indicates that Glycine is of benefit in some cancers but this research started off as an in vitro metabolomic assessment of what changes with regard to a large panel of substances on a large set of cancer cell lines.  This was followed by more research that appears to confirm the association between existing cancer, glycine expression/availability, and mortality.

 

http://www.ncbi.nlm....les/PMC3526189/

 

Certainly gives me pause.

 

Before making any conclusions, I think we need to address two questions:

 

First, this is in vitro study so cannot be translated directly to in vivo effect.

Second, and that is the main question indeed, can 140 μM concentration be reached in vivo with normal 5-15g of glycine supplemented orally, as that's the way most people consume it?

 

Can someone knowledgeable in analytical chemistry weigh in?

[niner]

 

Potential negative impact of glycine in enhanced cell proliferation in cancer.

 

First, this is in vitro study so cannot be translated directly to in vivo effect.

Second, and that is the main question indeed, can 140 μM concentration be reached in vivo with normal 5-15g of glycine supplemented orally, as that's the way most people consume it?

 

This site has extensive data on levels of glycine in various bodily fluids.  Plasma levels are typically in the 1-400 μM range, and that's without supplementation.

[evilbaga]

I didnt read the last 3 million pages but I recently read a Newsletter that talked about Glycine (and proline and gelatin/collagen) that seems relevant:

http://www.drdavidwi...2e561e6b651.pdf

 

To quote: "I think relative deficiencies in glycine and proline may be one of the most overlooked and under-reported threats to our health. And unless we make some changes soon, the threat can only get worse..."

[aza]

I've started edging back to gelatin (with a little bit of glycine powder mixed in) or crackling/pork belly, just because i was wondering if glycine isolated has effects as beneficial as glycine from food. Also i wonder if proline is also semi-essential like glycine or has further benefits to supplimentation. Many people thought that dietary glycine wasnt needed after all, i wonder if proline is a similar case or if both amino acids work together for better effect. I cant seem to find many studies about proline itself.

[Darryl]

I haven't encountered many articles on proline supplementation benefits, nor have I seen anything indicating proline is semi-essential.

 

One caveat against relying on high intakes of collagen or gelatin for glycine supplementation might be the greater risk of calcium oxalate kidney stones. Most oxalate in stones arises from endogenous synthesis, with glycine, hydroxyproline, glycolate, and vitamin C serving as precursors.

 

100 g of porkskin gelatin would have 26.4 g glycine and 13.5 g hydroxyproline. High hydroxyproline intake has been used to increase urinary calcium oxalate and stone formation. Eg

 

Khan SR et al. 2006. Modeling of hyperoxaluric calcium oxalate nephrolithiasis: experimental induction of hyperoxaluria by hydroxy-L-proline. Kidney international, 70(5), pp.914-923.

 

I haven't encountered any studies demonstrating similar elevations of urinary calcium oxalate and stone formation from glycine, which isn't to say its been exonerated.

 

So, in addition to being significantly more expensive as a source of glycine, gelatin also introduces a significant amount of hydroxyproline, which depending on predisposition and the rest of the diet, might push urinary oxalate to thresholds to levels stones become an issue. I've never experienced kidney stones, but I have witnessed a relative trying to pass one in excruciating pain. The experience was enough for me to caution against gelatin or high dose vitamin C supplementation in those with a history of kidney stones

Edited by Darryl, 27 January 2016 - 12:04 PM.

[docmaas]

I did cut back some on the glycine I take.  I've sort of decided though to treat it like sugar as far as cancer goes.  As far as I know I don't have cancer.  If at some point I do get it I will then decide if glycine supplementation is advisable.  Right now I probably take <20g/day usually @5g in the morning with aronia juice and another 5-10g in the evening in club soda mixed with True Orange.  I started it as a way to boost glutathione since as a then diagnosed diabetic I thought myself to be deficient.  I'm on pretty severe carb restriction and no longer in the diabetic category and have been dx'd with reactive hypoglycemia and told I don't have diabetes.  It's good to be aware of this research but I don't feel nearly as wary about it as I do about the berberine/goldenseal caused rat cancer I posted on another thread.  I definitely will not take berberine again.

 

Mike

Edited by docmaas, 01 February 2016 - 08:48 AM.

[Bryan_S]

Still waiting for some more followup from Professor Jun-Ichi Hayashi from the University of Tsukuba in Japan.

http://www.nature.co...icles/srep10434

 

Have we seen anyone shadow his research with their own?

[Coffeee]

i took 40 grams of l glycine and my dick stopped working for 2.6 years now...what should i do?

[Logic]

...

So, in addition to [Gelatine] being significantly more expensive as a source of glycine...

 

??!
I think you're buying it from the wrong place!?
I get it from a store/supermarket, or in bulk through my sister in the catering industry for a glycine amount that's way less than what glycine caps cost.

I hydrolyse it some more by adding warm water, stirring a lot and drinking it.
Cold water: it's gritty and sticks to your teeth.
Boiling:  it forms a snotty jelly in the bottom of the cup.

NB:

Vit C is a cofactor if you want to build cartilage in the old joints.
Taking it before bed (or exercise) can increase your natural HGH spike/level at those times, by as much as 8X.
http://www.ergo-log....gelatinegh.html

[Skyguy2005]

http://www.ncbi.nlm....ubmed/26383889 

 

Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan. 

 

Is this evidence for glycine? 

Edited by Skyguy2005, 12 March 2016 - 01:58 AM.

[Darryl]

I just skimmed through the publications featuring glycine in the title from the past year. These seemed interesting:

 

Huang & Chiang, 2016. Dietary glycine alters one-carbon metabolic kinetics in vivo. The FASEB Journal, 30(1 Supplement), pp.272-4.

 

High dietary glycine can promote folate dependent methionine synthesis (from homocysteine), consistent with our in vitro findings. These results showed that high dietary glycine promotes methionine remethylation in vitro and in vivo.

 

Liu et al, 2016. Glycine enhances muscle protein mass associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing TLR4 and NOD2 signaling in piglets challenged with LPS. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, pp.ajpregu-00043.

 

 

At 4 h after treatment with saline or LPS, blood and muscle samples were harvested. We found that 1.0% or 2.0% glycine increased protein/DNA ratio, protein content and RNA/DNA ratio in gastrocnemius or longissimus dorsi (LD) muscles. Glycine also resulted in decreased mRNA expression of muscle atrophy F-box (MAFbx) and muscle RING finger 1 (MuRF1) in gastrocnemius muscle. In addition, glycine restored the phosphorylation of Akt, mammalian target of rapamycin (mTOR), eukaryotic initiation factor 4E binding protein 1 (4E-BP1) and Forkhead Box O 1 (FOXO1) in gastrocnemius or LD muscles. Furthermore, glycine resulted in decreased plasma tumor necrosis factor-α (TNF-α) concentration and muscle TNF-α mRNA abundance. Moreover, glycine resulted in decreased mRNA expresson of toll-like receptor 4 (TLR4), nucleotide-binding oligomerization domain protein 2 (NOD2) and their respective downstream molecules in gastrocnemius or LD muscles. These results indicate glycine enhances muscle protein mass under an inflammatory condition.

 

Ham, et al, 2016. Glycine restores the anabolic response to leucine in a mouse model of acute inflammation. American Journal of Physiology-Endocrinology and Metabolism, 310(11), pp.E970-E981.

 

The nonessential amino acid glycine has anti-inflammatory and antioxidant properties and preserves muscle mass in calorie-restricted and tumor-bearing mice. We hypothesized that glycine would restore the normal muscle anabolic response to amino acids under inflammatory conditions. Relative rates of basal and leucine-stimulated protein synthesis were measured using SUnSET methodology 4 h after an injection of 1 mg/kg lipopolysaccharide (LPS). Whereas leucine failed to stimulate muscle protein synthesis in LPS-treated mice pretreated with l-alanine (isonitrogenous control), leucine robustly stimulated protein synthesis (+51%) in mice pretreated with 1 g/kg glycine. The improvement in leucine-stimulated protein synthesis was accompanied by a higher phosphorylation status of mTOR, S6, and 4E-BP1 compared with l-alanine-treated controls. Despite its known anti-inflammatory action in inflammatory cells, glycine did not alter the skeletal muscle inflammatory response to LPS in vivo or in vitro but markedly reduced DHE staining intensity, a marker of oxidative stress, in muscle cross-sections and attenuated LPS-induced wasting in C2C12 myotubes.

 

Ding et al, 2016. Plasma glycine and risk of acute myocardial infarction in patients with suspected stable angina pectoris. Journal of the American Heart Association, 5(1), p.e002621.

 

Plasma glycine was higher in women than in men and was associated with a more favorable baseline lipid profile and lower prevalence of obesity, hypertension, and diabetes mellitus (all P<0.001). After multivariate adjustment for traditional coronary heart disease risk factors, plasma glycine was inversely associated with risk of AMI (hazard ratio per SD: 0.89; 95% CI, 0.82–0.98; P=0.017). The inverse association was generally stronger in those with apolipoprotein B, low‐density lipoprotein cholesterol, or apolipoprotein A‐1 above the median (all P_interaction≤0.037).

 

Kawai et al. 2015. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. Neuropsychopharmacology, 40(6), pp.1405-1416.

 

In acute sleep disturbance, oral administration of glycine-induced non-rapid eye movement (REM) sleep and shortened NREM sleep latency with a simultaneous decrease in core temperature. Oral and intracerebroventricular injection of glycine elevated cutaneous blood flow (CBF) at the plantar surface in a dose-dependent manner, resulting in heat loss. Pretreatment with N-methyl-D-aspartate (NMDA) receptor antagonists AP5 and CGP78608 but not the glycine receptor antagonist strychnine inhibited the CBF increase caused by glycine injection into the brain. Induction of c-Fos expression was observed in the hypothalamic nuclei, including the medial preoptic area (MPO) and the suprachiasmatic nucleus (SCN) shell after glycine administration. Bilateral microinjection of glycine into the SCN elevated CBF in a dose-dependent manner, whereas no effect was observed when glycine was injected into the MPO and dorsal subparaventricular zone. In addition, microinjection of D-serine into the SCN also increased CBF, whereas these effects were blocked in the presence of L-701324. SCN ablation completely abolished the sleep-promoting and hypothermic effects of glycine. These data suggest that exogenous glycine promotes sleep via peripheral vasodilatation through the activation of NMDA receptors in the SCN shell.

[aza]

haha, i was just about to post that Plasma Glycine and Risk of Acute Myocardial Infarction in Patients With Suspected Stable Angina Pectoris paper. Good find darryl.

In any case, i found this information on gotu kola which i think might be relevant to glycine although i dont understand much of the terminology. https://www.ncbi.nlm...ubmed/11666118 " The aim of this study was to evaluate whether total triterpenic fraction of Centella asiatica (TTFCA), was effective in modulating collagen production over 12 months, by producing an increase in echogenicity in echolucent carotid plaques."     "In part II in the treatment group there was a significant difference in GSM (increase) at 12 months (p<0.05), improvement in texture (p<0.05) and a nonsignificant decrease in stenosis. No changes were observed in the placebo group. Events were observed in 6.5% of patients in the TTFCA group and in 11% in the control group (p<0.05). In conclusion these observations suggest a positive action of TTFCA on the stabilization of hypoechoic, low-density carotid plaques." The study got me wondering if increased collagen synthesis from glycine could help to stabilize plaque? Although i cant seem to find anything on it.

 

Edited by aza, 04 October 2016 - 06:43 AM.