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Would D-serine affect cortisol levels the same way phosphatidylserine does?

l-serine stress adrenals hpa testosterone phospholipids myelin soy hormones adrenaline

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#1 Guest_Funiture2_*

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Posted 23 June 2015 - 12:14 AM


Are the cortisol-lowering effects from phosphatidylserine due to its eventual breakdown into D-serine from L-serine or is the phosphatidylserine molecule responsible on its own? I can't seem to find info on this. Or another way to put this question is, would agonizing the NMDA receptor at the glycine site lower cortisol? Any help is appreciated.



#2 Guest_Funiture2_*

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Posted 23 June 2015 - 02:56 AM

I did find this:

 

http://www.ncbi.nlm....pubmed/11282259

"As prolactin and cortisol liberation is in part influenced through NMDA-receptors we investigated whether the elevation of prolactin or cortisol plasma levels is a class effect of NMDA-antagonists and might be an appropriate marker for studying NMDA-antagonistic potency."

"Ketamine increased serum prolactin and cortisol levels (p < 0.001), whereas memantine and placebo did not affect hormone levels."

 

If Ketamine, an NMDA antagonist can increase cortisol, then D-serine, an agonist of NMDA, should decrease it? Tell me if my thoughts on this are wrong.



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Also tagged with one or more of these keywords: l-serine, stress, adrenals, hpa, testosterone, phospholipids, myelin, soy, hormones, adrenaline

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