8 replies to this topic

[Rocket]

I wonder why there isn't any discussion of Trichostatin A?  It upregulates the gene responsible for GDF-11 which increases GDF-11, and with Lovastatin was found to reorganize heterochromatin (heterochromatin and aging was recently in the news).

[Bonee]

Would you please give us the source ?

 

thanks

[Rocket]

Would you please give us the source ?

 

thanks

 

There are papers in pubmed.

[Rocket]

http://www.salk.edu/...p?press_id=2080

[Tom Andre F. (ex shinobi)]

It does too much (for instance on follistatin) to be sure this drug is safe for human consumption

[Rocket]

It does too much (for instance on follistatin) to be sure this drug is safe for human consumption

 

What about follistatin?  If it increases muscle, GREAT!  Muscle loss is one of heavy hitters of the aging process.

 

I just read an article from this December that worms given Trichostatin A had their lives and healthspan extended. 

Edited by Rocket, 02 January 2016 - 12:36 AM.

[Rocket]

Activation of the Growth-Differentiation Factor 11 Gene by the Histone Deacetylase (HDAC) Inhibitor Trichostatin A and Repression by HDAC3

 

http://mcb.asm.org/c...24/12/5106.full

 

 

[Rocket]

Trichostatin elongates telomeres in another study:
www.ncbi.nlm.nih.gov/pubmed/24510582

[Sith]

Trichostatin is often overlooked in terms of its longevity benefits. In theory, it should be beneficial but it is still a novel drug and not much research has been done into its safety. I would, personally, stay away until more research is done.