YOU ARE SPOT ON MY FRIEND; Yes, excess serotonin causes gut issues; including diarrhea and trouble controlling bowel movement as well as nausea etc - it also causes you to over-react to sudden sounds and movements; including in agitation - also high levels of serotonin disrupt cognitive function - leading to deficits in emotional processing and intellectual function...in a lot of ways , excess serotonin mirrors frontal lobe deficits.
Symptoms / Signs of Too Much Serotonin / Excess Serotonin {SPECIFICS, EASY TO READ, CITED}
4 Natural OTC Serotonin Antagonists
5-HT3 Antagonists that are natural would be Ginger Root extract ; this may, in theory, help in reducing the nausea you experience with serotonin syndrome..however, 'TRUE' serotonin syndrome can be a life-threatening crisis which includes fast heart rate and hyperthermia/hypothermia, sweating, or lack of, high blood pressure and delirium as well as agitation and panic (mainly an over-jumpiness to sounds and lights)...
So the idea here is to keep some Cyproheptadine on hand..but in general, feverfew and Shilajit seem best to decrease serotonin...another idea is to consistently use Yohimbine , if you can handle it, along with Shilajit...yohimbine activates serotonin autoreceptors leading to decreased serotonin...so assuming your receptors are not desensitized - yohimbine and shilajit should be enough for you. 
Start with Shilajit 3 times a day.
Keep Ginger on hand or get the doc to write you a script for Ondansetron (Zofran) this helps stop nausea/vomiting and anxiety and helps with some of the psychological effects of excess serotonin... it's a safe med with basically no side-effects or liver toxicity and can be dosed daily to reduce anxiety..which supports the role of serotonin provoking anxiety and behavioral changes when it activates the type 3A, 2A and 4A subtypes.
ALSO - Add HIGH-DOSE L-LYSINE; it acts as a 5-HT4 antagonist which can help...so lysine , ginger and Shilajit should be perfect along with yohimbine at moderate doses.
Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5. Epub 2003 Dec 15.
L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats.
Abstract
The purpose of this investigation was to determine whether a nutritionally essential amino acid, l-lysine, acts like a serotonin receptor 4 (5-HT4) antagonist, and if l-lysine is beneficial in animal models of serotonin (5-HT)-induced anxiety, diarrhea, ileum contractions, and tachycardia and in stress-induced fecal excretion. The radioligand-binding assay was used to test the binding of l-lysine to various 5-HT receptors. The effects of l-lysine on 5-HT-induced contractions of isolated guinea pig ileum were studied in vitro. The effects of oral administration of l-lysine on diarrhea, stress-induced fecal excretion, and 5-HT-induced corticosterone release, tachycardia, and anxiety (an elevated plus maze paradigm) were studied in rats in vivo. l-Lysine (0.8 mmol/dl) inhibited (9.17%) binding of 5-HT to the 5-HT4 receptor, without any effect on 5-HT1A,2A,2B,2C,3 binding. l-Lysine (0.07 and 0.7 mmol/dl) blocked 5-HT-induced contractions of an isolated guinea pig ileum in vitro (P < 0.05 and P < 0.01). Orally applied l-lysine (1 g/kg of body weight) inhibited (P < 0.12) diarrhea triggered by coadministration of restraint stress and 5-hydroxytryptophane (10 mg/kg of body weight), and significantly blocked anxiety induced by the 5-HT4 receptor agonist (3.0 mmol/liter) in rats in vivo. No effects of l-lysine or the 5-HT4 receptor agonist on plasma corticosterone and heart rate were recorded. l-Lysine may be a partial 5-HT4 receptor antagonist and suppresses 5-HT4 receptor-mediated intestinal pathologies and anxiety in rats. An increase in nutritional load of l-lysine might be a useful tool in treating stress-induced anxiety and 5-HT-related diarrhea-type intestinal dysfunctions.
Edited by Area-1255, 24 September 2015 - 01:32 AM.
