6 replies to this topic

[sonshoku]

Does the L-dopa in Mucuna Pruriens bind to receptors and cause downregulation of dopamine receptors? Tolerance?

[Area-1255]

No. It contains precursors that convert directly into dopamine..doesn't bind directly however - if you take a TON OF IT - you are flooding the brain with dopamine in a like way to the parkinsons drug ; levodopa..it's basically the same thing - the herb contains the amino-chemical; L-DOPA but it would be in and out of your system quicker than say, carbidopa or LEVODOPA SRR. 

It does lower prolactin fairly effectively, and like 5-HTP - it doesn't depend on your brains hydroxylase enzymes thus your body/brain has no need to 'produce' dopamine in terms of synthesis because it is already in an active form - now on the other hand if you have a dopamine decarboxylase abnormalty then your brain may shuffle too much dopamine into your periphery or you may not have enough in the brain or not enough is evenly distributed..this can become an issue when using too much GREEN TEA EXTRACT with levodopa containing herbs or the pharmaceutical form of it..so be careful drinking too much green tea while on mucuna pruriens because dopamine may just float to your hands, feet, heart etc...most of us have enough in those places sooo....

[IWS]

No. It contains precursors that convert directly into dopamine..doesn't bind directly however - if you take a TON OF IT - you are flooding the brain with dopamine in a like way to the parkinsons drug ; levodopa..it's basically the same thing - the herb contains the amino-chemical; L-DOPA but it would be in and out of your system quicker than say, carbidopa or LEVODOPA SRR. 

It does lower prolactin fairly effectively, and like 5-HTP - it doesn't depend on your brains hydroxylase enzymes thus your body/brain has no need to 'produce' dopamine in terms of synthesis because it is already in an active form - now on the other hand if you have a dopamine decarboxylase abnormalty then your brain may shuffle too much dopamine into your periphery or you may not have enough in the brain or not enough is evenly distributed..this can become an issue when using too much GREEN TEA EXTRACT with levodopa containing herbs or the pharmaceutical form of it..so be careful drinking too much green tea while on mucuna pruriens because dopamine may just float to your hands, feet, heart etc...most of us have enough in those places sooo....

 

In respect to dopamine and prolactine, I'm taking BCAA for my liver condition and I noted they really down dopamine and up prolactine so my question is what do you think is better to compensate, L-Tyrosine or L-Dopa? Alos, are you aware of any other supplement/compound/substance that can be used to antagonize the above BCAA side effects?

Thanks.

[Area-1255]

 

No. It contains precursors that convert directly into dopamine..doesn't bind directly however - if you take a TON OF IT - you are flooding the brain with dopamine in a like way to the parkinsons drug ; levodopa..it's basically the same thing - the herb contains the amino-chemical; L-DOPA but it would be in and out of your system quicker than say, carbidopa or LEVODOPA SRR. 

It does lower prolactin fairly effectively, and like 5-HTP - it doesn't depend on your brains hydroxylase enzymes thus your body/brain has no need to 'produce' dopamine in terms of synthesis because it is already in an active form - now on the other hand if you have a dopamine decarboxylase abnormalty then your brain may shuffle too much dopamine into your periphery or you may not have enough in the brain or not enough is evenly distributed..this can become an issue when using too much GREEN TEA EXTRACT with levodopa containing herbs or the pharmaceutical form of it..so be careful drinking too much green tea while on mucuna pruriens because dopamine may just float to your hands, feet, heart etc...most of us have enough in those places sooo....

 

so my question is what do you think is better to compensate, L-Tyrosine or L-Dopa? 

L-Dopa, definitely. 

[sonshoku]

No. It contains precursors that convert directly into dopamine..doesn't bind directly however - if you take a TON OF IT - you are flooding the brain with dopamine in a like way to the parkinsons drug ; levodopa..it's basically the same thing - the herb contains the amino-chemical; L-DOPA but it would be in and out of your system quicker than say, carbidopa or LEVODOPA SRR. 

It does lower prolactin fairly effectively, and like 5-HTP - it doesn't depend on your brains hydroxylase enzymes thus your body/brain has no need to 'produce' dopamine in terms of synthesis because it is already in an active form - now on the other hand if you have a dopamine decarboxylase abnormalty then your brain may shuffle too much dopamine into your periphery or you may not have enough in the brain or not enough is evenly distributed..this can become an issue when using too much GREEN TEA EXTRACT with levodopa containing herbs or the pharmaceutical form of it..so be careful drinking too much green tea while on mucuna pruriens because dopamine may just float to your hands, feet, heart etc...most of us have enough in those places sooo....

 

that seems too good to be true...so if you can take it reguraly and it does not cause receptor tolerance/downregulation/rebound when stopping, why does not everyone take it?

Edited by sonshoku, 07 October 2015 - 02:41 PM.

[Area-1255]

 

No. It contains precursors that convert directly into dopamine..doesn't bind directly however - if you take a TON OF IT - you are flooding the brain with dopamine in a like way to the parkinsons drug ; levodopa..it's basically the same thing - the herb contains the amino-chemical; L-DOPA but it would be in and out of your system quicker than say, carbidopa or LEVODOPA SRR. 

It does lower prolactin fairly effectively, and like 5-HTP - it doesn't depend on your brains hydroxylase enzymes thus your body/brain has no need to 'produce' dopamine in terms of synthesis because it is already in an active form - now on the other hand if you have a dopamine decarboxylase abnormalty then your brain may shuffle too much dopamine into your periphery or you may not have enough in the brain or not enough is evenly distributed..this can become an issue when using too much GREEN TEA EXTRACT with levodopa containing herbs or the pharmaceutical form of it..so be careful drinking too much green tea while on mucuna pruriens because dopamine may just float to your hands, feet, heart etc...most of us have enough in those places sooo....

 

that seems too good to be true...so if you can take it reguraly and it does not cause receptor tolerance/downregulation/rebound when stopping, why does not everyone take it?

 

For the same reason/s you could make that argument about ANY supplement that one or another would proclaim to be beneficial...

 

• Not everyone knows about it.
• Everyone's genetics and individual threshold is different.
• Some people underestimate it or read negative reports; assuming how it would affect them without even trying it.
• Some are sensitive to it's partial-psychotropic effects; including the incredibly small amounts of DMT-analogues within the plant.

[airplanepeanuts]

In my experience the mucuna high (which can be really enjoyable) will be followed by a low.