145 replies to this topic

[jack black]

Matt, thanks for posting.
My hair loss accelerated since I boosted testosterone levels.
I've got to order that finasteride.

[Tubzy]

Hey guys, I'm no longer associated with PHG, so if I don't respond to the emails that is why.

From my personal experiences over the past two years or so, I think PG's do play a role but not silver bullet. I actually think PGE2 can be inflammatory too, in a negative way from how it can act as a messenger to pro inflammatory cytokines (not good).

I found a study where estrogen actually stimulates the release of PGE2, so again I think estrogen is the trigger of MPB and DHT is just sent to the tissue (scalp) as a defensive mechanism to antagonize it yet DHT gets the blame.

Edited by Tubzy, 01 March 2017 - 05:25 PM.

[Fletch]

Hey guys, I'm no longer associated with PHG, so if I don't respond to the emails that is why.

From my personal experiences over the past two years or so, I think PG's do play a role but not silver bullet. I actually think PGE2 can be inflammatory too, in a negative way from how it can act as a messenger to pro inflammatory cytokines (not good).

I found a study where estrogen actually stimulates the release of PGE2, so again I think estrogen is the trigger of MPB and DHT is just sent to the tissue (scalp) as a defensive mechanism to antagonize it yet DHT gets the blame.

 

Thanks for the update Tubzy. So given your estrogen theory and your apparent dissatisfaction with the PG approach, what is your current regimen and/or future plan to combat MPB? An antiestrogen? Arimidex? Tamoxifen? Please let us know a little more about your person experience with the PG approach. Was it using Seti, and PGE2, wounding with lithium, etc?

[Tubzy]

 

Hey guys, I'm no longer associated with PHG, so if I don't respond to the emails that is why.

From my personal experiences over the past two years or so, I think PG's do play a role but not silver bullet. I actually think PGE2 can be inflammatory too, in a negative way from how it can act as a messenger to pro inflammatory cytokines (not good).

I found a study where estrogen actually stimulates the release of PGE2, so again I think estrogen is the trigger of MPB and DHT is just sent to the tissue (scalp) as a defensive mechanism to antagonize it yet DHT gets the blame.

 

Thanks for the update Tubzy. So given your estrogen theory and your apparent dissatisfaction with the PG approach, what is your current regimen and/or future plan to combat MPB? An antiestrogen? Arimidex? Tamoxifen? Please let us know a little more about your person experience with the PG approach. Was it using Seti, and PGE2, wounding with lithium, etc?

 

 

Right now have been experimenting with topical taurine, topical niacinamide, topical DHEA (antagonizes cortisol), topical caffeine and selsun blue (selenium sulfide, supposedly a PGD2 inhibitor and anti fungal, but works well if that is the mechanism).  Possibly topical progesterone + dhea can work the best.  Progesterone blocks the estrogen and DHEA blocks the cortisol.  You can test this for yourself by putting them on your face as a topical before bed and your skin will glow in the morning.

.

PG approach just can help, but IMO doesn't work.  No one literally, not one person had results even close to Swiss Temples (if you did come across someone pls let me know).  Swiss temples didn't even get full regrowth hence why his blog has been inactive for like a year and 90% of results came from dut but even than adding all the excess stuff to the protocol still couldn't bring him back despite what he says.  I do think inhibiting prostaglandins can help though (i.e. aspirin).  Castor oil seems to help moderately just very viscous so I stopped a while ago.  Sorry to bring the bad news, it just my email is flooded even still with people so I just thought I get it out there.

 

Seti, OC000459 did help stop/slow down shedding topically.  Wounding can help but not groundbreaking IMO if you don't have anything else strong in the regimen.  PGE2 didn't really do much for me I used it plus is extremely fragile and expensive.  Never used lithium.  Other areas of looking into would be topical ATP, topical d-ribose, topical creatine etc.

 

There is actually a patent on topical creatine for hair growth...

Edited by Tubzy, 09 March 2017 - 01:05 AM.

[Fletch]

 

 

Hey guys, I'm no longer associated with PHG, so if I don't respond to the emails that is why.

From my personal experiences over the past two years or so, I think PG's do play a role but not silver bullet. I actually think PGE2 can be inflammatory too, in a negative way from how it can act as a messenger to pro inflammatory cytokines (not good).

I found a study where estrogen actually stimulates the release of PGE2, so again I think estrogen is the trigger of MPB and DHT is just sent to the tissue (scalp) as a defensive mechanism to antagonize it yet DHT gets the blame.

 

Thanks for the update Tubzy. So given your estrogen theory and your apparent dissatisfaction with the PG approach, what is your current regimen and/or future plan to combat MPB? An antiestrogen? Arimidex? Tamoxifen? Please let us know a little more about your person experience with the PG approach. Was it using Seti, and PGE2, wounding with lithium, etc?

 

 

Right now have been experimenting with topical taurine, topical niacinamide, topical DHEA (antagonizes cortisol), topical caffeine and selsun blue (selenium sulfide, supposedly a PGD2 inhibitor and anti fungal, but works well if that is the mechanism).  Possibly topical progesterone + dhea can work the best.  Progesterone blocks the estrogen and DHEA blocks the cortisol.  You can test this for yourself by putting them on your face as a topical before bed and your skin will glow in the morning.

.

PG approach just can help, but IMO doesn't work.  No one literally, not one person had results even close to Swiss Temples (if you did come across someone pls let me know).  Swiss temples didn't even get full regrowth hence why his blog has been inactive for like a year and 90% of results came from dut but even than adding all the excess stuff to the protocol still couldn't bring him back despite what he says.  I do think inhibiting prostaglandins can help though (i.e. aspirin).  Castor oil seems to help moderately just very viscous so I stopped a while ago.  Sorry to bring the bad news, it just my email is flooded even still with people so I just thought I get it out there.

 

Seti, OC000459 did help stop/slow down shedding topically.  Wounding can help but not groundbreaking IMO if you don't have anything else strong in the regimen.  PGE2 didn't really do much for me I used it plus is extremely fragile and expensive.  Never used lithium.  Other areas of looking into would be topical ATP, topical d-ribose, topical creatine etc.

 

There is actually a patent on topical creatine for hair growth...

 

 

Thanks for the update. I agree that dutasteride was largely responsible for his regrowth. That stuff is powerful; I've used it.

 

Castor diluted in DMSO and ethanol makes it a bit easier to apply, but you're right, it's really sticky stuff.

 

How do you know the progesterone/dhea isn't going systemic? I've tried I believe Now brand progesterone cream in the past but didn't care for the way it made me feel. As I recall it works as a gaba receptor agonsist, so it has a calming effect and a rebound type effect as well. Don't quote me on this, it's been a long time.

 

I dropped finasteride and my hair has been holding but definitely not as thick. I think green tea/caffeine has potential. I just make some green tea and spray it on my head.

 

There's patents on lots of things, but it doesn't mean they work necessarily. Do you know the supposed mechanism? Do you have a link for that one?

 

Do you use minoxidil? That stuff works but obviously goes systemic as it causes all other hair to grow too. Even out of your ears and places you didn't have hair before. It breaks down collagen so it ages you.

[orion602]

 

 

I'm not sure if I mentioned in this thread, but I started taking finasteride at 1.25 mg a day and had awesome results, and it's only been about 5 months. I also take licorice root, spearmint tea as well. What I've noticed is my hairline is coming down to more youthful level, rather than the "mature hairline" that is considered normal for adults. I've also noticed my hair thickness increase all over my scalp, it's pretty incredible considering my hair thickness when starting. I guess I didn't really notice, but I must've lost some thickness over the years, but since my hair was pretty good, it wasn't obvious. My grandfather and father lost most of their hair, so I'm not really taking a chance. 

 

 

hi Matt,

I have started experimenting with finas a month ago as well. How did you come up with dosing 1.25mg/day ?

Ordered mine somewhere from India and it says 5mg/pill.

I had no idea what dose is necessary to get desired effect so i started with splitting pill into 5 pieces (~1mg each) and taking twice a week (after 3-4 days). I concluded that its not enough for me (scalp itching returned after 2 days or less) so i increased dose to 1/4 of pill now - thats same as your 1.25mg. but itching starts to appear after 2.5-3 days now. So i guess 1.25mg/2days could be enough for me. but it will take few months to notice if it makes difference.

 

[Logic]

In the skin, we have previously shown that p14ARF expression leads to the accumulation of senescent cells in the epidermis, and that these cells are retained for weeks36. Here we show that treatment with ABT-737 eliminates most of these senescent cells, indicating that an anti-apoptotic signal is central to their retention in the tissue. In addition, p14ARF activation causes hair-follicle stem cells to arrest irreversibly, preventing follicle growth 36. We show here that ABT-737 allows re-entry of some of these bulge stem cells into the cell cycle, leading to an increase in overall stem cell numbers...

http://www.nature.co...les/ncomms11190

 

You're thinking 'that's all good and well, but as its not practicable advice, you're just wasting your time here."

Not so!
We are almost done with a group by of the senolytic Dasatinib and I am looking into getting the far more bioavailable equivalent of ABT-737, called Navitoclax:
http://www.longecity...m-nyles/page-10

 

Anecdotal reports from those that have used senolytic combination; Dasatinib + Quercetin seem to point to an age reversal of around 20% in years and specifically mention skin improvements...
It will be interesting to see what the senescent stem cell remover Navitoclax, followed by telomerase activators, does.

Edited by Logic, 19 March 2017 - 02:05 AM.

[Matt]

 

 

 

 

I'm not sure if I mentioned in this thread, but I started taking finasteride at 1.25 mg a day and had awesome results, and it's only been about 5 months. I also take licorice root, spearmint tea as well. What I've noticed is my hairline is coming down to more youthful level, rather than the "mature hairline" that is considered normal for adults. I've also noticed my hair thickness increase all over my scalp, it's pretty incredible considering my hair thickness when starting. I guess I didn't really notice, but I must've lost some thickness over the years, but since my hair was pretty good, it wasn't obvious. My grandfather and father lost most of their hair, so I'm not really taking a chance. 

 

 

hi Matt,

I have started experimenting with finas a month ago as well. How did you come up with dosing 1.25mg/day ?

Ordered mine somewhere from India and it says 5mg/pill.

I had no idea what dose is necessary to get desired effect so i started with splitting pill into 5 pieces (~1mg each) and taking twice a week (after 3-4 days). I concluded that its not enough for me (scalp itching returned after 2 days or less) so i increased dose to 1/4 of pill now - thats same as your 1.25mg. but itching starts to appear after 2.5-3 days now. So i guess 1.25mg/2days could be enough for me. but it will take few months to notice if it makes difference.

 

 

Standard does is 1 mg / day for MPB, so I cut it up in quarters. I think that it's not uncommon to shed initially, and then start thickening up. You're going to have a good idea between 4-6 months if it's working or not. It is possible you could take it every other day and it would work, but that's just something you'll have to experiment with. 

Edited by Matt, 19 March 2017 - 03:42 AM.

[Matt]

Maybe someone wants to weigh in on this study with regards to Quercetin + Finasteride?

https://www.ncbi.nlm...pubmed/15171697

 

"Finasteride alone caused a significant decrease in serum DHT level and prostate weight. Co-administration of quercetin with finasteride prevented the finasteride-induced decrease in serum DHT levels but significantly enhanced the reduction in wet prostate weight, which was reduced by 26.9% in finasteride-treated animals to 31.8%, 40.0% and 48.2% after finasteride given together with the three doses of quercetin"

[Logic]

Maybe someone wants to weigh in on this study with regards to Quercetin + Finasteride?

https://www.ncbi.nlm...pubmed/15171697

 

"Finasteride alone caused a significant decrease in serum DHT level and prostate weight. Co-administration of quercetin with finasteride prevented the finasteride-induced decrease in serum DHT levels but significantly enhanced the reduction in wet prostate weight, which was reduced by 26.9% in finasteride-treated animals to 31.8%, 40.0% and 48.2% after finasteride given together with the three doses of quercetin"

 

You did notice, from my previous post, that Quercetin kills of senescent cells?  (Senescent often = pre/cancerous cells)

These senolytics have anti fibrotic effects and I'm guessing that this, along with the decrease in SASP/inflammation and CD38 = increase in NAD+, SIRT, PARP (fixes DNA), telomerase staying in the nucleus, and improved, healthier, younger cell signalling has a lot to do with it.

[Tubzy]

Hey guys, I'm no longer associated with PHG, so if I don't respond to the emails that is why.

From my personal experiences over the past two years or so, I think PG's do play a role but not silver bullet. I actually think PGE2 can be inflammatory too, in a negative way from how it can act as a messenger to pro inflammatory cytokines (not good).

I found a study where estrogen actually stimulates the release of PGE2, so again I think estrogen is the trigger of MPB and DHT is just sent to the tissue (scalp) as a defensive mechanism to antagonize it yet DHT gets the blame.

Thanks for the update Tubzy. So given your estrogen theory and your apparent dissatisfaction with the PG approach, what is your current regimen and/or future plan to combat MPB? An antiestrogen? Arimidex? Tamoxifen? Please let us know a little more about your person experience with the PG approach. Was it using Seti, and PGE2, wounding with lithium, etc?

Right now have been experimenting with topical taurine, topical niacinamide, topical DHEA (antagonizes cortisol), topical caffeine and selsun blue (selenium sulfide, supposedly a PGD2 inhibitor and anti fungal, but works well if that is the mechanism). Possibly topical progesterone + dhea can work the best. Progesterone blocks the estrogen and DHEA blocks the cortisol. You can test this for yourself by putting them on your face as a topical before bed and your skin will glow in the morning.
.
PG approach just can help, but IMO doesn't work. No one literally, not one person had results even close to Swiss Temples (if you did come across someone pls let me know). Swiss temples didn't even get full regrowth hence why his blog has been inactive for like a year and 90% of results came from dut but even than adding all the excess stuff to the protocol still couldn't bring him back despite what he says. I do think inhibiting prostaglandins can help though (i.e. aspirin). Castor oil seems to help moderately just very viscous so I stopped a while ago. Sorry to bring the bad news, it just my email is flooded even still with people so I just thought I get it out there.

Seti, OC000459 did help stop/slow down shedding topically. Wounding can help but not groundbreaking IMO if you don't have anything else strong in the regimen. PGE2 didn't really do much for me I used it plus is extremely fragile and expensive. Never used lithium. Other areas of looking into would be topical ATP, topical d-ribose, topical creatine etc.

There is actually a patent on topical creatine for hair growth...

Thanks for the update. I agree that dutasteride was largely responsible for his regrowth. That stuff is powerful; I've used it.

Castor diluted in DMSO and ethanol makes it a bit easier to apply, but you're right, it's really sticky stuff.

How do you know the progesterone/dhea isn't going systemic? I've tried I believe Now brand progesterone cream in the past but didn't care for the way it made me feel. As I recall it works as a gaba receptor agonsist, so it has a calming effect and a rebound type effect as well. Don't quote me on this, it's been a long time.

I dropped finasteride and my hair has been holding but definitely not as thick. I think green tea/caffeine has potential. I just make some green tea and spray it on my head.

There's patents on lots of things, but it doesn't mean they work necessarily. Do you know the supposed mechanism? Do you have a link for that one?

Do you use minoxidil? That stuff works but obviously goes systemic as it causes all other hair to grow too. Even out of your ears and places you didn't have hair before. It breaks down collagen so it ages you.

Hey man, instead of answering your questions one by one I pretty much answered them in the thread I created here.

https://raypeatforum...eatments.12907/

[zorba990]

Hey guys, I'm no longer associated with PHG, so if I don't respond to the emails that is why.

From my personal experiences over the past two years or so, I think PG's do play a role but not silver bullet. I actually think PGE2 can be inflammatory too, in a negative way from how it can act as a messenger to pro inflammatory cytokines (not good).

I found a study where estrogen actually stimulates the release of PGE2, so again I think estrogen is the trigger of MPB and DHT is just sent to the tissue (scalp) as a defensive mechanism to antagonize it yet DHT gets the blame.

Thanks for the update Tubzy. So given your estrogen theory and your apparent dissatisfaction with the PG approach, what is your current regimen and/or future plan to combat MPB? An antiestrogen? Arimidex? Tamoxifen? Please let us know a little more about your person experience with the PG approach. Was it using Seti, and PGE2, wounding with lithium, etc?

Right now have been experimenting with topical taurine, topical niacinamide, topical DHEA (antagonizes cortisol), topical caffeine and selsun blue (selenium sulfide, supposedly a PGD2 inhibitor and anti fungal, but works well if that is the mechanism). Possibly topical progesterone + dhea can work the best. Progesterone blocks the estrogen and DHEA blocks the cortisol. You can test this for yourself by putting them on your face as a topical before bed and your skin will glow in the morning.
.
PG approach just can help, but IMO doesn't work. No one literally, not one person had results even close to Swiss Temples (if you did come across someone pls let me know). Swiss temples didn't even get full regrowth hence why his blog has been inactive for like a year and 90% of results came from dut but even than adding all the excess stuff to the protocol still couldn't bring him back despite what he says. I do think inhibiting prostaglandins can help though (i.e. aspirin). Castor oil seems to help moderately just very viscous so I stopped a while ago. Sorry to bring the bad news, it just my email is flooded even still with people so I just thought I get it out there.

Seti, OC000459 did help stop/slow down shedding topically. Wounding can help but not groundbreaking IMO if you don't have anything else strong in the regimen. PGE2 didn't really do much for me I used it plus is extremely fragile and expensive. Never used lithium. Other areas of looking into would be topical ATP, topical d-ribose, topical creatine etc.

There is actually a patent on topical creatine for hair growth...

Thanks for the update. I agree that dutasteride was largely responsible for his regrowth. That stuff is powerful; I've used it.

Castor diluted in DMSO and ethanol makes it a bit easier to apply, but you're right, it's really sticky stuff.

How do you know the progesterone/dhea isn't going systemic? I've tried I believe Now brand progesterone cream in the past but didn't care for the way it made me feel. As I recall it works as a gaba receptor agonsist, so it has a calming effect and a rebound type effect as well. Don't quote me on this, it's been a long time.

I dropped finasteride and my hair has been holding but definitely not as thick. I think green tea/caffeine has potential. I just make some green tea and spray it on my head.

There's patents on lots of things, but it doesn't mean they work necessarily. Do you know the supposed mechanism? Do you have a link for that one?

Do you use minoxidil? That stuff works but obviously goes systemic as it causes all other hair to grow too. Even out of your ears and places you didn't have hair before. It breaks down collagen so it ages you.

Hey man, instead of answering your questions one by one I pretty much answered them in the thread I created here.

https://raypeatforum...eatments.12907/

I'm curious about the reports, in that thread, of growth from dhea and pregnenolone topically, as I would have thought the opposite would occur. What's the proposed mechanism of action for that?

[Fletch]

 

Hey man, instead of answering your questions one by one I pretty much answered them in the thread I created here.

https://raypeatforum...eatments.12907/

 

 

 

 

Thanks Tubzy that's a huge help!  I haven't read the whole thing, so I don't know if you answered this but the topic was getting away where I stopped...

 

Why did you stop the Cloprostenol if the results were so good? It sounds ideal for me considering my main problem is having ever-finer hair as the follicles shrink in diameter. Minoxidol works great, but like you I can't handle the sides. I'm desperately trying to find something safe and effective to thicken up my hair.  It's so fine that I don't even see shed hair in the shower like other people. I've never been able to count them. Really, I doubt that I shed that much; it's just a gradual thinning of the hair and slow recession.

 

Edited by Fletch, 21 March 2017 - 05:07 AM.

[Tubzy]

Hey man, instead of answering your questions one by one I pretty much answered them in the thread I created here.

https://raypeatforum...eatments.12907/

Thanks Tubzy that's a huge help! I haven't read the whole thing, so I don't know if you answered this but the topic was getting away where I stopped...

Why did you stop the Cloprostenol if the results were so good? It sounds ideal for me considering my main problem is having ever-finer hair as the follicles shrink in diameter. Minoxidol works great, but like you I can't handle the sides. I'm desperately trying to find something safe and effective to thicken up my hair. It's so fine that I don't even see shed hair in the shower like other people. I've never been able to count them. Really, I doubt that I shed that much; it's just a gradual thinning of the hair and slow recession.

For the clopro is was more of just an experiment since long term there was no steady or guaranteed way of getting it. It was sent to me by another member from a different country who obtained it vet grade. So it was more of just an experiment. Although, after reading more into PGE2 and it's derivatives a kind of steered away from them as they are very inflammatory messenger within the body so that idea doesn't appeal to me as much anymore.

Take a look through that thread when you get a chance there are a few things you can take a look at. Selenium sulfide (selsun blue shampoo) can be the easiest and cheapest to start. Just make sure you leave it on for two cycle (5 min/ 10 min) and that should cut your shedding down and thicken your hair.

We are in the process of working with a close vendor and contributor on RP (Haidut/ideal labs), who may start selling ATP. Topical ATP looks pretty promising. When we start to experiment I'll let you know if you want to trial it with us.

Edited by Tubzy, 23 March 2017 - 03:35 PM.

[sindre]

I wish some smart people would comment on this:

Effect of Dieckol, a Component of Ecklonia cava, on the Promotion of Hair Growth

 

https://www.ncbi.nlm...10/?tool=pubmed

 

Ecklonia cava can block as much dht as propecia! why aren't more people excited by this? And it does it in a non-harmful way.

 

"The process of DHT inhibition is vastly different to finasteride. It's like comparing night and day. Finasteride destroys an enzyme, and ECE, uses oxidation reduction a completely natural process."

 

http://immortalhair....t=ecklonia cava

 

 

 

This stuff is also interesting:

https://www.ncbi.nlm...pubmed/28280377

Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process.

http://immortalhair....2-stage-process

Edited by sindre, 26 March 2017 - 07:24 AM.

[PeaceAndProsperity]

Nicotinic acid worked at 500mg every day for my 70 year old relative. It restored hair color and increased hair growth (everywhere) though it took some months and he still has hair loss (see my profile picture for an example). I hypothesize that higher dosages may fully restore his hair.

[Logic]

Nicotinic acid worked at 500mg every day for my 70 year old relative. It restored hair color and increased hair growth (everywhere) though it took some months and he still has hair loss (see my profile picture for an example). I hypothesize that higher dosages may fully restore his hair.

 

Nicotinic acid as in Niacin?  Taken orally?
Niacin Flushing is caused by PGD2 being released from cells into the bloodstream and was discussed as a possible therapy for hair loss earlier in this thread.
This is the 1st anecdotal evidence I have seen that it works however.

http://www.life-enha...-to-your-health

[Fletch]

I was checking out the reviews of nicotinamide riboside on Amazon and someone reported regrowth and darkening.

[Tubzy]

Use niacinamide instead. 500mg topically I use in water ever night. Thicker, darker and fuller hair. You can ever add it to your shampoo just let it sit for 10min or so. Niacimamide does not cause flushing.

[PeaceAndProsperity]

Nicotinic acid as in Niacin?  Taken orally?
Niacin Flushing is caused by PGD2 being released from cells into the bloodstream and was discussed as a possible therapy for hair loss earlier in this thread.
This is the 1st anecdotal evidence I have seen that it works however.

http://www.life-enha...-to-your-health

 

Yes, oral niacin. He is about to up his dose to 3g daily so we'll see how that progresses in the coming months, hopefully he'll have even more growth of his hair.

The fact that niacin can restore hair color is quite a thing, especially in someone who is now 71. I wonder what the reason is. Increased blood flow? Increased NAD synthesis? Anti-inflammatory properties? Metal chelation? Who knows..
 

[Tubzy]

I wish some smart people would comment on this: Effect of Dieckol, a Component of Ecklonia cava, on the Promotion of Hair Growth

https://www.ncbi.nlm...10/?tool=pubmed

Ecklonia cava can block as much dht as propecia! why aren't more people excited by this? And it does it in a non-harmful way.

"The process of DHT inhibition is vastly different to finasteride. It's like comparing night and day. Finasteride destroys an enzyme, and ECE, uses oxidation reduction a completely natural process."

http://immortalhair....t=ecklonia cava



This stuff is also interesting:
https://www.ncbi.nlm...pubmed/28280377 Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process.
http://immortalhair....2-stage-process

Honestly I have zero interest in anything that inhibits DHT/5AR after being on fin for two years. Side effects are horrible.

[BieraK]

Use niacinamide instead. 500mg topically I use in water ever night. Thicker, darker and fuller hair. You can ever add it to your shampoo just let it sit for 10min or so. Niacimamide does not cause flushing.

 

Do you use 500 mg dissolved in a solution for topical application?

I'm using for now nucotinamide+ribose and melatonin in a solution, I'm seeing my hair a bit ticker,, however I'm starting to see more grey hairs recently, I don't know if is something that has to do with with this solution or just age, I've 29 now.

[Nate-2004]

I didn't even see this thread till BieraK bumped it a few days ago. Can Tubsy provide an update on all this? Any significant progress with this after nearly 3 years?

 

I'd heard from various sources, namely via Rhonda Patrick, that EPA/DHA can reduce E2 series prostaglandins which are considered to be inflammatory cytokines. Why then would we want to increase these and why would this *cause* hair growth? Quite paradoxical if you ask me.

[Tubzy]

Hey, sorry the thread moved here

 

https://hackstasis.c...loss-options.7/

[BieraK]

UP Again:
Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice.

Xing F, Yi WJ, Miao F, Su MY, Lei TC.

Int J Mol Med. 2018 Jan 16. doi: 10.3892/ijmm.2018.3391. [Epub ahead of print]

Baicalin is a traditional Chinese herbal medicine commonly used for hair loss, the precise molecular mechanism of which is unknown. In the present study, the mechanism of baicalin was investigated via the topical application of baicalin to reconstituted hair follicles on mice dorsa and evaluating the effect on canonical Wnt/β‑catenin signaling in the hair follicles and the activity of dermal papillar cells. The results indicate that baicalin stimulates the expression of Wnt3a, Wnt5a, frizzled 7 and disheveled 2 whilst inhibiting the Axin/casein kinase 1α/adenomatous polyposis coli/glycogen synthase kinase 3β degradation complex, leading to accumulation of β‑catenin and activation of Wnt/β‑catenin signaling. In addition, baicalin was observed to increase the alkaline phosphatase levels in dermal papillar cells, a process which was dependent on Wnt pathway activation. Given its non‑toxicity and ease of topical application, baicalin represents a promising treatment for alopecia and other forms of hair loss. Further studies of baicalin using human hair follicle transplants are warranted in preparation for future clinical use.　

https://www.ncbi.nlm...pubmed/29336472

[granmasutensil]

Any update on whether using PGE2 and or Cloprostenol is worth it?

 

You can get Cloprostenol pretty easy now. You can get bigger sizes for cheaper.

https://www.walmart....a-2mL/199497535

 

Adenosine pan out and worth using? You can get a product with Triacetyladenosine so it is active far longer, it also has ursolic acid which also has hair benefits.

http://epharmnutriti...pspray-8oz.html

 

What about instead of inhibiting test conversion to DHT and the systematic issues, just block the DHT receptor topically with DIM an androgen receptor antagonist?

https://atpscience.c...9-dont-dim-wit/

 

What about degrading the androgen receptor with berberine topically?

https://www.ncbi.nlm...les/PMC3154574/

 

Anyone end up trying the Palmitoylethanolamide, Tretinoin, and Sodium Valproate recommended here? Sodium Valproate sounds good but is there any consensus on the Palmitoylethanolamide and Tretinoin?

https://www.longecit...es-with-effect/

 

Any thoughts on Sandalore?

https://www.nature.c...-05973-0#MOESM2

 

Would this peptide be worth using for stimulating progenitor cells?

http://www.lotioncra...ta_reproage.pdf

http://www.lotioncra...ge_peptide.html