Buildup of GATA4 protein pushes cell into static state of senescence
"...In healthy, dividing cells, GATA4 is quickly gobbled up and broken down. But this cleanup process slows down in damaged cells, causing the protein to build up and initiate senescence, the researchers found. This finding helps explain an apparent conundrum from previous studies showing that a cell’s self-digesting activity could promote or prevent a senescent fate..."
https://www.sciencen...-growing?tgt=nr
