21 replies to this topic

[Strangelove]

Parnate (tranylcypromine) its a very effective antidepressant, almost every drug rating site has it as a treatment for depression at the top... There are experiences at times like this...

 

"I have been treated for severe cyclic depressions (atypical), anxiety, and OCD since college and I am 47. Without effective medication, my illness is debilitating. In 1993, after trying many different antidepressants, I urged my psychiatrist to prescribe me the monoamine oxidase inhibitor, Nardil. WOW....somebody switched the lights on and the symptoms off. 90% of the time I was in remission with only brief minor periods of symptoms. Nardil was reformulated and stopped working, so I switched to Parnate. 160mg/day give 100% symptom relief (with 1200mg/day lithium). I mentally feel like I'm 20, bursting with mental energy. Many considered me brilliant prior to Parnate; but after years on it, my cognitive skills, retention, and creativity reached a new level."

 

 

Although tranylcypromine is not a new drug, is difficult to get a prescription for it, the reason is that you have to follow strict dietary restrictions in order to avoid side effects, the most serious being hypertension. The risk of hypertension depends on the deactivation of MAO (that breaks down tyramine) when the tranylcypromine reaches the stomach. Eating high tyramine foods that does not brake down in the stomach, brings tyramine to the brain that releases and takes the place of norepinephrine giving a sudden spike in blood pressure. If oral use of tranylcypromine did not have this side effect would probably be the most popular antidepressant. My idea is to buy the pure chemical and change route of administration in order to avoid the deactivation of MAO in the stomach. This can be done making a tranylcypromine nasal spray or just use it sublingually.

 

If there is interest for a very small group buy I found an American lab for the hemisulfate salt of tranylcypromine for a relatively good price of  $405 / 5 grams without shipping. Although I got a prescription from a doctor that is a friend and trust me to follow the dietary restrictions, I ll prefer to get the pure chemical. I am interested for 1 gram (at least) we also going to need another long-term member placing the order having a VAT# other than that I got the impression that would not be difficult to acquire it from the link below.

 

http://www.scbt.com/...lcypromine.html

 

 

[Strangelove]

Parnate rated first with Nardil (another generalized MAOI) over fifty common antidepressants.

 

http://www.askapatie...&SortOrder=DESC

 

Parnate rated 9.2 from 21 users.

 

http://www.drugs.com...depression.html

 

These results are common online, do not let the wikipedia or other pharmacy sites scare you away, especially if you have issues with depression. My main reasons taking it, is with the many benefits I am having together with NSI-189, the combination gives me a lot of brain energy!

[Reformed-Redan]

I'm highly interested in this compound. I would be interested for a group buy for this compound.

[Strangelove]

OK cool! Trust me, tranylcypromine has serious antidepressant potential!

 

Also if it works for you, you could use it indefinitely as its rare to get used to its effects. If you check on line experiences there are many that use it for decades. Only in the ask a patient site I linked before there are 12 people that have been using it for 20 and more years, with 33 years being the longest.

 

Some other effects are being more stable and feeling stronger in events that could create anxiety, have a way better feel of my movement as I walk and even getting a dopamine high in long walks and my mental energy in general has increased. A side effect that disappeared was the need to take an afternoon nap, also is more difficult to get asleep, although it has gone much better now that I take one dose in the morning.

 

Do you by any chance have a VAT# to place an order for it? I can buy 2 grams and there are two other members interested.

 

[dajoker]

on for a gram.

But only if there is a more serious description of the process of creating a nasal spray..

I am not going to have it by oral way for sure

seen that i drink regularly (red wine) and consume some cheese.

Haven't checked the other transactions, but from memory there was a bunch of marines literally dying after

eating the cheese.. and that ain't funny.

 

[focus83]

I have 64 * 10mg German brand Tranycypromine left. The brand is called Jatrosom. Expiration date 06/2017. I took it for several month and found it was the best and most natural feeling antidepressant I ever took ( and I took dozens!). However, after a few month intolerable anxiety and panicky feelings set it, so I had to quit.

 

PM me, if interested.

[Bukujutsu]

Diet is overblown + other information. Very good overviews:

http://www.psychotro...general-intro-2

http://d27vj430nutdm...97/109397.1.pdf

 

Selegiline/Deprenyl may protect against tyramine induced NE release: http://www.ncbi.nlm....pubmed/14726221

 

I also experienced terrible anxiety on it, likely due to the effect on NE. I've found I don't react well to any drugs with a significant effect on NE. For people with similar experiences and who suffer from anxiety to begin with, Nardil would likely be a much better choice.

 

Some responses to comments about this in the NSI thread:

 

Parnate its for people that need an activating drug and Nardil can help more with anxiety.

 

You can actually use a combination of Nardiland Parnate, which could be fascinating and incredible, but of course you need to be very careful. Nardil can actually be augmented with very low doses of stimulants as long as the effect on serotonin and norepinephrine is low enough. Dextro-amphetamine is what's commonly used, although Vyvanse should work as well. The former can easily be extracted from racemic amphetamine, which is very cheap in bulk from darknet markets: https://www.reddit.c...g_d2fma_on_the/

 

2-FA may be a much cheaper and more readily available option, the modification to the base amphetamine has been found to cause a much lower effect on NE. Same with 2-FMA, but I don't know if the effect on serotonin is low enough to allow them to be used safely. Although, there are drugs you can take to rapidly treat ensuing serotonin syndrome or a hypertensive crisis, but it's still an unpleasant event and I'm not sure I'd want to risk it.

https://psychonautwiki.org/wiki/2-FMA

 

As for the nasal and sublingual idea, I'm concerned that with sublingual application too much would go down the esophagus. I actually emailed Dr. Ken Gillman of www.psychotropical.com/ to ask him about various ROAs and he shared this concern. He said he couldn't advice me about nasal or rectal administration, unfortunately, but a "drip" is a common with other drugs used intranasally. I actually used it rectally, and before doing so found a good paper on MAOI metabolism to be sure it was safe and wouldn't lose efficacy. It appears that this is the case for Parnate and it doesn't need to undergo hepatic metabolism to produce anything beneficial, but not for Nardil. Amphetamine has much higher availability and faster onset with rectal admin, which, IIRC, Parnate is derived from, and I found this to be the case for it. Detailed it here: https://www.reddit.c..._people/cphfwrw

 

Don't be afraid to use it rectally if you've never used that route before, it's really easy, you just have to learn to be comfortable with your body.

 

Edited by Bukujutsu, 13 October 2015 - 10:37 AM.

[Junk Master]

I'm in for a gram if this is really going to happen.

[Bukujutsu]

For anyone interested, I now have pure powder for sale at only $35 a gram. I managed to receive a prescription for Nardil, so I'm selling off the last I have left: http://www.longecity...lable-for-sale/

[Shai Hulud]

I have a whole pack of Parnate 20 mg (100 tablets) left. Actually I would get it first at the pharmacy, as I have the prescription still here. It is the German Jatrosom brand. I also still have a lot left from the pack before that and possibly I could get even more prescribed. I switched to Nardil, but have to pay myself and get the prescription from another doctor. So if someone's interested, I'd be willing to sell them. Just pm me.

[Pasternak]

Anyone still interested?

[kurdishfella]

why would you want parnate when you can get other mao inhibitors more easy like deprenyl or methylene blue which do the same thing.

Edited by farshad, 03 June 2019 - 09:29 AM.

[Strangelove]

why would you want parnate when you can get other mao inhibitors more easy like deprenyl or methylene blue which do the same thing.

 

Saying that all MAOIs are the same is saying that all reuptake inhibitors are the same. I have tried all strong MAOIs and you can really feel its effects when deprenyl and (even more) methylene blue is subtle. In case anyone is interested I have some extra tranylcypromine hcl.

Edited by Strangelove, 03 June 2019 - 09:53 PM.

[YoungSchizo]

I have 90 tablets of 20mg Tracydal (Parnate) from Daleco Pharma (trade mark) in overflow from the Dutch Pharmacy. I can refill (at least) 90 tablets of 20mg every 2/3 months.

[kyle75]

Hey Young Guy (because, you know, you are so much more than just a young schizo),

 

Do you mean you can sell those or have I misunderstood you? 

 

Also did this group buy actually ever happen? I see that OP was almost four years back. 

[YoungSchizo]

Hey Young Guy (because, you know, you are so much more than just a young schizo),

 

Do you mean you can sell those or have I misunderstood you? 

 

Also did this group buy actually ever happen? I see that OP was almost four years back. 

 

Check PM

[NG_F]

90 tablets of whatever strength you desire    North America Only 

[YoungSchizo]

90 tablets of whatever strength you desire North America Only

You claim North America I'll claim Europe :D
Got a new stock of 210 20mg tablets of Tracydal/Parnate.

[jaiho]

Anyone know if tranylcypromine powder would have any downsides compared to using pills? Seems like a decent option for those unable to access Parnate.

[genshin]

Can you get the powder form? From alibaba or other markets?

Anyone know if tranylcypromine powder would have any downsides compared to using pills? Seems like a decent option for those unable to access Parnate.

 

[YoungSchizo]

I've quit Parnate, if someone is willing to run a trial, I have 133 tablets of 20mg left.

[YoungSchizo]

I will have Parnate in stock again very soon. 90 x 20mg tablets a month.

 

Anyone that is interested can PM me.