10 replies to this topic

[Doc Psychoillogical]

The Low down...

Been on Dextroamphetamine=Dex for 2+ years, 10mg 3xDaily, works wonders for me. Been Experiencing Anxiety mostly social and situational per usual, But new panic attacks, the typical symptoms. Assumed they are surfacing from my concious effort to supress anxiety, with no healthy release.

 

The Problemo...

To the Point Doc gave me a script for Clonazepam 0.5mg 2xDaily. Took it before my Dex, Doc said Clonazepam effects last 12 hours. but all three 10mg Dex tablets taken today might as well been skittles. Total loss of effectiveness, left me scatter brained and dull, drew a blank mid thought several times. Want to give Clonazepam a chance, anxiety was abolished, but so were my dex benefits.

 

Does anyone have any wisdom on my situation?

Any correct one before the other recommendation?

dosage changes?

Anything?

 

Would be greatly APPRECIATED, feels like im taking a step backward & wasting good $$$ and good Rx's

[Doc Psychoillogical]

***EARTH TO LONGECITY***

DO WE HAVE LIFE? ANYONE...?

  

**...OVER**

 

 

Attached Files

•  Lonely_Space1.jpg   124.32KB   1 downloads

Edited by landen.Barry@yahoo.com, 23 October 2015 - 09:49 PM.

[drg]

I was told by a doc you shouldn't mix stims and benzos. She said that is how they simulate bipolar in rats. Could be the usual doctor bullshit.

In any case I would not increase the dose. Stimulants and benzos have different mechanism of action so they will both be working at the same time without loss in potency.

The benzos can cause cognitive effects that will make it harder to focus... Drowziness fatigue low motivation which could be what is happening.

Not sure what to do... Guanfacine combos well with stimulants has off label use for anxiety and is not addictive. Could be an alternative.

[Valor5]

Guanfacine, back when I tried also for me helped with the horrible feelings after Ritalin and Focalin.

[Valor5]

Guanfacine, back when I tried also for me helped with the horrible feelings after Ritalin and Focalin.

It goes without saying but nobody here I believe believes what you take are brain healthy drugs. 

[Doc Psychoillogical]

 

Guanfacine, back when I tried also for me helped with the horrible feelings after Ritalin and Focalin.

It goes without saying but nobody here I believe believes what you take are brain healthy drugs. 

 

The drugs wouldn't be medicinally prescribed if they weren't. On the contrary, you're right personal pros and cons must be compared and side effects evaluated to possibly deem them harmful.

[gamesguru]

Lots of these chemicals are prescribed just to fill a need, or because there is a chance it could help you, or keep you coming back.

Doctors are supposed to obtain a firm diagnosis, and prescribe appropriate medicines.  Key word: supposed

Oftentimes they obtain a flimsy diagnosis, and prescribe inappropriate meds.  Oftentimes it is due to unconscious bias, and not them deliberately misleading you.

 

Everyone has a unique chemistry, and many people respond badly to benzodiazapines. Also with antidepressants.  For example, paxil was just ruled unsafe for teens.  About time.

http://theconversati...sentation-18306

People (both with mental illness and volunteers) who’ve taken antipsychotics also report a state of physical, mental and emotional suppression. Those suffering from mental disorders describe how the drugs can help to diminish disturbing thoughts and experiences, but at the cost of stifling important aspects of their personality such as initiative, motivation, creativity and sexual drive.

 

https://www.nlm.nih....ory_154655.html

"Ours says paroxetine is neither safe nor effective in the treatment of adolescents," Nardo added. "And I don't know of any example where two studies in the literature with the same data ever reached opposite conclusions."

Profiles of Cognitive Dysfunction in Chronic Amphetamine and Heroin Abusers
Groups of subjects whose primary drug of abuse was amphetamine or heroin were compared, together with age- and IQ-matched control subjects. The study consisted of a neuropsychological test battery which included both conventional tests and also computerised tests of recognition memory, spatial working memory, planning, sequence generation, visual discrimination learning, and attentional set-shifting. Many of these tests have previously been shown to be sensitive to cortical damage (including selective lesions of the temporal or frontal lobes) and to cognitive deficits in dementia, basal ganglia disease, and neuropsychiatric disorder. Qualitative differences, as well as some commonalities, were found in the profile of cognitive impairment between the two groups. The chronic amphetamine abusers were significantly impaired in performance on the extra-dimensional shift task (a core component of the Wisconsin Card Sort Test) whereas in contrast, the heroin abusers were impaired in learning the normally easier intra-dimensional shift component. Both groups were impaired in some of tests of spatial working memory. However, the amphetamine group, unlike the heroin group, were not deficient in an index of strategic performance on this test. The heroin group failed to show significant improvement between two blocks of a sequence generation task after training and additionally exhibited more perseverative behavior on this task. The two groups were profoundly, but equivalently impaired on a test of pattern recognition memory sensitive to temporal lobe dysfunction. These results indicate that chronic drug use may lead to distinct patterns of cognitive impairment that may be associated with dysfunction of different components of cortico-striatal circuitry.

 

on clonazepam

https://en.wikipedia...ognitive_status

http://memory.ucsf.e...nt/avoid/single

[Doc Psychoillogical]

Combination, Augmentation, Co-Administration and Prescribed use of...
CURRENTLY:
DEXTROAMPHETAMINE(DEXEDRINE)
30MG(INSTANT RELEASE) DAILY

CLONAZAEPAM(KLONOPIN) 
1MG DAILY

GABAPENTIN(NEURONTIN) 
1200MG DAILY 

This is the new combination I have been Legally prescribed, for diagnosed ADHD with Social/General Anxiety...


ANYONE ELSE HAVE ANY EXPERIENCE, INSIGHT, TIPS, ANY HELPFUL INFO AT ALL REALLY!
 

Attached Files

•  download.jpg   37.14KB   0 downloads

[Major Legend]

Combination, Augmentation, Co-Administration and Prescribed use of...
CURRENTLY:
DEXTROAMPHETAMINE(DEXEDRINE)
30MG(INSTANT RELEASE) DAILY

CLONAZAEPAM(KLONOPIN) 
1MG DAILY

GABAPENTIN(NEURONTIN) 
1200MG DAILY 

This is the new combination I have been Legally prescribed, for diagnosed ADHD with Social/General Anxiety...


ANYONE ELSE HAVE ANY EXPERIENCE, INSIGHT, TIPS, ANY HELPFUL INFO AT ALL REALLY!
 

 

Uhg that picture gives me the creeps. 

 

Well Clonazapem is a really really strong benzodiazepine, it's highly likely you are simply highly intolerant to it so the sedative effects are super strong, basically you need to go lower on the dosage there, or pick something weaker like Lorazepam (which works for a lot of people). Also Clonazepam doesn't do itself any favours by being in your blood 24 hours a day, not a great thing since benzos are notorious for physical dependence. 

 

In my opinion it's much better to op for something like Xanax or Lorazepam, which is cleaner and has a dopamine releasing effect and also has a much shorter half life. 

 

The dosage is probably the issue here, most people get knocked out by benzos when they start out.

 

Also you might really want to augment amphetamine with memantine, lots of evidence out there that memantine probably prevents tolerance from developing, which is a huge concern if dosing daily on amphetamines.

 

Edit: The sedative effect of Benzos are mechanically isolated from the anti-anxiety effects of benzos as they are different acting receptors. The scatter brain effect you are talking about is the sedative effect, which is also the mechanism of why benzos are physically addictive, the withdrawal of that is the opposite of sedative...

 

    Edit2: Also Benzos and Amphetamines do go well together which is why so many people are addicted to both together. The reason behind this is benzos      act on Gaba signalling which reduces the firing of neurones in your brain, which is why people feel intelligent in alcohol even if they are not because of    reduced signalling. 

 

   On the other hand amphetamines act on the dopamine system greatly increasing executive function on a completely different circuit, plus benzos also          happen to counter all the side effects of amphetamines such as anxiety, trembling and so on. On top of that benzos don't have all the bad side effects of       alchohol, like stinking for example.

Edited by Major Legend, 19 November 2015 - 07:52 PM.

[Doc Psychoillogical]

 

Combination, Augmentation, Co-Administration and Prescribed use of...
CURRENTLY:
DEXTROAMPHETAMINE(DEXEDRINE)
30MG(INSTANT RELEASE) DAILY

CLONAZAEPAM(KLONOPIN) 
1MG DAILY

GABAPENTIN(NEURONTIN) 
1200MG DAILY 

This is the new combination I have been Legally prescribed, for diagnosed ADHD with Social/General Anxiety...


ANYONE ELSE HAVE ANY EXPERIENCE, INSIGHT, TIPS, ANY HELPFUL INFO AT ALL REALLY!
 

 

Uhg that picture gives me the creeps. 

 

Well Clonazapem is a really really strong benzodiazepine, it's highly likely you are simply highly intolerant to it so the sedative effects are super strong, basically you need to go lower on the dosage there, or pick something weaker like Lorazepam (which works for a lot of people). Also Clonazepam doesn't do itself any favours by being in your blood 24 hours a day, not a great thing since benzos are notorious for physical dependence. 

 

In my opinion it's much better to op for something like Xanax or Lorazepam, which is cleaner and has a dopamine releasing effect and also has a much shorter half life. 

 

The dosage is probably the issue here, most people get knocked out by benzos when they start out.

 

Also you might really want to augment amphetamine with memantine, lots of evidence out there that memantine probably prevents tolerance from developing, which is a huge concern if dosing daily on amphetamines.

 

Edit: The sedative effect of Benzos are mechanically isolated from the anti-anxiety effects of benzos as they are different acting receptors. The scatter brain effect you are talking about is the sedative effect, which is also the mechanism of why benzos are physically addictive, the withdrawal of that is the opposite of sedative...

 

    Edit2: Also Benzos and Amphetamines do go well together which is why so many people are addicted to both together. The reason behind this is benzos      act on Gaba signalling which reduces the firing of neurones in your brain, which is why people feel intelligent in alcohol even if they are not because of    reduced signalling. 

 

   On the other hand amphetamines act on the dopamine system greatly increasing executive function on a completely different circuit, plus benzos also          happen to counter all the side effects of amphetamines such as anxiety, trembling and so on. On top of that benzos don't have all the bad side effects of       alchohol, like stinking for example.

 

 

Yeah picture was a little added bonus,

Read every word of the post, interesting,  I agree benzos compliment stimulants nicely. I guess my conundrum is why the gabapentin. Asked my DR what it would do for me, he only replied; 

"It will make the clonazepam more effective and wont affect the Dexedrine effects. and it stays effective long term"

Its Day three 3 and people have said they notice im more relaxed but also alot less out going. 

Which honestly, im loving the combo for work, but i do think it is blunting my personality. Is it possibly the Gabapentin??

[Doc Psychoillogical]

NEW CURRENT STACK/REGIMEN

 

1. Dexedrine (Dextromphetamine) Extended release 15mg

 

2X day 

 

2. Klonopin (Clonazepam) 0.5mg 

 

2X day

 

3. Zinc (Gluconate) 50mg

 

1-2X a day

 

ANY SUGGESTIONS OR BENEFICIAL ADDITIONS WOULD BE APPRECIATED!!