19 replies to this topic

[Busyboy]

Excluding diet, exercise, meditation and sleep.

 

For me, it would probably be Phenylpiracetam, since it has been effective at improving my focus, motivation and rapidity of thought where other nootropics have fallen short.

[Wingless]

I'd say Tianeptine sulfate, if that doesn't count I'd say Phenylpiracetam as well

[Busyboy]

I'd say Tianeptine sulfate, if that doesn't count I'd say Phenylpiracetam as well

Yeah, Tianeptine Sulfate is fine, should have said "Cognitive Enhancer" in the title to make it clearer. Sorry about that. Anyways, whys it your favorite?

[baccheion]

Cerebrolysin or N-Acetyl Semax Amidate.

[PalmAnita]

Ketamine! But that's not considered a nootropic probably and it could need to be stacked with a NADPH oxidase inhibitor to avoid long-term neurotoxic changes.

 

Nothing beats NMDA antagonists in terms of cognitive enhancement, sociability, anxiolysis, mood lift, motivation for me ...

[Mind]

Caffeine...duh!

 

Safe, effective, taken in natural form (coffee and tea) shown to lower mortality risk and lower the incidence of age-related diseases.

[MoreNowAgain]

I'd say either - Ibogaine or Ketamine. Ketamine not being a nootropic persay; but for me attenuating the worst of my severe depression is the best thing I can personally do for my own cognition at this point in my life.

Edited by MoreNowAgain, 25 November 2015 - 05:33 AM.

[PalmAnita]

Well, if memantine is considered to be a nootropic, then I'd say, low-dosage ketamine is one too. It's just heavily dosage and usage-pattern dependent, but the arylcyclohexylamines are much better than their average reputation (among non-users ... if you think neutrally about it, there's really no reason why benzodiazepines should get prescribed all over the way but low-dose ketamine not).

 

The widely used psychopharms like SSRIs etc. are at least as serious when looking at the potential and actual side effects. Probably the NMDA antagonists just happen to have a really good price : effect ratio and this scares people off. This is euphoric / can be abused at higher dosages (instead of being toxic, causing organ damage, whatever) so it must be bad. Ketamine has it's downsides too, of course, but every drug has them.

Edited by dopamimetiq, 25 November 2015 - 07:17 AM.

[Bluecheer]

I hate to be that guy... but ive found it the most effect thing so far, so LSD

Although I should note, I would only be micro dosing to the point of 1/10th what a normal person takes. ​

If your not counting that as a nootropic or mean a more the standard type, I would probably go hydergine... ​

Edited by Bluecheer, 25 November 2015 - 12:23 PM.

[montana2012]

I'd take PQQ, It expands my consciousness.

[gamesguru]

tea, bacopa, ginseng, ginkgo, or ginger

[sthira]

Coffee

[Ark]

Lions Mane

[Heisenburger]

Coffee

 

Totally unfair. Coffee shouldn’t count, as it is an indispensable substance which is necessary for life itself. We should get to pick ‘coffee’ and one other noot. Personally, I find this an extremely difficult question to answer. I’ll tentatively go with NSI-189. All the other noots are “nice,” but NSI-189 is the only one that really falls into the category of “life-changing” or “game changing.”

[fiftyyy]

Alpha GPC, the NOW Brand, tried other brand, but nothing has had so pronounced positive effect on cognition and motivation for me. As a side note, arousal is a definite plus.

 

Coffee? I dont drink that jittery stuff 

[Limburger]

S-adenosylmethionine. It's not for everyone, but when it works it fixes all my cognitive deficits and brings me right back to my old self.

[Lsdium]

 

 

 

 

Totally unfair. Coffee shouldn’t count, as it is an indispensable substance which is necessary for life itself. We should get to pick ‘coffee’ and one other noot. Personally, I find this an extremely difficult question to answer. I’ll tentatively go with NSI-189. All the other noots are “nice,” but NSI-189 is the only one that really falls into the category of “life-changing” or “game changing.”

 

 

Heisenburger, could you elaborate why NSI-189 have been a life-changing for you?

[sthira]

Totally unfair. Coffee shouldn’t count, as it is an indispensable substance which is necessary for life itself. We should get to pick ‘coffee’ and one other noot. Personally, I find this an extremely difficult question to answer. I’ll tentatively go with NSI-189. All the other noots are “nice,” but NSI-189 is the only one that really falls into the category of “life-changing” or “game changing.”

Heisenburger, could you elaborate why NSI-189 have been a life-changing for you?

Yes, I'd like to know, too, and also what dosages are you taking? 40 mg once, twice, or three times per day?

[Heisenburger]

NSI-189 has had only one effect on me that I am aware of—it has vastly diminished my lack of self-confidence. Before I started taking it, I was afraid to tackle difficult tasks out of fear that I wasn’t talented or intelligent enough to accomplish them. Now I realize that most goals are realizable with persistence and effort. I feel that this alone is sufficient reason to continue taking it. I take 40 mgs. every morning.

[Baten]

Low doses of selegiline might have helped me the most, for general health and well-being. Then again I wouldn't take it for 'the rest of my life', but rather as needed. Coffee is pretty indispensable, but I guess we're not taking it into account. And I'm not drinking coffee every day either, that would kill its benefit, for me. As far as nootropics go, I'm still not convinced what is the single best one so far. My honest finding is that most are underwhelming and can surely be lived without.

 

When I look back the level of my writing is quite a notch higher when I took pramiracetam. It blunted my emotions a little though. On the other hand, I get a similar effect with semax spray (writing, speaking seem better overall). Semax is on the subtle side, but there's no side effects and I do feel stronger intellectually. Plus, one spray goes a long way. While initially I thought different, I find that it doesn't seem to do much for brain fog though, so it guess it doesn't work like other noots that work on acetylcholine levels but rather something else entirely.

 

@harris most of us are not fans of those combination products supplement companies push out. Nootropics users tend to have their own custom regimen/nootropic stack. Combo supplements tend to be way too expensive, and not very well-rounded. Besides, everyone is different when it comes to their needs and their dosing.

Edited by Baten, 10 December 2015 - 04:46 PM.