691 replies to this topic

[Library]

I previously ordered 50g of Nilotinib. I probably used ~0.4 grams (400 mg). I don't like the stuff and I don't think it's for me. I just don't think it agrees with my phenotype and my metabolism.

I'm pretty sure this drug works as advertised. I really noticed it working. But I just think the risks vs. the reward are not worth it for me.

If anyone wants my Nilotinib (50g) let me know via private msg. I am asking what I paid for it (~$500).

I'd like to buy it ---

Is this a private message?

Maybe there is an email address that I don't see?



Library

[Library]

I'd like to buy it ---

Is this a private message?

Maybe there is an email address that I don't see?



Library

[nicof83]

Hello all,

Here is my story: a Cortico-basal degeneration has been diagnosed on my mother a few weeks ago. The first symptoms appeared one year ago.

Now, the symptoms are changing very quickly to the point that, now, she can no longer walk.

The specialist tells us that there is currently no hope for this disease and that time is running out before total paralysis.

Does any of you have heard about a good effect of the N on this kind of disease?

Can I join a Group By even if I am In France? (where it is impossible to buy N).

Thanks a lot. 

Nicof83

[Logic]

Hi all.
My apologies for my absence; work has to come 1st:
I dashed back to Mozambique with a new gearbox and some other bits for the gold plant and some parcels for the people there.
Everything is running  smoothly... for now... and the rainy season normally puts a damper on operations,
There is also a satellite internet link being put up at the site, so either way; I'm back!

 

Group buy Round 4:

The following people have shown interest:

splib                 300 grams
geo12the         ??                 (2nd time buying)
Bryan03           ??
Library             ??
Levanah10       50
jack romaine    ??

knasse             ??                (2nd time buying)

khalidnt            15?

Total                350+ grams

 

I hope I haven't omitted anyone? Please post if I have.

 

We need to get over the 500 gram minimum to get Round 4 going.
geo12the, Bryan03, Library, jack romaine please post the # of grams you would like. (I will PM everyone too)

 

If anyone else is interested; please post so here, with the amount you want.

Required info via to participate.  Via PM:

I will require the amount you want and your address to work out postage and PayPal fees.
Your Email Address as an alternate means of communication is also a good idea.
I will then send you a costing and payment details.
Once all the funds are collected; payment is made and the parcel shipped to the lab for testing.
The parcel is split up by the lab and posted to your address via USPS.

[Logic]

Hello all,

Here is my story: a Cortico-basal degeneration has been diagnosed on my mother a few weeks ago. The first symptoms appeared one year ago.

Now, the symptoms are changing very quickly to the point that, now, she can no longer walk.

The specialist tells us that there is currently no hope for this disease and that time is running out before total paralysis.

Does any of you have heard about a good effect of the N on this kind of disease?

Can I join a Group By even if I am In France? (where it is impossible to buy N).

Thanks a lot. 

Nicof83

 

 

Hello Nicof83

Sorry to hear about your mother.

 

I did a very quick search and it would seem that the cause of Corticobasal Degeneration is Alpha-Synuclein and Tau etc.

This is the same as with PD and the other neurodegenerative diseases and means that Nilotinib may well be useful for treating it.

https://www.ncbi.nlm...les/PMC4230508/

http://library.med.u.../CNS/CNSDG.html

http://brain.oxfordj...21/brain.aww230

Edited by Logic, 13 November 2016 - 12:33 AM.

[Logic]

I forgot to post Round 3's (redacted) lab report:

https://drive.google...iew?usp=sharing

Anyone who took part in these group buys is welcome to request the original report.

[Bryan03]

Has anyone seen positive, or negative, results from taking N so far?

[Logic]

Has anyone seen positive, or negative, results from taking N so far?

 

http://www.longecity...nib-rd-results/

See the PDF in my last post.
I wish I could find a link to participate in that survey!?

[Library]

My email message got returned --
The 4 boxes at upper right on the website open to more however, the little envelope shivers but doesn't open.

I'd like to buy 60 gm of N.

Library

[Library]

I'd like to buy 60 gm.

---Library

[Logic]

Group buy Round 4:
The following people have shown interest or committed to the buy:

 

Name               Amount (grams)

splib                 300 grams
geo12the         ??                 (2nd time buying)
Bryan03           ??
Library             60
Levanah10       50
jack romaine    50 
knasse             30               (2nd time buying)
khalidnt            15?
Total                505+ grams

 

We are over the 500 gram minimum, so Its time to start collecting funds.

 

For those that have not yet:

Required info via to participate.  Via PM:

• I will require the amount you want and your address to work out postage and PayPal fees.
• Your Email Address as an alternate means of communication is also a good idea.
• I will then send you a costing and payment details.
• Once all the funds are collected; payment is made and the parcel shipped to the lab for testing.
• The parcel is split up by the lab and posted to your address via USPS.

I should have the time to start sending PMs this evening.

[Library]

Have I missed my PM?

Can't find it

Library

[Logic]

Have I missed my PM?

Can't find it

Library

 

 

I have sent you a PM Library.

[Logic]

Group Buy round 4:

 

The following people have received costings for round 4 and some have already paid.  thx.
I hope I have not omitted anybody?

 

splib               300 grams
Bryan03           30
Library             60
jack romaine    50

knasse             30 (2nd time buying)

khalidnt            15
Nicof83             30
MarcB             100 (2nd time buying)
togl                   50
rikelme             10

 

Total               675 grams

 

If anyone else wants to join the group buy now's the time!

If anyone has friends on the various PD forums; do let them know.  I am not been made to feel welcome on there.

 

​I will be in Johannesburg on business until Monday or Tuesday and will reply to any latecomers then.
I hope to get the order finalised and paid for by next weekend so that the parcel can be shipped on Monday the 12th of Dec.

[centralFloridaMan]

I have decided to wait for more evidence of effectiveness of nilotinib before use so I have 80 grams I will sell at cost($10 per gram).  Please email me at ed@tuttle.cc or pm me if interested.  CentralFlMan

[45rpm]

Here's a novel, new therapy that dissolved brain plaques in mice with Alzheimers Disease.

 

Light therapy.

 

The researchers used LED lights that flashed at a certain frequency.

 

https://www.thesun.c...-in-its-tracks/

 

http://www.latimes.c...1206-story.html

Edited by 45rpm, 07 December 2016 - 08:39 PM.

[mikey]

Group Buy round 4:

 

The following people have received costings for round 4 and some have already paid.  thx.
I hope I have not omitted anybody?

 

splib               300 grams
Bryan03           30
Library             60
jack romaine    50

knasse             30 (2nd time buying)

khalidnt            15
Nicof83             30
MarcB             100 (2nd time buying)
togl                   50
rikelme             10

 

Total               675 grams

 

If anyone else wants to join the group buy now's the time!

If anyone has friends on the various PD forums; do let them know.  I am not been made to feel welcome on there.

 

​I will be in Johannesburg on business until Monday or Tuesday and will reply to any latecomers then.
I hope to get the order finalised and paid for by next weekend so that the parcel can be shipped on Monday the 12th of Dec.

 

I'll take 25 grams.

[45rpm]

Logic,

 

If it's not too late, could I also order 25 grams of N.

[Logic]

I have decided to wait for more evidence of effectiveness of nilotinib before use so I have 80 grams I will sell at cost($10 per gram).  Please email me at ed@tuttle.cc or pm me if interested.  CentralFlMan

 

There are a good # of informal reports scattered throughout this thread, for those who care to look, CentralFloridaMan.
I have summarized them here:
https://docs.google....dit?usp=sharing

 

Here are the 3, yes 3, anonymous reports I could find in all the Emails and PMs sent to me.  (I feel there were more that I somehow missed while going through some 200 documents):
https://docs.google....dit?usp=sharing

 

The reason for this is that Novartis holds a patent for Tasigna/Nilotinib. (Tasigna and Nilotinib are 2 names for the same thing, just in case there is any more confusion on this point)
This is why I had to 'jump through hoops of fire' to get the supplier to sell the stuff to me and the the reason for the disclaimer saying its for research & development purposes only.
ie: The supplier and the lab have serious and valid IP/legal concerns, as do many, and the only legal way to sell Nilotinib to people is for research and development.
This makes many reluctant to acknowledge owning and doing research with Nilotinib...!

 

Some more results and discussion can also be found in the Nilotinib R&D Results thread here:

http://www.longecity...nib-rd-results/

 

There are plans afoot to send everyone who bought Nilotinib a questionnaire or a link to a secure survey.
I/we will post more on this when we have 'all our ducks in a row'

[Logic]

Mikey

45rpm

 

I will send you costings tomorrow.
PM me your name and postal address and confirm the amount in grams of N you would like.

Optional info: Your Email address as an alternate means of communication and a phone # for USPS should you be away when they deliver.

 

I will close this buy and transfer the funds on Monday morning South Africa time, so if anyone else is interested...

[richard hnry]

  This video has an extremely interesting treatment for PD.  It uses 3 hormones and will be available in 3rd quarter of 2017.  It is a real eye opener and looks really good. It looks a lot better than Nilotnib.

Edited by richard hnry, 10 December 2016 - 02:07 AM.

[Ark]

http://m.liveleak.co...=904_1481310526

[Rawin]

I would also like to be included in any results of N use.

[Logic]

Group Buy round 4:

The following people have paid for round 4.
I am placing the order and paying the supplier now.  

ie: No more round 4 orders can be accepted.
A big thank you to everyone who ...'overpaid'. The extra funds are most welcome and being put aside for a new notebook = my online sanity!   Thx!

 

Name             Amount in grams
splib               300                                   
Bryan03           30                                   
Library             60 
jack romaine    50
knasse             30 (2nd buy)
khalidnt            15
Nicof83            30
MarcB            100 (2nd buy)   
togl                   50
rikelme             10 (2nd buy)
mlsirkis             50 (2nd buy)

45rpm               25 (2nd buy)

Mikey                25

Total         775 grams

 

I note that some people are buying both Nilotinib and Dasatinib.

http://www.longecity...om-nyles/page-3

​Most likely for R&D into its senescent cell and old malfunctioning mitochondria killing abilities, as well as its anti fibrotic properties.  In short: Anti aging properties.
I have not, as yet, looked for, or come across any literature on the concomitant use of Nilotinib, Dasatinib and Quercetin , CLA etc.

While the effect is quite likely to be additive and quite possibly synergistic, the side effects may well be too..!?

If anyone has found any literature or has any experience in this regard; plz post.

 

NB that Nilotinib can increase the QT Interval of the heart and can lead to heart failure in people with heart arrhythmias or similar heart issues.

Anyone with any hint of irregular heart rhythms (arrhythmias)/QT interval issues etc needs to be very-very wary of Nilotinib!
The testing of QT Interval and Potassium and Magnesium levels is obligatory in Nilotinib package inserts IIRC. I highly recommend doing so.
Too high levels of Potassium and/or Magnesium is as bad as too low..?

http://www.longecity...ndpost&p=771687

http://www.mayoclini...es/con-20025388

https://en.wikipedia...iki/QT_interval
 

Disclaimer:
I am not a doctor, nor do I claim to have any formal medical background.
I am not liable, either expressly or in an implied manner, nor claim any responsibility for any physical or emotional problems that may occur directly or indirectly from the use of any supplement or medication, or advice.
Products currently covered by valid patents are offered for R&D use in accordance with (i) 35 USC 271(e)+A13(1) in the U.S.; (ii) Section 69.1 of Japanese Patent Law in Japan; (iii) Section 11, No. 2 of the German Patent Act of 1981 in Germany; (iv) Section 60, Paragraph 5b of the U.K. Patents Act of 1977 in the U.K.; (v) Section 68B of the Patents Act of 1953 in New Zealand; (vi) such related legislation and/or case law as may be or become applicable in the aforementioned countries; and (vii) such similar laws and rules as may apply in various other countries. In the European Union, equivalent exemptions are allowed under the terms of EC Directives 2001/82/EC (as amended by Directive 2004/28/EC) and 2001/83/EC (as amended by Directives 2002/98/EC, 2003/63/EC, 2004/24/EC and 2004/27/EC). Any patent infringement issue and resulting liability is solely at buyer's risk.

Please read the warnings and contraindications etc carefully before beginning any research with Nilotinib or any other concomitant medication or supplement:
https://www.pharma.u...pdf/tasigna.pdf
http://www.fda.gov/S...n/ucm218929.htm

 

Edited by Logic, 12 December 2016 - 02:40 PM.

[mikey]

Logic said:

 

NB that Nilotinib can increase the QT Interval of the heart and can lead to heart failure in people with heart arrhythmias or similar heart issues.

Anyone with any hint of irregular heart rhythms (arrhythmias)/QT interval issues etc needs to be very-very wary of Nilotinib!
The testing of QT Interval and Potassium and Magnesium levels is obligatory in Nilotinib package inserts IIRC. I highly recommend doing so.
Too high levels of Potassium and/or Magnesium is as bad as too low..?

http://www.longecity...ndpost&p=771687

http://www.mayoclini...es/con-20025388

https://en.wikipedia...iki/QT_interval
 

I used to experience significant arrhythmias.

 

However, since I've been taking 3,000 mg of EPA/DHA (from fish oil) a day I almost never have them.

 

However, from what you're saying, Logic, it seems prudent to avoid Nilotinib.

 

I've already paid for it, though.

 

What can be done, Logic?

 

 

[Logic]

My apologies for disappearing for a few days:
I ended up in Cape Town visiting family and bought a 3G dongle that refused to work wit my version of windows.  Its taken 3 days and another 3G dongle to get back online!

The order is placed and with the courier to the lab.

 

[Logic]

 

Logic said:

 

NB that Nilotinib can increase the QT Interval of the heart and can lead to heart failure in people with heart arrhythmias or similar heart issues.

Anyone with any hint of irregular heart rhythms (arrhythmias)/QT interval issues etc needs to be very-very wary of Nilotinib!
The testing of QT Interval and Potassium and Magnesium levels is obligatory in Nilotinib package inserts IIRC. I highly recommend doing so.
Too high levels of Potassium and/or Magnesium is as bad as too low..?

http://www.longecity...ndpost&p=771687

http://www.mayoclini...es/con-20025388

https://en.wikipedia...iki/QT_interval
 

I used to experience significant arrhythmias.

 

However, since I've been taking 3,000 mg of EPA/DHA (from fish oil) a day I almost never have them.

 

However, from what you're saying, Logic, it seems prudent to avoid Nilotinib.

 

I've already paid for it, though.

 

What can be done, Logic?

 

 

 

 

Hmmm...  I should have posted sooner Mikey,
I did mention researching N..!

The order is placed and on its way to the lab.
Perhaps a latecomer is interested in taking over your order?

Short of a doctor friend who can do the above checks and at whom you can take a dose; I wouldn't risk it.
The above effect may also only occur after daily use for a time, rather than a one off dose..???  Research reqd!  
I noted earlier in the thread that BHT upregulated CYP3A4 and may be a way to lower N levels, but wouldn't coun

[Library]

Some suggestions from a lay-person
for preparing to take Nilotinib:

1. HEART

An EKG for arrhythmia is low tech, available at most little clinics.

Better:

From a Cardiologist, you can get more demanding tests:

1. "halter monitor" -- you wear it for 24 hr and on return, they analyze the recorded data for abnormalities.
2. Ultrasound/treadmill -- they run up your heart rate to see if you get arrhythmias under load and also video your valves in action for defects in functioning.

2. DRUG INTERACTIONS

•If you take any prescription drugs, go online and find the CYP 450 liver enzymes that metabolize them. Look at the list for 3A4 -- inhibitors and substrates all have to be discontinued--first. Notice that caffeine, cannabinol, grapefruit juice and theophylline (black tea and green tea) are also on the "no" list.

Don't take any N until you haven't taken anything metabolized by 3A4 for at least 2 weeks.

3. DOSAGE

•Its always a good idea to start low with any dosage since most side effects and adverse events are dose-dependent.

So if the target dose is 150 mg., one could start at 10 to 30 mg.; stay there for 2 weeks or more, and if uneventful, move up to 20 to 60 for another two weeks, and so on.

Even for a person beginning with 150mg., it is not realistic to expect improvements in 6 only weeks on a lifetime of accumulation (age 30-60=30 years!). Consider the dieter who thinks they can lose 20 lbs in a weekend. Biological processes can't be driven 100x faster in the opposite direction.

4. SUPERVISION

An Oncologist/Hematologist would be familiar with Nilotinib for Leukemia, but probably not neurodegeneration, so it's worth a try, but most people will be doing their own supervision.

See the Novartis website, other posts, for appropriate blood tests.

In addition, you need to keep a daily log of (at least) dosage, timing, activity level, mood, and symptoms to alert you to subtle patterns and changes that you could not possibly be aware of otherwise.

5. EMERGENCY

Keep your cellphone on you. Day and night. Always.

If at any time you feel odd, dizzy, a fluttering feeling in your chest, arm or chest pain--lie down on the ground wherever you are --breathe deep --and follow your pulse for consistent rhythm.

Call the paramedic rescue number (911 (US)) if there is the slightest doubt that you are perfect. Don't think twice about a false alarm. Nobody cares.

---- I am looking forward to any good advice from you ! ---

Library

[splib]

Has anyone heard of any interaction with rasagiline and N? I did notice that in the original Georgetown trial rasagiline was allowed, but the latest one (https://clinicaltria...how/NCT02954978) says " No mono-amine oxidase (MAO)-B inhibitors (Selegeline or rasagiline) are allowed at least 6 weeks before enrollment".

 

- splib

 

 

 

[splib]

Thanks Library for mentioning about cannabinol, I was getting ready to give that a try again at a higher dose this time.

 

What about nicotine?

 

- splib