3 replies to this topic

[brosci]

I recently started supplementing NR+Fisetin, usually before I exercise in the morning before breakfast @ 500mg NR + 100mg fisetin.  Looking at my post-prandial glucose levels, I've been seeing lower and lower values each day.  I'm curious if this might be related to these supplements and whether this is potential beneficial / potentially harmful / benign.

 

In the past, my glucose was usually up around 90-100 mg/dL at the 30m mark (occasionally as high as 120 mg/dL.)  I usually peak around the 45m mark (occasionally as high as 140 mg/dL or a bit above that, often in the 120-130's), then I'm back down in the 90-120 mg/dL range by the 60m mark.

 

After eating a banana, an orange, a half a plantain with ripe blueberries and coconut water, and a large bowl of rice (~150g of net carbohydrates) with some nuts, today I'm looking at a 45m postprandial glucose reading of 69 mg/dL.  Yesterday, it read 71 mg/dL at the 45m mark, and remained under 100 mg/dL.  Checking every 15m and looking around for a spike, it's difficult to find one, while in the past it was very obvious and easy.  I've also been consuming a bit more stevia and sugar alcohols.

Edited by brosci, 26 December 2015 - 09:15 PM.

[Bryan_S]

The NR should over time increase your insulin sensitivity and assist your body's ability to keep your glucose in check. Fisetin on the other hand is an unknown to me but its been suggested in mice with Alzheimer’s symptoms where pathways involved in cellular inflammation were activated. In those that had eaten fisetin, the pathways were dampened and anti-inflammatory molecules were produced improving memory. There have been no clinical trials on Fisetin yet to illustrate this in humans. If this is what you were seeking i.e. the anti-inflammatory effects, and reduced glucose then I would expect the Nicotinamide Riboside would be the more powerful of the 2 with far more study evidence illustrating these benefits.

 

Happy holidays

Edited by Bryan_S, 26 December 2015 - 10:29 PM.

[stefan_001]

Quick google search shows fisetin is an interesting compound:

Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice
http://onlinelibrary...acel.12185/full

Attenuates Sirt1 but on the downside appears to inhibit Sirt3:
http://www.ncbi.nlm....les/PMC3504108/

Reduces expression of RAGE:
- http://www.ncbi.nlm....pubmed/21738623

Worth to read a bit more about Fisetin, perhaps the Sirt3 inhibition can be compensated with for example magnolia extract.

Edited by stefan_001, 28 December 2015 - 10:52 PM.

[stefan_001]

bought some Fisetin, let's do I notice something. I am going to try it for its alleged lowering effect on glycation. BTW an error in my above text. It activates sirt1, not attenuates...

Edited by stefan_001, 12 January 2016 - 09:05 PM.