6 replies to this topic

[lysergic]

hey longecity

i'm wondering if someone can help me understand why i'll experience such a dramatic response and improvement in cognition and mood when dosing NSAID's

ibuprofen is by far the most noticeable, along with aspirin, naproxen and paracetamol having an equal effect as each other

this isn't placebo, as it's something which has repeated for the last few years whenever dosing

the feeling after taking one like ibuprofen is almost a kind of 'weight' or 'toxicity' being lost and melting away slowly

there's an increase in how i'm able to articulate myself in spoken and written language, along with a feeling that my mood is more 'stable' and 'insulated' against stress or setback

[nowayout]

Paracetamol is not an NSAID, though there has been studies on its beneficial effect on some mild mood disorders.

Edited by nowayout, 06 February 2016 - 03:15 PM.

[Dichotohmy]

Paracetamol is not an NSAID, though there has been studies on its beneficial effect on some mild mood disorders.

There's evidence paracetamol is in fact a cox-3 inhibitor that readily crosses the BBB. So paracetamol is anti-inflammatory and its ability to reach the brain most likely explains the benefit in mood disorders.

https://www.rndsyste...inally-revealed

I also benefit significantly in brain function and mood from ibuprofen. My pet explanation is that neuroinflammation disrupts communication between subregions in the limbic areas and beyond. Thus, the restoration of more normal neural functioning is the reason ibuprofen helps; thus looking for a neurotransmitter explanation is seeking a red herring. The effect for me diminishes in time, which makes me believe a psychological feeling of "relief" is also at play to amplify the positive effect.

http://www.longecity...an-opiate-high/

Edited by Dichotohmy, 10 February 2016 - 10:20 PM.

[lysergic]

hey, thank you for the detailed reply

after reading your post in the link, i can relate heavily to what's written, especially in regards to the depersonalization

currently i'm finding benefit from using methylphenidate, memantine and phenibut over the last year, to the point of maybe something like 85% of my symptoms, all while maintaining a healthy diet and sleep cycle, then bloodworks for liver and kidney function

i have also had no response to things like curcumin and DHA/EPA, but do find coQ10 helpful

in my own case, i'm leaning towards chronic fatigue syndrome being the diagnosis, as the symptoms and profile of response to substances fits no other disorder so well

edit:

i'll also notice a worsening in my symptoms after exercise, which d-ribose helps to alleviate if taken at 5000mg, three times a day, allowing the substance to build up over a course of two weeks

there's also a noticeable improvement in cognition from taking it

check out chronic fatigue and GABA/glutamate as a possible explanation for some of your own symptoms

Edited by lysergic, 11 February 2016 - 09:38 AM.

[EyeKicker]

I strongly reccomend encapsulated Celery Seed! This is a miracle antiinflamatory, with many other benefits! It doesn't deplete prostaglandins (the main problem with NSAIDs and causing ulcers) but actually balances this system. It is a cooling herb instead of warming like many herbs with similar effects. This stuff is amazing, I was praying to Christ to help me find a replacement for turmeric & Ginger (too warming for my liver & eczema issues) and He lead me to this awesome gift! It is also very good for acne ( I have almost no acne now), decreases brain inflammation!!! And acts as a fat soluble antioxidant, decreases Amelia's beta plaques, lowers blood pressure and more! Praise the risen son! Let me know what you guys think!

[EyeKicker]

And yes, it makes you feel great! I take it many times a day ( in grounded form of course) and it's so cheap, you can find it at most health food stores!! I usually take it with meat or foods that are very sugary or just cause stomac discomfort and it works like a charm, such a Godsend and almost none knows about it! It also increases insulin sensitivity

[mbdrinker]

Indometacin indeed improved mood for me, not ibuprophen, not diclophenac but I quitted it as nsaids damage hearing.