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Chronic Bacterial and Viral Infections in Neurodegenerative and Neurobehavioral Diseases

infection neurodegenerative neurobehavioral diseases

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#1 Logic

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Posted 24 February 2016 - 06:57 PM


This 'study' lists the pathogens associated with all the various neurodegenerative or neurobehavioral diseases and is an easy read.


Chronic Bacterial and Viral Infections in Neurodegenerative and Neurobehavioral Diseases

Often, patients with neurodegenerative or neurobehavioral diseases have chronic, neuropathic infections that could be important in disease inception, disease progression, or increasing the types or severities of signs and symptoms. Although controversial, the majority of patients with various neurodegenerative or neurobehavioral conditions, such as amyotrophic lateral sclerosis, multiple sclerosis, Alzheimer's disease, Parkinson's disease, and autistic spectrum disorders, show evidence of central nervous system or systemic bacterial and viral infections.

http://www.medscape....rticle/574944_1

 


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#2 medievil

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Posted 25 February 2016 - 12:12 AM

Im aware that bacterial, viral or parasetic infections play a big role in mental issues.

 

Anyone up for a monster antibiotic, antiviral and antiparasetic cocktail? i would be as some pathogens may not be indentified, and you can combine antivirals with antibiotics tc as long one doesnt stress the liver or whatever you know the drill.

 

Just takes time looking into what you want to target and put a regime togheter to attack all possible causes.


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#3 Logic

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Posted 25 February 2016 - 12:08 PM

Im aware that bacterial, viral or parasetic infections play a big role in mental issues.

 

Anyone up for a monster antibiotic, antiviral and antiparasetic cocktail? i would be as some pathogens may not be indentified, and you can combine antivirals with antibiotics tc as long one doesnt stress the liver or whatever you know the drill.

 

Just takes time looking into what you want to target and put a regime togheter to attack all possible causes.

 

I'm already on VCO = Lauric acid/Monolaurin & co.  That covers the antiviral and antibiotic side pretty well for something with 'no' side effects. ;)

 

BHT
Bavituximab: in phase II or III trials atm and can probably be group bought.

DRACO

Teixobactin https://en.wikipedia...ki/Rintatolimod

 

http://www.longecity...ytomegalovirus/


 



#4 medievil

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Posted 25 February 2016 - 05:30 PM

Theres only one med that works for toxiplasmosis, implicated in shizophrenia, as an alternative nutmeg essential oil is effective in rodents.

 

Just saying you can never make a cocktail that covers overything, except for bacteria, with broad spectrum antibiotics and powerfull anti parasetic agents leaving you unable to attack virusses in the same army approuch, and its perhaps virusses that are mostly implicated.

 

In autism theres evidence of the immume system still fighting certain vaccinations they had injected as kid.


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#5 Logic

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Posted 26 February 2016 - 12:12 AM

Theres only one med that works for toxiplasmosis, implicated in shizophrenia, as an alternative nutmeg essential oil is effective in rodents.

 

Just saying you can never make a cocktail that covers overything, except for bacteria, with broad spectrum antibiotics and powerfull anti parasetic agents leaving you unable to attack virusses in the same army approuch, and its perhaps virusses that are mostly implicated.

 

In autism theres evidence of the immume system still fighting certain vaccinations they had injected as kid.

 

 

Yep;  selectively killing everything you dont want while leaving what you do want unaffected would be very difficult.

I like bacteriophages for selectively killing off unwanted bacteria, but don't know that they would survive in the gut to do the required job there.
Do look into the things I mentioned though.   Bavituximab and DRACO  are very interesting and powerful antivirals.



#6 medievil

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Posted 26 February 2016 - 12:46 AM

If we had acces to led lights to cover the whole body we could take methylene blue or another dye with a photosentisiser to selectively kill pathogens including most virusses, im not sure wheter it works against parasites.



#7 gamesguru

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Posted 26 February 2016 - 01:02 AM

inb4 schizophrenia toxoplasmosis

Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review

HSV-1 levels in the cortex, cerebellum and ventricles of apoE3 transgenic mice were undetectable, while apoE4 transgenic mice showed significantly higher levels of HSV-1 in these brain regions.

 

Apolipoprotein E is a polymorphic and multifunctional protein with numerous roles in lipoprotein metabolism. The three common isoforms apoE2, apoE3 and apoE4 show isoform-specific functional properties including different susceptibilities to diseases. ApoE4 is an accepted risk factor for Alzheimer's disease and cardiovascular disorders. Recently, associations between apoE4 and infectious diseases have been demonstrated. This review summarises how apoE4 may be involved in the infection incidence and associated pathologies of specific infectious diseases, namely hepatitis C, human immunodeficiency virus disease and herpes simplex.

ApoE4 seems to be protective against chronic hepatitis C virus infection and retards fibrosis progression. In contrast apoE4 enhances the fusion rate of human immunodeficiency virus with target cell membranes, resulting in accelerated cell entry and faster disease progression. Its association with human immunodeficiency virus-associated dementia remains controversial. Regarding herpes simplex virus infection, apoE4 intensifies virus latency and is associated with increased oxidative damage of the central nervous system, and there is some evidence that herpes simplex virus infection in combination with the apoE4 genotype may be associated with an increased risk of Alzheimer's disease. In addition to reviewing available data from human trials, evidence derived from a variety of cell culture and animal models are considered in this review in order to provide mechanistic insights into observed association between apoE4 genotype and viral disease infection and pathology.


Edited by gamesguru, 26 February 2016 - 01:04 AM.


#8 Logic

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Posted 26 February 2016 - 09:32 AM

 

inb4 schizophrenia toxoplasmosis

Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review

HSV-1 levels in the cortex, cerebellum and ventricles of apoE3 transgenic mice were undetectable, while apoE4 transgenic mice showed significantly higher levels of HSV-1 in these brain regions.

 

Apolipoprotein E is a polymorphic and multifunctional protein with numerous roles in lipoprotein metabolism. The three common isoforms apoE2, apoE3 and apoE4 show isoform-specific functional properties including different susceptibilities to diseases. ApoE4 is an accepted risk factor for Alzheimer's disease and cardiovascular disorders. Recently, associations between apoE4 and infectious diseases have been demonstrated. This review summarises how apoE4 may be involved in the infection incidence and associated pathologies of specific infectious diseases, namely hepatitis C, human immunodeficiency virus disease and herpes simplex.

ApoE4 seems to be protective against chronic hepatitis C virus infection and retards fibrosis progression. In contrast apoE4 enhances the fusion rate of human immunodeficiency virus with target cell membranes, resulting in accelerated cell entry and faster disease progression. Its association with human immunodeficiency virus-associated dementia remains controversial. Regarding herpes simplex virus infection, apoE4 intensifies virus latency and is associated with increased oxidative damage of the central nervous system, and there is some evidence that herpes simplex virus infection in combination with the apoE4 genotype may be associated with an increased risk of Alzheimer's disease. In addition to reviewing available data from human trials, evidence derived from a variety of cell culture and animal models are considered in this review in order to provide mechanistic insights into observed association between apoE4 genotype and viral disease infection and pathology.

 

 

 

"...A somewhat wider range and higher levels of activity of fatty acids and monoglycerides have been found against herpes simplex virus type 1 (HSV-1), against which, in addition to monocaprin and lauric acid, palmitoleic acid and, to some extent, oleic acid cause a rapid inactivation of the virus (10)..."
http://www.ncbi.nlm....cles/PMC105821/
 

Coconut Oil:
Type of fatty acid                    pct
Caprylic saturated C8                9%
Decanoic saturated C10           10%
Lauric saturated C12                52%
Myristic saturated C14              19%
Palmitic saturated C16              11%
Oleic monounsaturated C18:1    8%
Other/Unknown                         5.3%

 

https://en.wikipedia...iki/Coconut_oil

VCO has the same lipid layer disrupting effect on a wide variety of Virii that use a lipid bilayer to disguise themselves as a nutrient to the immune system, like:
CMV (the Immune sys killer)
EBV
HIV

etc

 

You guys need to visit the supplements sub-forum more!  Its not all about un-trippy vitamin crap!   :)

"healthy body; healthy mind" and all that...


Edited by Logic, 26 February 2016 - 09:34 AM.

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#9 medievil

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Posted 26 February 2016 - 09:42 AM

i entirely agree with that, for example the gut is implicated in a ton of mental disorders and so forth.


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#10 gamesguru

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Posted 26 February 2016 - 09:45 AM

[coconut oil] has the same lipid layer disrupting effect on a wide variety of Virii that use a lipid bilayer to disguise themselves as a nutrient to the immune system, like:
CMV (the Immune sys killer)
EBV
HIV

 

not effective against HPV.

wonders if adding green tea or lemon juice or ginger or something might render it inert too.



#11 Logic

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Posted 26 February 2016 - 10:29 AM

 

[coconut oil] has the same lipid layer disrupting effect on a wide variety of Virii that use a lipid bilayer to disguise themselves as a nutrient to the immune system, like:
CMV (the Immune sys killer)
EBV
HIV

 

not effective against HPV.

wonders if adding green tea or lemon juice or ginger or something might render it inert too.

 

 

Ye HPV isn't lipid coated IIRC.

GoogleSiteSearch for kills HPV:  (in the search dropdown menu - top right)
https://cse.google.c...gsc.q=kills HPV

Now do that for  :

  • BHT
  • Bavituximab
  • DRACO

FFS! :)
Sometimes I wonder about  all those noots etc...
:)
 



#12 gamesguru

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Posted 26 February 2016 - 12:07 PM

good luck convincing your gf that BHT is safe to plug



#13 Logic

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Posted 26 February 2016 - 12:34 PM

good luck convincing your gf that BHT is safe to plug

 

???

BHT=Butylated Hydroxytoluene

gf?



#14 Omega 3 Snake Oil

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Posted 26 February 2016 - 03:09 PM

I've got chronic Lyme disease. Just started antibiotics a couple weeks ago.. also taking herbal tinctures pinella, banderol, samento all by Nutramedix. Seems to have helped somewhat.

Also used bee venom therapy for a few months, was seeing some results but I think I burnt out my adrenals or HPA axis and haven't felt right since. Bee venom is worth looking into for any chronic infection...



#15 gamesguru

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Posted 26 February 2016 - 03:15 PM

try goldenseal, for berberine.

Final report on the safety assessment of BHT(1).
Various mechanism studies suggested that BHT toxicity is related to an electrophillic metabolite. In a predictive clinical test, 100% BHT was a mild irritant and a moderate sensitizer. In provocative skin tests, BHT (in the 1% to 2% concentration range) produced positive reactions in a small number of patients. Clinical testing did not find any depigmentation associated with dermal exposure to BHT, although a few case reports of depigmentation were found. The Cosmetic Ingredient Review Expert Panel recognized that oral exposure to BHT was associated with toxic effects in some studies


Edited by gamesguru, 26 February 2016 - 03:17 PM.


#16 Sleepdealer

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Posted 26 February 2016 - 05:28 PM

I've seen this subject here and there recently. I saw a read on toxoplasmosis and how a latent infection can still affect your personality. It's scary how fragile and susceptible we are to parasites and foreign bodies.

 

 

Yep;  selectively killing everything you dont want while leaving what you do want unaffected would be very difficult.
I like bacteriophages for selectively killing off unwanted bacteria, but don't know that they would survive in the gut to do the required job there.

 

For the gut, fecal bacteriotherapy would be effective. It's under research now and is showing a lot of promise for various diseases, including Parkinsons disease. It can be transferred through freeze dried capsules, enemas and such.


Edited by Sleepdealer, 26 February 2016 - 05:30 PM.


#17 medievil

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Posted 26 February 2016 - 06:08 PM

Can bacteria, virusses and parasites run on ketones? if not then a ketogenetic diet is a option, just wondering as cancer cells cant run on ketones, but then again that are just cells...


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#18 Sleepdealer

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Posted 26 February 2016 - 07:14 PM

My guess would be that since viruses can't reproduce without a cell host, they would live off of what the cell has to offer when it is infested, which would be either glucose or ketone bodies. For bacteria and parasites I couldn't say.


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#19 gamesguru

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Posted 26 February 2016 - 09:03 PM

yeah dude.  no sugar might cause stress, which often activates viruses.



#20 normalizing

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Posted 27 February 2016 - 08:23 PM

Can bacteria, virusses and parasites run on ketones? if not then a ketogenetic diet is a option, just wondering as cancer cells cant run on ketones, but then again that are just cells...

cancer cells adapt to ketones, but i couldnt find the study ive seen in the past,  instead google led me to this summary; http://mybraincancer...use-ketone.html


Edited by normalizing, 27 February 2016 - 08:24 PM.


#21 gamesguru

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Posted 28 February 2016 - 02:53 AM

Antiviral and virucidal activities of natural products.
Natural products, in particular ingredients of foods and drinks we normally consume or metabolites present in human body at low concentrations, would have advantage over synthetic drugs as antiviral agents for safety concerns. For this reason, we have been studying natural products for their effects on virus inactivation and growth. Such natural products, which we have been focusing, include gallate derivatives, caffeine present in coffee, caffeic acid present in coffee and various fruits, ascorbic and dehydroascorbic acids and a cell metabolite, arginine.

Antiviral agents from plants and herbs: a systematic review.
Many antiviral compounds presently in clinical use have a narrow spectrum of activity, limited therapeutic usefulness and variable toxicity. There is also an emerging problem of resistant viral strains.

Many hundreds of herbal preparations with antiviral activity were identified and the results of one search presented as an example. Yet extracts from only 11 species met the inclusion criteria of this review and have been tested in clinical trials. They have been used in a total of 33 randomized, and a further eight nonrandomized, clinical trials. Fourteen of these trials described the use of Phyllanthus spp. for treatment of hepatitis B, seven reporting positive and seven reporting negative results. The other 10 herbal medicines had each been tested in between one and nine clinical trials. Only four of these 26 trials reported no benefit from the herbal product.

Potential application of marine algae as antiviral agents in medicinal foods.
Recently, a great deal of interest has been expressed regarding marine algae as potential antiviral agents. This contribution focuses on antiherpes virus therapeutic agents derived from marine algae which are considered as novel functional ingredients in antiherpes virus therapy.

An evaluation of the antioxidant and antiviral action of extracts of rosemary and Provençal herbs.
the spice cocktail inhibited human immunodeficiency virus (HIV) infection at very low concentrations which were also cytotoxic

New functionally-enhanced soy proteins as food ingredients with anti-viral activity.
Soy flavonoids, including isoflavones, have demonstrated anti-viral effects in vitro and in vivo. Recently, it was demonstrated that edible proteins can efficiently sorb and concentrate cranberry polyphenols, including anthocyanins and proanthocyanins, providing greatly stabilized matrices suitable for food products. The combination of cranberry and soy phytoactives may be an effective dietary anti-viral resource. Anti-viral properties of both cranberry juice-enriched and cranberry pomace polyphenol-enriched soy protein isolate (CB-SPI and CBP-SPI) were tested against influenza viruses (H7N1, H5N3, H3N2), Newcastle disease virus and Sendai virus

 

 

Glial Cell Responses to Herpesvirus Infections: Role in Defense and Immunopathogenesis
Glial cells can respond to herpesvirus infections through the production of cytokines and chemokines. Although specific interactions between resident glia and lymphocytes that infiltrate the infected brain remain to be defined, the presence of T cell chemotactic signals in microglial cell supernatants following infection with cytomegalovirus or herpes simplex virus has led to the concept that chemokines initiate a cascade of neuroimmune responses that result in defense of the brain against herpesviruses. While chemokines may play a defensive role by attracting T cells into the brain, aberrant accumulation of lymphocytes may also induce brain damage.

Herpes simplex virus induces neural oxidative damage via microglial cell Toll-like receptor-2
These studies demonstrate the importance of microglial cell TLR2 in inducing oxidative stress and neuronal damage in response to viral infection.

Role of Microglia in Central Nervous System Infections
New concepts that have emerged from these studies include the importance of cytokines and chemokines produced by activated microglia in neurodegenerative and neuroprotective processes and the elegant but astonishingly complex interactions between microglia, astrocytes, lymphocytes, and neurons that underlie these processes. It is proposed that an enhanced understanding of microglia will yield improved therapies of central nervous system infections, since such therapies are, by and large, sorely needed.

The Involvement of Microglial Cells in Japanese Encephalitis Infections

Microglia Play a Major Role in Direct Viral-Induced Demyelination


CCL2/Monocyte Chemoattractant Protein-1 Mediates Enhanced Transmigration of Human Immunodeficiency Virus (HIV)-Infected Leukocytes across the Blood–Brain Barrier: A Potential Mechanism of HIV–CNS Invasion and NeuroAIDS
These data suggest that CCL2, but not other chemokines, plays a key role in infiltration of HIV-infected leukocytes into the CNS


Edited by gamesguru, 28 February 2016 - 03:00 AM.

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#22 Logic

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Posted 28 February 2016 - 07:02 AM

 

try goldenseal, for berberine.

Final report on the safety assessment of BHT(1).
Various mechanism studies suggested that BHT toxicity is related to an electrophillic metabolite. In a predictive clinical test, 100% BHT was a mild irritant and a moderate sensitizer. In provocative skin tests, BHT (in the 1% to 2% concentration range) produced positive reactions in a small number of patients. Clinical testing did not find any depigmentation associated with dermal exposure to BHT, although a few case reports of depigmentation were found. The Cosmetic Ingredient Review Expert Panel recognized that oral exposure to BHT was associated with toxic effects in some studies

 

 

:)

There's a lot of controversy around BHT.

Its a man made antioxidant designed specifically to protect oils from going rancid and does a bloody good job of doing so. (NB the shit that rancid oil and internal lipid oxidation cause)

Then is was discovered that chickens, with BHT in their feed, weren't gett newcastle's disease IIRC.
This lead to a lot of research showing that BHT disrupted the lipid layer on lipid coated virii.
Then along came a study showing it caused cancer. (wonder who ...'sponsored' that..?!)
Said study used a HED of 30 grams a day for life IIRC to get the desired result..!

Rosmarinic Acid has replaced it in some products an has similar AV effects IIRC.

Recommended doses are between 250 and 1000 mg.
The higher doses have some side effects that can be ameliorated with vit K2 and Gelatine IIRC.

 

Some links to all this:
http://www.longecity...ndpost&p=598352
http://www.longecity...topic/4035-bht/
http://www.longecity...-of-taking-bht/

http://www.ncbi.nlm..../pubmed/8045471

http://www.longecity...rain-and/page-2

 

Anyway its mentioned as it may help clear some f the virii that cause 'Neurodegenerative and Neurobehavioral Diseases'
NB that VCO has the same effect.
I suspect the 2 may synergise in clearing a lot of unwanted virii.

NB that once the virii are inside a cell; neither can touch it...

You have to wait for the infected cell to pop and release its viral load and have either one or both of these in your system when the last infected cell pops  to completely clear an infection and that could be in 100 year's time..!?
IIRC an intravenous Liquorice extract shot activates all infected cells, causing them to pop.
 


Edited by Logic, 28 February 2016 - 07:06 AM.

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#23 Logic

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Posted 09 March 2016 - 03:55 PM

Dear 'Dangerous and irresponsible'  

 

Argue your point by posing your objections here. Come-on I dare you chicken shit! :)
You may be right.

I'm here to learn.  Are you?


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#24 medievil

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Posted 09 March 2016 - 05:37 PM

I also got a ill informed thing on my post, i wish ppl would elaborate more


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#25 Logic

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Posted 10 March 2016 - 01:19 AM

I also got a ill informed thing on my post, i wish ppl would elaborate more

 

Ye...

Sad really that some have decided that their knowledge is certain fact 

The may be correct but don't want to help you right..?

 

If its the "BHT is poison" thing it would be an interesting debate.

The tox studies I saw used huge, chronic doses to get negative effects.

One needs to entertain the possibility that there may be financial reasons to pay for such a study to keep your clients taking patented/profitable meds...
Just maybe its that good!?

Few are aware of the possible telomere 'cofactor' and Lipid/LDL antioxidant effects and all the positives that said effects have.

Or the mean life extension study.
 


Edited by Logic, 10 March 2016 - 01:31 AM.


#26 medievil

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Posted 10 March 2016 - 01:30 AM

Bht only works for certain viral infections either way, that said what is thest broad spectrum antiobiotic that are available to fight any possible bacterial infections? also parasite wise i only found 2 pretty toxic vet meds that could eliminate most parasites, but after analysing the risks its worth a try.

 

What would kill all bacterial and viral infections is methylene blue with a photosentiser and then exposing your body under certain lights like led light but i got no clue how youd do that.

 

Also probiotics are important, also the 42 essential minerals nor included in supplements.


Toxiplasmosis has recently been disproven to cause shizophrenia as an aside



#27 Sleepdealer

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Posted 11 March 2016 - 07:43 PM

 

Toxiplasmosis has recently been disproven to cause shizophrenia as an aside

 

It was? Where did you read that?



#28 birthdaysuit

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Posted 11 March 2016 - 11:22 PM

I’ve read some studies that acetic acid; not sure if diluted AC vinegar would work but the less diluted the better can break up biofilms and make the lyme bacterium more susceptible to various antibiotics. 

 


Edited by birthdaysuit, 11 March 2016 - 11:34 PM.


#29 playground

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Posted 12 March 2016 - 05:00 AM

There was a patent for the use of Ashitaba as a NGF promoter.

(note: there's no suggestion that Ashitaba _is_ an NGF promoter outside of that patent.

Companies post patents speculatively... or for marketing bullshit purposes)

 

The two ingredients in this patent were

1. Ashitaba and

2. Hops.

 

It appears that hops is very good at destroying biofilms and the hops in beer making

probably helped to keep the beer sterile.

 

you can freely purchase hops supplements, they're recommended to aid sleep

and reduce stress.  http://www.herbalrem...s.com/hops.html

 

 

 



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#30 playground

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Posted 12 March 2016 - 05:16 AM

 

Can bacteria, virusses and parasites run on ketones? if not then a ketogenetic diet is a option, just wondering as cancer cells cant run on ketones, but then again that are just cells...

cancer cells adapt to ketones, but i couldnt find the study ive seen in the past,  instead google led me to this summary; http://mybraincancer...use-ketone.html

 

 

Hi medievil,

 

Virtually all of the bacteria and viri that are pathogens to humans CAN NOT use ketones....

Processing ketones requires a whole new set of biochemical machinery.

 

Since pathogens generally proliferate, or die off, in proportion to their food supply

a ketogenic diet can rapidly suppress their numbers until their presence is low enough

for the immune system to cope with them in the usual ways.

 

You might also check out the literature on intermittent fasting.

 

There are pharma trolls, serving the interests of the pharma industry, 

that don't want you people to know this... they circulate contradictory results, lies

and misleading information.  It's done to erode your certainty.

 

Cancer cells feeding on ketones ?

It's almost certainly a load of bullshit.

It's there to sew confusion, it wont replicate.


Edited by playground, 12 March 2016 - 05:21 AM.






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