Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians
...It has long been known that chronic inflammation is associated with the ageing process in younger, more 'normal' populations, but it's only very recently we could mechanistically prove that inflammation actually causes accelerated ageing in mice...
This study, showing for the first time that inflammation levels predict successful ageing even in the extreme old, makes a strong case to assume that chronic inflammation drives human ageing too...
Telomere length does not predict successful ageing in the very and extreme old, but centenarians and their offspring maintain telomeres better than non-centenarians...
News article:
http://m.medicalxpre...-longevity.html
Study abstract:
http://www.ebiomedic...0081-5/abstract
What Causes Inflammation?
A Comprehensive Look At The Causes and Effects Of Inflammation
http://www.peertrain...flammation.aspx
Causes of chronic low level inflammation:
- Advanced Glycation Endproducts. (Catalysed by metal/heavy metal buildup)
- Chronic low level infections.
- Gut dysbiosis.
- Leaky gut with age.
- Fat Tissue
- Bad diet.
- ???
NB that almost all telomerase activators are NF-kB inhibitors...
And that thy have direct access/contact to the stem/progenitor cells of the gut.
The gut has one of the highest cell turnover rates in the body. ( = short telomeres..! )
