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quercetin micelle absorption bioavailability

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#91 TRUGAN

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Posted 22 June 2016 - 01:59 AM

 

 

You will get:

1 bottle (50ml) of the special liquid micelle quercetin, shipped to you within the USA.

 

In exchange, you promise:

1- That you are over 18 and will stay on at least a 1 month regimen and provide honest feedback and suggestions, during or after that month is up.

2- Try different dosages, but not go over my maximum suggested serving of 7 pumps (or squirts), and no more than that. 

3- Try it with food, hot/cold beverages or shakes, etc to see what you think makes it easy to take.

4- Take a "before picture" of your face and one afterwards to see if anything has changed after a month on the regimen. (Probably nothing, but I just wanted to cover this aspect)

5- That you are healthy and don't take meds or that your doc will approve of this before you take it.

 

Don't forget we have some work to do... I have to start over withe the pics... too much happened so far with getting sick and everything... But there's 185 1 squirt doses doses in this thing, right?

 

 

From Anthonys site:

 

 

Liquid Micelle Quercetin:
If you take exactly 1 serving a day, this product would last you over 260 days*. (However due to the limits of accuracy of the pump when squeezed, a full squeeze of the pump may provide between (0.166 ml and 0.26 ml at a time) and in actuality may last about 180 days or more. 

 

 

I have personally found the pumps to be very inaccurate so I notice the most I ever get from 3 pumps is a completely full 00 capsule but sometimes 3 pumps leaves a 1/4 of space left in the capsule so I just fill it full every time and count it as 3 pumps.



#92 shadowhawk

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Posted 22 June 2016 - 07:09 PM

I decided to also apply it topically to the few spots remaining.  I am going to have my wife write a short piece on what she saw.  Thanks YOLF for reminding us what this is about.  Reading niner's post several times I wonder if our age has anything to do with the results.  The longer you are alive the more impact.  ???


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#93 DeadMeat

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Posted 23 June 2016 - 03:00 PM

I believe solid lipid nanoparticles had always had a lower absorption. Heck, curcumin using solid lipid nanoparticles only had a modest 1.25 fold bioavailable increase, not even the 5 fold increase that quercetin had in your study: http://www.sciencedi...927776513004086

 

In that 1.25 study with curcumin, the type of solid lipid nanoparticles particles they used as a vehicle is different from the one used with quercetin. Also it's given intravenously. It's not surprising that there is little difference in bioavailability in the blood, when you inject everything straight into the blood.


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#94 YOLF

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Posted 24 June 2016 - 05:21 AM

Well, I put 6 squirts on my skin (face and other sensitive areas), and then took another 6 orally the next day. Skin results look great at ~24 hours. 

 

Now, I'm a former (teen/tween) smoker and any potent p53 activator seems to cause me lung problems (coughing and wheezing) that make me feel like I'm getting sick and can leave me open to lung infection if I'm not careful. I'm wondering if that's what lead to my last infection (it's rare that I get sick these days but it wasn't long after the last dose that I got sick) as I was basically better, then took this stuff and had some fairly significant die off of cells in my lungs leaving me open to reinfection. I think it may have even been within hours. I recovered w/in a few days last time. But I'm definitely happy with the improvement of appearance in my skin, will keep taking it and hope the results will continue and I'll regenerate my lungs in the process... even if I stick to lower doses. I took an immediately before pic and will take another after a few more days to post here if my results continue like this.

 

Oh, stained my pillow a tiny bit too, but nothing I can't live with... it's not like a curcumin/turmeric stain. Will wash tomorrow.


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#95 shadowhawk

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Posted 24 June 2016 - 10:27 PM

YOLF looks like you are trying it topically also.My wife is trying it as of this morning after watching me.  I got a bad sunburn on my face and I decided to try it after reading your post.  The toughest blemish spots seem to be responding as well.  I wonder if what is going on inside may be what should be the most dramatic as it kills damaged cells.

 


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#96 YOLF

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Posted 25 June 2016 - 10:07 PM

So my skin started peeling from the sunburn. It's peeling off in large contiguous pieces rather than patches as is usually the case... I could turn this stuff into writing material and autograph it, that's how contiguous it is. The peel was painless and virtually invisible... I wouldn't have known it was going to peel off... though underneath the peel it is somewhat sensitive yet. This to me would insist that the die off is more complete. Fewer if any damaged cells survived the burn to come back and cause skin cancer or aging skin someday. Perhaps it may have even taken some of the more aged and less resistant cells with it and will even result in some kind of hormetic gain?

 

Putting some CereVe Moisturizing Lotion on it to sooth the sensitivity under the skin. Have been using the CereVe Cleanser on it in the shower for the Hyaluronic Acids in it to keep the cells from shrinking to save themselves (these cells would lead to pathologies).

 

May put some topical IGF1 spray on the sensitive part and follow it with topical or oral MetaQ. IMO ECM and cellular turnover from growth factors should lead to a greater purge as stem cells will outcompete for resources and remodel things? Or the diffusion of cellular junk from the growth will decrease the cell attrition? Thoughts? Maybe I'll apply another round of senolytics to it topically to kill off any remaining weak/damaged cells and then do the IGF1?

 

Update, just took a shower, the cleanser seems to have made more of the skin separate. The skin looks shiny underneath and responds to squishing and pulling in ways that are somewhat younger and somewhat older... It looks like the skin is a little dehydrated in some areas or the cellular pattern is still compromised. I'm guessing another peel will occur, applying 2 squirts of MQ topically.

 

Attached File  sunburn and metaQ.jpg   71.51KB   2 downloads


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#97 TRUGAN

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Posted 27 June 2016 - 01:06 AM

Im up to 7 pumps a day with 2 pumps of meta curcumin but no changes in skin or vision. Better vision would have been nice as I am sick of having to use reading glasses.



#98 shadowhawk

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Posted 27 June 2016 - 10:26 PM

As luck would have it I got a bad sunburn the same time YOLF did and after reading his post I decided to try it on my burn and got the same result.  my skin lesions which did not fall off continue to get smaller as i use it topically. 


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#99 TRUGAN

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Posted 28 June 2016 - 12:26 AM

As luck would have it I got a bad sunburn the same time YOLF did and after reading his post I decided to try it on my burn and got the same result.  my skin lesions which did not fall off continue to get smaller as i use it topically. 

 

 

I tried it on my burn and it didnt do anything. Maybe you have to be 150 years old for this stuff to do anything but I did read how they are trying to use it to prevent burns to begin with. Im not convinced it does anything after the fact though.



#100 shadowhawk

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Posted 28 June 2016 - 01:23 AM

 

As luck would have it I got a bad sunburn the same time YOLF did and after reading his post I decided to try it on my burn and got the same result.  my skin lesions which did not fall off continue to get smaller as i use it topically. 

 

 

I tried it on my burn and it didnt do anything. Maybe you have to be 150 years old for this stuff to do anything but I did read how they are trying to use it to prevent burns to begin with. Im not convinced it does anything after the fact though.

 

OK  :)


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#101 TRUGAN

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Posted 28 June 2016 - 01:39 AM

Well it does make sense. The older or closer to death you are then the more of these bad cells you have. Young folks may not see any benefit from this or at least not a benefit that they can clearly see. Not all benefits are clearly measurable though.



#102 YOLF

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Posted 28 June 2016 - 08:29 AM

 

As luck would have it I got a bad sunburn the same time YOLF did and after reading his post I decided to try it on my burn and got the same result.  my skin lesions which did not fall off continue to get smaller as i use it topically. 

 

 

I tried it on my burn and it didnt do anything. Maybe you have to be 150 years old for this stuff to do anything but I did read how they are trying to use it to prevent burns to begin with. Im not convinced it does anything after the fact though.

 

The benefit for me wasn't making the burn go away, it was allowing me to peel it off all in one go with no pain. The pain would have told me that there were living cells coming off in the peel and those cells shouldn't go on to make me older or cancerous. The curcumin I took orally when I got the burn lowered the inflammation for a day or two... I'm 34. 

 

I can't say I've seen any improvements in my vision though... Maybe the opposite? It's probably something else, or I'm taking too many bioflavanoids concurrently. Also taking hCG lately which contains TSH, but I don't peel like this just taking TSH... 

 

How much did/do you take? What kind on lifestyle do you have?


Edited by YOLF, 28 June 2016 - 08:31 AM.


#103 YOLF

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Posted 28 June 2016 - 08:35 AM

Well it does make sense. The older or closer to death you are then the more of these bad cells you have. Young folks may not see any benefit from this or at least not a benefit that they can clearly see. Not all benefits are clearly measurable though.

Well, I am a former smoker, and I do have alot of cells that are probably sensitive to quercetin and senolytics and there is of course a cascade of senolysis that will occur elsewhere. I was also an undiagnosed celiac for 30+ years. You may be the kind of life extensionist that has always been in good shape and taken care of yourself... so you may not be able to trigger this cascade as well as I or ShadowHawk... though I don't really know much about his health.


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#104 mpe

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Posted 28 June 2016 - 11:24 AM

I have been consuming one pump per day for the last three days, I have noticed a general reduction in joint pain in the last two days; my occupation requires me to stand for up to eleven hours per day and for long periods of time and its very hard on the lower joints.

One negative aspect I have encountered today was a severe headache for no obvious reason, no booze, late night, change in diet, pollen or hit on the head.

I'll write again when I have something to say.

 

Mike


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#105 TRUGAN

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Posted 28 June 2016 - 01:35 PM

 

Well it does make sense. The older or closer to death you are then the more of these bad cells you have. Young folks may not see any benefit from this or at least not a benefit that they can clearly see. Not all benefits are clearly measurable though.

Well, I am a former smoker, and I do have alot of cells that are probably sensitive to quercetin and senolytics and there is of course a cascade of senolysis that will occur elsewhere. I was also an undiagnosed celiac for 30+ years. You may be the kind of life extensionist that has always been in good shape and taken care of yourself... so you may not be able to trigger this cascade as well as I or ShadowHawk... though I don't really know much about his health.

 

 

 

I work outside in the sun a lot and Im sure I have a lot of sun damage and I quit smoking at least 10 years ago. I wouldnt say Im living a very healthy lifestyle but I do take MitoQ every day and Niagen as well as a few other various supplements.



#106 TRUGAN

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Posted 28 June 2016 - 01:42 PM

I have been consuming one pump per day for the last three days, I have noticed a general reduction in joint pain in the last two days; my occupation requires me to stand for up to eleven hours per day and for long periods of time and its very hard on the lower joints.

One negative aspect I have encountered today was a severe headache for no obvious reason, no booze, late night, change in diet, pollen or hit on the head.

I'll write again when I have something to say.

 

Mike

 

 

It gave me terrible headaches at first. A couple of them were 3 day head aches that had me absolutely miserable and nothing would work on them. All that finally went away but I do have food allergies that Ive had forever so certain foods will give me headaches and it was the same type of headache so I think maybe I was just a little allergic to the quecertin and learned to tolerate it. Some foods are the same way for me in that I learn to tolerate them but then dont have them for a while and get the headaches again till my body adjusts to them.


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#107 shadowhawk

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Posted 28 June 2016 - 10:11 PM

 

As luck would have it I got a bad sunburn the same time YOLF did and after reading his post I decided to try it on my burn and got the same result.  my skin lesions which did not fall off continue to get smaller as i use it topically. 

 

 

I tried it on my burn and it didnt do anything. Maybe you have to be 150 years old for this stuff to do anything but I did read how they are trying to use it to prevent burns to begin with. Im not convinced it does anything after the fact though.

 

You mentioned someone may have to be 150 years old for it to do any good.  Do you know anyone 150 years old?  Do you have any skin lea sons or blemishes?


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#108 mpe

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Posted 29 June 2016 - 08:28 AM

 

I have been consuming one pump per day for the last three days, I have noticed a general reduction in joint pain in the last two days; my occupation requires me to stand for up to eleven hours per day and for long periods of time and its very hard on the lower joints.

One negative aspect I have encountered today was a severe headache for no obvious reason, no booze, late night, change in diet, pollen or hit on the head.

I'll write again when I have something to say.

 

Mike

 

 

It gave me terrible headaches at first. A couple of them were 3 day head aches that had me absolutely miserable and nothing would work on them. All that finally went away but I do have food allergies that Ive had forever so certain foods will give me headaches and it was the same type of headache so I think maybe I was just a little allergic to the quecertin and learned to tolerate it. Some foods are the same way for me in that I learn to tolerate them but then dont have them for a while and get the headaches again till my body adjusts to them.

 

 

Yes, the headache is unusual, I'm in its second day (unusual in itself) and nothing seems to help; I have noticed it has substantially diminished, but it was still strong enough that I chose not to go to work this morning.

I am a casual employee and so no work no pay. I don't take sick days without good cause.

 

Mike


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#109 TRUGAN

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Posted 29 June 2016 - 02:26 PM

 

 

I have been consuming one pump per day for the last three days, I have noticed a general reduction in joint pain in the last two days; my occupation requires me to stand for up to eleven hours per day and for long periods of time and its very hard on the lower joints.

One negative aspect I have encountered today was a severe headache for no obvious reason, no booze, late night, change in diet, pollen or hit on the head.

I'll write again when I have something to say.

 

Mike

 

 

It gave me terrible headaches at first. A couple of them were 3 day head aches that had me absolutely miserable and nothing would work on them. All that finally went away but I do have food allergies that Ive had forever so certain foods will give me headaches and it was the same type of headache so I think maybe I was just a little allergic to the quecertin and learned to tolerate it. Some foods are the same way for me in that I learn to tolerate them but then dont have them for a while and get the headaches again till my body adjusts to them.

 

 

Yes, the headache is unusual, I'm in its second day (unusual in itself) and nothing seems to help; I have noticed it has substantially diminished, but it was still strong enough that I chose not to go to work this morning.

I am a casual employee and so no work no pay. I don't take sick days without good cause.

 

Mike

 

 

 

 

You should be back to normal by tomorrow. You might need to take a break for a few days like I did and try again. Dont get crazy on the pumps till you know that you can tolerate it because the headaches are much more intense with each pump. At least you seem to think there is a benefit for you other than the benefit of the headache so it may be worth while for you to learn to tolerate it. Have you tried the regular 500mgs of quercertin?  Just wondering if that gave you a headache or the same benefit as well.


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#110 shadowhawk

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Posted 29 June 2016 - 08:30 PM

I have been consuming one pump per day for the last three days, I have noticed a general reduction in joint pain in the last two days; my occupation requires me to stand for up to eleven hours per day and for long periods of time and its very hard on the lower joints.

One negative aspect I have encountered today was a severe headache for no obvious reason, no booze, late night, change in diet, pollen or hit on the head.

I'll write again when I have something to say.

 

Mike

So Mike, one pump is light but you seem to notice a general reduction in joint pain and headaches the last two days.  Do

you yet attribute either reaction to Quercetin?   I have not had your symptoms yet but not all reactions to Quercetin are obvious and what occurs inside may be the most beneficial.  Look forward to your report.
 


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#111 TRUGAN

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Posted 29 June 2016 - 09:35 PM

 

I have been consuming one pump per day for the last three days, I have noticed a general reduction in joint pain in the last two days; my occupation requires me to stand for up to eleven hours per day and for long periods of time and its very hard on the lower joints.

One negative aspect I have encountered today was a severe headache for no obvious reason, no booze, late night, change in diet, pollen or hit on the head.

I'll write again when I have something to say.

 

Mike

So Mike, one pump is light but you seem to notice a general reduction in joint pain and headaches the last two days.  Do

you yet attribute either reaction to Quercetin?   I have not had your symptoms yet but not all reactions to Quercetin are obvious and what occurs inside may be the most beneficial.  Look forward to your report.
 

 

 

 

LOL...he clearly said he thought it helped his joint pain but the headache was probably from reading all your pointless posts like this one.


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#112 mpe

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Posted 29 June 2016 - 11:45 PM

Well I'm pleased to report the headache is gone this morning. A two day headache is very unusual, I've never had one before. Yes I do think it was the Quercetin as it was the only change to my routine/stack. I really hope it doesn't come back when I try higher doses in the future.
I was wondering if it maybe a good idea to split the doses say twelve hours apart as I increase them or take them only once a day, any suggestions?
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#113 shadowhawk

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Posted 30 June 2016 - 12:25 AM

 

 

I have been consuming one pump per day for the last three days, I have noticed a general reduction in joint pain in the last two days; my occupation requires me to stand for up to eleven hours per day and for long periods of time and its very hard on the lower joints.

One negative aspect I have encountered today was a severe headache for no obvious reason, no booze, late night, change in diet, pollen or hit on the head.

I'll write again when I have something to say.

 

Mike

So Mike, one pump is light but you seem to notice a general reduction in joint pain and headaches the last two days.  Do

you yet attribute either reaction to Quercetin?   I have not had your symptoms yet but not all reactions to Quercetin are obvious and what occurs inside may be the most beneficial.  Look forward to your report.
 

 

 

 

LOL...he clearly said he thought it helped his joint pain but the headache was probably from reading all your pointless posts like this one.

 

Beside the fact I didn't ask you and you have no way of answering for him I asked a question about Quercetin because he did not attribute his reactions directly to it.  You did.  He was reporting changes that had taken place the last three days.  I noticed you didn't answer my questions to you which were how many 150 year olds you claimed you knew and how many skin lesions and blemishes you had before you started the test. ???


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#114 TRUGAN

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Posted 30 June 2016 - 12:43 AM

Well I'm pleased to report the headache is gone this morning. A two day headache is very unusual, I've never had one before. Yes I do think it was the Quercetin as it was the only change to my routine/stack. I really hope it doesn't come back when I try higher doses in the future.
I was wondering if it maybe a good idea to split the doses say twelve hours apart as I increase them or take them only once a day, any suggestions?

.

 

I would take them all at the same time if you can tolerate it but wait till you no longer get headaches from 1 pump and then slowly increase. Once I worked my way up to 3 pumps I was ale to jump up to 6 and currently doing 7,

Splitting the doses may be fine as well. I guess we dont really know so youll have to experiment with it.



#115 shadowhawk

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Posted 30 June 2016 - 01:34 AM

Well I'm pleased to report the headache is gone this morning. A two day headache is very unusual, I've never had one before. Yes I do think it was the Quercetin as it was the only change to my routine/stack. I really hope it doesn't come back when I try higher doses in the future.
I was wondering if it maybe a good idea to split the doses say twelve hours apart as I increase them or take them only once a day, any suggestions?

Yes, I split mine half in the morning and half in the evening.  I also apply it topically but most of the blemishes are gone with the few sun damage exceptions.  Perhaps later we can buy the Quercetin in pill form but for now I intend to continue taking it based on the science and personal results.  Several supplements in my normal stack I have eased into.  I take Cranberry supplements as well as apple cider pills  to keep my system working well as well as a good macrobiotic.  Sense your headache has gone away I would suggest adding another squirt in the evening and see what happens. :)

 


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#116 Nate-2004

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Posted 30 June 2016 - 05:18 AM

Is this still going on? I'm in. Let me know more details about it. 



#117 YOLF

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Posted 30 June 2016 - 09:53 AM

Well I'm pleased to report the headache is gone this morning. A two day headache is very unusual, I've never had one before. Yes I do think it was the Quercetin as it was the only change to my routine/stack. I really hope it doesn't come back when I try higher doses in the future.
I was wondering if it maybe a good idea to split the doses say twelve hours apart as I increase them or take them only once a day, any suggestions?

Do you get headaches from DMAE or Centrophenoxine? I'm pretty well purged of my lipofuscin, but I'm wondering if dying glial cells are causing the headaches... that makes alot of assumptions though... any pathologies/dispositions?

 

DMAE eventually stopped causing me headaches when I used it periodically until I could take it daily, will probably try Centro again someday, but I'm thinking attack doses are best with senolytics unless they are toxic as you'll loose more old/damaged cells that way. Attack dosing once a week may even be better than daily dosing. I'm combining that with almost breakneck workouts.


Edited by YOLF, 30 June 2016 - 10:07 AM.

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#118 YOLF

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Posted 30 June 2016 - 10:14 AM

On that note, combination with alagebrium would probably be beneficial as these old cells are probably full of glucosepane. Even if it's thought not to work on the hardest to reach stuff, blood stream levels are still going to rise and if you don't stop it with something, at least some of it may pollute your healthier cells.


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#119 mpe

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Posted 01 July 2016 - 10:51 AM

 

Well I'm pleased to report the headache is gone this morning. A two day headache is very unusual, I've never had one before. Yes I do think it was the Quercetin as it was the only change to my routine/stack. I really hope it doesn't come back when I try higher doses in the future.
I was wondering if it maybe a good idea to split the doses say twelve hours apart as I increase them or take them only once a day, any suggestions?

Do you get headaches from DMAE or Centrophenoxine? I'm pretty well purged of my lipofuscin, but I'm wondering if dying glial cells are causing the headaches... that makes alot of assumptions though... any pathologies/dispositions?

 

DMAE eventually stopped causing me headaches when I used it periodically until I could take it daily, will probably try Centro again someday, but I'm thinking attack doses are best with senolytics unless they are toxic as you'll loose more old/damaged cells that way. Attack dosing once a week may even be better than daily dosing. I'm combining that with almost breakneck workouts.

 

 

Sorry I've never tried them


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#120 SearchingForAnswers

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Posted 02 July 2016 - 03:45 PM

I still haven't received mine...





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