40 replies to this topic

[gamesguru]

there are conflicting studies on gold


Size-dependent impairment of cognition in mice caused by the injection of gold nanoparticles.

Neurotoxicity following a very high dose of oral gold (auranofin) - NCBI

[sativa]

Injection??!
Very high dose of a substance that is a gold complex which contains Au as well as other components in its make up?!!

Aside from perhaps the first study you mentioned, I don't feel its relevant to ingesting a small dose of small, microscopic (usually nano sized) gold particles suspended in distilled water.

I mean please, show me things that more strongly imply colloidal gold is harmful.

I believe colloidal gold (or a form of it) was used traditionally as a medicinal remedy. Not that this totally justifies it's safety etc, but for me, it gives credibility.

Edited by sativa, 28 May 2016 - 06:38 PM.

[gamesguru]

to the best of my knowledge, these all involve non-ionic gold, colloidal or NP

http://www.uptodate....of-gold-therapy
http://jama.jamanetw...rticleid=292268


http://www.ncbi.nlm....les/PMC3126713/
http://www.ncbi.nlm....les/PMC2988217/

Edited by gamesguru, 28 May 2016 - 07:18 PM.

[psychejunkie]

Neuralsten is keeping hush hush about NSI's mechanism of action. It nigh activate TrkB or affect serotonin, who know? So you can't discount the possibility that it works similarly to older nootropics

It might also affect dopamine based on one user's reported side effects:

I'm getting ejaculatory anhedonia since NSI-189, despite ... either, which would suggest a dopaminergic activity going on as well, though on far lower levels than amphetamines.

Neurastem has clearly stated numerous times that NSI-189 MOA is different from mainstream anti depressants without altering channels, receptors, kinases or neurotransmitters levels.

Please, Do your googling before replying!

Edited by psychejunkie, 28 May 2016 - 07:20 PM.

[gamesguru]

you really trust a company to be tell the truth when it stands to profit from lying?

think of all the tests they would need to confirm the irrelevancy of all the mechanisms you mebtioned. lots

and think of all the customers they will lose when it's exposed that NSI exerts some of its effect thru trkb or 5ht. I predict none, cause that's not enough to undermine all the hype.

even so even so, why should an NT-independent neurogenesis be superior??

edit:
what are your thoughts on this article, sorry for the length
http://www.brainprot...nism-of-action/

two basic mechanisms are proposed, glucorticoid or serotonin. moderate levels of serotonin are clearly related to BDNF and neurogensis. as for the Glucocorticoid bit, I found this in a study.
"... we review the role of the glucocorticoid receptor, the main mediator of the stress response in the proliferation, differentiation, migration, and functional integration of newborn neurons in the hippocampus. We review a multitude of mechanisms regulating glucocorticoid receptor activity in relationship to adult neurogenesis."

Edited by gamesguru, 28 May 2016 - 08:05 PM.

[kurdishfella]

Progesterone n estrogen hormone female deriritives. Less women suffer from parkinsons etc than men and thats a sign they have better brain power/usage thus iq. Also blocking testosterone levels better immune

Edited by kurdishfella, 11 August 2021 - 06:14 PM.

[kurdishfella]

Thats why women mature faster

[kurdishfella]

N better smooth muscle movements. magnesium affects smell. etc

[Mr Matsubayashi]

there are conflicting studies on gold


Size-dependent impairment of cognition in mice caused by the injection of gold nanoparticles.

Neurotoxicity following a very high dose of oral gold (auranofin) - NCBI

 

The trick is to use a mortar and pestle instead of a blender when making your gold nanoparticles. They need a grinding rather than chopping motion.... lolol

 

But seriously, trying to increase IQ with stimulants or anything that develops tolerance is going down the wrong path. For those of us who have done physics its sort of the difference between power and energy. Having extra power isn't very helpful if you can only exert it for a couple of hours a day (in general context). Big increases in productivity can only result from power x time. Maybe the first thing worth optimising is your messy mind that gets distracted by every red ball. Get consistent and efficient sleep by staying off your phone and start forming good habits. 

 

Lets say you now meditate, sleep eight hours a day, eat healthy, in the process of getting more time I guarantee you have also unlocked a lot more power to apply during those productive hours. These are the low hanging fruit and the best starting place. 

[kurdishfella]

The best way of increasing brain power is by increasing fear/anxiety activity in the brain. Things that lower CB1 but also increase GABA-A  and B so you take in more stimuli at the same time. This will allow your brain to be more active in the normal state and you remember things more both longterm and shorterm . This doesn't necessary mean you will become more anxious mentally if you know how to control it.  And your body will run on ketones more which are very good for brain.

Edited by kurdishfella, 16 October 2021 - 02:57 PM.

[Paravani]

Something I've added to my stack over the last two weeks has recharged my brain, so that it feels that old enthusiasm for learning and developing new thought processes.

One aspect of aging that had been particularly frustrating for me was the feeling that my brain had slowed down, and I had to actually work at learning new things rather than simply absorbing them like a sponge. I've never had to work very hard to learn anything, and puzzles have always been a joy to solve... until the last few years, when I found myself avoiding learning new technology, resistant to developing new skills.

It was very uncomfortable to admit that my brain was growing old and stiff.

However, over the last few weeks I've been feeling like my old self again. I'm soaking up everything I'm reading in PubMed, and learning the endocrinology of aging in spite of having little background in biology or biochemistry.

Something has changed... a BIG change! ...and I suspect it's due to the 600mg of Co-Q10 I'm taking daily.

Another big change is that my chronic asthma is nearly gone. I used to need my rescue inhaler 6 times daily, even waking up to use it in the middle of the night. Now I only use it once a day, if that.

Again, I think it's due to the Co-Q10 I'm taking.

I'm due for my annual lung MRI this month. I'm VERY curious to know how it will have changed from last year's...

Happy aging! ;-D