In my opinion everything herbal is worth cycling off occasionally. The only question would be how much. Also, some things have very sharp drop-off like CoQ10, Vitamin D, I would argue that something like CoQ10 is simply a vitamin in all but name (vitaminish?). The more vitaminish it is, the simpler this would be. My consideration of CoQ10 as a vitamin is basically because of this cliff-like drop-off in feeling from taking it, similar to vitamin D.
The only references I can provide are: Skyguy2005. Sorry.
I'm quite skeptical about CoQ10 given all the debunking of claims around its usefulness. I recall reading into it a while back before deciding not to waste money on it. There was a lot of hype about it years ago and then a ton of research was done showing it did absolutely nothing.
WebMD gives it a C in evidence around most of the claims and a B with blood pressure conditions. The only A it gets is in very rare conditions of deficiency. NIH says the evidence is limited and inconclusive.
This guy gives it a little more credit for heart conditions while this guy blasts it as a money scam. As experimental as I like to be, I prefer strong evidence before I spend any money. I'm with Tim Minchin on alternative medicine. "What do we call alternative medicine that works? We just call it medicine."
Nearly every meta review of the stuff says it's not worth it unless you're on statin drugs or beta blockers. I take beta blockers occasionally for essential tremor but not enough to warrant spending money on this.
Telmisartan/micardis
it has antihypertensive and antiglycation properties
I'll have to look into that thanks. I'm only skeptical about the anti-glycation stuff because the latest news from SENS is that there's just no funding for research on AGE-breakers or anything of the sort. They only cited one project to develop an AGE-breaking drug and also mention every kind of attempt they made in this process and none of them were successful once human trials began. They could be in the dark about these other alternatives but I doubt it. If there were something out there that works I imagine they'd be on it. If it works in rats, the likelihood of it working in humans is slim, because from what I understand, rats don't have the same kind of glucosepane based AGEs that we do.
This thread has gone way off topic though, but the question I had has been answered for the most part. Cycling is useful for C60OO but the idea that some ROS is needed or that we can be too antioxidant has little supporting evidence. The exception being Vitamin E and Beta Carotene. Though this meta analysis concludes otherwise. I take vitamin A but only once every few days. My vitamin E comes from almonds and almond milk. My beta-carotene, or carotenoids in general will come from actual carrots, tomatoes and stuff.
Edited by Nate-2004, 01 June 2016 - 07:31 PM.
