142 replies to this topic

[farware]

Some further links:

 

http://sanjosefuncme...ding-leaky-gut/

 

 

When it comes to the treatment of leaky gut, there are two critical systems that need to be addressed:

• The Nitric Oxide Synthase system
• The Glutathione Recycling system

 

 

 

Also of note PQQ + NAC have anti-cancer properties:

 

http://www.ncbi.nlm....pubmed/20663290

 

 

I read reports that NAC increases RBC glutathione levels so fast that the crash will result in level below baseline, which means it's not a good modulator for a steady supply throughout the day. However, I would want to see some charts to verify that. If anyone can find a link to a NAC study that would be most interesting. If the drop is really so significant a better alternative could be Alpha Lipoic Acid which could also work well together with NADH. 

 

 

 In a previous study (Toxicology 156 (2001) 93) dithiothreitol (DTT) did not show any effect on intra- or extracellular glutathione concentrations in HeLa cell cultures but increased the effects of mercury ions on glutathione concentrations, whereas monothiols such as N-acetylcysteine (NAC) or glutathione did not.

http://www.ncbi.nlm....pubmed/12049840

 

 

ALA is a fatty acid that exists in the mitochondria and is involved in energy metabolism. Commonly taken with L-Carnitine supplements as they are related in mechanisms. ALA gives a short but potent reduction of oxidation by increasing anti-oxidant enzymes, and may decrease Blood Glucose acutely.

https://examine.com/...ha-lipoic-acid/

 

 

 

 

ALA is also an anti-aging supp. 

 

So ALA for glutathione and L-acetylcarnitine for NOS modulation seems to be a good solution. Be aware of blood glucose drop => may require to take precautions. If it drops too low you need some dextrose or whatever to counter it. D-Ribose also lowers blood sugar by increasing insulin for about 1-2 hours. So this is starting to be a real problem. You want low blood sugar but not too low or you will be feeling weak / sleepy / dizzy. Taking all at at the same time is not a good idea.

 

If I decide to investigate this further, I would start with ultra low doses. 

 

[farware]

Going to do a blood glucose test before trying that D-Ribose, not taking any chances: 

https://en.wikipedia...al_glucose_test

[Mind_Paralysis]

Seems like a very good idea, Farware, to take it a bit easy with this - it's not exactly sugar-pills. (hah! one could actually say some of them are tho, now couldn't you?)

 

Another note, btw - IBS-sufferers have reported slightly improved symptoms from a Low Calorie High Fat -diet, and since you mention how it lowers blood-glucose... Why not just SWITCH OUT your glucose to ketose instead? Logically, you should then be able to just POUR on the NAC, ALA, and D-ribose without any trouble whatsoever.

 

You can facilitate the shift from LFHC to LCHF by supplementing with these nifty little suckers:

 

Short-chain fatty acids!

https://en.wikipedia...hain_fatty_acid

 

Bit of info on their role in metabolism and such here (natural versions of them are produced in the body, from substances that take a loong time to digest):

 

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
http://www.ncbi.nlm....les/PMC3735932/
 

The fascinating thing about SCFA's is that they behave like glucose in your brain! They go straight through the blood-brain barrier and boost your brains energy-levels in a way similar to glucose and ketose.

Now, it should be possible, and probably is beneficial (just not as effective - but you're gonna' need more than the synthetics to feed you), to also supplement with medium-chain fatty acids, so have a look at that too:

 

Medium-chain triglyceride

https://en.wikipedia...in_triglyceride

 

Coconut-Oil, is for instance rich with these MCT's.

[farware]

Seems like a very good idea, Farware, to take it a bit easy with this - it's not exactly sugar-pills. (hah! one could actually say some of them are tho, now couldn't you?)

 

Another note, btw - IBS-sufferers have reported slightly improved symptoms from a Low Calorie High Fat -diet, and since you mention how it lowers blood-glucose... Why not just SWITCH OUT your glucose to ketose instead? Logically, you should then be able to just POUR on the NAC, ALA, and D-ribose without any trouble whatsoever.

 

You can facilitate the shift from LFHC to LCHF by supplementing with these nifty little suckers:

 

Short-chain fatty acids!

https://en.wikipedia...hain_fatty_acid

 

Bit of info on their role in metabolism and such here (natural versions of them are produced in the body, from substances that take a loong time to digest):

 

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
http://www.ncbi.nlm....les/PMC3735932/
 

The fascinating thing about SCFA's is that they behave like glucose in your brain! They go straight through the blood-brain barrier and boost your brains energy-levels in a way similar to glucose and ketose.

Now, it should be possible, and probably is beneficial (just not as effective - but you're gonna' need more than the synthetics to feed you), to also supplement with medium-chain fatty acids, so have a look at that too:

 

Medium-chain triglyceride

https://en.wikipedia...in_triglyceride

 

Coconut-Oil, is for instance rich with these MCT's.

 

I personally dont tolerate all of them well e.g. caprylic acid. But borage oil works (GLA). ALA seems to be a short-chain too? Anyway I think thats a question of your personal Omega3/Omega6 ratio, dont think it affects your blood glucose levels. NAC + D-Ribose will still lower your blood glucose levels regardless of what SCFs you add. Personally I tend to do better on Omega 6. The general population is deficient in Omega 3. 

 

As for other supps: I have been taking Zinc L-Carnosine for a while now. Only now do I realize that it has been one of the most beneficial supps so far. Fermented foods and Vitamin K is all good and well but it cant really repair your stomach tissue quickly. Zinc can. Chelated zinc can be taken on an empty stomach and do its job. 

 

Here's an interesting article on the anti-aging trio ALA+ALC+Carnosine which I is a fascinating read too: 

http://www.lifeexten...t_alpha/Page-01

Edited by farware, 13 August 2016 - 07:33 PM.

[farware]

The fascinating thing about SCFA's is that they behave like glucose in your brain! 

 

 

This is good to know thou .. wondering how that works. Below some interesting notes on SCFA. Methylation + Hormones + Serotonin + ATP are all secondary objectives really because if you treat the main issue then all that would work a lot easier. So we should establish what is the main thing to focus on? NOS modulation + GHS boost + Stealth Biofilm degradation to fix a leaky gut is a good start. Also re-colonization of healthy gut bacteria. Because you can boost your GHS but what does it matter if theres no healthy gut microbiota. SCFAs could be a good addon to deliver more energy but wondering if its overkill when you're already supplementing NADH directly. Longterm supplementation of NADH is probably not good (possible dependence?) and SCFAs would be a more natural way to boost NADH / ATP cycle. 

 

The decrease in physical exercise and increase in energy intake, especially seen in the Western world, disrupts the energy balance in humans and can lead to a complex of symptoms collectively denoted as the metabolic syndrome. Recently, dietary fibers have raised much interest, as they exert beneficial effects on body weight, food intake, glucose homeostasis, and insulin sensitivity (2–4). Epidemiological studies show an association between a higher fiber intake and a reduced risk of irritable bowel syndrome

To the microbial community SCFAs are a necessary waste product, required to balance redox equivalent production in the anaerobic environment of the gut - In the last few decades, it became apparent that SCFAs might play a key role in the prevention and treatment of the metabolic syndrome, bowel disorders, and certain types of cancer  http://www.ncbi.nlm....les/PMC3735932/  

Edited by farware, 13 August 2016 - 07:34 PM.

[Mind_Paralysis]

 

I personally dont tolerate all of them well e.g. caprylic acid. But borage oil works (GLA). ALA seems to be a short-chain too? Anyway I think thats a question of your personal Omega3/Omega6 ratio, dont think it affects your blood glucose levels. NAC + D-Ribose will still lower your blood glucose levels regardless of what SCFs you add. Personally I tend to do better on Omega 6. The general population is deficient in Omega 3. 

 

As for other supps: I have been taking Zinc L-Carnosine for a while now. Only now do I realize that it has been one of the most beneficial supps so far. Fermented foods and Vitamin K is all good and well but it cant really repair your stomach tissue quickly. Zinc can. Chelated zinc can be taken on an empty stomach and do its job. 

 

Here's an interesting article on the anti-aging trio ALA+ALC+Carnosine which I is a fascinating read too: 

http://www.lifeexten...t_alpha/Page-01

 

 

I think I probably didn't explain it very well in my last post, but here's the gist:

 

You don't need Glucose to function.

 

You can instead, gradually, replace all forms of starch and sugar in your diet, with various fats instead! : D It's called LCHF-diet, and is used as a method to get the pathologically obese into a slimmer state - once your body has been able to shift it's enzymatic production to instead create enzymes which primarily process fats, instead of sugars, you can then live off of fats, as if they were sugar!

This state is called ketosis - if you reach ketosis, it won't matter if your glucose drops - you're already using other forms of energy. It's supposed to lower body-wide inflammation as well, apparently, since a lot of unsavory micro-organisms enjoy feasting on your glucose - cut the glucose and they starve to death.

If you were in Ketosis, you could pour on really high doses of NAC and the like.

 

Here's an example:

You're on your way to work, about to drive. You notice that you are light-headed, DIZZY, because you have started eliminating sugar from your diet. You then pop a pill of SCFA's and in a matter of minutes the dizzyness and light-headedness disappears! You now drive to work with no problem.

 

 

 

 

This is good to know thou .. wondering how that works. Below some interesting notes on SCFA. Methylation + Hormones + Serotonin + ATP are all secondary objectives really because if you treat the main issue then all that would work a lot easier. So we should establish what is the main thing to focus on? NOS modulation + GHS boost + Stealth Biofilm degradation to fix a leaky gut is a good start. Also re-colonization of healthy gut bacteria. Because you can boost your GHS but what does it matter if theres no healthy gut microbiota. SCFAs could be a good addon to deliver more energy but wondering if its overkill when you're already supplementing NADH directly. Longterm supplementation of NADH is probably not good (possible dependence?) and SCFAs would be a more natural way to boost NADH / ATP cycle. 

 

 

"The decrease in physical exercise and increase in energy intake, especially seen in the Western world, disrupts the energy balance in humans and can lead to a complex of symptoms collectively denoted as the metabolic syndrome. Recently, dietary fibers have raised much interest, as they exert beneficial effects on body weight, food intake, glucose homeostasis, and insulin sensitivity (2–4). Epidemiological studies show an association between a higher fiber intake and a reduced risk of irritable bowel syndrome"

 

To the microbial community SCFAs are a necessary waste product, required to balance redox equivalent production in the anaerobic environment of the gut - In the last few decades, it became apparent that SCFAs might play a key role in the prevention and treatment of the metabolic syndrome, bowel disorders, and certain types of cancer  http://www.ncbi.nlm....les/PMC3735932/  

 

 

That's the idea! : D I got the idea from studying resistant starch a few months ago - and noticed that it was the SCFA's which were the key to their good effects.

And I believe the reason SCFA's behave like glucose in your brain, your entire body, is because they are so easily utilized! The short molecular length means that the enzymatic process to break them down, to use them as energy, is much, much quicker than for other fatty acids - in fact, it seems like they may be so easy to use that your cells don't need ANY processing of them - you just plug them into the cell! They are immediately sent into your brain, just like sugar, because it's easily utilized.

If the body detects a substance which it doesn't have to WASTE energy to utilize, then it will do so. = )
 

[farware]

 

 

I personally dont tolerate all of them well e.g. caprylic acid. But borage oil works (GLA). ALA seems to be a short-chain too? Anyway I think thats a question of your personal Omega3/Omega6 ratio, dont think it affects your blood glucose levels. NAC + D-Ribose will still lower your blood glucose levels regardless of what SCFs you add. Personally I tend to do better on Omega 6. The general population is deficient in Omega 3. 

 

As for other supps: I have been taking Zinc L-Carnosine for a while now. Only now do I realize that it has been one of the most beneficial supps so far. Fermented foods and Vitamin K is all good and well but it cant really repair your stomach tissue quickly. Zinc can. Chelated zinc can be taken on an empty stomach and do its job. 

 

Here's an interesting article on the anti-aging trio ALA+ALC+Carnosine which I is a fascinating read too: 

http://www.lifeexten...t_alpha/Page-01

 

 

I think I probably didn't explain it very well in my last post, but here's the gist:

 

You don't need Glucose to function.

 

You can instead, gradually, replace all forms of starch and sugar in your diet, with various fats instead! : D It's called LCHF-diet, and is used as a method to get the pathologically obese into a slimmer state - once your body has been able to shift it's enzymatic production to instead create enzymes which primarily process fats, instead of sugars, you can then live off of fats, as if they were sugar!

This state is called ketosis - if you reach ketosis, it won't matter if your glucose drops - you're already using other forms of energy. It's supposed to lower body-wide inflammation as well, apparently, since a lot of unsavory micro-organisms enjoy feasting on your glucose - cut the glucose and they starve to death.

If you were in Ketosis, you could pour on really high doses of NAC and the like.

 

Here's an example:

You're on your way to work, about to drive. You notice that you are light-headed, DIZZY, because you have started eliminating sugar from your diet. You then pop a pill of SCFA's and in a matter of minutes the dizzyness and light-headedness disappears! You now drive to work with no problem.

 

 

 

 

 

 

Keto diet seems incredibly stupid and not forward-thinking. Like some diet fad and its outdated at best. Its not how the human body works. Glucose is the primary energy source - you cant simply replace that with protein. However, supplementing sugars like D-Ribose and others mess with insulin so it actually makes sense to monitor blood glucose. 

 

I do not believe in Keto at all. Here's a good rundown why not:

http://freetheanimal...on-vlcketo.html

 

Also, all those Keto guys are cheating anyway. I'm a hardcore nutritionist at this point and I know that no matter what you eat you cant avoid sugar and carbohydrates to some extent, nor should you. The brain relies on it. You are basically screaming for Diabetes if you go on Keto diets or calorie-restriction and you are actively damaging your health.  

 

In fact, raw potatoes for example are some of the best fibers in the world. They are good to create a healthy gut flora. 

 

Our novel study does suggest that dietary gluten could modulate the incidence of type I diabetes by changing the microbiome. - See more at: http://www.drperlmut...h.pOaUAUjT.dpuf

 

#8 Try Resistant starch

http://main.poliquin...oesnt_Make.aspx

 

 

Gut vs. Gut: This is how & why Resistant Starch is working.

https://mrheisenbug....rch-is-working/

 

 

 

Ive recently introduced mashed raw potatoes into my diets again. Its incredible how well it works on the gut and your brain when you've been on a low-carb diet for some time. Cant really explain yet how it all works, need to read more

[farware]

Especially read this: 

https://mrheisenbug....rch-is-working/

 

I am going to send in a sample next few weeks to get a similar chart. I have now made some changes to my diet to include more carbs and lots of daily fermented fibers and will check in 3-4 months again, then in a year again. Will be interesting to see what that does to my cognitive performance and overall health.  

[farware]

"Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons."

 

In contrast, acute exposure to MK-801, a NMDA receptor antagonist, prevented glutamate cytotoxicity. These results indicate that chronic exposure to methylcobalamin protects cortical neurons against NMDA receptor-mediated glutamate cytotoxicity.

 

 

It is entirely possible that some of my issues with gluten and glutamate receptors stem from B12 deficiency. The problem is you can simply trust your blood tests to be accurate since they cant measure B12 in organs etc just in your blood stream, thats unreliable but wont change until we have some nanotech on the market. Personally I have been supplementing B12 and while it does help since I have a deficiency due to my hereditary blood disorder its not doing much in terms of balancing glutamate receptors. 

 

Also read that NAC is a NMDA antagonist, need to dig into that. GSH (Glutathione) seems to make so much sense since it can detox your entire body and help you get rid of unwanted metals! Simply dont forget to supplement with zinc and copper some hours afterwards, you dont want to flush everything out so to speak. Anyway, in my personal case a lot of problems got worse after a mercury dental filling was removed. I replaced all of them several years ago. Although it was supposedly done professionally and I took some Chlorella I wasnt aware of GSH back then so its very likely that there was still a lot of mercury circulating in my body or stored somewhere. Also possible since I eat a lot of fish and seafoods. So NAC seems to really help in that regard. Just wish I had known about it a lot earlier.  

[farware]

Ok so I hate being a maximalist, going to dig into Ketosis to see if its actually viable but Im skeptical: 

 

http://blogs.scienti...r-advantageous/

http://eatingacademy...od-state-part-i

 

[Mind_Paralysis]

I actually do think a *very* strict Resistant Starch diet could be a good alternative to LCHF/Ketosis though - if you eat enough of it, then eventually you'll get most of your energy from the SCFA's, and as I understand it, there are several SCFA's which have a great deal of chemical similarity to the ketone-bodies the body produces from a primarily fat-based energy diet.

 

That's actually one of the reasons I started looking into it! : D I have several severely obese friends, and I figured LCHF would be too hard for them to follow through on.

 

Out of curiosity, can you find any evidence of anyone on a LCHF-diet which is also using NAC-supplementation? Would be interesting to see what the effects are - especially if they're doing HIGH-dose! ; ) Remember, that's the original goal of the diet in this thread: to find a way for you to enhance your gut-lining to the point of CAST-IRON, without lowering your energy-levels completely.

[farware]

I actually do think a *very* strict Resistant Starch diet could be a good alternative to LCHF/Ketosis though - if you eat enough of it, then eventually you'll get most of your energy from the SCFA's, and as I understand it, there are several SCFA's which have a great deal of chemical similarity to the ketone-bodies the body produces from a primarily fat-based energy diet.

 

That's actually one of the reasons I started looking into it! : D I have several severely obese friends, and I figured LCHF would be too hard for them to follow through on.

 

Out of curiosity, can you find any evidence of anyone on a LCHF-diet which is also using NAC-supplementation? Would be interesting to see what the effects are - especially if they're doing HIGH-dose! ; ) Remember, that's the original goal of the diet in this thread: to find a way for you to enhance your gut-lining to the point of CAST-IRON, without lowering your energy-levels completely.

 

I am thinking I will stick to NAC + High Protein + Selected Carbs + Fermented Fiber. Due to my liver issues I am very biased against going on a Keto diet. Going to do an analysis of my gut flora thou. Its expensive (130 bucks) but at least I have data I can use to see whether I am making progress or not. No doubt at the moment I must have a pretty messed up gut flora so it will be interesting to see what sticking to this diet for 6 months will result in. Once I have compiled the data I will post the results here. May write a short booklet on supps too along with my personal notes and make it available for free. 

Edited by farware, 16 August 2016 - 02:10 PM.

[farware]

Just recently read that depression can be cured by balancing noradrenaline and acetylcholine

 

Some interesting notes:

"Galantamine combines increases the concentration and action of acetylcholine in the brain"

"Long-term treatment with Galantamine increased the connections between neurons in the brains of Alzheimer’s patients "

"Galantamine may have antidepressant effects (R) and improve sleep quality in dementia patients "

"Galantamine decreases brain inflammation" 

"Galantamine activates the cholinergic anti-inflammatory pathway; one of the fundamental anti-inflammatory pathways in human biology, which protects the body from prolonged exposure to systemic inflammation." 

"Galantamine given to autistic children, alongside Risperidone (an antipsychotic medication),  improved symptoms of autism, such as irritability, lethargy, and social withdrawal " 

"Galantamine may enhance expressive language and communication in autistic adults " 

"Galantamine may counteract the damaging effects of kynurenic acid, of which increased levels have been associated with cognitive problems characteristic of schizophrenia" 

"Galantamine improves the AMPA-mediated signaling pathway which could protect the brain and improve memory in schizophrenics" 

https://selfhacked.c...ptoms_of_Autism

 

I am personally affected by the following: ASD, Chronic Inflammation, Brain Inflammation, Social Withdrawal, Poor Language Skills (Spoken, not Written), Depression

It's curious how so many Alzheimer drugs work in ASD. Makes me believe that Acetylcholine is really what it all comes down to. Also note the AMPA pathway in schizophrenia 

 

 

So my rating of supps effective for ASD (Note ASD is/was a subtype of schizophrenia and may work for SCD as well):

 

1. NADH: 9/10
2. Galantamine: 10/10 
3. Carnosine: 9/10 
4. Whey Protein/Lactoferrin 6/10 

 

But when you read through my other posts, I cant stress enough how important all the other cycles are: Hormone support, Methylation, Serotonin. NADH is basically a Serotonin supp helping convert B6 which is crucial in 5HTP->Serotonin conversion process and B6 is deficient in ASD but it goes far beyond that. 

 

Also Galantamine may work on NOS:

 

Galantamine also reduced L-NAME-induced decreases in NO synthase levels. However, mecamylamine obliterated galantamine’s efficacy to counter the L-NAME-induced decrease in NO synthase levels. Thus, galantamine protects maze behavior from L-NAME-induced impairment, which may be mediated by NO activation via the nicotinic ACh receptor-related pathway. Indeed, galantamine has been found to stimulate nicotinic ACh receptor activity

 

 

Again, ACh receptor pathway ... wondering how nicotine patches may work on ASD 

 

Just found this, seems some are already using nicotine patches for ADHD, cognitive impairment: 

http://brainblogger....mpairment-away/

 

 

On a quest to make his brain work better, a writer delves into the evidence for why the world’s most notorious alkaloid may be the best bet for a true cognitive enhancer

http://www.scientifi...marter-excerpt/

 

 

Ok apparently nicotine patches can become an addiction. I dont seem to get addicted to stuff easily so I will give it a trial run. Will report back  

 

 

 

[farware]

Apparently there is a species of gut bacteria that can help with social behavior. SO this + Gala is a dream combo to fix social issues + cognitive issues.

 

By adding this bacteria species back to the guts of affected mice, the researchers were able to reverse some of their behavioral deficits, which are reminiscent of symptoms of autism spectrum disorders (ASDs) in humans. The investigators are now looking to explore the effects of probiotics on neurodevelopmental disorders in future work.

https://www.scienced...60616140723.htm

 

 

Fortunately L.Reuteri is commercially available:

http://nootriment.co...obiotics-drops/

 

I believe one huge issue could be that many autistic childs were not breastfed and lack certain gut species that normally contribute to the normal development of a child. Not sure if there are any stats on that thou but would be interesting to include in a study

 

 

 

 

[farware]

After a lot of digging into my genes, I concluded that most of my problems stem from Celiac disease (symptoms: mouth ulcers, tingling in hands, poor weight gain, joint pain, stretch marks) and ulcerative colitis that got worse after a stressful period in my life and coffee abuse. This increased gut permeability and that leaky gut caused more severe ASD symptoms that I previously was unaware of. It's possible that gluten has caused ADHD throughout my life and other symptoms close to autism. Its just remarkable how closely this resembles mild ASD / Aspergers and it could very well be that ASD is very much related to celiac. 

 

http://www.beyondcel...sease/symptoms/

 

I basically have like 20 fold chances of getting Crohns (I have like 10 implicated SNPs all increasing the odds considerably) so Celiac could just be a precursor but hopefully I can manage it and prevent further progression towards further autoimmune disorders. 

 

Also, regarding biofilms I think they are essential to health and not taking NAG (glucosamine) because it could enhance biofilm creation of parasites is probably flawed thinking especially since many studies claim it can reverse autoimmunity. However, it is probably a good idea not to overdose and enhance healthy gut microbes via proteins, L.Reuteri, Lactoferrin, Carnosine, etc too at the same time. 

 

The large intestine is lined with a protective mucus layer made up of large sugar molecules called O-glycans. One role of the mucus is to separate bacteria and immune cells in the colon. In ulcerative colitis, the mucus layer is severely degraded, allowing the bacteria and immune cells to fight, causing inflammation.

http://omrf.org/2011...r-root-colitis/

 

So basically if your gut has no protective layer its constantly fighting the bad guys. NAG may help to restore that layer. 

 

Lastly, as mentioned I think that Schizophrenia may be an auto-immune disease as well. It has given me a lot of insight into the implicated pathways and genes. Only it seems to affect the brain even more like nerve gases. 

 

 

[farware]

Apparently funghi and other parasites use NAG for cell walls, just like us humans do so they attach to NAG rather than your intestines: 

http://www.metabolic...ti-consumption/

http://www.curezone....fm.asp?i=976129

 

This could explain why it would help with autoimmune disorders as well. Since the body is no longer busy fighting parasites that attach themselves to the gut linen, they can focus on the free-floating ones and your gut can heal. Makes a lot of sense when you think about it. That in turn will then lead to less problems with your glutamate receptors and you will experiences fewer symptoms. 

 

However, Western cooks should simply re-introduce fermentation to ALL foods and no one would have problems anymore. Fermentation is key

[Mind_Paralysis]

The relation between celiac and ASD in humans can't be big though, mate - as you recall I posted a review which showed no real benefit to the core symptoms of ASD by cutting all gluten from patients diet - Celiac has been disproven, but not the gut itself.

You may of course have celiac anyway, so if you feel healthier without gluten, then keep at it. Celiac doesn't cause ASD though - seems more like both are symptoms of some other, deeper autoimmune dysfunction (I'd say ASD is a combo of several other dysfunctioning systems as well, as you mentioned earlier).

Out of curiosity, what's the main benefit of fermentation? I know it increases the nutritional value of a lot of foods - but why is that? Is it because the fermenting bacteria (acidophilus-like?) breaks down toxins and plant-antinutrients?

[Mind_Paralysis]

Btw, here's something new for you ta' chew on: BET-epigenetics!

 

Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice

http://jem.rupress.o...rendmd-shared=1

 

Never heard of these proteins, but apparently the "bromodomain and extraterminal domain–containing proteins" (BETs) are highly epigenetically modulating proteins, which correlate to several of the ASD-implicated genes.

 

So, something to consider, yes? Enhancing BET-epigenetic modulation? Not sure how that's done, but it's bound to be hell'a' powerful stuff - epigenetics ussually are.

 

Perhaps it's possible to find a candidate drug or peptide which upregulates BET? You could then start a potential group buy for that compound.

Edited by Stinkorninjor, 19 August 2016 - 10:03 AM.

[farware]

The relation between celiac and ASD in humans can't be big though, mate - as you recall I posted a review which showed no real benefit to the core symptoms of ASD by cutting all gluten from patients diet - Celiac has been disproven, but not the gut itself.

You may of course have celiac anyway, so if you feel healthier without gluten, then keep at it. Celiac doesn't cause ASD though - seems more like both are symptoms of some other, deeper autoimmune dysfunction (I'd say ASD is a combo of several other dysfunctioning systems as well, as you mentioned earlier).

Out of curiosity, what's the main benefit of fermentation? I know it increases the nutritional value of a lot of foods - but why is that? Is it because the fermenting bacteria (acidophilus-like?) breaks down toxins and plant-antinutrients?

 

Yea its not what I wanted to say, but that leaky gut can cause ASD symptoms and celiac causes IBS and leaky gut. For me it makes sense why certain meds / supps like Stablon can work on both ASD via glutamate receptors and indirectly on IBS etc

[Mind_Paralysis]

Ey btw, I just found a reference that could indicate some interaction between Tianeptine and your resistant starch -diet.

 

Check this out:

Tianeptine, a new tricyclic antidepressant metabolized by beta-oxidation of its heptanoic side chain, inhibits the mitochondrial oxidation of medium and short chain fatty acids in mice.

http://www.ncbi.nlm..../pubmed/2597170

 

Microvesicular steatosis, however, requires very large doses in mice (0.75 mmol/kg i.p., i.e. 600-times the oral dose in humans), and is therefore unlikely to occur in humans.

 

 

Steatosis means liver damage, right? Fatty liver. Seems like it will pretty much never happen in humans though. But I am curious if the last paragraph truly clears Tianepine of any suspicions of interfering with SCFA-metabolism?

What do you think? Is there a possibility that Tianeptine could make you MORE TIRED, inhibit your energy-uptake, if you eat mostly resistant starch?

Edited by Stinkorninjor, 21 August 2016 - 04:17 PM.

[farware]

Just a quick update. I think this may be interesting for people with early onset schizophrenia: 

https://www.psycholo...d-schizophrenia

 

Apparently you can prevent acute outbreak by going gluten-free in some rare cases. When I lost my gallblader I lost my detox organ so that would explain why it took so long for celiac to show symptoms. 

 

In one such study, approximately 10% of schizophrenic patients had improvement in their symptoms by elimination of dietary gluten

http://nutritionandm.../1743-7075-6-10

 

When I look at the list of negative symptoms I definitely fit some of them but none of the cognitive symptoms. Could be that by going going gluten-free you can prevent further progression. Glyphosate may be implicated - would be interesting to see how many foods in Canada are sprayed with Roundup (popular herbicide) since Canada is one country with the highest incident rate. 

 

I also believe to have found a way to diagnose Celiac disease without invasive procedures. 

 

[farware]

 

New Research Confirms Gliadin-Schizophrenia Link

The latest study to confirm the gluten-schizophrenia link was published this month in the World Journal of Biological Psychiatry and titled, "Elevated gliadin antibody levels in individuals with schizophrenia." Researchers compared the blood work of 950 schizophrenics with 1,000 healthy controls. They discovered that the odds ratio of having anti-gliadin IgG antibodies was 2.13 times higher in schizophrenics, indicating that t the least schizophrenics are more likely to experience an adverse immune response to wheat proteins.

http://www.greenmedi...s-schizophrenia

 

[Mind_Paralysis]

 

New Research Confirms Gliadin-Schizophrenia Link

The latest study to confirm the gluten-schizophrenia link was published this month in the World Journal of Biological Psychiatry and titled, "Elevated gliadin antibody levels in individuals with schizophrenia." Researchers compared the blood work of 950 schizophrenics with 1,000 healthy controls. They discovered that the odds ratio of having anti-gliadin IgG antibodies was 2.13 times higher in schizophrenics, indicating that t the least schizophrenics are more likely to experience an adverse immune response to wheat proteins.

http://www.greenmedi...s-schizophrenia

 

 

An interesting find, certainly.

 

But you don't have Schizophrenia, yes? Although there are some similarities, Autism is just as distinctly different from Schiz as it is from ADHD.

 

I'm thinking what this recent find would lead more to wouldn't be that eliminating gluten gets rid of the problems, more that they would perhaps alter or aleviate them slightly - because as I understand it, there are signs of Schizophrenia in societies which eat far less gluten than us westerners - for instance, India and Africa. It just appears as if the sympoms have a different quality to them - for instance, in societies wherein the belief in spirits is great, the Schizo's are not as much of cast-outs as in western society, and this might then explain why African schizo's have more positive voices - they instead tell them jokes or try to give them relationship-advice et c.

 

I believe the current evolutionary hypothesis is that shaman's and the like were all schizophrenics, and these traits where then allowed to survive as they served a purpose in religion, which unifies a tribe and gives answers to things which at the time, were impossible to answer.

 

 

Reason I think this is because recent genetic studies has actually proved a very important facet of the disease - synaptic pruning. If you've got Schiz, then Dihexa might turn out to be the ultimate wonder-drug.

 

Synaptic pruning is an interesting symptom pathology which both Schiz and Autism share, but with a distinctly different quality - schiz is a progressive disease, related to greater and greater loss of white matter, while Autism is mostly static - you have the symptoms which you are born with, and that's it. To some extent, certain social skills and symptoms can even be improved through mental exercise such as social training, given enough time.

 

With Schiz it's the other way around - it's nowhere but down into the rabbit-hole - which actually lends some credence to the evolutionary theory - in the stone-age, the mean average life-span was only something like 35 years old...! That's not that far away from the breakout of most Schiz - meaning that the symptoms may not always have become as exacerbated as in todays modern society - they didn't eat gluten and they didn't live long enough to become truly impaired.

 

Btw, how's the resistant starch challenge going? Everything cool?

Edited by Stinkorninjor, 04 September 2016 - 11:25 AM.

[jack black]

 

I also believe to have found a way to diagnose Celiac disease without invasive procedures. 

 

Please don't keep us hanging in suspense.

 

[farware]

 

 

I also believe to have found a way to diagnose Celiac disease without invasive procedures. 

 

Please don't keep us hanging in suspense.

 

 

 

I would need someone that has just been diagnosed and is possibly still eating gluten because the test wont work when you've been on a gluten-free diet for some time in order to verify my findings. Without verification its pretty useless. 

 

But if its reproducable and fits 90% of all cases do you think someone would publish that in a magazine so we can get this info out there? I really hate the idea of invasive procedures when there are better ways. 

[gamesguru]

What.. you just do an IgA test, or take note of digestive problems, mood, and energy levels?  Or what am I missing?

[farware]

What.. you just do an IgA test, or take note of digestive problems, mood, and energy levels?  Or what am I missing?

 

No, you look at the stool sample and what kind of species you find there. Depending on certain levels I can tell you whether you have celiac - at least thats my theory. Then backed with a gene test looking at some SNPs I can up the odds to 95-100% 

 

I am pretty sure too but I will probably create a survey and pay a couple people to take it to complete this research. Its useless without verification. 

 

So for me its great, Im now on a 100% gluten free diet. I now understand the link between Asperger and Celiac a lot better

 

 

Interestingly, the first description of Asperger syndrome was made by Hans Asperger, in 1961, and he was actually describing the behaviors of a group of 12 celiac children who he perceived as being excessively introverted, fearful of people, moody and unable to enjoy human interaction. These same children became friendly, flexible and independent thinkers after 2 years gluten-free.

http://www.beyondcel...ebinarfinal.pdf

 

A lot of Asperger cases have celiac but celiac is not causing autism, its just causing social behavior that mirrors that of autism. As discussed, autism is probably causing a defect in intestinal villi from birth. Celiac causes damage to villi over time and then affects your brain, gut, liver, etc. Thats also the reason why Tianeptine works so well for me personally because it modulates glutamate receptors and creates a balance in the brain.  

 

So with that knowledge I now know that I have celiac disease and its rather unlikely that I have Aspergers ... When you live with celiac for many year it starts to affect other organs and it has (thyroid age 18). 

 

Im just wondering how all this relates to schizophrenia. We know that autism is basically a subtype of schizophrenia. I have all the genes for schizophrenia and celiac, why then did I not get schizophrenia? 

 

there's a funny thing about schizophrenia, turns out that quite a few of the adultschizophrenics on an inpatient psychiatric unit in 1967 happened to have a major history of celiac disease (gluten/wheat intolerance) as children. As in 50-100 times the amount of celiac disease that one would expect by chance

 

 

In A Case Report of the Resolution of Schizophrenic Symptoms on a Ketogenic Diet, a high fat, low carb, low protein diet (thus very low in wheat) results in the remission of psychotic symptoms in a single case report.

http://nutritionandm.../1743-7075-6-10

 

Same principle: Some ppl with schizophrenia do well on a gluten-free diet, even going into remissions, some dont. Some with Asperger can go into remission, some wont. 

 

What is the missing link here? 

 

There is only one thing that can cause this explosion in ADHD, autism cases that we have witnessed and that is how we process foods. 

 

http://farmwars.info/?p=11700

 

I believe there is a good chance that certain chemicals accumulate in the gut and brain. Thanks to damaged villi they get absorbed and enter the bloodstream and cause havoc. 

Edited by farware, 08 September 2016 - 01:54 AM.

[jack black]

I generally agree with you, but you should use proper terminology. Celiac disease is not common in ASD. Gluten sensitivity is:
https://www.autismsp...reactivity-real

BTW what's your HLA-DQ status in 23andMe?

Not that it matters much: http://www.medscape....warticle/807390

But the HLA-DQ8 is present in my whole family.

Edited by jack black, 08 September 2016 - 01:12 PM.

[farware]

I generally agree with you, but you should use proper terminology. Celiac disease is not common in ASD. Gluten sensitivity is:
https://www.autismsp...reactivity-real

BTW what's your HLA-DQ status in 23andMe?

Not that it matters much: http://www.medscape....warticle/807390

But the HLA-DQ8 is present in my whole family.

 

No that was my point, not only gluten sensitivity seems to occur in ASD but also celiac. However this is mostly true for a subtype of ASD previously called Asperger. This new classification doesnt make so much sense when talking about this its only good for diagnosis. Anyway, most high-functioning autism cases seem to also have celiac. 

 

However I couldnt find any studies on how common it is, so maybe common is the wrong word. 

[farware]

In regards to DQ2 - its either DQ2 or DQ8 according to this http://www.ncbi.nlm....pubmed/11922565 - Wondering how they apply genoset IDs - what does the .2 stand for? 

 

Yes I have DQ2

 

gs221

Autoimmune disorder risk in Europeans This genoset tags the DQ2.2 haplotype in Europeans, and thus increased risk gluten intolerance and for autoimmune disorders such as celiac disease.

 

But this SNP is more relevant

 

rs3184504 is a nonsynonymous SNP in the SH2B3 gene, and it is also known as R262W. In a recent (2008) study of non-HLA SNP associations of 1600+ celiac disease patients, this SNP was considered one of the most significan

Edited by farware, 08 September 2016 - 04:34 PM.