142 replies to this topic

[jack black]

In regards to DQ2 - its either DQ2 or DQ8 according to this http://www.ncbi.nlm....pubmed/11922565 - Wondering how they apply genoset IDs - what does the .2 stand for? 

 

 

 

 

The relationship of DQ2 and coeliac disease, however, is complex because there are multiple DQ2 isoforms. The DQ α⁵β² (DQ2.5) isoform is strongly associated with CD.

 

https://en.wikipedia.org/wiki/HLA-DQ2

[farware]

Thanks.

 

DQ2.2 (me): 

 

A small percentage of coeliac disease are associated with this haplotype, and some disease causing gliadins are presented by DQ2.2.

 

 

 

• Schizophrenia Research, 2010: Individual with schizophrenia have a novel immune response to gliadin distinct from those with celiac disease (i.e. absence of antibodies to the transglutaminase enzyme and the HLA-DQ2/DQ8 genetic locus of susceptibility.[v]

 

See the link between autism, schizophrenia and celiac? The link is gliadin.

 

DQ2 is most common in Western Europe, North Africa and East Africa. Highest frequencies are observed in parts of Spain and Ireland;

 

So it is both evolutionary + a modern disease due to wheat being used in every product. Interesting that schizophrenics do not seem to have antibodies to transglutaminase.

 

I still believe autism and schizophrenia should be re-classified as an auto-immune diseases and not as brain disorders because clearly there is a link to auto-immunity. Instead of attacking the intestines, anti-gliadin antibodies may be attacking the central nervous system and that's what changes the physiology of affected people. 

 

This also explains why SCZ patients would react so well to L-Lysine, because it directly works on the nervous system:

http://www.ncbi.nlm....les/PMC3094237/

 

Not sure if I mentioned this in the thread but Lysine is very useful for celiac too. At least it worked wonders for me at times and really helps to calm the nervous system. 

 

 

 

 

 

 

 

Edited by farware, 08 September 2016 - 06:57 PM.

[farware]

Many times people that were diagnosed as bipolar or manic depressive or whatever seem to simply be celiace (of course that will only be a small percentage but that small percentage could be thousands of people out there). Because diagnosis is so unreliable thanks to colonscopy being a completely unreliable tool I bet many people will never get a proper diagnosis and continue to ingest wheat. And even when they do, they dont realize that wheat is everywhere and its just astounding in what kind of products you will find wheat. 

 

It's far more reliable to look at your genes + stool sample to diagnose celiac. So I am currently writing a book about all of this and will hopefully be able to come up with some funds to research this properly. I may not have the scientific background but I can see that this research would be valuable to a lot of people and no one seems to be doing it, so I'll just do it. Maybe I can confirm my findings, maybe not. 

Edited by farware, 08 September 2016 - 07:06 PM.

[Mind_Paralysis]

 

I generally agree with you, but you should use proper terminology. Celiac disease is not common in ASD. Gluten sensitivity is:
https://www.autismsp...reactivity-real

BTW what's your HLA-DQ status in 23andMe?

Not that it matters much: http://www.medscape....warticle/807390

But the HLA-DQ8 is present in my whole family.

 

No that was my point, not only gluten sensitivity seems to occur in ASD but also celiac. However this is mostly true for a subtype of ASD previously called Asperger. This new classification doesn't make so much sense when talking about this its only good for diagnosis. Anyway, most high-functioning autism cases seem to also have celiac. 

 

However I couldnt find any studies on how common it is, so maybe common is the wrong word. 

 

 

Wait, wait, wait... You've been building your case fairly well, but I'm still not sure how your findings can co-exist with this recent meta-study which I posted?

 

Gluten-free and casein-free diets in the treatment of autism spectrum disorders: A systematic review

http://www.sciencedi...750946709001111

Notice that it says disorder(S) - so the study most likely included several variants of the disease. (i.e patients with different amounts of points on the ASD-scale)

 

If removing gluten doesn't help symptoms, then why would the Celiac-disease or gluten-sensitivity found in ASD-patients be connected to the actual Autism?

 

 

Isn't it more probable that it's merely a small subset of ASD-sufferers which have gluten-sensitivity as a core mechanism in their pathology? Because of the study I posted above, I actually think this is the case - it would mean you are both right and wrong at the same time.

 

An autoimmune-disorder may well be the core mechanism for many types of ASD, but said Auto-immune disorder then varies - this would then explain why so few people would see any benefit from gluten-free diet - their immune systems are misreacting to OTHER irritants.

 

Now, that may of course not be something you need to, or want to, look further into - because if Celiac or Gluten-sensitivity is the mechanism which is important for you, then you're good, set to go.

 

It is something which other people need to take into account though:

 

What other common auto-immune problems have been recorded in ASD-sufferers?

[farware]

A subset of children with autism displays increased immune reactivity to gluten, the mechanism of which appears to be distinct from that in celiac disease. The increased anti-gliadin antibody response and its association with GI symptoms points to a potential mechanism involving immunologic and/or intestinal permeability abnormalities in affected children.

http://www.ncbi.nlm....les/PMC3688832/

 

IMO: 

Autism closer to celiac than SCZ. SCZ seems all about CNS and the brain, wheras autism and celiac is all about the gut. So SCZ is closer to a brain disease than the other two from what Ive read so far. 

 

So with autism you have gene defects that damage the villi regardless of whether you ingest wheat or not but wheat obviously damages them even more. With SCZ you have the body attacking the CNS and brain directly not just indirectly via the gut. 

 

The scans showed that people at their first episode had less brain tissue than healthy individuals. The findings suggest that those who have schizophrenia are being affected by something before they show outward signs of the disease.https://now.uiowa.ed...a-affects-brain

 

 

So could the own body attack the brain and induce psychosis that way?

 

Bacterium can reverse autism-like behaviour in mice

http://www.nature.co...in-mice-1.14308

 

 

Edited by farware, 08 September 2016 - 07:22 PM.

[jack black]

Bacterium can reverse autism-like behaviour in mice

http://www.nature.co...in-mice-1.14308

 

 

This is one cool discovery. This could be a breakthrough indeed.

 

Now, about the gluten vs ASD, I'm with Stinkorninjor, association is not causation. What if ASD have leaky guts that causes the anti-gliadin antibody response? Those anti-gliadin antibodies tend to be IgG rather than IgA (more typical for celiac disease).  The abnormal gut flora hypothesis is very compelling to me.

 

There is some recent and very convincing support too: https://www.scienced...60616140723.htm

 

Could it as simple as one capsule of probiotic a day? Not quite.

 

 

“Remarkably, treatment with L. reuteri significantly improved sociability and preference for social novelty in MHFD offspring,” the researchers concluded.

[...]

However, adding L. reuteri did not treat anxiety and repetitive behaviors in the affected offspring, meaning that such bacterial “reconstitution” could be helpful in treating social disorders associated with autism, but not other behavioral ones.

 

Edited by jack black, 08 September 2016 - 11:09 PM.

[farware]

 

Bacterium can reverse autism-like behaviour in mice

http://www.nature.co...in-mice-1.14308

 

 

This is one cool discovery. This could be a breakthrough indeed.

 

Now, about the gluten vs ASD, I'm with Stinkorninjor, association is not causation. What if ASD have leaky guts that causes the anti-gliadin antibody response? Those anti-gliadin antibodies tend to be IgG rather than IgA (more typical for celiac disease).  The abnormal gut flora hypothesis is very compelling to me.

 

There is some recent and very convincing support too: https://www.scienced...60616140723.htm

 

Could it as simple as one capsule of probiotic a day? Not quite.

 

 

“Remarkably, treatment with L. reuteri significantly improved sociability and preference for social novelty in MHFD offspring,” the researchers concluded.

[...]

However, adding L. reuteri did not treat anxiety and repetitive behaviors in the affected offspring, meaning that such bacterial “reconstitution” could be helpful in treating social disorders associated with autism, but not other behavioral ones.

 

 

Do you have a source for that (IgA being more typical for celiac)?

 

As it happens my blood test was negative for both IgA and igG but my stool sample was positive for very low IgA - another indicator of celiac 

 

Also I think we are talking about the same thing, as I mentioned I believe that people with ASD simply have an inherited gene that causes leaky gut they cant do much about and thats why the social and behavioral issues in ASD and celiac both mirror each other because they both stem from the fact that the villi are damaged. Celiacs can do something about it and can fully recover. 

 

As it happens I also read a similar article and started taking L. Reuteri - from day one it started improving my symptoms. Still a long road to full recovery but L. Reuteri + No Gluten Diet + Tianeptine + Other support I listed previously (hormones, methylation, detox, serotonin) is working well for me so far. 

 

My real argument was that many cases get mis-diagnosed due to poor diagnostics. E.g. Celiac can be misdiagnosed as Asperger or Schizophrenia. Those patients could fully recover on a gluten-free diet. 

 

What is interesting to figure out what could be causing the immune system to attack the brain directly? There must be other chemicals in play that were introduced after world war 2 and simply were never replaced. At least thats my take on things. 

Edited by farware, 09 September 2016 - 02:53 AM.

[farware]

Just a quick update on supplements that I found noteworthy. As you may know ASD patients often lack B6. P5P however is needed to make taurine. 

 

Taurine is needed for proper visual function and vision seems impaired in ASD.

 

http://bodyecology.c..._in_taurine.php

 

Taurine is also an excellent longevity supplement.

 

Taurine promotes cardiovascular health, insulin sensitivity, electrolyte balance, hearing function, and immune modulation.

http://www.lifeexten...taurine/page-01

 

 

What I find noteworthy is that it is an immune-modulator. A lot of supps either lower the immune system too much or make it too aggressive (then you deal with food sensitives, chemical sensitivies etc). Taurine seems perfect as an addon supp for ASD, Celiacs - especially since it can prevent heart attacks (has to do with the liver support and lowering LDL oxidation if I remember correctly)

 

I always keep removing it from my stack but it definitely has its place in a perma-stack. Its cheap and works. I dont have to mention it can cure ADHD like no other supp once you have addressed methylation issues. 

 

So for visual + hearing support (both impaired in ASD + Celiac) this is perfect. 

 

 

 

 

 

 

 

 

Edited by farware, 09 September 2016 - 04:03 AM.

[jack black]

So could the own body attack the brain and induce psychosis that way?

 

 

The answer is: YES.

 

 

References

1. ↵
   1. Davison K

   . Autoimmunity in psychiatry. Br J Psychiatry 2012; 200: 353–5.

   Abstract/FREE Full Text
2. 1. Chen SJ,
   2. Chao YL,
   3. Chen CY,
   4. Chang CM,
   5. Wu ECH,
   6. Wu CS,
   7. et al

   . Prevalence of autoimmune diseases in in-patients with schizophrenia: nationwide population-based study. Br J Psychiatry 2012; 200: 374–80.

   Abstract/FREE Full Text
3. ↵
   1. Nicholson TRJ,
   2. Ferdinando S,
   3. Krishnaiah RB,
   4. Anhoury S,
   5. Lennox BR,
   6. Mataix-Cols D,
   7. et al

   . Prevalence of anti-basal ganglia antibodies in adult obsessive-compulsive disorder: cross-sectional study. Br J Psychiatry 2012; 200: 381–6.

   Abstract/FREE Full Text
4. ↵
   1. Dalmau J,
   2. Tüzün E,
   3. Wu HY,
   4. Masjuan J,
   5. Rossi JE,
   6. Voloschin A,
   7. et al

   . Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol 2007; 61: 25–36.

   CrossRefMedlineWeb of Science
5. ↵
   1. Wandinger KP,
   2. Saschenbrecker S,
   3. Stoecker W,
   4. Dalmau J

   . Anti-NMDA-receptor encephalitis: a severe, multistage, treatable disorder presenting with psychosis. J Neuroimmunol 2011; 231: 86–91.

   CrossRefMedlineWeb of Science

[Mind_Paralysis]

 

A subset of children with autism displays increased immune reactivity to gluten, the mechanism of which appears to be distinct from that in celiac disease. The increased anti-gliadin antibody response and its association with GI symptoms points to a potential mechanism involving immunologic and/or intestinal permeability abnormalities in affected children.

http://www.ncbi.nlm....les/PMC3688832/

 

IMO: 

Autism closer to celiac than SCZ. SCZ seems all about CNS and the brain, wheras autism and celiac is all about the gut. So SCZ is closer to a brain disease than the other two from what Ive read so far. 

 

So with autism you have gene defects that damage the villi regardless of whether you ingest wheat or not but wheat obviously damages them even more. With SCZ you have the body attacking the CNS and brain directly not just indirectly via the gut. 

 

The scans showed that people at their first episode had less brain tissue than healthy individuals. The findings suggest that those who have schizophrenia are being affected by something before they show outward signs of the disease.https://now.uiowa.ed...a-affects-brain

 

 

So could the own body attack the brain and induce psychosis that way?

 

Bacterium can reverse autism-like behaviour in mice

http://www.nature.co...in-mice-1.14308

 

 

Yes, the newest research imply that SCZ have hyper-production of Kynurenic Acid, which is an NMDA-antagonist, which may be the source of the positive symptoms. The negative symptoms are connected to mGlur2-3 alterations in the PFC.

 

Meanwhile, even newer genetic data shows that they have several genes related to synaptic pruning in hyper-expression mode! In essence, SCZ is, just like was theorized around 70 years ago, a form of dementia - excessive pruning which shreds synapses, hence the loss of brain-matter - possibly related to the glutamate-issues which has been recorded.

 

Strangely enough, the dementia of Alzheimers may be working in an almost reverse way of the dementia of SCZ... because ALZ can be treated with NMDA-antagonists, while SCZ gets progressively worse with such treatment.
 

[farware]

Great finds you two. Starting to make more sense now. Im still trying to piece together some things on how to protect the brain from attacks and how to promote neurogenesis to heal it and for some reason it keeps leading me back to Vitamin K

 

What research exists shows that vitamin K and particular the K2 MK4 form are capable of protecting brain cells in vitro from certain types of damage that could be connected to many neurological diseases

https://emediahealth...iple-sclerosis/

 

That paper mentions how K2 is involved in the brain’s production of sphingolipids which include sulfatides. Present in high concentrations in brain cell membranes, sphingolipids are now known to possess important cell signaling functions in addition to their structural role

 

[jack black]

i can see how gluten enteropathy can cause vit K deficiency. i was not aware of the brain (nor bone)  connection of the K2 though.

 

now, coming back to the gluten vs autism conundrum, especially as the gluten-free diet didn't work in that one study, it just occurred to me, the study was flawed. the success of diet in autism is reported in Gluten Free/Casein Free: http://www.gfcfdiet....cessstories.htm or Gluten Free/Dairy Free/Sugar Free: http://www.dailymail...-cured-son.html

 

but, i would not be surprised if autism had several causes and the bad bacteria/leaky gut was just one of them.

 

BTW, i started taking home made kefir with L. reuteri and not having any major breakthroughs yet. sadly it's milk based, so not casein free.

Edited by jack black, 25 September 2016 - 02:27 AM.

[Mind_Paralysis]

i can see how gluten enteropathy can cause vit K deficiency. i was not aware of the brain (nor bone)  connection of the K2 though.

 

now, coming back to the gluten vs autism conundrum, especially as the gluten-free diet didn't work in that one study, it just occurred to me, the study was flawed. the success of diet in autism is reported in Gluten Free/Casein Free: http://www.gfcfdiet....cessstories.htm or Gluten Free/Dairy Free/Sugar Free: http://www.dailymail...-cured-son.html

 

but, i would not be surprised if autism had several causes and the bad bacteria/leaky gut was just one of them.

 

BTW, i started taking home made kefir with L. reuteri and not having any major breakthroughs yet. sadly it's milk based, so not casein free.

 

But what I posted was a systematic review, not a single study - no results, or to be accurate no verifiable and consistent results. Now, that may be caused by the reviewed studies simply being rubbishly made, which may explain the results of the review, so perhaps there's still some merit to the idea.

 

What I would vaguer, and guess, is that these dietary interventions are simply effective for a very small subset of Autistic children.

 

It should also be recalled, that the vast majority of celiac-sufferers do not display anywhere near enough behavioural alterations from their diet, that the symptoms can be likened to Aspergers Syndrome, or other, more disabling autistic disorders.
 

Most just feel pain and diarrhoea.

 

 

And the original idea behind cassein-free and gluten-free diets was that similar behavioural symptoms have been recorded among opiate-abusers - i.e social difficulties and stereotypical behaviour - hence, by using reverse-engineering from schizophrenic theoring, (it's been known for AGES that NMDA-antagonists can cause psychosis and schiz-like behaviour, even the brain-fog is similar to negative symptoms) the theory went that perhaps Autists have an overload of endogenous opioids, causing permanent alterations to behaviour.

 

The gut-problems was then found to be a recurring commorbidity with Autism, hence some started wondering if perhaps these hypothetical endogenous opioids were entering the Autists through diet.

 

The search then went for finding potential dietary sources of opioid-like substances, and dairy and gluten-containing plants were found to be the most potent sources. (they both also, incidentally, taste DANGEROUSLY good! Holy sh*t, I got milk! ^^ And buns! Cinnamon-buns are droool... so many active substances! )

 

However, while this research was going on, the original idea of endogenous opioids were found to be failed: no exagerated amount of opioids or metabolites were found in Autist pheces and urine.

 

 

Now, there are a few possibilities to take into account here:

 

Opiod-receptor mutations - like ADHD have mutations in faulty D-receptors, Schiz in mGlur and so on, then perhaps the problem for Autism ISN'T over-production: It's super-sensitivity to opioids!

 

This could explain why they don't have more metabolites or higher serum-levels: they don't need to, to get the behavioural issues.

 

However, since the proof of these diets aren't yet set in stone, we shouldn't get hung up on that: after all, there are more than one opioid-type receptor in the body, these compounds may not all be selective to the same ones!

 

Meaning, you could have hyper-sensitivity to Sigma-agonists, but if Gluten and Cassein are only selective for Delta, then there's no point in excluding them. It won't change sh*t.

 

Maybe it turns out corn-starch has Sigma-agonists, so while excluding Gluten you're eating a giant heaping of corn STILL... well, then your symptoms won't change worth a damn.

 

 

SO... returning to this:

 

1. What other Auto-immune-disorders are common among Autists? What other auto-immune disorders, other then the gut, has a WIDE systemic effect?

 

2. What other substances are there, than Gluten and Cassein which contain opiate-like substances?

 

3. Have opiate-antagonists, SELECTIVE ones, been trialed for the treatment of Autism? Are there other options than Naltrexone?

 

4. Is there genetic data on opiate-receptors, transporters and the like? Does anyone with Autism, to ANY extent, have any unusual mutations in these genes?

[jack black]

First, there is more to the celiac than diarrhea. depression is also common in addition to neurological problems. You could argue that low vitamines due to malabsorption may play a role.

Second, maybe the value of those diets is the ketogenic state and/or better vitamines absorption?

It's possible that people with autism have congenital predispositions and bad diet in utero or early childhood triggers the disease.

[farware]

Sorry not much time lately to write much, but here's the progress I made. I'm now on a completely gluten-free diet. After introducing L.Reuteri my problems became a little worse at first, but I expected some setbacks. I intend to order some noopept, because I believe I may have some mild form of arthritis or a strange inflammatory reaction in my legs which is somewhat of a comorbid symptom of celiac. Here's the study why a nootropic may help: https://www.ncbi.nlm...ubmed/12109295 

 

My celiac-related depression is mostly caused by low PEA which I can fix by drinking raw cacao so thats a great help to fix my serotonin processing. I also take 5HTP occasionally to boost that entire process. It simply makes me feel like everything is going to be ok  

 

5HTP -> NADH + [B6 -> P5P]  -> Serotonin  

 

I have a gene defect that causes inefficient B6 conversion into P5P so I am supplementing directly. This is also less toxic because it doesnt enter the brain. 

 

So all in all I'm making progress. I am thinking about starting to travel again. I'm happier and the PEA allows me to explore new concepts in certain areas (my obsession at the moment is mostly new technology that will reshape civilization and investments). 

 

It's still going to be a long road to recovery I'm afraid :( 

 

At least I found a good replacement for milk: Almond or rice-milk. 

 

Related links on longecity:

 

http://www.longecity...ootropic/page-5

 

• Noopept stimulates the expression of NGF and BDNF in rat hippocampus:
  http://www.ncbi.nlm....pubmed/19240853
• Neuroplasticity - exercise-induced response of peripheral brain-derived neurotrophic factor:
  http://www.ncbi.nlm....pubmed/20726622
• Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice: http://www.ncbi.nlm....les/PMC1908237/
• Uridine: http://www.longecity...ne-uridine-dha/

 

 

 

[Mind_Paralysis]

 

Sorry not much time lately to write much, but here's the progress I made. I'm now on a completely gluten-free diet. After introducing L.Reuteri my problems became a little worse at first, but I expected some setbacks. I intend to order some noopept, because I believe I may have some mild form of arthritis or a strange inflammatory reaction in my legs which is somewhat of a comorbid symptom of celiac. Here's the study why a nootropic may help: https://www.ncbi.nlm...ubmed/12109295 

 

My celiac-related depression is mostly caused by low PEA which I can fix by drinking raw cacao so thats a great help to fix my serotonin processing. I also take 5HTP occasionally to boost that entire process. It simply makes me feel like everything is going to be ok

 

5HTP -> NADH + [B6 -> P5P]  -> Serotonin  

 

I have a gene defect that causes inefficient B6 conversion into P5P so I am supplementing directly. This is also less toxic because it doesnt enter the brain. 

 

So all in all I'm making progress. I am thinking about starting to travel again. I'm happier and the PEA allows me to explore new concepts in certain areas (my obsession at the moment is mostly new technology that will reshape civilization and investments). 

 

It's still going to be a long road to recovery I'm afraid :( 

 

At least I found a good replacement for milk: Almond or rice-milk. 

 

Related links on longecity:

 

http://www.longecity...ootropic/page-5

 

• Noopept stimulates the expression of NGF and BDNF in rat hippocampus:
  http://www.ncbi.nlm....pubmed/19240853
• Neuroplasticity - exercise-induced response of peripheral brain-derived neurotrophic factor:
  http://www.ncbi.nlm....pubmed/20726622
• Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice: http://www.ncbi.nlm....les/PMC1908237/
• Uridine: http://www.longecity...ne-uridine-dha/

 

 

Eyy, some great references! = )

 

I'm a bit curious though, why would L. Reuteri worsen your symptoms? I thought you took it as a supplement because it's an important bacteria in the colon?

 

None the less, I am VERY glad to hear that you are feeling better! : D

 

I'm feeling better as well btw - NSI-189 really seems to be doing something with my Hippocampus...! It's a bit up and down, a bit rocky, but overall, I can see an improvement in cognition and function.

[YOLF]

Been skimming this topic for mention of an antidepressant that I thought I saw that improves motivation through inhibition of a particular serotonin receptor (iirc)?  If I skipped it, I'd appreciate someone reminding me what the MoA was. But I'll drop my experience with celiacs disease recovery too.

 

Psyllium, ginger, and Bioperine - work in combination... if you're still experiencing gut problems, this can help with nutrient absorption and will keep your body from throwing the baby out with the bathwater. 

 

I had very severe chest pains when taking a vitamin K1 and K2 complex as a celiac (it would happen after a few days to a few weeks of taking it continuously), but hasn't happened since removing gluten.

 

I also found that I was running a deficit of lots of minerals and switching to unfiltered water helped alot as well as taking boron, molybdenum, Mg/Ca, and Zn/Cu. Getting more iron is important too after any incidence of gluten poisoning.

 

Royal Jelly, pregnenolone, DHEA, and T boosting supplements helped alot as did perhaps tocotrienols.

 

An overkill probiotic is also wonderful. Get one with as much of everything possible in it.

Edited by YOLF, 08 October 2016 - 06:21 AM.

[jack black]

Been skimming this topic for mention of an antidepressant that I thought I saw that improves motivation through inhibition of a particular serotonin receptor (iirc)? If I skipped it, I'd appreciate someone reminding me.

Inositol and 5HT2a?
Not sure of the motivation part.

Edited by jack black, 08 October 2016 - 01:52 PM.

[farware]

Been skimming this topic for mention of an antidepressant that I thought I saw that improves motivation through inhibition of a particular serotonin receptor (iirc)?  If I skipped it, I'd appreciate someone reminding me what the MoA was. But I'll drop my experience with celiacs disease recovery too.

 

Psyllium, ginger, and Bioperine - work in combination... if you're still experiencing gut problems, this can help with nutrient absorption and will keep your body from throwing the baby out with the bathwater. 

 

I had very severe chest pains when taking a vitamin K1 and K2 complex as a celiac (it would happen after a few days to a few weeks of taking it continuously), but hasn't happened since removing gluten.

 

I also found that I was running a deficit of lots of minerals and switching to unfiltered water helped alot as well as taking boron, molybdenum, Mg/Ca, and Zn/Cu. Getting more iron is important too after any incidence of gluten poisoning.

 

Royal Jelly, pregnenolone, DHEA, and T boosting supplements helped alot as did perhaps tocotrienols.

 

An overkill probiotic is also wonderful. Get one with as much of everything possible in it.

 

Not sure which one you are looking for, if I remember anything I'll post it later

 

Thanks for the recommendations. I don't really understand the chest pains, because celiacs are often deficient in K1/K2 and it's supposed to help with blood clotting and prevent heart disease. Chest pain is to me a warning sign, maybe do some research on possible causes how vitamin K could cause this and depending on age talk to a doc. Personally the pain I used to deal with is around the lymph nodes. It seems like chest/heart pain at first but then I realized it's the lymph node working too hard.

 

Mg/Ca balance

 

The things you mentioned I am currently taking as well: Ginger, Pregnenolone, DHEA, Zn/Cu, Mg/Ca and a bunch of others ... I noticed it's very easy to get these out of balance, e.g. take too much calcium or too much magnesium and that would either result in constipation or the opposite and the same is true for other as well like Zn/Cu. Interesting that you switched to unfiltered water, definitely a good idea because water contains so many minerals 

 

The most problematic for me currently is finding a balance for iron. Mg/Ca is easy: Epsom salts + Calcium-D3-Vitk pills 

 

DMAE 

 

Anyway, I'm doing much better now but I still have some down days due to messed up NT's. When that happens I usually take 100mg of DMAE, drink some raw cacao - basically what this does is boost all NT's (Dopa+Sero in particular) and cacao acts like a MAOA. Basically that way you have a lot of circulating NTs. I read some threads on longecity where the op warns about longterm use but the findings were based on rat studies and not very meaningful. DMAE is neuroprotective and well tolerated. I'd be WAY more careful with 5HTP because that only boosts Serotonin but depletes Dopamine, whereas DMAE boosts all NT's, which is basically what I need to be fine and get in a flow state. 

 

Sum up: 

• Proper mineral intake  
• Proper NTs precursors
• Proper methylation (b12, folate, b6=>p5p)
• Diet high in choline (fish, rice) and 100% gluten-free. Protein in the morning, little food in the evening
• More sunlight / moving
• Good to know: Raw cacao is MAOA(=keep NTs circulating for longer), Red grape juice with Iron is easily absorbed by the body. P5P is needed for proper 5HTP -> Serotonin processing
• Osteoporosis prevention: Calcium+K1/K2 
• Too much Serotonin: Can result in heart disease / heart valve disease

 

On Celiac: 

 

Imo celiac should get new screening tools. It is likely that many cases go undiagnosed because they lack IgA antibodies and even a colonscopy is not 100%. The most common symptoms: Acne (skin detox), depression, thyroid disorder, shifting constipation/diarrhea, food sensitivies, fatigue, ADHD, thin body, auto-immunity, discolored teeth. 

 

I hope this helps to clear some things up for people wondering whether they have celiac, strong gluten sensitivy or Asperger which can be easily misdiagnosed. I also found several genes that may result in autism-like behavior, will have to look them up again

[Mind_Paralysis]

Been skimming this topic for mention of an antidepressant that I thought I saw that improves motivation through inhibition of a particular serotonin receptor (iirc)?  If I skipped it, I'd appreciate someone reminding me what the MoA was. But I'll drop my experience with celiacs disease recovery too.

 

Psyllium, ginger, and Bioperine - work in combination... if you're still experiencing gut problems, this can help with nutrient absorption and will keep your body from throwing the baby out with the bathwater. 

 

I had very severe chest pains when taking a vitamin K1 and K2 complex as a celiac (it would happen after a few days to a few weeks of taking it continuously), but hasn't happened since removing gluten.

 

I also found that I was running a deficit of lots of minerals and switching to unfiltered water helped alot as well as taking boron, molybdenum, Mg/Ca, and Zn/Cu. Getting more iron is important too after any incidence of gluten poisoning.

 

Royal Jelly, pregnenolone, DHEA, and T boosting supplements helped alot as did perhaps tocotrienols.

 

An overkill probiotic is also wonderful. Get one with as much of everything possible in it.

 

As far as I know, there can be only one Selective Serotonin Antagonist which improves motivation AND has any kind of potential use in the treatment of Autism...

 

Nearly every Autist alive seems to have some form of circadian disease - an inability to control their circadian rhytm correctly - hence a lot of Melatonin is prescribed.

 

This all sums up one of the weakest antidepressants out there - AGOMELATINE!

 

Through 5ht2c-antagonism it increases dopamine and norepinephrine in the Prefrontal Cortex - hence it has shown potential for ADHD, while also enhancing circadian rhythm through MT-agonism.

 

Similar drugs, or stronger versions of Agomelatine, could show quite a bit potential in many diseases... (bipolar disorder is one - but Ago itself has actually failed efficacy in the treatment of BD-depression - it's too weak.)

 

MORE 5ht2c-antagonism, followed by a bit of 5ht2A-antagonism along with the MT-agonism should do the trick for General Anxiety...! Should improve a hundrefold on many sleep-disorders as well - especially if the drug could do the 5ht2a-antagonism + MT-agonism first, and then slowly ramp up 5ht2c-antagonism during the day! : ) Incredible results could be had, I tell ya'...!

Edited by Stinkorninjor, 08 October 2016 - 11:44 PM.

[farware]

 

 

An overkill probiotic is also wonderful. Get one with as much of everything possible in it.

 

Going through some old posts to figure some stuff out. Since I recently took such a probiotic and had a severe potentially life-threatening reaction (was close to passing out) I would strongly advise everyone to carefully study the strains in your probiotics. Some strains can aggravate inflammation to a really enormous degree (there are some studies on it see below) , that in turn can cause a severe shock reaction where the body attacks the thyroid and/or other organs. Especially if you have some kind of autoimmune disease

 

• https://www.ncbi.nlm.../pubmed/9493081
• https://www.ncbi.nlm...les/PMC3918159/
• https://www.ncbi.nlm...pubmed/21535768

 

L. casei may be what you are looking for and may not cause as much inflammation but you really need to be careful with probiotics, that is not harmless stuff, your entire body is made up of bacteria and as I explained this can result in severe reactions especially if you already suspect Celiac, IBS, Crohns or have an autoimmune disease

 

Again, be very careful with the strains and never take the full dosage 

[YOLF]

 

 

 

An overkill probiotic is also wonderful. Get one with as much of everything possible in it.

 

Going through some old posts to figure some stuff out. Since I recently took such a probiotic and had a severe potentially life-threatening reaction (was close to passing out) I would strongly advise everyone to carefully study the strains in your probiotics. Some strains can aggravate inflammation to a really enormous degree (there are some studies on it see below) , that in turn can cause a severe shock reaction where the body attacks the thyroid and/or other organs. Especially if you have some kind of autoimmune disease

 

• https://www.ncbi.nlm.../pubmed/9493081
• https://www.ncbi.nlm...les/PMC3918159/
• https://www.ncbi.nlm...pubmed/21535768

 

L. casei may be what you are looking for and may not cause as much inflammation but you really need to be careful with probiotics, that is not harmless stuff, your entire body is made up of bacteria and as I explained this can result in severe reactions especially if you already suspect Celiac, IBS, Crohns or have an autoimmune disease

 

Again, be very careful with the strains and never take the full dosage 

 

I hadn't heard anything about that, but heat killed organisms produce different responses than live organisms, even if they die in your gut. I'm sorry to hear you had a reaction. I do see that another dozen strains or so have been commercialized since that statement. I've swallowed as many as five doses twice a day after taking ABX with only beneficial effects of the Swanson 16 strain complex and vitacost 15 strain complex. I'm a celiac w/ non-pharma managed inverse psoriasis. I've also used these to treat gluten sickness when it happens, and have taken them prior to knowing I was a celiac.

[Gediminas Jesinas]

Confusion, attention, memory and attention as well insomnia are also problems in schizophrenia.