Wishing you all Happy Christmas!!
Of course withdrawing from Heroin can't be compared to discontinuing AD's.
Also both terms have a pretty similar meaning.
The problem is that however this syndrome is called, unfortunately it is something i will be facing pretty
soon because i am stopping Wellbutrin and start taking Valdoxan instead due to hair loss issues.
This absolutely sucks because Wellbutrin was the only AD that helped a bit more than all the other AD's.
On the contrary having no hair loss issues in your life and loose 1/3 of your hair in two weeks, is a reason
of becoming depressed even if you are the most happy person in the world.
So staying on it is out of the question.
By the way, i would appreciate it, if anyone could share some information about Valdoxan.
So what about the CERC 501 group buy? Are we close to ordering it from a lab?
Has anyone heard of LDN (Low dose Naltrexone?).
There are people who insist that it really helped them with depression issues.
Ey! I'm wishing you all a happy christmas as well! = D
I agree that the syndrome is troublesome - Dr's should inform patients better about it, and work with them to make a correct tapering-schedule, should they feel the need to go off the Serotonergic drug.
You have nothing to fear going off Wellbutrin (bupropion) though! It doesn't really have Discontinuation-effects - only extremely sensitive patients have ever reported such effects - and they are generally not of the same quality as the Serotonergic drugs. Bupropion is a weak reuptake-inhibitor of Norepinephrine and Dopamine, as well as a weak releasing-agent (it shares properties with both Methylphenidate and amphetamine, as such), however it is mostly a fairly strong nicotinic antagonist.
(it's no doubt the stimulating effects of Bupropion which is )
I've gone off Wellbutrin 300 mg cold turkey a total of... let's see now... 4 times! No problem with any discontinuation.
I've been on Valdoxan (agomelatine) several times as well - it doesn't have discontinuation-effects either. Both Bupropion and Agomelatine are what we would call 'atypical' antidepressants, AD's which doesn't effect serotonin-reuptake at all, or who have poorly understood mechanisms. Agomelatine is alas, a fairly weak antidepressant... however, since you are Bipolar, there may be a better effect on YOU - it enhances circadian rhytms, which are a method of action of both Valproate and Lithium. Agomelatine however, needs to be taken at night - same time every day, or it will disturb your CR and you will end up even worse off than before. (this is especially important for you, since you have a mild form of Bipolar)
Agomelatine (valdoxan) can sometimes be slightly stimulating during the day for some people, because of 5htc-antagonism, which increases dopaminergic and norepinephrinergic activity in the Pre-Frontal Cortex - because of this action, high dosages have been found to have slight effects on ADHD-symptoms. However, for most people, this action is too weak to effect them much, but, for some, this leads to anxiety when the drug wears off.
Now then! I don't know how close we are to getting this rolling... we need at least about 6 more people, I believe, before we can make any synthesis, as that would probably be about enough people to make it cost-effective.
I'm getting better each day, so hopefully I'll be able to help Tolerant out a bit with this, soon. Just need about two months on both NSI-189 and Atomoxetine.
Edited by Stinkorninjor, 25 December 2016 - 01:21 PM.
