4 replies to this topic

[forever healthy]

being APOE3/4 myself i have compiled some research to build a holistic view on the implications of APOE4 for our knowledge base:

 

https://brain.foreve...splay/PUB/APOE4

 

feedback welcome

 

best michael

 

 

[jjnz]

I can't see your papers without a log in but I was reading this the other day, a study from NZ linking apoe4 to health outcomes in a population having amalgam fillings

http://www.ncbi.nlm....pubmed/12897404

Pinch of salt might be required, not sure

[ceridwen]

Although an APOE4 carrier I was found to have normal Mercury levels but I have neurdegeneration.

[laurence]

I found a working link: 

 

https://brain.foreve...isplay/EN/APOE4

 

I'm also 3/4 and this provides a nice summary.

[RWhigham]

TUDCA and ApoE4   The Unexpected Uses of Urso- and Tauroursodeoxycholic Acid in the Treatment of Non-liver Diseases TUDCA improves apolipoprotein E4 (APOE4) macrophage survival and function.  Increased cell death was observed in APOE4 macrophages when stimulated with LPS or oxidized LDL and was due mainly to potentiation of ER stress signaling and JNK phosphorylation. TUDCA attenuated LPS- and oxLDL-induced apoptosis of APOE4 macrophages to levels observed in APOE3 macrophages.