I would like to discuss about the interaction between C60EVOO and NR. Here are two studies that I know so far.
(1)http://www.ncbi.nlm....pubmed/24188530(It seems that, under light exposure, C60 and NADH(NAD+) interact, and then it appears to produce not only singlet oxygen(s) but also superoxide anion(s). This paper was mentioned by Turnbuckle in the http://www.longecity...e-6#entry778950, but it is not clear whether it is liposomal fullerene(lipid soluble fullerene usually dissolved in olive oil).
(2)http://www.ncbi.nlm....pubmed/11082711(This study concerns about the interactions between water soluble C60-PVP and NADH(or NAD+). It appears that this interaction may generate O2-(superoxides), but may also produce other reactive species which are concerning).
Other than personal and subjective experiences posted in the side effects thread, there are some theoretical rationales regarding C60 and NAD+ precursor interactions as above papers(maybe, we don't know its significance).
Even so, don't we already have NADH and NAD+ in our cells that have mitochondria for cellular respiration? Then, everyone who takes C60EVOO without taking NR would have the interactions between C60 and NAD+ anyhow because they already have natural level of NADH (NAD+) in their cells and plasma.
In this situation, taking NAD+ precursors will raise the NAD+ levels. In NR advertisement, 100mg of Nicotinamide Riboside raises about 33% of NAD+ while 300mg of Nicotinamide RIboside raises about 50% of NAD+.
Then, taking NAD+ precursors such as NR would amplify the negative interactions of C60 with NAD+ and its side effects corresponding to NAD+ increments by taken dosages. However, as mentioned, this interaction and side effects already exist even without taking NAD+ precursors.
http://www.ncbi.nlm....pubmed/24360282 As demonstrated in the study, NAD+ declines with age and, if there are significant interaction concerns, would this translate that concurrently taking both C60EVOO and NR will result in lesser and lesser side effects in older individuals? As I know, in Baati's study, rats were given with C60EVOO starting from 20s(in young age) in human age translation, but it still increases the maximum lifespan somewhat by 90%.
Edited by Graviton, 12 July 2016 - 10:17 AM.