4 replies to this topic

[Nate-2004]

This is a thread for all things Honokiol related. Studies, discussion on administration, bioavailability, effects, experiences etc. I'll dig up and extract what I can from other threads as I have time.

 

Three studies of interest, two copied from the NR thread:

 

Honokiol as a topical solution to skin inflammation.

 

http://www.ncbi.nlm....pubmed/23380623

 

Magnolol and honokiol, predominant active compounds in the family Magnoliaceae, are known to exhibit strong anti-inflammatory activities against dermal disorders. We attempted to modify the structures of magnolol and honokiol by methoxylation to optimize the skin delivery ability. Absorption of these permeants into and through the skin was performed at both an infinite dose and saturated solubility. Superoxide anion and elastase released from human neutrophils were the biomarkers used to examine anti-inflammatory potencies of these permeants. The safety of the permeants was evaluated by keratinocyte viability and in vivo bioengineering techniques. Topical magnolol and honokiol at an infinite dose (7.5 mM) showed skin accumulations of 0.22 and 0.16 nmol/mg, respectively. Methoxylation significantly enhanced their skin absorption. Deposition amounts of dimethylmagnolol and dimethylhonokiol were respectively 15- and 7-fold greater than those of magnolol and honokiol. Contrary to the skin accumulation results, the transdermal penetration across skin decreased following methoxylation. No transdermal delivery occurred for dimethylhonokiol. Skin uptake of 4'-O-methylhonokiol was 2-fold higher than that of 2-O-methylhonokiol, although they are isomers. Methoxylated permeants demonstrated selective absorption into follicles, which showed 3-5-fold higher follicular amounts compared to magnolol and honokiol. The relative order of anti-inflammatory activities was honokiol>2-O-methylmagnolol>dimethylhonokiol>magnolol. The other compounds exhibited negligible or negative responses in activated neutrophils. Magnolol and honokiol induced slight but significant keratinocyte cytotoxicity and stratum corneum disruption. Daily administration of methoxylated permeants, especially dimethylhonokiol, produced no skin irritation for up to 7 days. Methoxylated magnolol and honokiol can be efficient and safe candidates for treating inflammatory skin disorders.

 

Comment: What's methoxylation? Is honokiol hydrophilic or lipophilic?

 

Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors.

Song JM1, Anandharaj A1, Upadhyaya P1, Kirtane AR2, Kim JH1,3, Hong KH4, Panyam J1,2, Kassie F1,3.

http://www.ncbi.nlm....pubmed/27458163

 

From Mitochondria to Meditation: An Integrative Approach to Enhancing Cognitive Function

http://www.naturopat...in Function.pdf

Edited by Nate-2004, 11 August 2016 - 08:13 PM.

[Nate-2004]

This post is copied from Bryan_S:

 

SIRT3 regulates progression and development of diseases of aging

Published Online: June 29, 2015

http://dx.doi.org/10...tem.2015.06.001

 

Highlights

• •Acetylation influences almost every major mitochondrial pathway.
• •Mice lacking SIRT3 develop several diseases of aging at an accelerated rate.
• •SIRT3KO mice might be considered a model of accelerated aging.

The mitochondrial sirtuin SIRT3 is a protein deacylase that influences almost every major aspect of mitochondrial biology, including nutrient oxidation, ATP generation, reactive oxygen species (ROS) detoxification, mitochondrial dynamics, and the mitochondrial unfolded protein response (UPR). Interestingly, mice lacking SIRT3 (SIRT3KO), either spontaneously or when crossed with mouse models of disease, develop several diseases of aging at an accelerated pace, such as cancer, metabolic syndrome, cardiovascular disease, and neurodegenerative diseases, and, thus, might be a valuable model of accelerated aging. In this review, we discuss functions of SIRT3 in pathways involved in diseases of aging and how the lack of SIRT3 might accelerate the aging process. We also suggest that further studies on SIRT3 will help uncover important new pathways driving the aging process.

 

Asor google alerts doesn't always keep up with whats going on. It's keyword based and often you need a number of search terms to generate consistent results. The article above was generated off the search term SIRT3 which we know is associated with mitochondrial biology. Here is another link for you, its one of a number of topic aggregator's, this one is from Cell Press.

http://www.cell.com/...-and-metabolism

 

I'm especially interested in what can be done to keep our SIRT3 active. I previously mentioned Honokiol as a Sirt3 activator and have added this to my regiment. It is a plant polyphenol. There was also a interesting article about it in April. Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3. As many of us have read there are very few options for treating cardiac hypertrophy and now its believed SIRT3 may play a roll in ameliorating it. Who knew?

 

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice.

http://www.ncbi.nlm....pubmed/19652361

 

Ancient herbal therapy can prevent -- and reverse -- cardiac hypertrophy in mice

http://www.scienceda...50414125815.htm

 

 

 

The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and aging

http://www.sciencedi...022282811004706

 

 

Abstract 16685: Honokiol Blocks Cardiac Hypertrophic Response via Activation of SIRT3

http://circ.ahajourn...bstracts/A16685

 

Edited by Nate-2004, 11 August 2016 - 08:16 PM.

[stefan_001]

This site has a some articles:

http://www.timelessl...x.php/honokiol/

[Nate-2004]

I found a much cheaper, "bulk like" source than Swanson today at Liftmode. 50g for $29 vs Swanson's 50g for $58.

Edited by Nate-2004, 11 August 2016 - 09:34 PM.

[Nate-2004]

This article indicates that honokiol is a lipophilic compound.

 

Magnoliae officinalis cortex (MOC), a main ingredient in >200 types of Chinese formulae commonly used in clinics, is a widely used traditional Chinese medicine for symptomatic treatment of gastrointestinal functional diseases. It is the dried bark of Magnolia officinalis Rehd. et Wils. (MO) and its variation, M. officinalis Rehd. et Wils. var. biloba Rehd. et Wils. (MOB). Previous chemical studies focused on its lipophilic ingredients such as lignans, lipophilic alkaloids and volatile oils (1–8). Large pharmacological surveys suggested that magnolol (MG) and honokiol (HK), bioactive lipophilic compounds in MOC, have anticancer, antistress, antioxidant, anti-inflammatory, hepatoprotective and neuroprotective effects (6, 9–11). 

 

Edited by Nate-2004, 16 August 2016 - 03:22 AM.