Can we share ideas about taking C60oo at the same period of taking other hormetic supplements such as curcumin, honokiol?
In addition to that, I would like to further discuss about effectiveness of c60oo on aging in human, separated from mouse longevity study.
I will divide these issues into two questions.
1. First of all, if there is a concern of down-regulation of antioxidant system in the body due to an external endogenous mimetic antioxidant C60oo, will taking C60oo be bad in our anti-oxidant body defense system in a long run? Can suddenly withdrawing C60oo during anytime in lifespan end up with down-regulated beneficial defense genes or switched off longevity, health promoting related genes. This issue was actually discussed in homeostasis thread.
And, please see the below paper.
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a principal transcription factor that regulates expression of several antioxidant genes via binding to the antioxidant response element and plays a crucial role in cellular defence against oxidative stress. In this study we investigated whether activation of the Nrf2/antioxidant response element pathway contributes to the cytoprotective effects of C60(OH)24. Our results showed that C60(OH)24 enhanced nuclear translocation of Nrf2 and upregulated expression of phase II antioxidant enzymes, including heme oxygenase-1 (HO-1), NAD(P)H: quinine oxidoreductase 1, and γ-glutamate cysteine ligase in A549 cells. ... Furthermore, pretreatment with C60(OH)24 attenuated hydrogen peroxide-induced apoptotic cell death in A549 cells, and knockdown of Nrf2 by small interfering ribonucleic acid diminished C60(OH)24-mediated cytoprotection. Taken together, these findings demonstrate that C60(OH)24 may attenuate oxidative stress-induced apoptosis via augmentation of Nrf2-regulated cellular antioxidant capacity, thus providing insights into the mechanisms of the antioxidant properties of C60(OH)24. (http://www.ncbi.nlm....ubmed/24812508)
Someone mentioned in the past thread that taking C60oo at the same period of hormetic(LLLT) supplements can counteract their supplemental hormetic effects so that antioxidant defense can be diminished.
But, one key element Nrf2 showing hormesis gene expression increased after treatment of derivatives of C60.
It is unclear which concept is right. Does C60oo downregulate our hormetic mechanisms in any senses?(natural, environmental or supplements' hormetic responses) This can be antioxidant mechanism or other mechanisms.
Would it be wise to separate hormetic supplements aside from C60oo period? Or, taking both supplements at the same time would be OK or augment its hormetic effects?
2. If mouse susceptible to cancer live about 90% longer, then doesn't it mean c60oo has more meaning as an anti-cancer drug rather than a longevity promoting agent? Then, it might be doubtful that much more cancer resistant human would have the similar anti-aging effects as mouse longevity study.
Suppose that life-extension of mouse is based on anti-cancer effects which can be obtained from either endogenous mimetic antioxidant C60oo or hormetic supplements such as curcumin.
In some studies, curcumin, green tea extract, and resveratrol etc... as hormetic agents was/were not able to prolong life-extension.(http://www.ncbi.nlm....pubmed/22451473, http://www.ncbi.nlm.nih.gov/pubmed/23432089), but, ironically, rather C60oo(endogenous mimetic antioxidant) prolongs their life-span in Baati's study.
Curcumin, green tea, and resveratrol are famous for their anti-cancer effects, and if these are good anti-cancer supplements, mouse might live longer than control group. But, they did not in a significant level. It is confusing since mouse are prone to cancer and those hormetic supplements(curcumin, green tea extract, and resveratrol) could achieve life-extension through anti-cancer effects as C60oo's anti-cancer effects prolong the lifespan of mouse with tumor suppression in Baati's study. What makes a such difference between two cases? We think that hormesis can be a good job in a long run, but rather endogenous mimetic antioxidant concept is puzzling in this situation.(different longevity effects) Even, it is suspected if C60oo can be endogenous mimetic antioxidant or not. (Is it?)
Can C60oo achieve life-extension through other mechanisms other than anti-cancer effects? If this is not true, why are people taking C60oo even human are much more resistant to cancer incidence compared to mouse?
Edited by Graviton, 15 August 2016 - 02:40 AM.
