Yes, these Pan-mTOR inhibitors could be the next big thing in aging and all the diseases that come with that. The main thing about these mTor inhibitors is that they inhibit other signal pathways that Rapamycin does not. But with so little clinical research, how does one decide about dosing and dosing schedules. I'm inclined to wait and this is why.
Rapamycin is very safe. It has been taken daily for many years by transplant patients. No doubt dosing and dosing schedules are very important. But looking at the elderly immunology trial back in 2014, they took up to 20 mg weekly with very few side effects and these were very elderly volunteers. They went onthat the 20 mg dose almost completely blocked the mTor signal and that the 5 mg weekly dose blocked over 50% of the signal. Other mice trials have confirmed that the higher the dose, the better the aging benefits. While the immunology trial used a rapalog Everolimus which has a shorter half life and less effect on mTor2 we know that we probably do not have to block the signal completely in order to be effective. Any dose from 10-15 mg should be very effective at blocking from 80-90% of the mTor1 signal without causing major side effects. If one does experience side effects you can always back off and they disappear. If one wanted to experiment with yourself you could slowly up your weekly dosage until you experience an unwanted side effect and then back off safely.
Another big factor is cost. Everolimus is very expensive somewhere around $5 mg or much more. I purchase Sirolimus for $1.50 mg all in. I should mention that I also take Metformin, low dose aspirin, and a statin. Metformin and aspirin works in synergy with Rapamycin to delay aging.
My goal is to feel as happy as the dog smiling in this caption. He is 13 years old( the equivalent of 80 years old), but has the energy of a much younger dog. His image was taken from the DogProject at Washington State University trial. The dog has also showed up on numerous UTube videos. Just google Dogproject/Rapamycin dogs. You cannot imagine at a younger age how you will feel once aging really kicks in. At 50 yo, I was running 1/2 marathons and felt great. I slowed down in my later 50's, but it really hit me after age 60. So no matter how good a shape your in it it's going to hit you eventually.
Of course, my goals at 70 yo are different than someone who is younger than me. As mentioned before I would not recommend Rapamycin for a young person below the age of 60 unless they are taking it for another medical reason.
Mikhail Blagosklonny, Phd has also stated that this sort of intervention could save Medicare. Much less trips to the Doctor and hospital. In mouse studies, when it came time to die, they died quickly without dragging on for a long time.
LongeCity
