Wow, guys, I look away for a few days and this topic has EXPLODED!
Some posts are a little off-topic (NR) but at least it's toned down a little since MikeDC went relatively quiet. I do take NR along with Sirolimus, but still, we all know how to find NR threads, so let me try to get us back to the topic's original purpose; sharing details of our RAPAMYCIN experiments, and hopefully results.
Valijon, a long time ago I offered to take everybody's info - age, dosing scheme and results and put them in an organized table of some sort, but had no takers. We seem to be a secretive bunch. I'll offer again: send your basic info to me and I will compile it for everyone.
I've been taking 6 mg once a week for 8 weeks. Before that I took smaller doses, but that's probably not important.
A little over a week ago, I decided to change my dosing scheme, and so far I'm glad I did. But it's a little complicated to explain, and I want to run my math past everyone to make sure it's correct, so please read the following carefully. I really do want constructive corrections, comments, and criticism.
I'll start with what I've learned about R's normal half-life. According to 2 sources, it's between 57 and 63 hours, so on avg 60 hours or 2.5 days. Taking 6 mg once a week, R remaining in the body would look like this:
6mg @ 0 days (+ any left over from previous dose)
3mg @ 2.5 days
1.5mg @ 5 days
0.75mg @ 7.5 days
This seems sub-optimal to me; it drops off too quickly. From discussions here and elsewhere, it seems that it's better to have a good dose that stays high for 2-4 days, then have a steeper drop-off on the last 2-3 days (roughly).
Some of you may remember a brief discussion about grapefruit juice (GJ). Drinking 8 oz of GJ a day significantly lowers P450 enzymes that would normally break down R.
This means that drinking GJ a few hours before taking Sirolimus, you can increase the effective dose by 350%. By continuing to take 8 oz of GJ a day, the effective half-life is also extended, so that the drop-off is slower. Stopping the GJ after 2-3 days should return the half-life to normal after another 2 days or so. Taking 2 mg of Sirolimus after drinking GJ might look more like this:
2 mg x 3.5 =
7 mg (+ any left over from previous dose)
6 mg @ 2.5 days (stop drinking GJ)
3 mg @ 5 days
1.5 mg @ day 7.5
Compare these scenarios. For the 2nd, the level stays higher for 2.5 days before dropping down. If you want to be more aggressive, taking 3 mg of Sirolimus after drinking GJ might look like this:
3 mg x 3.5 =
10.5 mg (+ any left over from previous dose)
9 mg @ 2.5 days (stop drinking GJ)
4.5 mg @ 5 days
2.25 mg @ day 7.5
This last scheme might be over doing it, and some people might start experiencing side effects that are seen with higher doses. Or maybe not.
I've been doing the 2 mg (+ GJ for the first 2 days) last week and yesterday, and my results took a good jump. So far, it's still too early to be sure, and this could still be a placebo effect. I'm able to do more reps with heavier weights, 60% more push-ups, jog up hills faster, etc. I continue to lose about a pound a week. Most of all, I feel better and more inclined to eat better and exercise more. I know this is subjective, but I do feel a sense of well-being, especially in the first few days of the week. One other bonus: I had a moderately severe fungal infection on a big toe, and now it's gone. R is an anti-fungal after all.
Edited by Jaris, 26 March 2017 - 09:26 PM.
. Warren Buffet says he lives on MacDonald's and Coca Cola, BTW.
