9 replies to this topic

[Jordan23]

Hi there,

I know there's been a lot of threads around this topic lately but i'm wondering if anyone has any more information specifically on increasing acetylcholinesterase activity in the brain.

So far I have found that Tyrosine might do so: http://www.sciencedi...197018612003026

And there maybe evidence that forskolin does aswell.

If not perhaps something that will increase aCH uptake? I'm interested in racetams but discouraged that they may increase aCH receptor sensitivity. I think that I have an overactive synthesizing enzyme from excessive fish oil use. I think this because if I limit my choline intake in foods I feel fine, but as soon as I have even the smallest amount of choline in food I get high aCH symptoms. 

[jack black]

Have you considered that you have ACh esterase deficit due to genetics or food or environmental contamination with pesticides?

[Jordan23]

It came from excessive fish oil use over a long period of time, coupled with calcium to make things worse. I'm now left with persistent high aCH symtoms, and low dopamine symptoms, even months after discontinuing them, which leaves me baffled to be honest.

[Polyamine]

Perhaps the prolonged use of fish oil led to an increase in heavy metal accumulation which can increase acetylcholine levels.  Does pasta or rice cause you problems?  Most of the other foods high in choline are rich in nitrogen and perhaps you have an imbalance in nitrogen fixing gram negative anaerobes?  IMO, this can lead to the problems you are having.

[Jordan23]

Had pasta 2 days ago, didn't notice any major negative effects but for some stiffness in the neck, but I think that was due to the cheese (source of choline) I put with it.

I am unfamiliar with the role of nitrogen in this? The biggest and most devastating symptom i'm facing is depression. 

 

[Polyamine]

Had pasta 2 days ago, didn't notice any major negative effects but for some stiffness in the neck, but I think that was due to the cheese (source of choline) I put with it.

I am unfamiliar with the role of nitrogen in this? The biggest and most devastating symptom i'm facing is depression. 

 

 

As you know, there are many different things that can cause depression.  Since you are interested in acetylcholine, you should investigate the role that aluminum toxicity plays in blocking the conversion of BH2 to BH4.  Nitrogen fixing bacteria can increase the burden on the ornithine pathway which will slow the neurotransmitter pathway and that is not where I would start my investigation.  I'd look for BH4 problems before I went into nitrogen issues, especially if brain fog isn't a problem.  I'd look at potential lower pH levels altering normal functioning by altering electron distribution of substrates.  That begins in the GI tract.
 

[Jordan23]

Yeah brain fog is one of the only symptoms I ussually do not have issues with.

Apologies, I understand very little about all of this, what I know has been learned in a few weeks from Wikipedia and the like. Just about everything you wrote I know nothing about haha.

Can you give me some links to read, and how to know if I have issues with BH4 or aluminium buildup?

Cheers.

[Jordan23]

I should probably clarify that I may have overstated the affect choline foods have on me.

Whilst a complete reduction in choline sourced foods definitely alleviates my symptoms a great deal, they aren't completely gone. I had started drinking coffee again for the first time in months and I have been reacting very positively to it at least for a few days.

Not realising at the time that I may have been conflating this improvements entirely on limiting my choline intake. Which was more likely a combination of the two.

Edited by Jordan23, 27 August 2016 - 03:07 PM.

[longcity90]

Updating the post, what else could help the cholinesterase enzyme if there are symptoms of inhibition?

[longcity90]

Is there anyone who can help me? ☹️