Woah, that's pretty intense! Just for curiosity's sake, if you could only make three changes where each change added, replaced, removed, upped expression, lowered expression, or disabled entirely one and only one gene for each change, what would you do? As a mild example, upping expression of the NPTN gene for the benefits relating to intellect as one of the changes.
It has been observed that some individuals have negligible loss of neural function at very advanced ages, neurons transplanted from one animal to a new host with twice the lifespan live twice as long, even in humans virtually genetically identical neurons to most of the population lasted decades more 50% longer lifespan in Jeanne Calment the 122 year old official record holder.
I'm not sure what ensures negligible neuron function loss or what enables these cells to last 50% longer than the average human lifespan. Some have even suggested that neurons exhibit negligible senescence and that it is the aging of supporting tissue that causes neurodegeneration, an interesting hypothesis.
Whatever master regulator(s) ensures the optimal set of maintenance and repair, which perhaps may enable negligible senescence at the cellular level,(known at least 2x lifespan in rodents and known at least 1.5x avg lifespan in human), that would be interesting.
No offense but this sort of thinking stems from firstly not knowing human biology and secondly ascribing to an already disproved and illogical theory for how humans came to exist.
You would simply kill yourself if you tried to change your DNA in the way that you are suggesting.
Perhaps you know not of chimeras, animals with the cells of entirely different species within them? Even in animals foreign cells from other species can be implanted in adult animals within protective materials that isolate them from immune response.
The issue with massive genetic change would be an immune reaction, but you can take care of that by modifying the immune system first, in which case it could tolerate arbitrary genetic modification.
The idea of imbuing a human with super organs, that is organs that do not age self regenerate can survive oxygen water food deprivation and high levels of toxins and may perform additional functions, is entirely within what is allowed by physical laws.
As pertain human origins evolution, the mechanism of natural selection, from a common ancestor. This has not been disproved.
PS
Also note that there are harmful parasitic unicellular and multicellular organism that CAN exist within the human body even in large quantities without killing it. Cellular machinery that was not parasitic but rather beneficial of entirely different genetic nature can be incorporated into the body, and can also be used to replace existing organs.
Edited by Castiel, 18 September 2016 - 04:14 AM.