135 replies to this topic

[Quaker32]

No I haven't properly explored them but am slowly slowly getting round to improving my diet etc. I am currently treating physical pain with acupuncture and am improving my diet. It is hard but I can do it,

 

Still can't work out if the sertraline is helping or not. How weird! Underneath all of this is incredibly intense and painful emotional experiences that I am having. 

 

I am beginning to see why I am feeling so bad at the moment. The last year and the terrible nature of it has more than likely led into this dislocation as a coping mechanism. 

 

I see the Dr next week. I actually went ahead and ordered 30 pills of naltrexone online but am keeping that more as insurance than anything else. 

 

 

[Catwoman]

If you search on Dr.Bob forum (Psycho Babble) you can find some anecdotal reports on the use of naltrexone(to reverse tolerance or poop out). That one doc who wrote he gives it to his patients with much succes (way back then anyway) so others on the forum tried it. Most of these folks couldnt tolerate it, even when they took it with food...

I think sertraline act different for everybody but I already had sleep problems. Most common side effect.

[Quaker32]

Did you find that sertraline or other psychiatric drugs changed the way that you felt emotions or your internal diagloue? 

[Catwoman]

The ssri's that I took didn't flatten my emotions (a complaint you read about often). I felt normal, maybe even more sensitive. But they weren't bothering me. I've always been a sensitive person. What happened was that I slowly didn't have so much unwanted thoughts anymore. This process gave me more confidence, I was able to let go of the frustration. I don't know how much of this feeling was coming from more serotonin hanging around.


With sertraline I don't know. I'm on my third day with 25 mg. Though I don't think SSRI's are interchangeable I still think it could have the same effect. Escitalopram made me a little sluggish the last couple of years. It is the most selective of all SSRI's; I think it could deplete dopamine and that is why I wasn't so motivated. I hope that sertraline is more stimulating.

Edited by Catwoman, 05 January 2017 - 10:48 AM.

[Quaker32]

I don't think sertraline is that stimulating but its not completely sedating as well. You should be fine there, no worries.

[Mind_Paralysis]

Sertraline is generally considered to be the most stimulating of the SSRI's - especially at the higher dosages, which you would need for OCD anyway.

It actually worked very well for me at MAXIMUM DOSAGE - 200 mg's took away every single care in the world that I had. = ) However, it also interfered with the Methylphenidate I was using, at that level - which actually makes sense, because it has affinity for DAT at such dosages, meaning that the two started cancelling each others effects on DAT and NE out, at such dosages.

 

You whoever, won't have that to worry about - Sertraline is, because of it's mild stimulatory effects, considered to be the SSRI least likely to cause sexual dysfunction.

[Catwoman]

Sertraline is generally considered to be the most stimulating of the SSRI's - especially at the higher dosages, which you would need for OCD anyway.

It actually worked very well for me at MAXIMUM DOSAGE - 200 mg's took away every single care in the world that I had. = ) However, it also interfered with the Methylphenidate I was using, at that level - which actually makes sense, because it has affinity for DAT at such dosages, meaning that the two started cancelling each others effects on DAT and NE out, at such dosages.

 

You whoever, won't have that to worry about - Sertraline is, because of it's mild stimulatory effects, considered to be the SSRI least likely to cause sexual dysfunction.

Sounds promising. I will increase to 50 and stay there for a few weeks. Not really convinced that it will help after the escitalopram debacle but we'll see. I'm on day four and on the lowest dose (25 mg). The first night I slept for just a few hours. Mostly because of hart palpitations and I wasn't tired either.
I figured I shouldn't trigger the palpitations and I've been sleeping OK for three nights in a row.

I think escitalopram had a mild side effects profile, followed by sertraline. Paroxetine causes sexual dysfunction and weight gain with most people (or so it seems).
My general doctor wanted to put me on it...silly because my new pdoc isn't a fan. His first choice would be escitalopram and sertraline right after.

Quaker, if sertraline isn't giving you the desired effect after 8 weeks you could consider switching to another SSRI.
Have you ever been on a TCA or SNRI?


 

Edited by Catwoman, 06 January 2017 - 10:49 AM.

[Quaker32]

Paroextine completely killed my ability to get an erection. I didn't actually mind, but I wouldn't want that in the long-term.

 

But I did notice a huge desire to socialise and be amongst people. Amazing actually - it's very powerful.

 

No, never before. Because of my problem with addiction, I don't want anything that will boost dopamine or noradrenaline too much. I think these are the neurotransmitters that I should be cutting back on a bit.

 

I wonder because of how far gone I was, if anything that I do take, will just need more time. It might be closer to 16 weeks or something because of how fucked up I am. I don't know though.

 

Another option I am thinking about is low-dose antipsychotic to help with anxiety and intrusive thoughts - but not aripiprazole because that has dopamine agonist effects and has made some pope turns o compulsive sex and gambling. 

[hdl_1]

I didn't read all the thread so sorry if it's been addressed.

The following thread is about a similar experience and the consensus is dp/dr.

http://www.longecity...tion-is-please!

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[Quaker32]

thanks dude - yes it has been. dpr/dr sounds about right. 

 

is this due to the sertraline?...i have lots of DRUG cravings, and a "flashback" of remembering what the rush of MDMA feels like. i feel really tempted to get on the drugs again but go even harder like doing ephedrine again or getting cocaine.

 

obviously a poor idea. 

 

something about my current chemical-configuration in my brain is absolutely not right. granted because i have dp/dr but I feel impulsive in a different sort of way than i do with sex addiction.

 

i suppose its not quite compulsivity, but more of a "euphoric recall"and curiosity to take drugs again, and engage in some crazy sexual activities.

 

[hdl_1]

Probabaly not a good idea. Look into the nootropic Mexidol. Is is effective agains alcohol cravings (not sure if it works on others) and also has anxyolitic properties.

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[Quaker32]

Ok. Things are NOT going well.

 

I believe that I have both psychological and physiological causes of DP - both need addressing but I do not know how to go about it. I would probably start with the psychological and see how I feel after engaging with a dissociation-friendly therapist, then evaluate where I am at and see if any medication particularly helps. 

[Mind_Paralysis]

What I see in this and other threads about DP/DR, is that unless you used some NMDA-antagonistic or other fishy chemical to get into this state, it seems to be connected to INTENSE feelings of shame and punishment. (a defense-mechanism of some sort, to numb you, so as to allow continous combat against something taxing)

 

This DOES imply that the Kappa Opioid -system is involved, and lo and behold, that's certainly an area of treatment under investigation right now - several threads about it on DP/DR-forums as well.

 

Have you considered joining the CERC-501 group buy thread? Cerc-501 is a potent Kappa-antagonist, currently undergoing research as an antidepressant - in theory, it fixes punishment sensitivity and the effects of it.

 

Check it out here:

 

http://www.longecity...pa-antagonists/

Edited by Stinkorninjor, 09 March 2017 - 05:55 PM.

[Quaker32]

I read a paper about the use of naltrexone in DP/DE but the authors warned that whilst you can get medications which will reduce the dp/dr, the person has to be ready to be able to deal with the resultant feelings that MAY emerge. After all, that could be what led into this state via a defense mechanism (hypothesised). I'm pushing my mental health team to secure me a place for psychological help as well. 

[Valor5]

Two points
1. The purpose center or the having an aim, even interest, passion reside in the Striatum.
2. In order for the mind to take an interest and form a habit I think is the responsibility of the basal ganglia.

This info comes from a writer named Duhigg in two separate books. "The power of habit" and "smarter better faster." Dopamine being absolutely critical. My question is if this can be rehabilitated perhaps by following some sort of instructions that would turn a person into an automaton but perhaps feelings can be regained perhaps doubtful because I feel I have been living an automaton life the last twenty years not as fun as my first twenty and it is nearly impossible for me to for an interest, aim passion and stick to it...We will see I may just have to do my best as an automaton.

[Robinvanpersie]

This might sound stupid but since it seems like you're not feeling any better - try watch a bunch of Alan Watts videos on YouTube. He's great at explaining "spiritual" stuff in a way that feels logical to even Atheists.

My guess is that you might experience some sort of awakening where your ego has been broken down.

This is also quite interesting: