As of now only Muad' Dib received it in the UK, but give it a little more time, it will be an extremely bad lack if all envelopes have been withheld. Even if they hold one for testing they should not keep the others. From my experience, I really think is a delay and not a long one.
This is my experience with Vorinostat as of now.
As it has been discussed in the past, vorinostat is not an anxiolytic for everyday use, but something to help to go over situations that make us stuck, and hopefully rewire our brain and help us erase conditioned fear from past experiences. In my experience with 10-50 mg doses, the effects you can consciously perceive are very subtle but you can still see that you can go over difficult to face events more calmly and initiate new behaviors. They were a few times that I had a very strong anxiolytic effect when I was in fearful state thinking that some damaging event was ready to unfold.
If I abstract a little from my experience, the fear-reducing effect is most observable in situations that could threaten our well being in evolutionary terms, for me is mostly connected with social events like a speech in a crowd and (surprisingly at first) dating. I guess everyone could try it on different occasions, but I will mention one case of events that has been the most helpful for me.
I am a fan of psychology in general, and some years back I started looking in some more practical aspects on dating psychology and theory from "pick up artists", in what females find attractive and why, in personality characteristics of males. Mostly out of curiosity I tried to start conversations with appealing females, in the back and forth commute to work and few other occasions, were (in a more friendly) fashion I spoke to tens of women over a two years period, but somehow I found it extremely difficult to show direct interest and ask for a phone number even when using large dose of phenibut or other anxiolytic something seemed not right.
It was a random occasion (after using vorinostat) that surprisingly I asked for a phone number, as well in another occasion send a text message in an ex that I have been thinking for years but I always got stuck. It was like "maybe I should text her" (got no weird feeling that something is not right and did it). It may not seem much, but in both cases I was stuck for years, and it was a random effect, I did not use Vorinostat with the intention to ask someone out (I never do this if I am not 100% sure for a positive reply) or (eventually) text my ex, I just got unstuck. This got me thinking that there is something to it, thinking in what ways I could get the most benefits.
My best experience so far (same with StevesPetRat) was to get over a serious relationship with not too much pain, I was surprised both of the strong anxiolytic effects I got with 50mg, continuing with a dose every other day for 300mg in total I was in a state that I will probably need more than a couple months to get not thinking about it, been in a low mood. I started realizing that there is some strong component of fear in separation, probably a primal evolutionary fear that a good chance has been lost to "spread your genes" apart from the emotional connection. From a past experience, Vorinostat did not just give immediate anxiolytic effects, but thinking it over in a much calmer state, curbed the negative emotions permanently.
Having tried it in different circumstances, the most benefits and my favorite activity these days to use vorinostat for is an idea I got from Tim Ferris. I will think what is the one action that if I get unstuck and go forward will have the most beneficial effects in my life. I will use a 100mg vorinostat dose these days, and then think in a very detailed manner everything unfolding in the worst case scenario. I will stay calm and in control and calmly think all the counteractions I can manage and if the end result is something I can live with. If this is done a few times using vorinostat could have major positive implications like start a venture like a business or change in career you have been thinking for years, deciding to end a failing long term relationship, or anything else that was holding you back due to fear of the unknown and comfort of a supporting routine. I got unstuck after the third time and took the first steps towards a part-time startup (I still need my day job) in a far more collected state. It was an old idea, that I now got to progress, having the fear that if this will not work out I might get stuck some more years in my current day job. I still do the 100mg calm down session once a week, the results are very cumulative.
You can use it for PTSD, specific phobias for anyone that has it (speaking in crowds for me) or anything else that would curb fear/anxiety without a loss in cognitive abilities that benzodiazepines can give. Although the anxiolysis you get from Vorinostat seems to be very effective in some cases. As I said before I was going to meet my girlfriend for the possible break up and Vorinostat calmed me like a xanax dose will do with no loss of cognition due to its hypnotic effects, but does not work as gaba anxiolytics and I do not know what kind of anxieties might curb.
The best use for me right now is to use it strategically with fearful/anxious thought patterns that if I can go over would have long-term implications. As I also described in a previous post public speaking in small groups is far easier now, asking out for dates had a snowball effect from that first event (it was a common reaction while on Vorinostat) even when I was not thinking much about it in my pc, sending facebook messages for a date out, and now is far easier also. At this time I will continue with going over specific future situations in my mind thinking the worst case scenario in as much detail I can, using 100mg doses and calmly thinking my options. It seems true in a good degree that doing what you are afraid the most (but you leave it aside) its often the first thing you should act on... I also recently started reading the book below to get a framework of how to think about risk and fear.
Something else I want to try after repairing my old oasis CES device is to test, if the 100Hz frequency that activates the right insula to suppress fear from the right amygdala, could possibly give better results while on vorinostat.
Edited by Strangelove, 28 June 2018 - 04:22 PM.
