No replies to this topic

[macropsia]

Does anyone know anything about the specific means by which pregabalin influences Glutamic Acid Decarboxylase? There seems to me to be a specific dose at which its effects, even when only taken at night, switch over from a shorter to a longer duration of action. My suspicion/hope is that this corresponds to its 'secondary' activity kicking in. It is useful as an antiglutamatergic and seems to help somewhat with blood-sugar control even at the lowest dosed formulation, (which may have to do only with suppression of the cognitive effects of [what I hypothesize to be; don't have a means to test this quite yet] hyperglycemia i.e., some sort of glutamate efflux secondary to inflammation, or may, already, be a foretaste of what one gets at higher doses, i.e., GAD induction) but higher doses have a more substantial and somewhat different effect which, while subjectively differentiable, I'm not sure if I understand pharmacologically.