3 replies to this topic

[tunt01]

Pomegraniin A is implicitly suggested as an alternative activator of SOD2/SIRT3 to Urolithin, Resveratrol.  All data is in vitro, but seems interesting nonetheless.

 

It would be interesting to know why Johan Auwerx went with Urolithin A and if he ever evaluated Pomegraiin A.

 

Zhao, C., Sakaguchi, T., Fujita, K., Ito, H., Nishida, N., & Nagatomo, A. et al. (2016). Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation. Oxidative Medicine And Cellular Longevity, 2016, 1-9. doi:10.1155/2016/2927131

 

 

 

Zhao, et al. (2016) 

 

 

 

SIRT3 activity of various polyphenols in Caco-2 cells in vitro.

 

 

 

 

SOD2 activity from Pomegraniin A is SIRT3 dependent.

 

 

Pomegraiin A shows a superior GSH/GSSG ratio in Caco-2 treated cells

 

 

 

[tunt01]

Pomegraniin A is a potent inhibitor of advanced glycation end (AGE) product formation.

 

Ito H, e. (2016). Ellagitannin oligomers and a neolignan from pomegranate arils and their inhibitory effects on the formation of advanced glycation end products. - PubMed - NCBI . Ncbi.nlm.nih.gov. Retrieved 14 December 2016, from https://www.ncbi.nlm...pubmed/24444944

 

 

 

Pomegraniin A is the best inhibitor of AGEs in various polyphenols and Aminoguanidine as a positive control in vitro.  Urolithins exhibit little/no control over AGEs.

[Tom Andre F. (ex shinobi)]

very interesting.

 

Something strange: Fisetin is shown as the best SIRT3 activator while this study that studied carefully the details of binding sites and ligand interactions between sirtuins and their activators, Fisetin was found as a SIRT1 activator and a SIRT3 inhibitor... https://www.ncbi.nlm...les/PMC3504108/

 

We need some info there

[Logic]

I like Icariin and PQQ. (accessible)

I started using HGW after posting on page 2 of this thread:

http://www.longecity...rt-2-its-sirt3/

 

http://www.longecity...ndpost&p=565043

http://www.longecity...ndpost&p=564210

http://www.longecity...ndpost&p=564225

 

Pomegraniin A looks very interesting.
Is it available as a supplement at a clinically effective dosage?

 

Edited by Logic, 16 February 2017 - 04:44 PM.