139 replies to this topic

[Blanker]

I just lost my job because of this I don't know what to do anymore I.just feel like there's no hope and I'm fried.

[hdl_1]

There's hope. I lately added probiotics to my regimen of supplements and I'm impressed by the results. I'm actually getting some warm feelings/emotions back.
Probiotics are known to modulate the immune system, reduce inflamation and aid in the production of all major neurotransmitters. Also, they help fixing a leaking gut which in itself can create a while bunch of issues.
Look at making them at home from strains found in Kefir/Bio-K/Biogaia reuteri atcc 6475 or others. It's quite simple. Just look for making yogourt at home recipes.
Other supplements of interest: melatonin + adaptogens (lion's mane, ashwagandha, etc.)

[Blanker]

There's hope. I lately added probiotics to my regimen of supplements and I'm impressed by the results. I'm actually getting some warm feelings/emotions back.
Probiotics are known to modulate the immune system, reduce inflamation and aid in the production of all major neurotransmitters. Also, they help fixing a leaking gut which in itself can create a while bunch of issues.
Look at making them at home from strains found in Kefir/Bio-K/Biogaia reuteri atcc 6475 or others. It's quite simple. Just look for making yogourt at home recipes.
Other supplements of interest: melatonin + adaptogens (lion's mane, ashwagandha, etc.)

I'm quite impressed by this actually felt a little emotion following it absolutely astonishing. Probiotics something as simple ad yoghurt and a nice improvement. Thanks for this much appreciated! I actually felt a little of my Joy return amazing how can I dose this high Nd can leaky gut be caused by metal toxicity and what are generally the reasons for leaky gut.
 

Edited by Mind, 13 September 2019 - 05:36 PM.

[Blanker]

Hey also how the ashwagandha going for you? Have you tried selak, any peptides in particular, or nsi-189 hdl_1, I was also thinking of noopept, If you cod enlighten with any experience I would be very grateful. I actually felt a return of my self with just injesting yoghurt high in probiotics and having whey as well worked wonders, going to try higher amounts as only had one glass of whey with yoghurt and icecream mix so looking.forward to the results.
I wouldn't call it huge improvement or wonders more accurately decent.improvement.

[Quaker32]

i don't know what causes leaky guy but try eating chicken bone carcass broth. sounds ridiculous. but i hear very good things about it. i need to try it. i can send a recipe over if you like.

 

i want to try probiotics.

[hdl_1]

Hey also how the ashwagandha going for you? Have you tried selak, any peptides in particular, or nsi-189 hdl_1, I was also thinking of noopept, If you cod enlighten with any experience I would be very grateful. I actually felt a return of my self with just injesting yoghurt high in probiotics and having whey as well worked wonders, going to try higher amounts as only had one glass of whey with yoghurt and icecream mix so looking.forward to the results.
I wouldn't call it huge improvement or wonders more accurately decent.improvement.

I'm glad you felt a difference. I didn't try any of the experimental drugs since they are somewhat out of my comfort zone. As for peptides, I do want to try Cerebrolysin as soon as someone can buy it for me directly from an european pharmacy.

In my experience of about a year and half with supplements and some nootropics I found that healing comes with time and in steps of small improvements.

In my quest for healing I targeted neurotransmitters precursors to balance mood, anti inflamatories/antioxydants supplements to reduce systemic inflamation, adaptogens (to modulate stress response/ regulate the hpa axis), brain repair/circulation and now probiotics for gut health (see link below).

Autoimmunity and the Gut
https://www.ncbi.nlm...les/PMC4036413/

As for nootropics, I find that Noopept (with Alpha GPC) is just awesome in providing a sustained focus and get rid of the brain fog. I take some others which were created at origin as anti ischemic such as Mildronate and Mexidol (on and off needs to be cycled) for better brain circulation.

I created my stacks on a day/night schedule, putting the adaptogens and some others at night to improve repair and to have a great night sleep (which I have 99% of the time lol - Ashawaganda and the other adaptogens work great). The day time supplements are geared for productivity.

On a side note, do you snore? wake up gasping for air? someone told you that you stop breathing for a few seconds at night? Read about sleep apnea which may create all kind of symptoms since your brain is not able to rest and repair itself.

Below is what I'm currently taking and with which i've seen improvements both on short and long term.

Day:
NAC,
B6 (P5P),
B12 (methylcobalamin),
Vit C,
MSM,
Trimethylglycine,
Myo-Inositol,
Curcumin 95%/Piperine,
L-Tryptophan (half dose - about 250mg),
L-Phenylalanine (small dose about 150mg),
Lion's Mane,
Alpha GPC,
Citicoline (recently added Ceraxon but CDP Choline would work just fine - this seems to enhance another set of neurotransmitters than Alpha GPC), Noopept,
Mildronate,
Mexidol (did about 4 weeks initially, now about 1 week every few months. This one is somewhat special. I think it modulated the dopamine system and takes a short time to act. Effects seem to be long lasting but can't really be productive when on it.)

Night:
NAC,
B6 (P5P),
B12 (methylcobalamin),
Vit C,
Vit D,
Zinc Picolinate,
Magnesium Bisglycinate,
MSM,
Trimethylglycine,
Myo-Inositol,
Curcumin 95%/Piperine,
L-Tryptophan (half dose - about 250mg),
Melatonin (15mg),
L-Theanine,
Bacopa Monierri,
Ashwagandha,
Lion's Mane,
Valerian root (on and off)
L-Arginine,
Mildronate

Probiotics 3-4 times a day (250ml) home made Bio-K and Kefir. Looking to get Bio Gaia with Lactobacillus reuteri ATCC PTA 6475.

One more thing: not a nootropic but a healthy diet rich in fruits and vegetable helps as well. [emoji1]

I hope that you'll find what's working for you. Give yourself time and enjoy small improvements, eventually you'll realise that all the small improvements have now become a big one!

Edited by hdl_1, 24 January 2017 - 01:51 AM.

[Quaker32]

Which probiotic supplement do you use? I want to buy one, but I am worried about getting one form he shops that is "too strong" or something like that. I could be worrying excessively, but I just want to be sure before I purchase it (as well as cost etc). thanks.

[hdl_1]

Which probiotic supplement do you use? I want to buy one, but I am worried about getting one form he shops that is "too strong" or something like that. I could be worrying excessively, but I just want to be sure before I purchase it (as well as cost etc). thanks.

You can buy any probiotic and then multiply it at home. So far I bought and multiplied bio-k (3 capsules $15) and kefir (1L about $6).
The recipe is simple. Heat your oven at 150 F. Lowest setting could be higher so just stop the oven when it reaches 150F. Take any amount of milk (non skimmed - full fat)and mix it with the probiotic (The initial mix was about 1 capsule of Bio-K or 250ml of kefir to a half gallon of milk). Put the mix in the oven overnight and let it there.
In the morning, with the mix still inside, reheat the oven to 120F this time and stop it when it reaches the temperature.
Leave the mix inside the oven until the evening.
At this point, after 24h, your mix should be ready and you can enjoy. Store it in the fridge. You can use what you made to refill so no need to redo the process with bought probiotics. Just add milk when you have about 5oz left and repeat the heating process.
Enjoy!

[Quaker32]

thanks.

 

would ordinary high strength probiotics work as well? the kind that you can leave in your fridge. i've seen a few in health stores near me.

 

is there any danger from excess probiotics in the body? or any particular strains that i should or shouldn't look out for?

[hdl_1]

thanks.

would ordinary high strength probiotics work as well? the kind that you can leave in your fridge. i've seen a few in health stores near me.

is there any danger from excess probiotics in the body? or any particular strains that i should or shouldn't look out for?

Any strength would work. I'm not aware of any side effects. I drink 1L a day lol. The rule of the thumb is get as many strains as possible since they work synergisticaly with each other.

[bigbang]

Thanks for the post, sentics.

 

My issue doesn't seem to be simply anhedonia, however. It's more of a complete loss/disconnection of "self." I've had anhedonia before, but I still had my "self," my inner voice/monologue was still present. Now my mind is always "silent" and blank, like I've completely dissociated from my self/ego/mind. I believe this is severe DP. Do you also have that? It's like I walk around like a ghost, just this constant awareness. I feel stuck in an eternal, timeless moment of void/nothingness. No emotions, no feelings, I seem to have completely dissociated from myself and my own mind. I truly do hope meds can fix this and bring my self/inner voice back, but I don't know how they'd do that.

 

I was thinking of trying ketamine infusion therapy, as well, but again - I'm not sure this is mere depression - it's like a completely blank state, just conscious awareness.

 

hi.

 

a silent mind is an okay thing.  for some people, that's the goal.  you could very well be wide awake in eternity (i am).  take a look at the om symbol, particularly samadhi consciousness. 

 

also, you should notice that you very much do have a voice (you're using it to communicate) so you're not at a total loss.  if you had a total inability to express that would be different.  you have awareness of the condition you're in and you're able to articulate it to others.  you do have some sense of self even if feels foreign to you right now.

 

you have a lot of psychiatric concepts but i think you'd benefit from learning other belief systems (psychiatry is just one of many belief systems).

Attached Files

•  b6cbefb1a6a46a282d3efa9e46d5da6d.jpg   154.46KB   3 downloads

[bigbang]

Medications aren't damaging. Besides anti psychotics having a slim chance to induce long term side effects.

If you're adamant about avoiding meds, you could try NSI-189.

 

yes, antipsychotics (neuroleptics) can have very bad long term adverse effects.  http://education.mad...ectures/1654374

Edited by bigbang, 27 January 2017 - 10:54 PM.

[dreamedm]

bigbang, I appreciate your input, but you're confusing "enlightenment" - which is what some people strive for - for dp/dr. The latter is a silent mind and a total disconnection from others, resulting in a void like state - a constant awareness of nothingness/dissociation. This is not okay, and it is not what people strive for. In enlightenment, the mind is also quiet but you're connected to yourself and others/the world.

[AlmostEasy]

I don't think I have ME/CFS. I've checked out the symptoms. Blank mind is also a result of depersonalization.

 

It would be an absolutely monumental mistake to throw out the baby with the bathwater.  The resources I posted are about all these crossover symptoms the majority of the time, like 99.5% of the time.  ME/CFS is fairly rare but people flock to it because it sounds vaguely familiar and that's just where the discussions have begun to take place.  I would not rob yourself of all the precious information over there on Phoenix Rising and the roadmap to treatment page.  You will not find that anywhere else.

 

Good luck!

[cnsbroken]

I've sevens studies regarding SSRI"s regarding nerve axon retardation in receptors throughout the brain and actual elimination of receptor and.no new receptor neurogenesis so is it a potential that we are in fact incurable of our cognitive deficits and other problems ad no Neuroregenisis in these are as only particular in the hippocampus region.

 

Hello man, sorry to hear your situation although mine isn't all that different since 1,5 year when I was prescribed sertraline(SSRI) and stopped it abruptly after 2 months of 200mg dose a day(I have OCD).

Since then I have no life and returning to taking sertraline, or trying tianeptine did nothing.

 

I won't lie, I registered on the forum just right now because I saw you mention these studies, and I am soon to be back at the psychiatric clinic where I took sertraline. I have some sources(studies also) on protracted withdrawal syndrome, which is what I experience and I am going to present them to MD's there. I am not naive that will change nearly unrecognized condition into something they can adress, but I intend to receive ECT therapy, and would be super grateful if you shared those studies with me. I will attach them to what I've found on my issue(ofc I can share my findings to you as well if you want, although you may not be particularly interested in them as the nature of the problem stems from WD in my case).

 

But I have one thread link which is in line with your symptoms(as well mine):

http://www.longecity...ndpost&p=613668

Edited by cnsbroken, 20 February 2017 - 07:52 PM.

[jaiho]

Ask your psychiatrists to follow this AD algorithm. It's pretty spot on.

 

Triple reuptake inhibition + 5ht2a/c antagonism.  Lots of dopamine transmission happening with it.

It has a very high chance of destroying blank mind, which is a deep deep depression.

 

http://psychotropica...al-ad-algorithm

 

[Quaker32]

jaiho, have you got a link about the blank mind thing being a symptom of very deep depression?

 

i feel extremely depressed as well as depersonalised/derealised. i have no motivation to do anything other than lie down.

[jaiho]

Blank mind is not listed as a symptom anywhere i can find other than anecdotal. There are an immense amount of symptoms attached to severe depression.

You can't isolate blank mind as a symptom.

 

I only know that it is from my own experience with depression. When i have had the depression treated, the blank mind went away, as did so many other symptoms.

[Quaker32]

thanks. what medication ddi you take?

 

have you ever had severe brain fog: cognitive deficits, poor short term memoryt real, spatially disorientated etc. it seems to be commonly seen in DP/DR disorder. i would be extremely grateful if you could provide any information on that and what might be effective.

 

also, did you have any psychological therapies or make big lifestyle changes?

[MichaelTheAnhedonic]

In my case unfortunately, I think it's still simple schizophrenia. Latest MRI showed enlarged ventricles, increased prefrontal space and little atrophy at cerebellum. The thing is that when I'm on dopaminergic substances I feel a lot better (well, everyone would do). The blank mind is decreased immensely @ dopaminergic substances. Negative symptoms of schizophrenia are probably caused by huge deficits in the mesocortcal dopamine pathway which explains why DNRI like methylphenidate is helping a lot. The downside of taking stimulants is of course the comedown and nutritional deficiencies in my case. I think I flushed electrolytes from my body and got 2 panic attacks lately. 

[jaiho]

thanks. what medication ddi you take?

 

have you ever had severe brain fog: cognitive deficits, poor short term memoryt real, spatially disorientated etc. it seems to be commonly seen in DP/DR disorder. i would be extremely grateful if you could provide any information on that and what might be effective.

 

also, did you have any psychological therapies or make big lifestyle changes?

 

Zoloft + Nortriptyline.

 

At high dose, Zoloft is a SDRI, and Nortriptyline is a potent NRI.

Very effective for all those symptoms which i also had, especially the DP/DR, washed away like it's nothing.

 

It's also effective for negative symptoms of schizophrenia, as those are mostly Anhedonia/Flat effect symptoms. The dopamine transmission from this combo is excellent and sustainable, unlike stimulants.

 

I haven't tried psychological therapies, my depression appears to be genetic as it runs in the family. This kind is effective when treated with drugs.

Edited by jaiho, 22 February 2017 - 03:18 AM.

[MichaelTheAnhedonic]

Can Amitriptyline be used instead nor? Only ami is available in my country.

 

[jaiho]

Yes, Amitriptyline has nortriptyline as a metabolite.

Can also be combined with Zoloft, but you can try Amitriptyline by itself at first.

[Quaker32]

thanks for the info jaiho.

 

i've got a bit of a problem though. in addition to the dp/dr, i also have a problem with sex addiction which my doctor is aware of. he is in fact going to refer me to a specialist doctor for that. 

 

i experience cravings, and to cut the cravings down my doctor (and I) suggested using either naltrexone or amisulpriude which is a pure D2/D3 blocker. I tried the naltrexone and it was not effective, it made me feel more depressed and tired. However that could also be because of the depersonalised state that I have been in. Maybe when I recover form that, I could tolerate it better.

 

Anyway, we may try amisulpride next, but could these medications make the blank mind worse? Do you know what can be done?

 

It's really messed up how bad I feel. I wake up every hour or so, feeling an extreme kind of emotional/psychological pain. It is absolutely horrible. I have no drive, motivation, internal monologue or sense of being in my own body. I  also have body distortions, like it feels that the top of my head has been horizontally removed, sort of like an open coconut. Sadly, it feels like my IQ has dropped. 

Edited by Quaker32, 22 February 2017 - 09:56 AM.

[Blanker]

Keep reporting back guys some very useful information here.

Been taking NSI-189 and just reinstated florouxetine both at 1x 20mg daily.


The confusing part of.this delemir in my case is the fact and addition of setraline cold turkeys multiple times over the interval of decline.

I can relate directly with what.you are saying Quaker and I am also very intrigued in trying the amitriptyline/zoloft combo even in rregards to zoloft being useless and having such a bad experience with it following first few months usage.

I also hate that hollow headed feeling of disorientation Quaker it sucks major nut.

Hope for the best this information had the potential at least this combo to be miraculous. It seems I have become hypersensitive to mostly anything I put in my body, all drugs seem to have mostly negative reactions maybe symbolizing a cns.issue I do not know.
Have you guys considered therapy from a dissociation specialist I feel it could be really useful in our instances. I just hope I'm not ringed from cold turkeys on ssri.

[Blanker]

I think seeing a specialist In dissociation would be a wise move as well can't seem to find one or at least It is difficult in New Zealand.

I hope to God SSRI"s don't exaggerate or produce long term or even permanent damage due to oxidation or retardation of neuronal axons. And being so young I guess genetic expression of neuroplasticity as well I think I read regarding prozac.

[Blanker]

Also regarding Michael the Anhedonic about schizophrenia, should enlarged ventricles on MRI determine negative shizo as well as you were saying you had positive symptoms etc.

I am wondering best way to get referred for MRI but I heard they are very expensive taking insurance out of the equation.

[Blanker]

I tried methylphenidate for this Michael and it seemed to make me more spaced and worse but allowed me to be more talkative etc.

Never removed the blank mind hmm so shizo might not be the culprit. So to what level does methylphenidate work for you, completely restores your emotions and normal train of thought? No hollow spaced dp/dr type feelings? Very intrigued.

You also were the guy that tried dexmethylphenidate right? Difference from methylphenidate in experience?

Also I wonder how long have you been searching to cure this online for? And what have you tried?

Edited by Destroyedbeing, 22 February 2017 - 10:40 AM.

[sentics]

just a single anecdote but sounding good, also i think it's nice to have SRI and NRI with one compound. of course there's effexor but from what i read Clomaprimine (anafrinil) doesn't make you antsy like effexor does:

 

 

"I recovered! With the help of the medication clomipramine (Anafranil)"

 

http://www.dpselfhel...et-jeff-abugel/

Edited by sentics, 22 February 2017 - 02:52 PM.

[MichaelTheAnhedonic]

I tried methylphenidate for this Michael and it seemed to make me more spaced and worse but allowed me to be more talkative etc.

Never removed the blank mind hmm so shizo might not be the culprit. So to what level does methylphenidate work for you, completely restores your emotions and normal train of thought? No hollow spaced dp/dr type feelings? Very intrigued.

You also were the guy that tried dexmethylphenidate right? Difference from methylphenidate in experience?

Also I wonder how long have you been searching to cure this online for? And what have you tried?

 

Nah, I didn't tried dexMPH. It's not even available in my country. Anyway, I've never experienced positive symptoms if you are talking about hearing voices, delusions and hallucinations. Well, there was a 1 or 2 hallucinations when I was a child but I really don't know what caused it. Maybe from flu, maybe it was a dream but a dream wouldn't last so long in my memory I think. MPH doesn't restore all emotions but it restores ability to think, concentrate, feel more pleasure from activity, decreases my apathy in general. How long I'm like this? It has been almost 6 years. I'm 21, first symptoms started when I was 15. Really. I noticed very slight difference in my behaviour after stressful situation involving gf and a friend. So far, no luck. Docs are completely ignorant idiots in my case. I've proven that I'm right regarding what it might be. They were declaring to me that it's probably personality disorder, psychological thing. And I called it bullshit. But what can I do alone againts docs who completed their education? So, I decided to wait more time and got an MRI from neurologist. Bang! The results are the proof that's something more is happening and it's not a psychological phenomena! Currently waiting for hospitilization and further investigation of my case.

Edited by MichaelTheAnhedonic, 23 February 2017 - 01:45 AM.