20 replies to this topic

[jpars82]

Hey everyone,

It's been a long time since I've posted here. Anyways, has anyone else ever tried Trivastal(piribedil)? I tried it for the first time today. I've noticed better concentration, improvement with information processing, verbal fluency, etc. It's completely different than any other dopamine agonist I've tried. Hopefully, the effects continue. Has anyone had experience with it?

[dr feelwell]

Yes, I've been using Trivastal (piribedil) for quite some time, and have to say its the best dopaminergic drug out there, without side-effects. Pretty much same effects as yours + libido over the roof ;-)

[catshmat]

Where is this obtained?

[johnmk]

I second that question.

[FunkOdyssey]

Looks interesting...

Psychomotor and cognitive effects of piribedil,
a dopamine agonist, in young healthy volunteers
by
Schuck S, Bentue-Ferrer D, Kleinermans D,
Reymann JM, Polard E, Gandon JM, Allain H.
Laboratoire de Pharmacologie Experimentale et Clinique,
Universite de Rennes I - Faculte de Medecine,
CS 34317, 35 043 Rennes cedex, France.
Fundam Clin Pharmacol. 2002 Feb;16(1):57-65

ABSTRACT

    Piribedil is a dopamine agonist acting on D2 and D3 central nervous system dopamine receptors. This drug has been administered to 12 young healthy male volunteers (age 22 +/- 2 years) according to a single center randomized, double-blind, two ways cross-over, placebo controlled trial, including a washout period of one week. Placebo and piribedil were administered by a single intravenous infusion over 2 h (3 mg). Psychomotor performance and cognitive functions were assessed through a standardized and computerized psychometric tests battery and a continuous electroencephalogram (EEG) mapping. Piribedil improved simple reaction time (P=0.02), immediate (P=0.045 and 0.004), and delayed free recall (P=0.05), dual coding test (P=0.02) and increased theta and fast beta waves on the EEG (P < 0.05 and 0.001, respectively). No deleterious effect was observed on the tests exploring attention and concentration via the other procedures. It is concluded that a single intravenous perfusion of piribedil 3 mg improves alertness and the information processing speed within the central nervous system, in healthy volunteers.

[jpars82]

I thought I'd add that it also is an antagonist of presynaptic a2-adrenoreceptors enhancing central noradrenergic transmission. I obtained it through: http://www.1drugstore-online.com

http://www.bbonlinepharmacy.com also has a decent price but I haven't tried order from here yet.

[benson123]

are there any side effects with this drug?

[benson123]

would Trivastal be considered a stimulant?

[benson123]

What is the most effective dose?

[johnmk]

Dopamine receptor agonism could in fact be more sedative than stimulating. Dopamine receptor agonists have historically been explored for blood pressure reduction effects, in fact (hydergine, for example). This particular effect has proven small so it's not used for that purpose anymore, generally. There are other mechanisms to increase dopaminergic neurotransmission -- anything that involves directly increasing neurotransmitter in the synaptic cleft will generally be stimulating. Receptor agonists don't do that. Methylphenidate et al. will be stimulating.

[jpars82]

Yeah, I've found most dopamine agonists to be somewhat sedating(Mirapex, Bromo, Cabergoline). I don't notice any sedating effect with Trivastal though. I think it's because of the additional noradrenergic properties. I'm interested to hear if other people have a similar experience.

[opales]

Dunno if anyone has seen this already but here is a chart comparing different DAs, found through M&M

http://www.medscape....439737_tab.html

[benson123]

Can Trivastal be taken when needed or does it have to be taken continuosly?

[edward]

Any update on Trivastal (Piribedil). Anyone else tried this recently. Any of those who tried it before still take it?

[edward]

Anybody?... mmm I guess this is one of those really obscure nootropics that went out of fashion and no one still takes it.

Edited by edward, 05 June 2008 - 03:04 AM.

[desperate788]

Hey everyone,

It's been a long time since I've posted here. Anyways, has anyone else ever tried Trivastal(piribedil)? I tried it for the first time today. I've noticed better concentration, improvement with information processing, verbal fluency, etc. It's completely different than any other dopamine agonist I've tried. Hopefully, the effects continue. Has anyone had experience with it?

Piribedils effect on concentration cumulative or is it a instant concentration enhancer?

[tjcbs]

I tried trivestal briefly, and I HATED it. Both times I tried it I descended into a hopeless depression-like feeling which lasted for the rest of the day. I lied huddled under blankets shivering on my couch, eating take out food with a kind of desperation. To each his own, I have 27 tablets left if anyone (US preferred) wants to take them off my hands for $45 shipping included.

[jacobjerondin]

It's absolutely insane how much reports on this one vary - either people love it or they hate it, as seen in this thread. It's a partial dopamine agonist, so it's quite a bit safer than a full dopamine agonists. I'm very much considering trying it given how promising some of the reports seem to be.

 

Anyone have any new updates to share about this stuff? Any information would be highly appreciated

[John250]

What benefit would this have over Ropinirole?

[jacobjerondin]

What benefit would this have over Ropinirole?

I've considered that question very carefully John. My answer is that 1) it is an alpha 2 receptor antagonist which counteracts the sleepiness and sleep attacks that dopamine agonists including ropi are known for. The way I found out about Piribedil is through someone on the social anxiety support forum saying that it didn't give them sleep attacks like ropi did. 2) It's only a partial dopamine agonist (like hydergine) which seems it should be much safer to use long term without risking the notoriously terrible (and potentially permanent) DAWS.

[John250]

I've considered that question very carefully John. My answer is that 1) it is an alpha 2 receptor antagonist which counteracts the sleepiness and sleep attacks that dopamine agonists including ropi are known for. The way I found out about Piribedil is through someone on the social anxiety support forum saying that it didn't give them sleep attacks like ropi did. 2) It's only a partial dopamine agonist (like hydergine) which seems it should be much safer to use long term without risking the notoriously terrible (and potentially permanent) DAWS.

Very interesting I did not consider the lethargy part. So then what benefit with this drug have opposed to Selegiline?