52 replies to this topic

[Major Legend]

I assume a lot of people haven't tried Cerebrolysin because it needs to be injected and is insanely costly.

 

I'm not joking when I say i've probably tried every single damn nootropic, supplement. In fact I've been doing this for like 10 years...

 

So I have a stack partially based off Heisenberg on this forum. I use NSI-189, Fasoracetam, amongst many other things. I haven't changed my stack much for the last 2-3 years.

 

Like many people I had never considered Cerebrolysin because I have never injected myself with anything yet.

 

A few days ago I saw my local pharmacy had Memoprove in stock, which I did more research in which I found rave reviews for Cerebrolysin, but also

for Memoprove which has N-PEP-12 , a isolated peptide of the main active pharmaceutical in Cerebrolysin, the tablet itself is enteric coated.

 

I was doubtful it would work and then it did.

 

There had been one thing that I have been unable to get from my current nootropic stack - the feeling of youth. I always feel slow these days

compared to when I was 18-20, I always look back and wish I could get that kind of mental energy back, the way I wouldn't get tired at night and

want to go home. 

 

Cerebrolysin brought it back, this enthusiasm and mental speed, and youthful positive energy, and not being mentally tired so easily. I flew through my 

work which in the past would have shattered me, and I chatted up a 23 year old girl whilst walking home, I was mentally quick and positive, she loved it.

It was like when I was 20 again, I could just feel this youthful mental energy all over me.

 

The only problem is COST, this stuff is really really expensive, but man - it feels like a brain hormone increase (whatever that is). I guess you could say

it's what you wished Testosterone would be like for the brain.

 

So...I am thinking about injections.

 

(I am not on it as I type this, in case you are thinking it isn't written very well, I am about to sleep lol)

 

Warning: Intransal has a lot of strange adverse effects with Cerebrolysin, just in case people think intranasal would work. You can google this.

 

 

Edited by Major Legend, 17 January 2017 - 04:38 PM.

[Major Legend]

Just wanted to add I used a Memoprove product from a Austria company called Ever Pharma, my understanding is the formulation is different from the US version. 

 

I was also taking like 3 spread out over the day, each time the effects will magnify, but if I take it together it would be too much a give me a small headache. So 3 X 90mg . Which is very expensive.

Edited by Major Legend, 17 January 2017 - 04:42 PM.

[monowav]

have you done any tests to see if you developed antibodies CNTF? 

[Major Legend]

have you done any tests to see if you developed antibodies CNTF? 

 

Nope, why?

[resveratrol_guy]

Major Legend, to be clear, you're actually taking (oral) Memoprove, not (injectable) Cerebrolysin, depsite the title of this thread. You attribute your surprising results to N-PEP-12 (science paper here), which is the component common to both.

That would be interesting, because a few years back, Ceretropic was selling P21, another Cerebrolysin derivative. It generated some interest here on Longecity as a result of promising research, but then it suddenly became unavailable. I can see that it's once again available over there, as injectable and intranasal. My guess is that taking both Memoprove and P21 would result in a synergistic neurotrophic effect without the dubious ramifications of injecting what is literally pig brain extract. The thread is worth a read, though, because P21 caused some problems.

As long as we're on a neurotrophic roll here, why not throw in intranasal insulin as well?

Personally, if I were to try this, I would want to be on a very strict diet supplemented with NSAIDs and/or Longvida, because the last thing I would want to do is create new neurons in a polluted environment.

Anyway please keep us informed on your progress. Maybe you're really pushing neurogenesis and/or synaptogenesis. Or maybe you're just doing some temporary trick with neurotransmitters that will soon disappear thanks to homeostasis. Or, even worse, you might be burning something out like in all those piracetam anecdotes around here. In any event, you have my sincere appreciation for being such a bold guinea pig.
 

[Major Legend]

Major Legend, to be clear, you're actually taking (oral) Memoprove, not (injectable) Cerebrolysin, depsite the title of this thread. You attribute your surprising results to N-PEP-12 (science paper here), which is the component common to both.

That would be interesting, because a few years back, Ceretropic was selling P21, another Cerebrolysin derivative. It generated some interest here on Longecity as a result of promising research, but then it suddenly became unavailable. I can see that it's once again available over there, as injectable and intranasal. My guess is that taking both Memoprove and P21 would result in a synergistic neurotrophic effect without the dubious ramifications of injecting what is literally pig brain extract. The thread is worth a read, though, because P21 caused some problems.

As long as we're on a neurotrophic roll here, why not throw in intranasal insulin as well?

Personally, if I were to try this, I would want to be on a very strict diet supplemented with NSAIDs and/or Longvida, because the last thing I would want to do is create new neurons in a polluted environment.

Anyway please keep us informed on your progress. Maybe you're really pushing neurogenesis and/or synaptogenesis. Or maybe you're just doing some temporary trick with neurotransmitters that will soon disappear thanks to homeostasis. Or, even worse, you might be burning something out like in all those piracetam anecdotes around here. In any event, you have my sincere appreciation for being such a bold guinea pig.
 

 

Correct, this was also lead from the fact that I had read from a Longecity post somewhere with a user called sunshine that he experienced both and the effects were vastly similiar.

 

There are also some horror stories on reddit regarding intranasal cerebrolysin (or P21), there doesn't seem to be the same level of glowing accounts from my quick reading from intranasal cerebrolysin, apart from causing side effects and perhaps damage to the membranes in the nose. https://www.reddit.com/r/Nootropics/comments/3i90ek/for_those_whove_tried_it_how_does_cerebrolysin/

 

The traditional consensus is that peptides don't deal well with adsorption, but there is obviously a lot we don't know about these membranes, for example intranasal shouldn't really deliver to the brain due to the huge size of certain peptides, yet there is ample evidence to suggest it does cross the BBB

 

I doubt it is neurogenesis, the effects wouldn't be that quick and at any rate it didn't feel like NSI-189, which does feel like neurogenesis (complete with forgetting old things in exchange for learning new things quicker). 

 

It's more likely in my view to simply substitute for the brain hormones lost due to the natural process of aging, perhaps there are neurogenesis effects in the long term ( some previous anecdotal have mentioned permanent improvements)

 

In terms of injection pig brain extract could be risky (prions and all that), though I haven't read of any bad reports yet. I'm in two minds about injections, I also can't imagine buying 31 needles every month to do it, however Memoprove is unaffordable.

 

Also I would add that intranasal is very limited in terms of delivery, it would be very hard to deliver 90mg intranasally, I find the intranasal sprays probably the reason why people don't feel anything from it.

 

In fact at 90mg the effects are only slight brightening in brain facilities, but the anti-fatigue effects are pretty amazing. So you have to go to 180mg 270mg to really get the super effects I was experiencing.

 

Everyone is different though, so can't say my experience will be the same as others.

 

P21 definitely isn't what I am taking - https://www.reddit.com/r/Nootropics/comments/3502d3/has_any_ever_tried_p21_from_ceretropic_did_you/

Edited by Major Legend, 17 January 2017 - 06:12 PM.

[BlueCloud]

"Correct, this was also lead from the fact that I had read from a Longecity post somewhere with a user called sunshine that he experienced both and the effects were vastly similiar."

This thread maybe ? : http://www.longecity...ried-memoprove/

[Izan]

any increase in libido? and memory enhancement?

[Major Legend]

"Correct, this was also lead from the fact that I had read from a Longecity post somewhere with a user called sunshine that he experienced both and the effects were vastly similiar."

This thread maybe ? : http://www.longecity...ried-memoprove/

 

Yes I believe that was the thread. I am not sure if sunshine stayed on it or not. Longecity turns out to be still be one of the best source for information about nootropics, simply because of its vast archives.

[Major Legend]

any increase in libido? and memory enhancement?

 

Certainly, libido is much easier to come across when you have mental energy in the first place   I would say the youthful mental energy contributes to improved libido, as a secondary effect though, not primary. Since I am a pervert anyways I think it just enhances my attraction to the opposite sex more, rather than actually give me a hard-on...

 

In terms of memory, recall feels improved but mainly on medium to long-term memory, I don't detect any improvements in working memory (as I still rely on vast amounts of paper to stay on top of my business) (it's a tough one to crack), though of course a reduction of mental fatigue makes recall seemingly easier anyways. I think a lot of N-PEP-12's effects can be attributed to fatigue reduction in the short term anyways (which is often a symptom of reduced brain function), though the effects feel very hormone like and nothing like Amphetamines or caffeine.

 

I have been learning Javascript / Node.js / React.js and Meteor and I do feel my recall of things learned is much better, like I can remember the code clearer, though I don't think it works to improve your ability to pattern recognize or solve problems like Coloracetam or Fasoracetam or Noopept. Mental clarity, and heightened mental speed and and quality of observation would be more an apt description. I think it's easier to say it made me feel like when I was 19 and bursting with jokes, enthusiasm and ideas rather than try to describe the exact effects which is harder because it isn't exactly like a stimulant or nootropic - it's something else.

 

This is highly subjective though, it would also be hard to prove as I am always on nootropics - I guess I will measure this in the progress I make in my business and ability to make apps/websites by the end of the year.

 

Oh caffeine is greatly elevated on it, to the point that coffee is just way too much, which is very weird since i've long been intolerant to even 3 shots of coffee, so I can't imagine what that would be like since 1 cup of English breakfast tea works incredibly on N-PEP-12.

Edited by Major Legend, 18 January 2017 - 02:02 AM.

[resveratrol_guy]

Thanks for the additional details. First of all, I don't think that rapid effects preclude neurogenesis. For instance, Longvida improves memory within hours, but induces neurogenesis over several weeks in rat studies.

 

Secondly, you might consider following the Bredesen Protocol for dementia prevention for a synergistic effect, even if you're unwilling to try intranasal insulin. Lostfalco introduced us to this video on his thread:

 

It would be a shame if you performed such a remarkable feat in one facet of brain function, only to leave other areas neglected, thereby undermining your longterm improvement.

[Baten]

Just wanted to add I used a Memoprove product from a Austria company called Ever Pharma, my understanding is the formulation is different from the US version. 

 

I was also taking like 3 spread out over the day, each time the effects will magnify, but if I take it together it would be too much a give me a small headache. So 3 X 90mg . Which is very expensive.

 

How expensive, exactly? Anyway to order this through the web? Sure sounds very promising.

[Plasticperson]

Has anyone tried p21?

[jack black]

are we talking about this?

http://www.memoprovememory.com/

$50+S&H/30 doses.

[Major Legend]

I'm not sure if it's the same thing, box is definitely different i paid about 70usd, mine is from ever pharma
... i think it might be the same thing even the box is different

[theCLK]

MajorLegend, on the link connected to your stack - it just reroutes to this page - what is your stack, i'm intrigued..

[resveratrol_guy]

Has anyone tried p21?

Yes. sunshinefrost, for one, seems to have done so.

[Major Legend]

MajorLegend, on the link connected to your stack - it just reroutes to this page - what is your stack, i'm intrigued..

 

My stack is Fasoracetam 100mg, NSI 189 30mg, Noopept 20mg (all Sublingual) , Wellbutrin 300mg, Nicotine Lozenge 3x a day (only 3 days a week - Monday, Tuesday and Wednesday). I will cycle to VPX redline extreme (preworkout drink) on thursdays and onward, and take a complete break from everything on Sunday. 

 

On top of this for socialising and anti-anxiety I use Khemcorp's Oxytocin Nasal Spray and sometimes Sublingual Propranolol solution (which I use for sleep also sometimes instead of Melatonin).

 

I also take 30mg Memantine everyday for anti-tolerance...I am not really sure if I am taking real Memantine though, as I can't really feel its effects, but you get paranoid about Nicotine tolerance which is why I am on it.

 

Every Monday I will spend an hour on functional programming exercises to get my brain going.

 

I did use to have Colouracetam and C60 in there, but I dropped it because it was too much work to take, and C60 has a whole bunch of safety concerns. Heisenberg's stack also contained methylene blue I think. It is very good and like he advised I mix my own solution using a magnetic stirrer.

 

I take a daily supplement of Astaxanthin and Life Extension Liver Efficiency (which contain extramel for anti-fatigue), I have a ton of other extreme measures for my Eczema and chronic inflammation but its not applicable to cognitive use.

 

At night DIM, DHEA 200mg, ZINC 30mg and Nettle Root Extract for Testosterone, before I am old enough and can afford TRT...

 

With my newly added N-PEP-12 I have phenomenal energy, I worked all day yesterday, went to a pub crawl, went to a design workshop for 2 hours (where I chatted up another girl and got her number) partied till 4am with uni students, danced like crazy ( felt good all the way) and woke up today fresh...amazing! I feel no fatigue nor hangover.

 

Edited by Major Legend, 20 January 2017 - 08:49 AM.

[warmerdam]

[...] Or, even worse, you might be burning something out like in all those piracetam anecdotes around here. [...]

 

Sorry for off-topic, but could you please point me to these "burning something piracetam anecdotes"... I looked but could not find them.
 

Thank you

[resveratrol_guy]

 

[...] Or, even worse, you might be burning something out like in all those piracetam anecdotes around here. [...]

 

Sorry for off-topic, but could you please point me to these "burning something piracetam anecdotes"... I looked but could not find them.
 

Thank you

 

 

Ha! You're not the first to ask me about this. If you do a local search for "piracetam burnout" or "experience" or "brain fog" you'll find a number of anecdotes from people who claim it worked for a while, say a few months, then left them irreversibly dumbed down. It's not as simple as it sounds, of course: there are also strategies which attempt to avert the burnout (chronic cessation, metabolic support, etc.), theories as to why it occurs (e.g. translocation of choline to the forebrain, thereby starving the postcortical region), and theories as to which of the zillion paracetam analogs are magical and thus not susceptible to burnout. Then of course there are folks who never claim to have had a problem. In all the noise, the only firm conclusion to be made is that this family of drugs is riddled with red flags, but deserves further research because it does work very well in certain circumstances.

 

This is one reason that I find cerebrolysin peptides to be a safer proposition: they're narrowly defined and don't suffer from the analog zoo situation that we have in the racetams.

[Major Legend]

ummm long story short, some guy claimed taking megadosing Piracetam (4000mg+) has great effects, and lots of people tried it and turned out it does...for a while induce some kind of hypomania anyways, it was all very good until tolerance developed to Piracetam and they crashed...the Piracetam became less and less effective over time, however I am not aware that the Piracetam did any lasting damage to anyone involved compared to some of the more dangerous drugs tried here (dopamine agonists). As far my experience goes, I tried this for a while and tolerance to Piracetam develops rapidly, like any other drug, not sure if it applies to other racetams, but certainly that was the experience of most people. Noopept is far better and consistent anyways.

[jack black]

MajorLegend, on the link connected to your stack - it just reroutes to this page - what is your stack, i'm intrigued..

My stack is Fasoracetam 100mg, NSI 189 30mg, Noopept 20mg (all Sublingual) , Wellbutrin 300mg, Nicotine Lozenge 3x a day (only 3 days a week - Monday, Tuesday and Wednesday). I will cycle to VPX redline extreme (preworkout drink) on thursdays and onward, and take a complete break from everything on Sunday.

On top of this for socialising and anti-anxiety I use Khemcorp's Oxytocin Nasal Spray and sometimes Sublingual Propranolol solution (which I use for sleep also sometimes instead of Melatonin).

I also take 30mg Memantine everyday for anti-tolerance...I am not really sure if I am taking real Memantine though, as I can't really feel its effects, but you get paranoid about Nicotine tolerance which is why I am on it.

Every Monday I will spend an hour on functional programming exercises to get my brain going.

I did use to have Colouracetam and C60 in there, but I dropped it because it was too much work to take, and C60 has a whole bunch of safety concerns. Heisenberg's stack also contained methylene blue I think. It is very good and like he advised I mix my own solution using a magnetic stirrer.

I take a daily supplement of Astaxanthin and Life Extension Liver Efficiency (which contain extramel for anti-fatigue), I have a ton of other extreme measures for my Eczema and chronic inflammation but its not applicable to cognitive use.

At night DIM, DHEA 200mg, ZINC 30mg and Nettle Root Extract for Testosterone, before I am old enough and can afford TRT...

With my newly added N-PEP-12 I have phenomenal energy, I worked all day yesterday, went to a pub crawl, went to a design workshop for 2 hours (where I chatted up another girl and got her number) partied till 4am with uni students, danced like crazy ( felt good all the way) and woke up today fresh...amazing! I feel no fatigue nor hangover.

Wow. That's a massive stack. How long have you been taking npep12?

[Major Legend]

 

 

MajorLegend, on the link connected to your stack - it just reroutes to this page - what is your stack, i'm intrigued..

My stack is Fasoracetam 100mg, NSI 189 30mg, Noopept 20mg (all Sublingual) , Wellbutrin 300mg, Nicotine Lozenge 3x a day (only 3 days a week - Monday, Tuesday and Wednesday). I will cycle to VPX redline extreme (preworkout drink) on thursdays and onward, and take a complete break from everything on Sunday.

On top of this for socialising and anti-anxiety I use Khemcorp's Oxytocin Nasal Spray and sometimes Sublingual Propranolol solution (which I use for sleep also sometimes instead of Melatonin).

I also take 30mg Memantine everyday for anti-tolerance...I am not really sure if I am taking real Memantine though, as I can't really feel its effects, but you get paranoid about Nicotine tolerance which is why I am on it.

Every Monday I will spend an hour on functional programming exercises to get my brain going.

I did use to have Colouracetam and C60 in there, but I dropped it because it was too much work to take, and C60 has a whole bunch of safety concerns. Heisenberg's stack also contained methylene blue I think. It is very good and like he advised I mix my own solution using a magnetic stirrer.

I take a daily supplement of Astaxanthin and Life Extension Liver Efficiency (which contain extramel for anti-fatigue), I have a ton of other extreme measures for my Eczema and chronic inflammation but its not applicable to cognitive use.

At night DIM, DHEA 200mg, ZINC 30mg and Nettle Root Extract for Testosterone, before I am old enough and can afford TRT...

With my newly added N-PEP-12 I have phenomenal energy, I worked all day yesterday, went to a pub crawl, went to a design workshop for 2 hours (where I chatted up another girl and got her number) partied till 4am with uni students, danced like crazy ( felt good all the way) and woke up today fresh...amazing! I feel no fatigue nor hangover.

Wow. That's a massive stack. How long have you been taking npep12?

 

It's my third week now and I don't take it daily as it would be too expensive, the effects are rather instantaneous so I can just take it as I need.

 

As for my massive stack, it's not massive if you consider the fact that I only take the majority of it for 3 days a week, and take a full break every Sunday. I've learned from experience that the likelihood of anything to stop working due to tolerance/homeostasis is very high for almost every class of psychotropic.

Hence the need to cycle and to use different pathways instead of just one.

 

I am now interested in HDAC inhibitors maybe once a week to get rid of my long fear of successful/high value people.

[theCLK]

 

I am now interested in HDAC inhibitors maybe once a week to get rid of my long fear of successful/high value people.

 

 

How are you approaching that? Dosage and of what! Vorinostat? 

[Major Legend]

 

 

I am now interested in HDAC inhibitors maybe once a week to get rid of my long fear of successful/high value people.

 

 

How are you approaching that? Dosage and of what! Vorinostat? 

 

 

I'm still thinking about it...I posted questions on the Vorinostat thread. The fear removal sounds really interesting and novel, but about as interesting as the concern of using a drug that's supposedly for cancer (stopping cell cycles at higher dosages).

 

It seems that the consensus is to not go over 50mg.

[sunshinefrost]

 

Has anyone tried p21?

Yes. sunshinefrost, for one, seems to have done so.

 

 

i did try it, thinking it would match cerebrolysin's benefits,  and i noticed something wrong with it right at first try. I felt burning sensation as soon as it entered my body. I suspect that the vial may have been infected because it felt like i was squirting vinegar inside my body. Did anyone else experienced issues with ceretropic's products ?

 

This is one of the first posts i'm doing since a few years.  i had a brutal battle with mold exposition because of a water-damaged building. I bacame hyper sensitive to mold and had to buy another house, I lost interest in many aspect of my life but slowly healing from it.  

Edited by sunshinefrost, 23 January 2017 - 09:44 PM.

[Major Legend]

 

 

Has anyone tried p21?

Yes. sunshinefrost, for one, seems to have done so.

 

 

i did try it, thinking it would match cerebrolysin's benefits,  and i noticed something wrong with it right at first try. I felt burning sensation as soon as it entered my body. I suspect that the vial may have been infected because it felt like i was squirting vinegar inside my body. Did anyone else experienced issues with ceretropic's products ?

 

This is one of the first posts i'm doing since a few years.  i had a brutal battle with mold exposition because of a water-damaged building. I bacame hyper sensitive to mold and had to buy another house, I lost interest in many aspect of my life but slowly healing from it.  

 

 

I think they overplay the extent of their quality control, portraying the extreme sophistication of their processes, in reality I imagine like all other companies they have trouble being consistent when they receive constant barrage of orders on a huge variety of completely different chemicals batch after batch.

 

This is normal, afterall they are the go-to site for nootropics/enhancement chemicals these days. The sales volume of their network of sites must be gigantic, so lapses in quality control is highly possible.

I bought Memantine from Ceretropic for example, and it really didn't have the same effects as taking Sun Pharma tablets (Admenta), thats the extent of my experience.

 

I think P21 may have safety issues on its own, as you are not the only one to experience weird side effects when it is used nasally, it might be chemically active on other things.

 

Contaminated water would cause infections, not burning sensations, as far as I know Ceretropic uses bacteriostatic water, so I think the culprit is more likely to be P21 itself, which is why I think people should go for N-PEP-12 instead.

 

N-PEP-12 on the other hand is thoroughly tested, trialed and FDA approved.
 

[FW900]

Where are people buying Cerebrolysin nowadays, given that nootropic (or was it nootropics).eu is no more?

[resveratrol_guy]

N-PEP-12 on the other hand is thoroughly tested, trialed and FDA approved.

 

Yeah sorta kinda. Can you provide more info on your own experience? You said it acts quickly, although one study just looked at it 6 hours after dosing, and found memory performance improvement. How long does it last? Has it started to lose effect yet? What else have you noticed? Personally I can't help but see a similarity to PRL-8-53.

 

The only problem I have with these noots is that they might operate exclusively on a neurotransmitter level, as opposed to a trophic level. So in the end we have something like Prozac or Aricept, which makes you feel great and function OK while your neurodegeneration progresses under the table. At some point, the drugs no longer work, and the true extent of damage becomes suddenly apparent, in which case, it would have been better to have been aware of the steady deterioration, which might have alerted one to make more enduring improvements through other strategies.

 

OTOH, there is some connection between neurotransmitter activity and the induction of trophic processes. For instance, this is what dreaming is all about.  So in this sense, a potent but superficial patch might induce neurogenesis and synaptogenesis.

 

The question is... is N-PEP-12 superficial, or something more?

Edited by resveratrol_guy, 24 January 2017 - 06:10 AM.

[Major Legend]

 

N-PEP-12 on the other hand is thoroughly tested, trialed and FDA approved.

 

Yeah sorta kinda. Can you provide more info on your own experience? You said it acts quickly, although one study just looked at it 6 hours after dosing, and found memory performance improvement. How long does it last? Has it started to lose effect yet? What else have you noticed? Personally I can't help but see a similarity to PRL-8-53.

 

The only problem I have with these noots is that they might operate exclusively on a neurotransmitter level, as opposed to a trophic level. So in the end we have something like Prozac or Aricept, which makes you feel great and function OK while your neurodegeneration progresses under the table. At some point, the drugs no longer work, and the true extent of damage becomes suddenly apparent, in which case, it would have been better to have been aware of the steady deterioration, which might have alerted one to make more enduring improvements through other strategies.

 

OTOH, there is some connection between neurotransmitter activity and the induction of trophic processes. For instance, this is what dreaming is all about.  So in this sense, a potent but superficial patch might induce neurogenesis and synaptogenesis.

 

The question is... is N-PEP-12 superficial, or something more?

 

Dreams are definitely more vivid on N-PEP-12, I would emphasize vivid because they are far more detailed and clear, but not more emotional. 

Thats why I cycle and rarely take something all the time. 

I think it lasts about 6 hours actually, I think the anti-fatigue effects are the most prominent, notably not being tired in the evening, this effect is still there. Being able to function with little sleep.

The other new effect is similar to NSI-189, where I am learning things faster, but also losing some instinctual skills developed via age, it's like I am seeing the words more as they are, not as my years of experience tells me. It's hard to describe this kind of thing, it's a cool thing and also a bad thing at the same time.  (  have dropped NSI-189 off my stack)

 

It makes sense because I have a lot of old skills that are simply redundant in todays world, and if that gets replaced by more up to date skills that's fine for me.

For the mood effects(feeling young again) I mentioned in my first post, I pretty much figured out you need to take 3 tablets which is 270mg.

This is so expensive that there is no way I can take it as much as I want.

 

I don't feel my mental abilities or productivity has increased at all, rather I just feel being able to fully access them like you are when you wake up. 

I think tolerance is likely to develop (tolerance is complicated and not just about receptors), other aspects like physiological tolerance, psychological tolerance can be a factor.